青蒿琥酯在肺部疾病的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

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骆琼珍 ¹ ,  林江涛 ²

1. ;
2. ;

Corresponding author：

林江涛, Email: jiangtao_l@263.net

Keywords：

DOI：

10.7507/1671-6205.2015147

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Citation： 骆琼珍, 林江涛. 青蒿琥酯在肺部疾病的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(6): 611-614. doi: 10.7507/1671-6205.2015147 Copy

1.	Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol,2014,15:544.
2.	Ndour PA, Lopera-Mesa TM, Diakité SA, et al. Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J Infect Dis,2015,211:290-297.
3.	Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-a-induced production of proinflammatory cytokines via inhibition of NF-kB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology,2007,46:920-926.
4.	Shahbazfar AA, Zare P, Ranjbaran M, et al. A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines. J Cancer Res Ther,2014,10:1057-1062.
5.	Saeed ME, Kadioglu O, Seo EJ, et al. Quantitative structure-activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1. Anticancer Res,2015,35:1929-1934.
6.	Liu L, Zuo LF, Zuo J, et al. Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep,2015,12:1465-1472.
7.	Xu Y, Liu W, Fang B, et al. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases. Eur J Pharmacol,2014,744:1-9.
8.	He R, Forman M, Mott BT, et al. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety. Antimicrob Agents Chemother,2013,57:4208-4214.
9.	Edwards BK, Noone AM, Mariotto AB, et al. Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer,2014,120:1290-1314.
10.	Lin JJ, Lake J, Wall MM, et al. Association of patient-provider communication domains with lung cancer treatment. J Thorac Oncol,2014,9:1249-1254.
11.	Zhao Y, Jiang W, Li B, et al. Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int Immunopharmacol,2011,11:2039-2046.
12.	Sequist LV, Bell DW, Lynch TJ, et al. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol,2007,25,587-595.
13.	Ma H, Yao Q, Zhang AM, et al. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.Molecules,2011,16:10556-10569.
14.	张祖贻,余世庆,苗立云,等.青蒿琥酯联合NP方案治疗中晚期非小细胞肺癌的随机对照研究.中西医结合学报,2008,6:134-138.
15.	Zhou C, Pan W, Wang XP, et al. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J Cell Physiol,2012,227:3778-3786.
16.	苗立云,张祖贻.青蒿琥酯选择性抗肺腺癌细胞的作用及机制.现代医学,2006,34:15-17.
17.	Bao F, Yuan P, Yuan X, et al. Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cance. J Thorac Dis,2014,6:1697-1703.
18.	Rasheed SA, Efferth T, Asangani IA, et al. First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer, 2010,127:1475-1485.
19.	Bergmann KC. Asthma. Chem Immunol Allergy,2014,100:69-80.
20.	Bice JB, Leechawengwongs E, Montanaro A. Biologic targeted therapy in allergic asthma. Ann Allergy Asthma Immunol,2014,112:108-115.
21.	Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One,2011,6:e20932.
22.	Tan SS, Ong B, Cheng C. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol,2014,50:451-458.
23.	Ho WE, Cheng C, Peh HY, et al. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. Free Radic Biol Med,2012,53:498-507.
24.	黄发军,詹光杰,张宏.青蒿琥酯对哮喘大鼠肺组织TLR-4及TGF-β₁表达的影响.中国医药生物技术,2011,6:266-269.
25.	陈磊.青蒿琥酯对哮喘大鼠模型治疗作用的实验研究.2009(学位论文).
26.	Ng DS, Liao W, Tan Ws, et al. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine,2014,21:1638-1644.
27.	Yao H, Hwang JW, Sundar IK, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol,2013,305:L615-L624.
28.	Atkinson JJ, Lutey BA, Suzuki Y, et al. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med,2011,183:876-884.
29.	Magenta D, Sangiovanni E, Basilico N, et al. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop,2014,140:77-83.
30.	Geramizadeh B, Jowkar Z, Karami L, et al. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iran Red Crescent Med J,2013,15:e7508.
31.	Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med,2008,178:592-604.
32.	Louhelainen N, Myllarniemi M, Rahman I, et al. Airway biomarkersof the oxidant burden in asthma and chronic obstructive pulmonary dis-ease:current and future perspectives. Int J Chron Obstruct Pulmon Dis,2008,3:585-603.
33.	Li HX, Wang HL, Wang HJ, et al. Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis. Eur Rev Med Pharmacol Sci,2014,18:3199-3204.
34.	许光兰,梁劲松,以敏,等.青蒿琥酯对肺纤维化大鼠肺组织转化生长因子β₁的影响.广西医科大学学报,2008,25:400-403.
35.	许光兰,陈平,梁劲松,等.青蒿琥酯对实验性肺纤维化大鼠治疗作用及其机理研究.临床医学工程,2009,16:6-8.
36.	王昌明,张孝飞,谭宁,等.青蒿琥酯对人胚肺成纤维细胞系HFL-1细胞增殖、凋亡的影响及机制.山东医药,2010,50:33-35.
37.	Ding DW, Zhang YH, Huang XE, et al. Bufalin induces mitochondrial pathway-mediated apoptosis in lung adenocarcinoma cells. Asian Pac J Cancer Prev,2014,15:10495-10500.
38.	王昌明,黎洪秀,张孝飞,等.Fas及FasL和Caspse-3在青蒿琥酯诱导人胚肺成纤维细胞凋亡中的表达.中国组织工程研究与临床康复,2011,15:3785-3788.
39.	孙艳辉.青蒿琥酯对百草枯致大鼠肺损伤机制的干预性研究.2011(学位论文).
40.	孙沥.百草枯中毒大鼠血清细胞因子的动态变化及青蒿琥酯的干预.2011(学位论文).

1. Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol,2014,15:544.
2. Ndour PA, Lopera-Mesa TM, Diakité SA, et al. Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J Infect Dis,2015,211:290-297.
3. Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-a-induced production of proinflammatory cytokines via inhibition of NF-kB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology,2007,46:920-926.
4. Shahbazfar AA, Zare P, Ranjbaran M, et al. A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines. J Cancer Res Ther,2014,10:1057-1062.
5. Saeed ME, Kadioglu O, Seo EJ, et al. Quantitative structure-activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1. Anticancer Res,2015,35:1929-1934.
6. Liu L, Zuo LF, Zuo J, et al. Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep,2015,12:1465-1472.
7. Xu Y, Liu W, Fang B, et al. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases. Eur J Pharmacol,2014,744:1-9.
8. He R, Forman M, Mott BT, et al. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety. Antimicrob Agents Chemother,2013,57:4208-4214.
9. Edwards BK, Noone AM, Mariotto AB, et al. Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer,2014,120:1290-1314.
10. Lin JJ, Lake J, Wall MM, et al. Association of patient-provider communication domains with lung cancer treatment. J Thorac Oncol,2014,9:1249-1254.
11. Zhao Y, Jiang W, Li B, et al. Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int Immunopharmacol,2011,11:2039-2046.
12. Sequist LV, Bell DW, Lynch TJ, et al. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol,2007,25,587-595.
13. Ma H, Yao Q, Zhang AM, et al. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.Molecules,2011,16:10556-10569.
14. 张祖贻,余世庆,苗立云,等.青蒿琥酯联合NP方案治疗中晚期非小细胞肺癌的随机对照研究.中西医结合学报,2008,6:134-138.
15. Zhou C, Pan W, Wang XP, et al. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J Cell Physiol,2012,227:3778-3786.
16. 苗立云,张祖贻.青蒿琥酯选择性抗肺腺癌细胞的作用及机制.现代医学,2006,34:15-17.
17. Bao F, Yuan P, Yuan X, et al. Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cance. J Thorac Dis,2014,6:1697-1703.
18. Rasheed SA, Efferth T, Asangani IA, et al. First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer, 2010,127:1475-1485.
19. Bergmann KC. Asthma. Chem Immunol Allergy,2014,100:69-80.
20. Bice JB, Leechawengwongs E, Montanaro A. Biologic targeted therapy in allergic asthma. Ann Allergy Asthma Immunol,2014,112:108-115.
21. Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One,2011,6:e20932.
22. Tan SS, Ong B, Cheng C. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol,2014,50:451-458.
23. Ho WE, Cheng C, Peh HY, et al. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. Free Radic Biol Med,2012,53:498-507.
24. 黄发军,詹光杰,张宏.青蒿琥酯对哮喘大鼠肺组织TLR-4及TGF-β₁表达的影响.中国医药生物技术,2011,6:266-269.
25. 陈磊.青蒿琥酯对哮喘大鼠模型治疗作用的实验研究.2009(学位论文).
26. Ng DS, Liao W, Tan Ws, et al. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine,2014,21:1638-1644.
27. Yao H, Hwang JW, Sundar IK, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol,2013,305:L615-L624.
28. Atkinson JJ, Lutey BA, Suzuki Y, et al. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med,2011,183:876-884.
29. Magenta D, Sangiovanni E, Basilico N, et al. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop,2014,140:77-83.
30. Geramizadeh B, Jowkar Z, Karami L, et al. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iran Red Crescent Med J,2013,15:e7508.
31. Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med,2008,178:592-604.
32. Louhelainen N, Myllarniemi M, Rahman I, et al. Airway biomarkersof the oxidant burden in asthma and chronic obstructive pulmonary dis-ease:current and future perspectives. Int J Chron Obstruct Pulmon Dis,2008,3:585-603.
33. Li HX, Wang HL, Wang HJ, et al. Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis. Eur Rev Med Pharmacol Sci,2014,18:3199-3204.
34. 许光兰,梁劲松,以敏,等.青蒿琥酯对肺纤维化大鼠肺组织转化生长因子β₁的影响.广西医科大学学报,2008,25:400-403.
35. 许光兰,陈平,梁劲松,等.青蒿琥酯对实验性肺纤维化大鼠治疗作用及其机理研究.临床医学工程,2009,16:6-8.
36. 王昌明,张孝飞,谭宁,等.青蒿琥酯对人胚肺成纤维细胞系HFL-1细胞增殖、凋亡的影响及机制.山东医药,2010,50:33-35.
37. Ding DW, Zhang YH, Huang XE, et al. Bufalin induces mitochondrial pathway-mediated apoptosis in lung adenocarcinoma cells. Asian Pac J Cancer Prev,2014,15:10495-10500.
38. 王昌明,黎洪秀,张孝飞,等.Fas及FasL和Caspse-3在青蒿琥酯诱导人胚肺成纤维细胞凋亡中的表达.中国组织工程研究与临床康复,2011,15:3785-3788.
39. 孙艳辉.青蒿琥酯对百草枯致大鼠肺损伤机制的干预性研究.2011(学位论文).
40. 孙沥.百草枯中毒大鼠血清细胞因子的动态变化及青蒿琥酯的干预.2011(学位论文).

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