硫酸镁用于支气管哮喘急性发作：老药新问题_Chinese Journal of Respiratory and Critical Care Medicine

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周光红 ¹ ,  龙怀聪 ²

1. ;
2. ;

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龙怀聪, Email: longhc69@163.com

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DOI：

10.7507/1671-6205.201606024

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Citation： 周光红, 龙怀聪. 硫酸镁用于支气管哮喘急性发作：老药新问题. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(2): 181-185. doi: 10.7507/1671-6205.201606024 Copy

1.	Green RH. Asthma in adults (acute): magnesium sulfate treatment. BMJ Clin Evid, 2016, pii: 1513.
2.	Al-Eyadhy AA, Temsah MH, Alhaboob AA, et al. Asthma changes at a pediatric intensive care unit after 10 years: Observational study. Ann Thorac Med, 2015, 10(4): 243-248.
3.	Haury VG. Blood serum magnesium in bronchial asthma and its treatment by the administration of magnesium sulfate. J Lab Clin Med, 1940, 26: 340-341.
4.	Yoshioka H, Hirota K, Sato T, et al. Spasmolytic effect of magnesium sulfate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs. Acta Anaesthesiol Scand, 2001, 45(4): 435-440.
5.	Davalos Bichara M, Goldman RD. Magnesium for treatment of asthma in chilren. Can Fam Physician, 2009, 55(9): 887-889.
6.	Mangat HS, D’Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J, 1998, 12(2): 341-344.
7.	Nanniai U, Pendino JC, Coma RA, et al. Magnesium sulfate as a vehicle fornebulized salbutamol in acute asthma. Am J Med, 2000, 108(3): 193-197.
8.	Del Castillo J, Engbaek L. The natures of the neuromuscular block produced by magnesium. J Physiol, 1954, 124(2): 370-384.
9.	Cairns CB, Kraft M. Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients. Acad Emerg Med, 1996, 3(12): 1093-1097.
10.	Rolla G, Bucca C, Bugiani M, et al. Reduction of histamine-induced bronchoconstriction by magnesium in asthmatic subjects. Allergy, 1987, 42(3): 186-188.
11.	Bichara MD, Goldman RD. Magnesium for treatment of asthma in children. Can Fam Physician, 2009, 55(9): 887-889.
12.	Goodacre S, Cohen J, Bradburn M, et al. The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technol Assess, 2014, 18(22): 1-168.
13.	Kew KM, Kirtchuk L, Michell CI. Intravenous magnesium sulfate for treating adults with acute asthma in the emergency department. Cochrane Database Syst Rev, 2014, (1): CD010909.
14.	Singhi S, Grover S, Bansal A, et al. Randomised comparison of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute severe asthma. Acta Paediatr, 2014, 103(12): 1301-1306.
15.	Shedd GC, Noe SM. Intravenous magnesium sulfate reduces rates of mechanical ventilation in pediatric asthma. Adv Emerg Nurs J, 2014, 36(1): 3-8.
16.	Torres S, Sticco N, Bosch JJ, et al. Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial. Arch Argent Pediatr, 2012, 110(4): 291-296.
17.	Rowe BH, Bretzlaff J, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev, 2000, 3: CD001490.
18.	Hirashima J, Yamana H, Matsui H, et al. Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma. Respirology, 2016, 21(4): 668-673.
19.	The Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA), 2015. Available from: http://www.ginasthma.org/.
20.	Powell C, Dwan K, Milan SJ, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev, 2012, (12): CD003898.
21.	Gallegos-Solórzano MC, Pérez-Padilla R, Hernández-Zenteno RJ. Usefulness of inhaled magnesium sulfate in the coadjuvant management of severe asthma crisis in an emergency department. Pulm Pharmacol Ther, 2010, 23(5): 432-437.
22.	Hossein S, Pegah A, Davood F, et al. The effect of nebulized magnesium sulfate in the treatment of moderate to severe asthma attacks: a randomized clinical trial. Am J Med, 2016, 34(5): 883-886.
