Nocturnal oximetry saturation monitoring combined with clinical score in preliminary screening of obstructive sleep apnea hypopnea syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

HU Bi ^1,2 , WANG Maoyun ¹ , LEI Fei ^1,3 , WANG Yiwei ¹ ,  LIANG Zongan ¹

1. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;
2. Department of Respiratory and Critical Care Medicine, Chengdu Shangjin Nanfu Hosipital, Chengdu, Sichuan 611730, P.R.China;
3. Sleep Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;

Corresponding author：

LIANG Zongan, Email: liang.zongan@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Oxyhemoglobin saturation; Clinical score

DOI：

10.7507/1671-6205.201605039

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Objective To discuss the screening and diagnostic value of nocturnal oximetry saturation monitoring combined with clinical score (CS) for patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 106 snorers were recruited in the analysis whose general information and medical history were collected respectively. All patients received polysomnography (PSG) and oximeter monitoring. The patients were divided into a non-OSAHS group and an OSAHS group according to apnea hypopnea index (AHI). A correlation analysis was made between PSG-AHI and oximeter-ODI to analyze the diagnostic sensitivity and specificity of different ODI combined with CS for OSAHS. Results The AHI, ODI, CS for the non-OSAHS group were 1.8±1.4 times/h, 2.6±3.5 times/h and 1.0±0.8; while for the OSAHS group they were correspondingly 37.3±23.9 times/h, 31.0±24.1 times/h, 2.6±1.1. There was a significant correlation between ODI and AHI (r=0.943, P<0.01). The sensitivity and specificity of ODI≥5 times/h combined with CS≥2 for diagnosis of OSAHS were 91.7% and 94.1% respectively, which had the value of preliminary screening. The sensitivity and specificity of ODI≥10 times/h combined with CS≥2 for diagnosis of OSAHS were 77.8% and 100.0% respectively, which would not result in misdiagnose for severe patients with AHI >30 times/h, so it could be an index of severe OSAHS screening. Conclusion Nocturnal oxyhemoglobin saturation monitoring combined with clinical score is of significant value for initial diagnosis of OSAHS.

Citation： HU Bi, WANG Maoyun, LEI Fei, WANG Yiwei, LIANG Zongan. Nocturnal oximetry saturation monitoring combined with clinical score in preliminary screening of obstructive sleep apnea hypopnea syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 245-249. doi: 10.7507/1671-6205.201605039 Copy

1.	中华医学会呼吸病学分会睡眠呼吸障碍学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指(2011 年修订版). 中华结核和呼吸杂志, 2012, 35(1): 9-12.
2.	张向宁, 王建达, 乔华, 等. OSAHS 患者呼吸紊乱指数与术后并发症的关系. 医学临床研究, 2012, 29(1): 182-183.
3.	赵阳, 李建瑞, 王利伟, 等. 北京市朝阳区成人打鼾及阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中国医药导报, 2013, 10(27): 108-111.
4.	林其昌, 黄建钗, 丁海波, 等. 福州市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中华结核和呼吸杂志, 2009, 32(3): 193-197.
5.	黄赛瑜, 项松洁, 倪丽艳, 等. 温州地区健康体检人群中阻塞性睡眠呼吸暂停低通气综合征的流行现状. 中国预防医学杂志, 2009, 10(3): 1013-1015.
6.	上海市医学会呼吸病学分会睡眠呼吸疾病学组. 上海市 30 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中华结核和呼吸杂志, 2003, 26(5): 268-272.
7.	李明娴, 王莹, 华树成, 等. 长春市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学现况调查. 中华结核和呼吸杂志, 2005, 28(12): 833-835.
8.	Williams AJ, Yu G, Santiago S, et al. Screening for sleep apnea using pulse oximetry and a clinical score. Chest, 1991, 100(3): 631-635.
9.	阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)写作组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版). 中华全科医师杂志, 2015, 14(7): 509-515.
10.	Neubauer JA. Invited review: physiological and pathophysiological response to intermittent hypoxia. J Appl Physiol, 2001, 90(4): 1593-1599.
11.	Van Eyck A, Lambrechts C, Vanheeswijck L, et al. The role of nocturnal pulse oximetry in the screening for obstructive sleep apnea in obese children and adolescents. Sleep Med, 2015, 16(11): 1409-1412.
12.	刘慧萍, 王巍, 鲁宏华, 等. 腕表式动态血氧仪对阻塞性睡眠呼吸暂停低通气综合征筛查价值的研究. 天津医药, 2016, 44(4): 478-481.
13.	韩芳, 陈尔璋, 魏海琳, 等. 夜间血氧饱和度监测对睡眠呼吸暂停综合征的诊断价值. 中华结核和呼吸杂志, 1999, 22(6): 332-334.
14.	王春艳, 李静, 韩旭, 等. 动态血氧饱和度监测在睡眠呼吸暂停低通气综合征诊断中的应用. 临床内科杂志, 2006, 23(10): 698-700.

1. 中华医学会呼吸病学分会睡眠呼吸障碍学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指(2011 年修订版). 中华结核和呼吸杂志, 2012, 35(1): 9-12.
2. 张向宁, 王建达, 乔华, 等. OSAHS 患者呼吸紊乱指数与术后并发症的关系. 医学临床研究, 2012, 29(1): 182-183.
3. 赵阳, 李建瑞, 王利伟, 等. 北京市朝阳区成人打鼾及阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中国医药导报, 2013, 10(27): 108-111.
4. 林其昌, 黄建钗, 丁海波, 等. 福州市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中华结核和呼吸杂志, 2009, 32(3): 193-197.
5. 黄赛瑜, 项松洁, 倪丽艳, 等. 温州地区健康体检人群中阻塞性睡眠呼吸暂停低通气综合征的流行现状. 中国预防医学杂志, 2009, 10(3): 1013-1015.
6. 上海市医学会呼吸病学分会睡眠呼吸疾病学组. 上海市 30 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中华结核和呼吸杂志, 2003, 26(5): 268-272.
7. 李明娴, 王莹, 华树成, 等. 长春市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学现况调查. 中华结核和呼吸杂志, 2005, 28(12): 833-835.
8. Williams AJ, Yu G, Santiago S, et al. Screening for sleep apnea using pulse oximetry and a clinical score. Chest, 1991, 100(3): 631-635.
9. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)写作组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版). 中华全科医师杂志, 2015, 14(7): 509-515.
10. Neubauer JA. Invited review: physiological and pathophysiological response to intermittent hypoxia. J Appl Physiol, 2001, 90(4): 1593-1599.
11. Van Eyck A, Lambrechts C, Vanheeswijck L, et al. The role of nocturnal pulse oximetry in the screening for obstructive sleep apnea in obese children and adolescents. Sleep Med, 2015, 16(11): 1409-1412.
12. 刘慧萍, 王巍, 鲁宏华, 等. 腕表式动态血氧仪对阻塞性睡眠呼吸暂停低通气综合征筛查价值的研究. 天津医药, 2016, 44(4): 478-481.
13. 韩芳, 陈尔璋, 魏海琳, 等. 夜间血氧饱和度监测对睡眠呼吸暂停综合征的诊断价值. 中华结核和呼吸杂志, 1999, 22(6): 332-334.
14. 王春艳, 李静, 韩旭, 等. 动态血氧饱和度监测在睡眠呼吸暂停低通气综合征诊断中的应用. 临床内科杂志, 2006, 23(10): 698-700.

Chinese Journal of Respiratory and Critical Care Medicine

Nocturnal oximetry saturation monitoring combined with clinical score in preliminary screening of obstructive sleep apnea hypopnea syndrome

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