_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

耿申 ¹ , 吴婷 ² , 周威 ² , 芮昱雯 ² , 何骞 ¹ , 李红星 ² , 施毅 ² ,  苏欣 ¹

1. ;
2. ;

Corresponding author：

苏欣, Email: suxinjs@163.com

Keywords：

DOI：

10.7507/1671-6205.201605016

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Citation： 耿申, 吴婷, 周威, 芮昱雯, 何骞, 李红星, 施毅, 苏欣. . Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(1): 96-99. doi: 10.7507/1671-6205.201605016 Copy

1.	Zhou Z, Connell MC, Macewan DJ. TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal, 2007, 19(6):1238-1248.
2.	Gorska MM, Liang Q, Stafford S J, et al. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med, 2007, 204(7):1637-1652.
3.	Lucas R, Lou J, Morel DR, et al. TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria. J Leukoc Biol, 1997, 61(5):551-558.
4.	van Buul JD, van Rijssel J, van Alphen FP, et al. Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One, 2010, 5(6):e11336.
5.	Sumagin R, Lomakina E, Sarelius IH. Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling. Am J Physiol Heart Circ Physiol, 2008, 295(3):H969-H977.
6.	Bird MD, Morgan MO, Ramirez L, et al. Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice. J Burn Care Res, 2010, 31(4):652-660.
7.	Schnyder-Candrian S, Quesniaux VF, Di Padova F, et al. Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol, 2005, 175(1):262-269.
8.	Brook M, Tchen CR, Santalucia T, et al. Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol, 2006, 26(6):2408-2418.
9.	Ronkina N, Kotlyarov A, Dittrich-Breiholz O, et al. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol, 2007, 27(1):170-181.
10.	Han SJ, Choi KY, Brey PT, et al. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. J Biol Chem, 1998, 273(1):369-374.
11.	Kotlyarov A, Neininger A, Schubert C, et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol, 1999, 1(2):94-97.
12.	Su X, Ao L, Zou N, et al. Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27. Biochim Biophys Acta, 2008, 1783(9):1623-1631.
13.	Hedges JC, Dechert MA, Yamboliev IA, et al. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem, 1999, 274(34):24211-24219.
14.	Ma WJ, Cheng S, Campbell C, et al. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem, 1996, 271(14):8144-8151.
15.	Sun DP, Lin CY, Tian YF, et al. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol, 2013, 34(5):3059-3069.
16.	Ross J. mRNA stability in mammalian cells. Microbiol Rev, 1995, 59(3):423-450.
17.	Dean JL, Wait R, Mahtani KR, et al. The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol, 2001, 21(3):721-730.
18.	Lejbkowicz F, Goldberg-Cohen I, Levy AP. New horizons for VEGF. Is there a role for nuclear localization?. Acta Histochem, 2005, 106(6):405-411.
19.	Lin FY, Chen YH, Lin YW, et al. The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc Biol, 2006, 26(12):2622-2629.
20.	Donahue JM, Chang ET, Xiao L, et al. The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells. Biochem J, 2011, 437(1):89-96.