23.	Powell CV, Kolamunnage-Dona R, Lowe J, et al. MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children. Health Technol Assess, 2013, 17(45): v-vi, 1-216.
24.	Zorc JJ. The addition of nebulised magnesium to the standard asthma therapy for children with severe symptoms results in small improvements in asthma severity scores. Evid Based Med, 2014, 19(3): 95.
25.	Alansari K, Ahmed W, Davidson BL, et al. Nebulized magnesium for moderate and severe pediatric asthma: a randomized trial. Pediatr Pulmonol, 2015, 50(12): 1191-1199.
26.	Wang H, Xiong Y, Gong C, et al. Effect of inhaled magnesium sulfate on bronchial hyperresponsiveness. Indian J Pediatr, 2015, 82(4): 321-327.
27.	Petrou S, Boland A, Khan K, et al. Economic evaluation of nebulized magnesium sulphate in acute severe asthma in children. Int J Technol Assess Health Care, 2014, 30(4): 354-360.
28.	Chesley LC, Tepper I. Some effects of magnesium loading upon renal excretion of magnesium and certain other electrolytes. J Clin Invest, 1958, 37(10): 1362-1372.
29.	Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med, 2000, 154(10): 979-383.
30.	Gürkan F, Haspolat K, Boşnak M, et al. Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. Eur J Emerg Med, 1999, 6(3): 201-205.
31.	Pabon H, Monem G, Kissoon N. Safety and efficacy of magnesium sulfate infusions in children with status asthmaticus. Pediatr Emerg Care, 1994, 10(4): 200-203.
32.	Devi PR, Kumar L, Singhi SC, et al. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr, 1997, 34(5): 389-397.
33.	British National Formulary 71(BNF 71), 2016. Available from: http://www.bnf.org/bnf/.
34.	Irazuzta JE, Paredes F, Pavlicich V, et al. High-dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study. Pediatr Crit Care Med, 2016, 17(2): e29-33.
35.	Egelund TA, Wassil SK, Edwards, et al. High-dosemagnesium sulfateinfusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study. Intensive Care Med, 2013, 39(1): 117-122.
36.	British Guideline on the Management of Asthma, 2011.[2011-04-01] Available from: http://www.brit-thoracic.org.uk/.
37.	Sellers WF. Inhaled and intravenous treatment in acute severe and life-threatening asthma. Br J Anaesth, 2013, 110(2): 183-190.
38.	Al-Eyadhy AA, Temsah MH, Alhaboob AA, et al. Asthma changes at a pediatric intensive care unit after 10 years: Observational study. Ann Thorac Med, 2015, 10(4): 243–248.
39.	Sellers WF, Ahmad I, Bathke PS, et al. Intravenous magnesium sulphate prevents intravenous salbutamol tachycardia in asthma. Br J Anaesth, 2010, 105(6): 869-870.
40.	Kokotajlo S, Degnan L, Meyers R, et al. Use of intravenous magnesium sulfate for the treatment of an acute asthma exacerbation in pediatric patients. J Pediatr Pharmacol Ther, 2014, 19(2): 91-97.
41.	Al-Fares AA, Abdulmalek KA, Al-Herz W. Magnesium sulfate-induced nonallergic anaphylaxis. Ann Allergy Asthma Immunol, 2007, 98(3): 303.
42.	Thorp JM Jr, Katz VL, Campbell D, et al. Hypersensitivity to magnesium sulfate. Am J Obstet Gynecol, 1989, 161(4): 889-890.
43.	Sanders G. Dose of magnesium sulphate for severe acute asthma. Anaesth Intensive Care, 2009, 37(4): 674-675.
44.	Hashimoto Y, Nishimura Y, Maeda H, et al. Assessment of magnesium status in patients with bronchial asthma. J Asthma, 2000, 37(6): 489-496.
45.	Amin M, Abdel-Fattah M, Zaghloul SS. Magnesium concentration in acute asthmatic children. Iranian J Pediatr, 2012, 22(4): 463-467.
46.	Kazaks AG, Uriu-Adams JY, Albertson TE, et al. Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial. J Asthma, 2010, 47(1): 83-92.
47.	Bede O, Surányi A, Pintér K, et al. Urinary magnesium excretion in asthmatic children receiving magnesium supplementation: a randomized, placebo-controlled, double-blind study. Magnes Res, 2003, 16(4): 262-270.

