Clinical Study on Artieral Infusion Chemotherapy Combined with <sup>125</sup>I Seed Implantation in Treatment of NSCLC_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

RenWeichao ,  SunChengjian , WangYanhua , LiuTonghui , ZhaoXiaolong , WangHongyu

Department of Interventional Radiology, The Affliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China;

Corresponding author：

SunChengjian, Email: chengjiansun2009@163.com

Keywords：

Non-small cell lung cancer; ¹²⁵I seed implantation; Artieral infusion; Chemotherapy

DOI：

10.7507/1671-6205.2016060

Video：

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Objective To evaluate the clinical efficacy and safety of artieral infusion chemotherapy combined with ¹²⁵I seed implantation in treatment of non-small cell lung cancer (NSCLC). Methods Between February 2012 to June 2014, 34 patients with unresectable NSCLC received ¹²⁵I seed implantation, in which 16 patients also received artieral infusion chemotherapy. All the patients were followed up and two months after ¹²⁵I seed implantation the thoracic CT scanning was carried out in all patients. The response to treatment was evaluated in accordance with Response Evaluation Criteria in Solid Tumors and the accumulated survival rate was analyzed by means of Kaplan-Meier. Results The operation successful rate was 100% and no severe complications were observed. Two months later the thoracic CT scanning showed that patients who only received ¹²⁵I seed implantation with a total effective rate of 72.2% and those received artieral infusion chemotherapy combined with ¹²⁵I seed implantation with an effective rate of 87.5%, with no significant difference between two groups in the effective rate (χ²=1.122, P>0.05). Median survival time of two groups was 361 days and 470 days (χ²=2.985, P < 0.05), respectively. Survival rate of 1 year was 43.5% and 83.5%(χ²=4.101, P < 0.05), respectively. Conclusion Artieral infusion chemotherapy combined with ¹²⁵I seed implantation is safe, reliable and effective in treatment of unresectable NSCLC, which can prolong the patient's survival time.

Citation： Ren Weichao, Sun Chengjian, Wang Yanhua, Liu Tonghui, Zhao Xiaolong, Wang Hongyu. Clinical Study on Artieral Infusion Chemotherapy Combined with ¹²⁵I Seed Implantation in Treatment of NSCLC. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(3): 256-260. doi: 10.7507/1671-6205.2016060 Copy

1.	Cady B, Jenkins RL, Steele GD Jr, et al. Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg, 1998, 227:566-571.
2.	Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45: 228-247.
3.	Hoffman PC, Mauer AM, Yokes EE. Lung cancer. Lancet, 2000, 355:479-485.
4.	Nesbitt JC, Putnam JB Jr., Walsh GL, et al. Survival in early-stage non-small cell lung cancer. Ann Thorac Surg, 1995, 60:466-472.
5.	Rami-Porta R, Ball D, Crowley J, et al. The lASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol, 2007, 2:593-602.
6.	储水鑫.肺癌放疗并发症的中药治疗.中国中西医结合外科杂志, 2011, 12:645.
7.	李任飞, 王月东, 闫龑, 等.¹²⁵I粒子植入治疗非小细胞肺癌近期疗效评估.介入放射学杂志, 2014, 23:65-68.
8.	赵明星, 刘文天, 王邦茂, 等.近距离放射治疗在消化系肿瘤治疗中的应用前景.国际消化杂志, 2013, 33:160-179.
9.	李忠福, 苏东峰, 张延军, 等.支气管动脉灌注化疗与全身静脉化疗治疗中晚期肺癌疗效观察.中国介入放射学, 2008, 2:327-329.
10.	王忠敏, 黄钢, 陈克敏, 等.放射性粒子组织间植入治疗技术指南的建议.介入放射学杂志, 2009, 18:641-644.
11.	Dubben HH, Beck-Bornholdt HP. Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H. Acta Oncol, 1993, 32:79-82.
12.	Durand RE. Tumor repopulation during radiotherapy: quantitation in two xenografted human tumors. Int J Radiat Oncol Biolphys, 1997, 39: 803-808.
13.	Fietkau R. Concomitant radio chemotherapy of advanced non-small cell lung cancer. Lung Cancer, 2001, 33:65-76.
14.	曹贵文, 李学达, 孙莉宁, 等.¹²⁵I放射性粒子植入对兔肝癌微血管密度及血管内皮生长因子的影响.当代医学, 2011, 17:108-112.
15.	Johnson M, Colonias A, Parda D, et al. Dosimetric and technical aspects of intraoperative I-125 brachytherapy for stage Ⅰ non-small cell lung cancer. Phys Med Biol, 2007, 52:1237-1245.
16.	Nakanishi M, Umeda Y, Demura Y, et al. Effective use of multi-arterial infusion chemotherapy for advanced non-small cell cancer patients:four clinical specified cases. Lung Cancer, 2007, 55:241-247.
17.	Sura S, Yorke E, Jackson A, et al. High-dose radiotherapy for the treatment of inoperable non-mall cell lung cancer. Cancer, 2007, 19:238-242.
18.	赵书元.¹²⁵I粒子植入联合支气管动脉灌注化疗治疗中晚期肺癌的临床研究.中国医药指南, 2013, 11:87-88.
19.	鞠再双, 王林, 李建新, 等.¹²⁵I粒子植入犬胃壁组织放射性损伤的实验研究.中国微创外科杂志, 2014, 14:468-471.