21.	Vazquez-Chantada M, Fernandez-Ramos D, Embade N, et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology, 2010, 138(5):1943-1953.
22.	Kawai T, Lal A, Yang X, et al. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol, 2006, 26(8):3295-3307.
23.	Leandersson K, Riesbeck K, Andersson T. Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. Nucleic Acids Res, 2006, 34(14):3988-3999.
24.	Gray LC, Hughes TR, van den Berg CW. Binding of human antigen R (HuR) to an AU-rich element (ARE) in the 3'untranslated region (3'UTR) reduces the expression of decay accelerating factor (DAF). Mol Immunol, 2010, 47(16):2545-2551.
25.	Mazroui R, Di Marco S, Clair E, et al. Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol, 2008, 180(1):113-127.
26.	Sandler H, Stoecklin G. Control of mRNA decay by phosphorylation of tristetraprolin. Biochem Soc Trans, 2008, 36(Pt 3):491-496.
27.	Galbiati V, Carne A, Mitjans M, et al. Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin. Arch Toxicol, 2012, 86(2):239-248.
28.	Suswam E, Li Y, Zhang X, et al. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res, 2008, 68(3):674-682.
29.	Balakathiresan NS, Bhattacharyya S, Gutti U, et al. Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2009, 296(6):L1012-L1018.
30.	Anant S, Houchen CW. HuR and TTP: two RNA binding proteins that deliver message from the 3' end. Gastroenterology, 2009, 136(5):1495-1498.
31.	Ogilvie RL, Sternjohn JR, Rattenbacher B, et al. Tristetraprolin mediates interferon-gamma mRNA decay. J Biol Chem, 2009, 284(17):11216-11223.
32.	Chen F, Shyu AB, Shneider BL. Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability. Hepatology, 2011, 54(4):1371-1378.
33.	Winzen R, Kracht M, Ritter B, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J, 1999, 18(18):4969-4980.
34.	Shi JX, Su X, Xu J, et al. MK2 posttranscriptionally regulates TNF-alpha-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol, 2012, 302(8):L793-L799.
35.	Damarla M, Parniani AR, Johnston L, et al. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol, 2014, 50(5):932-941.
36.	Lafarga V, Cuadrado A, Lopez de Silanes I, et al. p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21^Cip1 mRNA mediates the G₁/S checkpoint. Mol Cell Biol, 2009, 29(16):4341-4351.
37.	Palanisamy V, Park NJ, Wang J, et al. AUF1 and HuR proteins stabilize interleukin-8 mRNA in human saliva. J Dent Res, 2008, 87(8):772-776.
38.	Xu J, Su X, Shi JX, et al. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R. Chin Med J (Engl), 2013, 126(22):4322-4326.
39.	Tzeng HP, Ho FM, Chao KF, et al. β-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. Am J Respir Crit Care Med, 2003, 168(1): 85-91.
40.	Shi JX, Su X, Xu J, et al. HuR post-transcriptionally regulates TNF-α-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin. Respir Physiol Neurobiol, 2012, 181(2): 154-161.
41.	徐瑾, 史家欣, 卢鑫, 等. 急性肺损伤时小鼠肺组织MK2和HuR表达的变化. 中国急救医学, 2013, 33(2):160-163, 插1.