1. Green RH. Asthma in adults (acute): magnesium sulfate treatment. BMJ Clin Evid, 2016, pii: 1513.
2. Al-Eyadhy AA, Temsah MH, Alhaboob AA, et al. Asthma changes at a pediatric intensive care unit after 10 years: Observational study. Ann Thorac Med, 2015, 10(4): 243-248.
3. Haury VG. Blood serum magnesium in bronchial asthma and its treatment by the administration of magnesium sulfate. J Lab Clin Med, 1940, 26: 340-341.
4. Yoshioka H, Hirota K, Sato T, et al. Spasmolytic effect of magnesium sulfate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs. Acta Anaesthesiol Scand, 2001, 45(4): 435-440.
5. Davalos Bichara M, Goldman RD. Magnesium for treatment of asthma in chilren. Can Fam Physician, 2009, 55(9): 887-889.
6. Mangat HS, D’Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J, 1998, 12(2): 341-344.
7. Nanniai U, Pendino JC, Coma RA, et al. Magnesium sulfate as a vehicle fornebulized salbutamol in acute asthma. Am J Med, 2000, 108(3): 193-197.
8. Del Castillo J, Engbaek L. The natures of the neuromuscular block produced by magnesium. J Physiol, 1954, 124(2): 370-384.
9. Cairns CB, Kraft M. Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients. Acad Emerg Med, 1996, 3(12): 1093-1097.
10. Rolla G, Bucca C, Bugiani M, et al. Reduction of histamine-induced bronchoconstriction by magnesium in asthmatic subjects. Allergy, 1987, 42(3): 186-188.
11. Bichara MD, Goldman RD. Magnesium for treatment of asthma in children. Can Fam Physician, 2009, 55(9): 887-889.
12. Goodacre S, Cohen J, Bradburn M, et al. The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma. Health Technol Assess, 2014, 18(22): 1-168.
13. Kew KM, Kirtchuk L, Michell CI. Intravenous magnesium sulfate for treating adults with acute asthma in the emergency department. Cochrane Database Syst Rev, 2014, (1): CD010909.
14. Singhi S, Grover S, Bansal A, et al. Randomised comparison of intravenous magnesium sulphate, terbutaline and aminophylline for children with acute severe asthma. Acta Paediatr, 2014, 103(12): 1301-1306.
15. Shedd GC, Noe SM. Intravenous magnesium sulfate reduces rates of mechanical ventilation in pediatric asthma. Adv Emerg Nurs J, 2014, 36(1): 3-8.
16. Torres S, Sticco N, Bosch JJ, et al. Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital: a randomized, controlled trial. Arch Argent Pediatr, 2012, 110(4): 291-296.
17. Rowe BH, Bretzlaff J, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev, 2000, 3: CD001490.
18. Hirashima J, Yamana H, Matsui H, et al. Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma. Respirology, 2016, 21(4): 668-673.
19. The Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA), 2015. Available from: http://www.ginasthma.org/.
20. Powell C, Dwan K, Milan SJ, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev, 2012, (12): CD003898.
21. Gallegos-Solórzano MC, Pérez-Padilla R, Hernández-Zenteno RJ. Usefulness of inhaled magnesium sulfate in the coadjuvant management of severe asthma crisis in an emergency department. Pulm Pharmacol Ther, 2010, 23(5): 432-437.
22. Hossein S, Pegah A, Davood F, et al. The effect of nebulized magnesium sulfate in the treatment of moderate to severe asthma attacks: a randomized clinical trial. Am J Med, 2016, 34(5): 883-886.
23. Powell CV, Kolamunnage-Dona R, Lowe J, et al. MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children. Health Technol Assess, 2013, 17(45): v-vi, 1-216.
24. Zorc JJ. The addition of nebulised magnesium to the standard asthma therapy for children with severe symptoms results in small improvements in asthma severity scores. Evid Based Med, 2014, 19(3): 95.
