血管内皮生长因子和神经菌毛素-1 在肺爆震伤诊疗中的应用_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

潘建光 ,  赖国祥

福建医科大学福总临床医学院南京军区福州总医院呼吸与危重症医学科（福建福州 350025）;

Corresponding author：

赖国祥, Email: laiguoxiang2007@163.com

Keywords：

DOI：

10.7507/1671-6205.201607024

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Citation： 潘建光, 赖国祥. 血管内皮生长因子和神经菌毛素-1 在肺爆震伤诊疗中的应用. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 296-299. doi: 10.7507/1671-6205.201607024 Copy

1.	Smith JE. The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 291-294.
2.	刘军, 赵富丽, 吴健, 等. 昆山" 8·2”爆炸事故存活伤员损伤特点及救治分析. 中华急诊医学杂志, 2015, 24(9): 952-957.
3.	Clapson P, Pasquie rP, Perez JP, et al. Blast lung injuries. Rev Pneumol Clin, 2010, 66(4): 245-253.
4.	Mellor SG, Cooper GJ. Analysis of 828 servicemen killed or injured by explosion in Northern Ireland 1970-84: the Hostile Action Casualty System. Br J Surg, 1989, 76(10): 1006-1010.
5.	Bauman RA, Ling G, Tong L, et al. An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma, 2009, 26(6): 841-860.
6.	Wolf SJ, Bebarta VS, Bonnett CJ, et al. Blast injuries. Lancet, 2009, 374(9687): 405-415.
7.	Skotak M, Wang F, Alai A, et al. Rat injury model under controlled field-relevant primary blast conditions: acute response to a wide range of peak overpressures. J Neurotrauma, 2013, 30(13): 1147-1160.
8.	Kirkman E, Watts S, Cooper G. Blast injury research models. Phil Trans R Soc B, 2011, 366(1652): 144-159.
9.	Joseph B, Bentley TL, Wessner KA, et al. Blast Overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma, 2009, 26(6): 827-840.
10.	Wong JM, Marsh D, Abu-Sitta G, et al. Biological foreign body implantation in victims of the London July 7th suicide bombings. J Trauma 2006, 60(2): 402-404.
11.	Chapman LE, Sullivent EE, Grohskopf LA, et al. Postexposure interventions to prevent infection with HBV, HCV, or HIV, and tetanus in people wounded during bombings and other mass casualty events-United States, 2008: recommendations of the Centers for Disease Control and Prevention and Disaster Medicine and Public Health Preparedness. Disaster Med Public Health Prep, 2008, 2(3): 150-165.
12.	Clint BD. Force protection and infectious risk mitigation from suicide bombers. Mil Med, 2009, 174(7): 709-714.
13.	Eshkol Z, Katz K. Injuries from biologic material of suicide bombers. Injury, 2005, 36(2): 271-274.
14.	Yeh DD, Schecter WP. Primary blast injuries-an updated concise review. World J Surg, 2012, 36(5): 966-972.
15.	Kirkman E, Watts S. Characterization of the response to primary blast injury. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 286-290.
16.	Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?. Thorax 2006, 61(7): 621-626.
17.	Kaner RJ, Crystal RG. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med, 2001, 7(4): 240-246.
18.	Foster RR, Hole R, Anderson K, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol, 2003, 284(6): F1263-F1273.
19.	Andrew RL, Nassif BN, Ann B, et al. Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome. J Crit Care, 2009, 24(2): 236-242.
20.	Wild JR, Staton CA, Chapple K, et al. Neuropilins: expression and roles in the epithelium. Int J Exp Pathol, 2012, 93(2): 81-103.
21.	Barratt S, Medford A R, Millar AB. Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome. Respiration, 2014, 87(4): 329-342.