1. Cady B, Jenkins RL, Steele GD Jr, et al. Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg, 1998, 227:566-571.
2. Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45: 228-247.
3. Hoffman PC, Mauer AM, Yokes EE. Lung cancer. Lancet, 2000, 355:479-485.
4. Nesbitt JC, Putnam JB Jr., Walsh GL, et al. Survival in early-stage non-small cell lung cancer. Ann Thorac Surg, 1995, 60:466-472.
5. Rami-Porta R, Ball D, Crowley J, et al. The lASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol, 2007, 2:593-602.
6. 储水鑫.肺癌放疗并发症的中药治疗.中国中西医结合外科杂志, 2011, 12:645.
7. 李任飞, 王月东, 闫龑, 等.¹²⁵I粒子植入治疗非小细胞肺癌近期疗效评估.介入放射学杂志, 2014, 23:65-68.
8. 赵明星, 刘文天, 王邦茂, 等.近距离放射治疗在消化系肿瘤治疗中的应用前景.国际消化杂志, 2013, 33:160-179.
9. 李忠福, 苏东峰, 张延军, 等.支气管动脉灌注化疗与全身静脉化疗治疗中晚期肺癌疗效观察.中国介入放射学, 2008, 2:327-329.
10. 王忠敏, 黄钢, 陈克敏, 等.放射性粒子组织间植入治疗技术指南的建议.介入放射学杂志, 2009, 18:641-644.
11. Dubben HH, Beck-Bornholdt HP. Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H. Acta Oncol, 1993, 32:79-82.
12. Durand RE. Tumor repopulation during radiotherapy: quantitation in two xenografted human tumors. Int J Radiat Oncol Biolphys, 1997, 39: 803-808.
13. Fietkau R. Concomitant radio chemotherapy of advanced non-small cell lung cancer. Lung Cancer, 2001, 33:65-76.
14. 曹贵文, 李学达, 孙莉宁, 等.¹²⁵I放射性粒子植入对兔肝癌微血管密度及血管内皮生长因子的影响.当代医学, 2011, 17:108-112.
15. Johnson M, Colonias A, Parda D, et al. Dosimetric and technical aspects of intraoperative I-125 brachytherapy for stage Ⅰ non-small cell lung cancer. Phys Med Biol, 2007, 52:1237-1245.
16. Nakanishi M, Umeda Y, Demura Y, et al. Effective use of multi-arterial infusion chemotherapy for advanced non-small cell cancer patients:four clinical specified cases. Lung Cancer, 2007, 55:241-247.
17. Sura S, Yorke E, Jackson A, et al. High-dose radiotherapy for the treatment of inoperable non-mall cell lung cancer. Cancer, 2007, 19:238-242.
18. 赵书元.¹²⁵I粒子植入联合支气管动脉灌注化疗治疗中晚期肺癌的临床研究.中国医药指南, 2013, 11:87-88.
19. 鞠再双, 王林, 李建新, 等.¹²⁵I粒子植入犬胃壁组织放射性损伤的实验研究.中国微创外科杂志, 2014, 14:468-471.

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Clinical Study on Artieral Infusion Chemotherapy Combined with ¹²⁵I Seed Implantation in Treatment of NSCLC

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Clinical Study on Artieral Infusion Chemotherapy Combined with ¹²⁵I Seed Implantation in Treatment of NSCLC