25. Alansari K, Ahmed W, Davidson BL, et al. Nebulized magnesium for moderate and severe pediatric asthma: a randomized trial. Pediatr Pulmonol, 2015, 50(12): 1191-1199.
26. Wang H, Xiong Y, Gong C, et al. Effect of inhaled magnesium sulfate on bronchial hyperresponsiveness. Indian J Pediatr, 2015, 82(4): 321-327.
27. Petrou S, Boland A, Khan K, et al. Economic evaluation of nebulized magnesium sulphate in acute severe asthma in children. Int J Technol Assess Health Care, 2014, 30(4): 354-360.
28. Chesley LC, Tepper I. Some effects of magnesium loading upon renal excretion of magnesium and certain other electrolytes. J Clin Invest, 1958, 37(10): 1362-1372.
29. Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med, 2000, 154(10): 979-383.
30. Gürkan F, Haspolat K, Boşnak M, et al. Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. Eur J Emerg Med, 1999, 6(3): 201-205.
31. Pabon H, Monem G, Kissoon N. Safety and efficacy of magnesium sulfate infusions in children with status asthmaticus. Pediatr Emerg Care, 1994, 10(4): 200-203.
32. Devi PR, Kumar L, Singhi SC, et al. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr, 1997, 34(5): 389-397.
33. British National Formulary 71(BNF 71), 2016. Available from: http://www.bnf.org/bnf/.
34. Irazuzta JE, Paredes F, Pavlicich V, et al. High-dose magnesium sulfate infusion for severe asthma in the emergency department: efficacy study. Pediatr Crit Care Med, 2016, 17(2): e29-33.
35. Egelund TA, Wassil SK, Edwards, et al. High-dosemagnesium sulfateinfusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study. Intensive Care Med, 2013, 39(1): 117-122.
36. British Guideline on the Management of Asthma, 2011.[2011-04-01] Available from: http://www.brit-thoracic.org.uk/.
37. Sellers WF. Inhaled and intravenous treatment in acute severe and life-threatening asthma. Br J Anaesth, 2013, 110(2): 183-190.
38. Al-Eyadhy AA, Temsah MH, Alhaboob AA, et al. Asthma changes at a pediatric intensive care unit after 10 years: Observational study. Ann Thorac Med, 2015, 10(4): 243–248.
39. Sellers WF, Ahmad I, Bathke PS, et al. Intravenous magnesium sulphate prevents intravenous salbutamol tachycardia in asthma. Br J Anaesth, 2010, 105(6): 869-870.
40. Kokotajlo S, Degnan L, Meyers R, et al. Use of intravenous magnesium sulfate for the treatment of an acute asthma exacerbation in pediatric patients. J Pediatr Pharmacol Ther, 2014, 19(2): 91-97.
41. Al-Fares AA, Abdulmalek KA, Al-Herz W. Magnesium sulfate-induced nonallergic anaphylaxis. Ann Allergy Asthma Immunol, 2007, 98(3): 303.
42. Thorp JM Jr, Katz VL, Campbell D, et al. Hypersensitivity to magnesium sulfate. Am J Obstet Gynecol, 1989, 161(4): 889-890.
43. Sanders G. Dose of magnesium sulphate for severe acute asthma. Anaesth Intensive Care, 2009, 37(4): 674-675.
44. Hashimoto Y, Nishimura Y, Maeda H, et al. Assessment of magnesium status in patients with bronchial asthma. J Asthma, 2000, 37(6): 489-496.
45. Amin M, Abdel-Fattah M, Zaghloul SS. Magnesium concentration in acute asthmatic children. Iranian J Pediatr, 2012, 22(4): 463-467.
46. Kazaks AG, Uriu-Adams JY, Albertson TE, et al. Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial. J Asthma, 2010, 47(1): 83-92.
47. Bede O, Surányi A, Pintér K, et al. Urinary magnesium excretion in asthmatic children receiving magnesium supplementation: a randomized, placebo-controlled, double-blind study. Magnes Res, 2003, 16(4): 262-270.

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