22.	Jia H, Cheng L, Tickner M, et al. Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. Br J Cancer, 2010, 102(3): 541-552.
23.	Fantin A, Herzog B, Mahmoud M, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development, 2014, 141(3): 556-562.
24.	Ding MH, Liu L, Hu CX, et al. Expression of VEGF R2 and NRP-1 in non-small cell lung cancer and their clinical significance. Chin J Cancer Res, 2014, 26(6): 669-677.
25.	Shim EJ, Chun E, Kang HR, et al. Expression of semaphorin 3A and neuropilin 1 in asthma. J Korean Med Sci, 2013, 28(10): 1435-1442.
26.	Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9(6): 669-676.
27.	Song J, Lu H, Zheng X, et al. Effects of vascular endothelial growth factor in recovery phase of acute lung injury in mice. Lung, 2015, 193(6): 1029-1036.
28.	Yang Y, Hu SL, Xu XP, et al. The vascular endothelial growth factors-expressing character of mesenchymal stem cells plays a positive role in treatment of acute lung injury in vivo. Mediators Inflamm, 2016: ID2347938. Available at: https://www.hindawi. com/journals/mi/2016/2347938/.
29.	Le A, Zielinski R, He C, et al. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med, 2009, 180(5): 396-406.
30.	Kasahara Y, Tuder RM, Tarasevicienestewart L, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 2000, 106(11): 1311-1319.
31.	马强, 吴占庆, 杨培雄, 等. 急性呼吸窘迫综合征患者血清中血管内皮生长因子、肿瘤坏死因子-α 和降钙素原的表达. 中国老年学杂志, 2015, 35(20): 5842-5843.
32.	Cross LJ, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin, 2011, 27(2): 355-377.
33.	张曌, 张师海. 血管内皮生长因子在急性肺损伤中的表达及作用机制[毕业论文]. 华中科技大学, 2010.
34.	Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med, 2002, 166(10): 1332-1337.
35.	蒋云书, 陈建荣, 张文彬, 等. 急性肺损伤/急性呼吸窘迫综合征患者呼出气冷凝液中血管内皮生长因子 A 检测的临床意义. 中国呼吸与危重监护杂志, 2011, 10(2): 135-138.
36.	Koh H, Tasaka S, Hasegawa N, et al. Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology, 2008, 13(2): 281-284.
37.	Iain MJ, Mackenzie B, Tunnicliffe B. Blast injuries to the lung: epidemiology and management. Phil Trans R Soc B, 2011, 366(1562): 295-299.
38.	李毅, 邹曰坤, 蒋富强. 大剂量氨溴索对海水浸泡致急性肺损伤犬体内 SP-A、SP-B 含量的影响. 海南医学院学报, 2014, 20(8): 1038-1040.
39.	李自强, 林庆安, 张雷, 等. 山莨菪碱对海水淹溺性肺水肿的治疗作用. 中国医师杂志, 2005, 7(5): 592-594.
40.	侯晓彬, 李廷慧, 金文波, 等. 地塞米松和山莨菪碱在胸部爆炸伤致急性肺损伤中的防治作用. 中国急救医学, 2008, 28(6): 531-535.
41.	潘珍, 黎嘉文. 大剂量盐酸氨溴索对肺部的保护作用的 Meta 分析. 中国药房, 2014, 25(32): 3041-3045.
42.	Seam N, Meduri GU, Wang H, et al. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med, 2012, 40(2): 495-501.
43.	Weekes CD, Beeram M, Tolcher AW, et al. A phase Ⅰ study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest New Drugs, 2014, 32(4): 653-660.
44.	Jarvis A, Allerston CK, Jia H, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem, 2010, 53(5): 2215-2226.
45.	Eichholz A, Merchant S, Gaya AM, et al. Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther, 2010, 3: 69-82.
46.	Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355(24): 2542-2550.
47.	佟昌慈, 柳云恩, 张玉彪, 等. 体外膜肺氧合对撞击伤致急性肺损伤细胞因子表达影响. 创伤与急危重病医学, 2016, 4(1): 6-9.
48.	Hua F, Wang X, Zhu L. Terlipressin decreases vascular endothelial growth factor expression and improves oxygenation in patients with acute respiratory distress syndrome and shock. J Emerg Med, 2013, 44(2): 434-439.

