• The Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China;
LiuChunli, Email: chunli@gird.cn
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Objective To explore whether nesiritide (recombinant human brain natriuretic peptide, rh-BNP) could be used to treat pulmonary artery hypertension. Methods A 34-year-old female patient with severe symptomatic idiopathic pulmonary artery hypertension was reported, who was refractory to routine therapies, including prostacyclin. Therapy with continuous nesiritide infusion resulted in significant decrease in pulmonary vascular resistance and an improvement in dyspnea. The relevant literature was reviewed. Results The clinical symptoms of this patient relieved significantly after nesiritide therapy. Literature review showed that nesiritide could increase the production of nitrogen oxides and cyclic guanosine monophosphate in the body, so as to dilate the vessels which were shrunk due to hypoxia and low down the pulmonary vascular resistance. Conclusion Nesiritide is useful to treat severe pulmonary artery hypertension, and combination with phosphodiesterase type-5 inhibitors may be a brand new therapy of value.

Citation: WuLulu, ZhouYing, ZhangNuofu, LiuChunli. Reversibility of Medically Unresponsive Idiopathic Pulmonary Artery Hypertension with Nesiritide:One Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(6): 592-595. doi: 10.7507/1671-6205.2015142 Copy

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