泛素连接酶Hrd1与呼吸系统疾病_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陈文琼 ^1,2 ,  胡瑞成 ² , 戴爱国 ²

1. ;
2. ;

Corresponding author：

胡瑞成, Email: huruicheng@hotmail.com

Keywords：

DOI：

10.7507/1671-6205.2016025

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Citation： 陈文琼, 胡瑞成, 戴爱国. 泛素连接酶Hrd1与呼吸系统疾病. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 99-101. doi: 10.7507/1671-6205.2016025 Copy

1.	苏建禄, 胡瑞成, 戴爱国.内质网应激与肺疾病研究进展.山东医药, 2013, 53:83-86.
2.	Hampton RY, Gardner RG, Rine J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell, 1996, 7:2029-2044.
3.	王花枝, 姜迪譞, 胡瑞成, 等.内质网相关性降解与呼吸系统疾病.国际呼吸杂志, 2014, 555-560.
4.	Bordallo J, Plemper RK, Finger A, et al. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell, 1998, 9:209-222.
5.	Deak PM, Wolf DH. Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem, 2001, 276:10663-10669.
6.	Kaneko M, Ishiguro M, Niinuma Y, et al. Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett, 2002, 532:147-152.
7.	Omura T, Kaneko M, Onoguchi M, et al. Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains. J Pharmacol Sci, 2008, 106:512-519.
8.	Amano T, Yamasaki S, Yagishita N, et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev, 2003, 17:2436-2449.
9.	Yamamoto K, Suzuki N, Wada T, et al. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. J Biochem, 2008, 144:477-486.
10.	Haynes CM, Titus EA, Cooper AA. Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell, 2004, 15:767-776.
11.	Meusser B, Hirsch C, Jarosch E, et al. ERAD:the long road to destruction. Nat Cell Biol, 2005, 7:766-772.
12.	Kaneko M, Okuma Y, Nomura Y. Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease:possible involvement of HRD1, a novel molecule related to endoplasmic reticulum stress, in Alzheimer's disease. J Pharmacol Sci, 2012, 118:325-330.
13.	Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell, 2010, 143:579-591.
14.	Zattas D, Hochstrasser M. Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol, 2015, 50:1-17.
15.	Gao B, Lee SM, Chen A, et al. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep, 2008, 9:480-485.
16.	Yagishita N, Ohneda K, Amano T, et al. Essential role of synoviolin in embryogenesis. J Biol Chem, 2005, 280:7909-7916.
17.	Yagishita N, Yamasaki S, Nishioka K, et al. Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol, 2008, 4:91-97.
18.	Janciauskiene SM, Bals R, Koczulla R, et al. The discovery of alpha1-antitrypsin and its role in health and disease. Respir Med, 2011, 105:1129-1139.
19.	Wang H, Li Q, Shen Y, et al. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility. Mol Cell Biochem, 2011, 346:137-145.
20.	Wan J, Chai H, Yu Z, et al. HIF-1alpha effects on angiogenic potential in human small cell lung carcinoma. J Exp Clin Cancer Res, 2011, 30:77.
21.	Swinson DE, O'Byrne KJ. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clin Lung Cancer, 2006, 7:250-256.
22.	Kim H, Bhattacharya A, Qi L. Endoplasmic reticulum quality control in cancer:Friend or foe. Semin Cancer Biol, 2015, 33:25-33.
23.	Sun S, Shi G, Han X, et al. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A, 2014, 111:582-591.
24.	Yamasaki S, Yagishita N, Sasaki T, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J, 2007, 26:113-122.
25.	Wu ZZ, Sun NK, Chien KY, et al. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol, 2011, 82:1630-1640.
26.	王花枝.干预Hrd1表达对A549细胞顺铂耐药性的影响.南华大学(学位论文), 2014.
27.	Cyr DM. Arrest of CFTRDeltaF508 folding. Nat Struct Mol Biol, 2005, 12:2-3.
28.	Ballar P, Ors AU, Yang H, et al. Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1. Int J Biochem Cell Biol, 2010, 42:167-173.
29.	Valle CW, Vij N. Can correcting the DeltaF508-CFTR proteostasis-defect rescue CF lung disease? Curr Mol Med, 2012, 12:860-871.
30.	Maguire JA, Mulugeta S, Beers MF. Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells. Am J Respir Cell Mol Biol, 2011, 44:404-414.
31.	Nakajima F, Aratani S, Fujita H, et al. Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced collagen secretion in an in vitro model of stress-related interstitial pneumonia. Int J Mol Med, 2015, 35:110-116.
32.	Li L, Shen Y, Ding Y, et al. Hrd1 participates in the regulation of collagen 1 synthesis in renal fibrosis. Mol Cell Biochem, 2014, 386:35-44.