1. Zhou Z, Connell MC, Macewan DJ. TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal, 2007, 19(6):1238-1248.
2. Gorska MM, Liang Q, Stafford S J, et al. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med, 2007, 204(7):1637-1652.
3. Lucas R, Lou J, Morel DR, et al. TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria. J Leukoc Biol, 1997, 61(5):551-558.
4. van Buul JD, van Rijssel J, van Alphen FP, et al. Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One, 2010, 5(6):e11336.
5. Sumagin R, Lomakina E, Sarelius IH. Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling. Am J Physiol Heart Circ Physiol, 2008, 295(3):H969-H977.
6. Bird MD, Morgan MO, Ramirez L, et al. Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice. J Burn Care Res, 2010, 31(4):652-660.
7. Schnyder-Candrian S, Quesniaux VF, Di Padova F, et al. Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol, 2005, 175(1):262-269.
8. Brook M, Tchen CR, Santalucia T, et al. Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol, 2006, 26(6):2408-2418.
9. Ronkina N, Kotlyarov A, Dittrich-Breiholz O, et al. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol, 2007, 27(1):170-181.
10. Han SJ, Choi KY, Brey PT, et al. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. J Biol Chem, 1998, 273(1):369-374.
11. Kotlyarov A, Neininger A, Schubert C, et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol, 1999, 1(2):94-97.
12. Su X, Ao L, Zou N, et al. Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27. Biochim Biophys Acta, 2008, 1783(9):1623-1631.
13. Hedges JC, Dechert MA, Yamboliev IA, et al. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem, 1999, 274(34):24211-24219.
14. Ma WJ, Cheng S, Campbell C, et al. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem, 1996, 271(14):8144-8151.
15. Sun DP, Lin CY, Tian YF, et al. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol, 2013, 34(5):3059-3069.
16. Ross J. mRNA stability in mammalian cells. Microbiol Rev, 1995, 59(3):423-450.
17. Dean JL, Wait R, Mahtani KR, et al. The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol, 2001, 21(3):721-730.
18. Lejbkowicz F, Goldberg-Cohen I, Levy AP. New horizons for VEGF. Is there a role for nuclear localization?. Acta Histochem, 2005, 106(6):405-411.
19. Lin FY, Chen YH, Lin YW, et al. The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc Biol, 2006, 26(12):2622-2629.
20. Donahue JM, Chang ET, Xiao L, et al. The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells. Biochem J, 2011, 437(1):89-96.
21. Vazquez-Chantada M, Fernandez-Ramos D, Embade N, et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology, 2010, 138(5):1943-1953.
22. Kawai T, Lal A, Yang X, et al. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol, 2006, 26(8):3295-3307.
23. Leandersson K, Riesbeck K, Andersson T. Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. Nucleic Acids Res, 2006, 34(14):3988-3999.
24. Gray LC, Hughes TR, van den Berg CW. Binding of human antigen R (HuR) to an AU-rich element (ARE) in the 3'untranslated region (3'UTR) reduces the expression of decay accelerating factor (DAF). Mol Immunol, 2010, 47(16):2545-2551.
25. Mazroui R, Di Marco S, Clair E, et al. Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol, 2008, 180(1):113-127.
26. Sandler H, Stoecklin G. Control of mRNA decay by phosphorylation of tristetraprolin. Biochem Soc Trans, 2008, 36(Pt 3):491-496.
27. Galbiati V, Carne A, Mitjans M, et al. Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin. Arch Toxicol, 2012, 86(2):239-248.
28. Suswam E, Li Y, Zhang X, et al. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res, 2008, 68(3):674-682.
29. Balakathiresan NS, Bhattacharyya S, Gutti U, et al. Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2009, 296(6):L1012-L1018.
30. Anant S, Houchen CW. HuR and TTP: two RNA binding proteins that deliver message from the 3' end. Gastroenterology, 2009, 136(5):1495-1498.
31. Ogilvie RL, Sternjohn JR, Rattenbacher B, et al. Tristetraprolin mediates interferon-gamma mRNA decay. J Biol Chem, 2009, 284(17):11216-11223.
32. Chen F, Shyu AB, Shneider BL. Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability. Hepatology, 2011, 54(4):1371-1378.
33. Winzen R, Kracht M, Ritter B, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J, 1999, 18(18):4969-4980.
34. Shi JX, Su X, Xu J, et al. MK2 posttranscriptionally regulates TNF-alpha-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol, 2012, 302(8):L793-L799.
35. Damarla M, Parniani AR, Johnston L, et al. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol, 2014, 50(5):932-941.
36. Lafarga V, Cuadrado A, Lopez de Silanes I, et al. p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21^Cip1 mRNA mediates the G₁/S checkpoint. Mol Cell Biol, 2009, 29(16):4341-4351.
37. Palanisamy V, Park NJ, Wang J, et al. AUF1 and HuR proteins stabilize interleukin-8 mRNA in human saliva. J Dent Res, 2008, 87(8):772-776.
38. Xu J, Su X, Shi JX, et al. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R. Chin Med J (Engl), 2013, 126(22):4322-4326.
39. Tzeng HP, Ho FM, Chao KF, et al. β-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. Am J Respir Crit Care Med, 2003, 168(1): 85-91.
40. Shi JX, Su X, Xu J, et al. HuR post-transcriptionally regulates TNF-α-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin. Respir Physiol Neurobiol, 2012, 181(2): 154-161.
41. 徐瑾, 史家欣, 卢鑫, 等. 急性肺损伤时小鼠肺组织MK2和HuR表达的变化. 中国急救医学, 2013, 33(2):160-163, 插1.

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