1. Smith JE. The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 291-294.
2. 刘军, 赵富丽, 吴健, 等. 昆山" 8·2”爆炸事故存活伤员损伤特点及救治分析. 中华急诊医学杂志, 2015, 24(9): 952-957.
3. Clapson P, Pasquie rP, Perez JP, et al. Blast lung injuries. Rev Pneumol Clin, 2010, 66(4): 245-253.
4. Mellor SG, Cooper GJ. Analysis of 828 servicemen killed or injured by explosion in Northern Ireland 1970-84: the Hostile Action Casualty System. Br J Surg, 1989, 76(10): 1006-1010.
5. Bauman RA, Ling G, Tong L, et al. An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma, 2009, 26(6): 841-860.
6. Wolf SJ, Bebarta VS, Bonnett CJ, et al. Blast injuries. Lancet, 2009, 374(9687): 405-415.
7. Skotak M, Wang F, Alai A, et al. Rat injury model under controlled field-relevant primary blast conditions: acute response to a wide range of peak overpressures. J Neurotrauma, 2013, 30(13): 1147-1160.
8. Kirkman E, Watts S, Cooper G. Blast injury research models. Phil Trans R Soc B, 2011, 366(1652): 144-159.
9. Joseph B, Bentley TL, Wessner KA, et al. Blast Overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma, 2009, 26(6): 827-840.
10. Wong JM, Marsh D, Abu-Sitta G, et al. Biological foreign body implantation in victims of the London July 7th suicide bombings. J Trauma 2006, 60(2): 402-404.
11. Chapman LE, Sullivent EE, Grohskopf LA, et al. Postexposure interventions to prevent infection with HBV, HCV, or HIV, and tetanus in people wounded during bombings and other mass casualty events-United States, 2008: recommendations of the Centers for Disease Control and Prevention and Disaster Medicine and Public Health Preparedness. Disaster Med Public Health Prep, 2008, 2(3): 150-165.
12. Clint BD. Force protection and infectious risk mitigation from suicide bombers. Mil Med, 2009, 174(7): 709-714.
13. Eshkol Z, Katz K. Injuries from biologic material of suicide bombers. Injury, 2005, 36(2): 271-274.
14. Yeh DD, Schecter WP. Primary blast injuries-an updated concise review. World J Surg, 2012, 36(5): 966-972.
15. Kirkman E, Watts S. Characterization of the response to primary blast injury. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 286-290.
16. Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?. Thorax 2006, 61(7): 621-626.
17. Kaner RJ, Crystal RG. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med, 2001, 7(4): 240-246.
18. Foster RR, Hole R, Anderson K, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol, 2003, 284(6): F1263-F1273.
19. Andrew RL, Nassif BN, Ann B, et al. Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome. J Crit Care, 2009, 24(2): 236-242.
20. Wild JR, Staton CA, Chapple K, et al. Neuropilins: expression and roles in the epithelium. Int J Exp Pathol, 2012, 93(2): 81-103.
21. Barratt S, Medford A R, Millar AB. Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome. Respiration, 2014, 87(4): 329-342.
22. Jia H, Cheng L, Tickner M, et al. Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. Br J Cancer, 2010, 102(3): 541-552.
23. Fantin A, Herzog B, Mahmoud M, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development, 2014, 141(3): 556-562.
24. Ding MH, Liu L, Hu CX, et al. Expression of VEGF R2 and NRP-1 in non-small cell lung cancer and their clinical significance. Chin J Cancer Res, 2014, 26(6): 669-677.
25. Shim EJ, Chun E, Kang HR, et al. Expression of semaphorin 3A and neuropilin 1 in asthma. J Korean Med Sci, 2013, 28(10): 1435-1442.
26. Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9(6): 669-676.
27. Song J, Lu H, Zheng X, et al. Effects of vascular endothelial growth factor in recovery phase of acute lung injury in mice. Lung, 2015, 193(6): 1029-1036.
28. Yang Y, Hu SL, Xu XP, et al. The vascular endothelial growth factors-expressing character of mesenchymal stem cells plays a positive role in treatment of acute lung injury in vivo. Mediators Inflamm, 2016: ID2347938. Available at: https://www.hindawi. com/journals/mi/2016/2347938/.
29. Le A, Zielinski R, He C, et al. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med, 2009, 180(5): 396-406.
30. Kasahara Y, Tuder RM, Tarasevicienestewart L, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 2000, 106(11): 1311-1319.
31. 马强, 吴占庆, 杨培雄, 等. 急性呼吸窘迫综合征患者血清中血管内皮生长因子、肿瘤坏死因子-α 和降钙素原的表达. 中国老年学杂志, 2015, 35(20): 5842-5843.
32. Cross LJ, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin, 2011, 27(2): 355-377.
33. 张曌, 张师海. 血管内皮生长因子在急性肺损伤中的表达及作用机制[毕业论文]. 华中科技大学, 2010.
34. Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med, 2002, 166(10): 1332-1337.
35. 蒋云书, 陈建荣, 张文彬, 等. 急性肺损伤/急性呼吸窘迫综合征患者呼出气冷凝液中血管内皮生长因子 A 检测的临床意义. 中国呼吸与危重监护杂志, 2011, 10(2): 135-138.
36. Koh H, Tasaka S, Hasegawa N, et al. Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology, 2008, 13(2): 281-284.
37. Iain MJ, Mackenzie B, Tunnicliffe B. Blast injuries to the lung: epidemiology and management. Phil Trans R Soc B, 2011, 366(1562): 295-299.
38. 李毅, 邹曰坤, 蒋富强. 大剂量氨溴索对海水浸泡致急性肺损伤犬体内 SP-A、SP-B 含量的影响. 海南医学院学报, 2014, 20(8): 1038-1040.
39. 李自强, 林庆安, 张雷, 等. 山莨菪碱对海水淹溺性肺水肿的治疗作用. 中国医师杂志, 2005, 7(5): 592-594.
40. 侯晓彬, 李廷慧, 金文波, 等. 地塞米松和山莨菪碱在胸部爆炸伤致急性肺损伤中的防治作用. 中国急救医学, 2008, 28(6): 531-535.
41. 潘珍, 黎嘉文. 大剂量盐酸氨溴索对肺部的保护作用的 Meta 分析. 中国药房, 2014, 25(32): 3041-3045.
42. Seam N, Meduri GU, Wang H, et al. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med, 2012, 40(2): 495-501.
43. Weekes CD, Beeram M, Tolcher AW, et al. A phase Ⅰ study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest New Drugs, 2014, 32(4): 653-660.
44. Jarvis A, Allerston CK, Jia H, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem, 2010, 53(5): 2215-2226.
45. Eichholz A, Merchant S, Gaya AM, et al. Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther, 2010, 3: 69-82.
46. Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355(24): 2542-2550.
47. 佟昌慈, 柳云恩, 张玉彪, 等. 体外膜肺氧合对撞击伤致急性肺损伤细胞因子表达影响. 创伤与急危重病医学, 2016, 4(1): 6-9.
48. Hua F, Wang X, Zhu L. Terlipressin decreases vascular endothelial growth factor expression and improves oxygenation in patients with acute respiratory distress syndrome and shock. J Emerg Med, 2013, 44(2): 434-439.

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血管内皮生长因子和神经菌毛素-1 在肺爆震伤诊疗中的应用

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