1. 苏建禄, 胡瑞成, 戴爱国.内质网应激与肺疾病研究进展.山东医药, 2013, 53:83-86.
2. Hampton RY, Gardner RG, Rine J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell, 1996, 7:2029-2044.
3. 王花枝, 姜迪譞, 胡瑞成, 等.内质网相关性降解与呼吸系统疾病.国际呼吸杂志, 2014, 555-560.
4. Bordallo J, Plemper RK, Finger A, et al. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell, 1998, 9:209-222.
5. Deak PM, Wolf DH. Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem, 2001, 276:10663-10669.
6. Kaneko M, Ishiguro M, Niinuma Y, et al. Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett, 2002, 532:147-152.
7. Omura T, Kaneko M, Onoguchi M, et al. Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains. J Pharmacol Sci, 2008, 106:512-519.
8. Amano T, Yamasaki S, Yagishita N, et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev, 2003, 17:2436-2449.
9. Yamamoto K, Suzuki N, Wada T, et al. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. J Biochem, 2008, 144:477-486.
10. Haynes CM, Titus EA, Cooper AA. Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell, 2004, 15:767-776.
11. Meusser B, Hirsch C, Jarosch E, et al. ERAD:the long road to destruction. Nat Cell Biol, 2005, 7:766-772.
12. Kaneko M, Okuma Y, Nomura Y. Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease:possible involvement of HRD1, a novel molecule related to endoplasmic reticulum stress, in Alzheimer's disease. J Pharmacol Sci, 2012, 118:325-330.
13. Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell, 2010, 143:579-591.
14. Zattas D, Hochstrasser M. Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol, 2015, 50:1-17.
15. Gao B, Lee SM, Chen A, et al. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep, 2008, 9:480-485.
16. Yagishita N, Ohneda K, Amano T, et al. Essential role of synoviolin in embryogenesis. J Biol Chem, 2005, 280:7909-7916.
17. Yagishita N, Yamasaki S, Nishioka K, et al. Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol, 2008, 4:91-97.
18. Janciauskiene SM, Bals R, Koczulla R, et al. The discovery of alpha1-antitrypsin and its role in health and disease. Respir Med, 2011, 105:1129-1139.
19. Wang H, Li Q, Shen Y, et al. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility. Mol Cell Biochem, 2011, 346:137-145.
20. Wan J, Chai H, Yu Z, et al. HIF-1alpha effects on angiogenic potential in human small cell lung carcinoma. J Exp Clin Cancer Res, 2011, 30:77.
21. Swinson DE, O'Byrne KJ. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clin Lung Cancer, 2006, 7:250-256.
22. Kim H, Bhattacharya A, Qi L. Endoplasmic reticulum quality control in cancer:Friend or foe. Semin Cancer Biol, 2015, 33:25-33.
23. Sun S, Shi G, Han X, et al. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A, 2014, 111:582-591.
24. Yamasaki S, Yagishita N, Sasaki T, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J, 2007, 26:113-122.
25. Wu ZZ, Sun NK, Chien KY, et al. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol, 2011, 82:1630-1640.
26. 王花枝.干预Hrd1表达对A549细胞顺铂耐药性的影响.南华大学(学位论文), 2014.
27. Cyr DM. Arrest of CFTRDeltaF508 folding. Nat Struct Mol Biol, 2005, 12:2-3.
28. Ballar P, Ors AU, Yang H, et al. Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1. Int J Biochem Cell Biol, 2010, 42:167-173.
29. Valle CW, Vij N. Can correcting the DeltaF508-CFTR proteostasis-defect rescue CF lung disease? Curr Mol Med, 2012, 12:860-871.
30. Maguire JA, Mulugeta S, Beers MF. Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells. Am J Respir Cell Mol Biol, 2011, 44:404-414.
31. Nakajima F, Aratani S, Fujita H, et al. Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced collagen secretion in an in vitro model of stress-related interstitial pneumonia. Int J Mol Med, 2015, 35:110-116.
32. Li L, Shen Y, Ding Y, et al. Hrd1 participates in the regulation of collagen 1 synthesis in renal fibrosis. Mol Cell Biochem, 2014, 386:35-44.

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泛素连接酶Hrd1与呼吸系统疾病

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