补充维生素D:哮喘治疗新手段?_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

刘瑶琦 , 赵海金 ,  蔡绍曦

南方医科大学南方医院呼吸与危重症医学科慢性气道疾病实验室(广东广州 510515);

Corresponding author：

蔡绍曦, Email: caishaox@fimmu.com

Keywords：

DOI：

10.7507/1671-6205.2016072

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Citation： 刘瑶琦, 赵海金, 蔡绍曦. 补充维生素D:哮喘治疗新手段?. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(3): 305-309. doi: 10.7507/1671-6205.2016072 Copy

1.	Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol, 2009, 19:73-78.
2.	Holick MF. Vitamin D deficiency. N Engl J Med, 2007, 357:266-281.
3.	Kerley CP, Elnazir B, Faul J, et al. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulm Pharmacol Ther, 2015, 32:60-74.
4.	Hansdottir S, Monick MM, Hinde SL, et al. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol, 2008, 181:7090-7099.
5.	Adorini L, Penna G, Giarratana N. Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands. J Steroid Biochem Mol Biol, 2004, 89-90(1-5):437-441.
6.	Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol, 2012, 188:2127-2135.
7.	Keating P, Munim A, Hartmann JX. Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol, 2014, 112:154-162.
8.	Drozdenko G, Heine G, Worm M. Oral vitamin D increases the frequencies of CD38⁺ human B cells and ameliorates IL-17-producing T cells. Exp Dermatol, 2014, 23:107-112.
9.	Agrawal T, Gupta GK, Agrawal DK. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. Clin Exp Allergy, 2013, 43:672-683.
10.	Vasiliou JE, Lui S, Walker SA, et al. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease. Allergy, 2014, 69:1380-1389.
11.	Boonstra A, Barrat FJ, Crain C, et al. 1α, 25-Dihydroxyvitamin D3 has a direct effect on naive CD4⁺ T cells to enhance the development of Th2 cells. J Immunol, 2001, 167:4974-4980.
12.	Zosky GR, Hart PH, Whitehouse AJ, et al. Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age. Ann Am Thorac Soc, 2014, 11:571-577.
13.	Camargo CA Jr, Ingham T, Wickens K, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics, 2011, 127:180-187.
14.	Allan KM, Prabhu N, Craig LC, et al. Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. Eur Respir J, 2015, 45:1027-1036.
15.	Erkkola M, Kaila M, Nwaru BI, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy, 2009, 39:875-882.
16.	Miyake Y, Sasaki S, Tanaka K, et al. Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J, 2010, 35:1228-1234.
17.	Gale CR, Robinson SM, Harvey NC, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr, 2008, 62:68-77.
18.	Hansen S, Maslova E, Strøm M, et al. The long-term programming effect of maternal 25-hydroxyvitamin D in pregnancy on allergic airway disease and lung function in offspring after 20 to 25 years of follow-up. J Allergy Clin Immunol, 2015, 136:169-176.
19.	Pike KC, Inskip HM, Robinson S, et al. Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 2012, 67:950-956.
20.	Wills AK, Shaheen SO, Granell R, et al. Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function. Clin Exp Allergy, 2013, 43:1180-1188.
21.	Gazibara T, den Dekker HT, de Jongste JC, et al. Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: The Generation R Study. Clin Exp Allergy, 2016, 46:337-346.
22.	Baïz N, Dargent-Molina P, Wark JD, et al. Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J Allergy Clin Immunol, 2014, 133:147-153.
23.	van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma:the PIAMA birth cohort study. Pediatr Allergy Immunol, 2011, 22:784-793.
24.	Hollams EM, Hart PH, Holt BJ, et al. Vitamin D and atopy and asthma phenotypes in children:a longitudinal cohort study. Eur Respir J, 2011, 38:1320-1327.
25.	Mai XM, Langhammer A, Camargo CA Jr, et al. Serum 25-hydroxyvitamin D levels and incident asthma in adults:the HUNT Study. Am J Epidemiol, 2012, 176:1169-1176.
26.	Thuesen BH, Heede NG, Tang L, et al. No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults. Allergy, 2015, 70:1501-1504.
27.	Thuesen BH, Skaaby T, Husemoen LL, et al. The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults. Clin Exp Allergy, 2015, 45:265-272.
28.	Bener A, Ehlayel MS, Tulic MK, et al. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol, 2012, 157:168-175.
29.	Freishtat RJ, Iqbal SF, Pillai DK, et al. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr, 2010, 156:948-952.
30.	Niruban SJ, Alagiakrishnan K, Beach J, et al. Association between vitamin D and respiratory outcomes in Canadian adolescents and adults. J Asthma, 2015, 52:653-661.
31.	Checkley W, Robinson CL, Baumann LM, et al. 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru. Clin Exp Allergy, 2015, 45:273-282.
32.	Niruban SJ, Alagiakrishnan K, Beach J, et al. Association of vitamin D with respiratory outcomes in Canadian children. Eur J Clin Nutr, 2014, 68:1334-1340.
33.	Wawro N, Heinrich J, Thiering E, et al. Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies. BMC Pediatr, 2014, 14:286.
34.	Salas NM, Luo L, Harkins MS, et al. Vitamin D deficiency and adult asthma exacerbations. J Asthma, 2014, 51:950-955.
35.	Brehm JM, Acosta-Pérez E, Klei L, et al. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med, 2012, 186:140-146.
36.	Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from costa rica. Allergy Asthma Immunol Res, 2013, 5:283-288.
37.	Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol, 2010, 126:52-58.
38.	Samrah S, Khatib I, Omari M, et al. Vitamin D deficiency and level of asthma control in women from North of Jordan: a case-control study. J Asthma, 2014, 51:832-838.
39.	Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis, 2013, 57:392-397.
40.	Confino-Cohen R, Brufman I, Goldberg A, et al. Vitamin D, asthma prevalence and asthma exacerbations:a large adult population-based study. Allergy, 2014, 69:1673-1680.
41.	Arikoglu T, Kuyucu S, Karaismailoglu E, et al. The association of vitamin D, cathelicidin, and vitamin D binding protein with acute asthma attacks in children. Allergy Asthma Proc, 2015, 36:51-58.
42.	Sutherland ER, Goleva E, Jackson LP, et al. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med, 2010, 181:699-704.
43.	Brehm JM, Celedón JC, Soto-Quiros ME, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med, 2009, 179:765-771.
44.	Korn S, Hübner M, Jung M, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res, 2013, 14:25.
45.	Gupta A, Sjoukes A, Richards D, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med, 2011, 184:1342-1349.
46.	Arshi S, Fallahpour M, Nabavi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol, 2014, 113:404-409.
47.	de Groot JC, van Roon EN, Storm, et al. Vitamin D reduces eosinophilic airway inflammationin nonatopic asthma. J Allergy Clin Immunol, 2015, 135:670-675.
48.	Majak P, Olszowiec-Chlebna M, Smejda K, et al. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol, 2011, 127:1294-1296.
49.	Tachimoto H, Mezawa H, Segawa T, et al. Improved control of childhood asthma with low-dose, short-term vitamin D supplementation: a randomized, double-blind, placebo-controlled trial. Allergy, 2016 Feb 3.doi:10.1111/all.12856.[Epub ahead of print].
50.	Castro M, King TS, Kunselman SJ, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA, 2014, 311:2083-2091.
51.	Martineau AR, MacLaughlin BD, Hooper RL, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma(ViDiAs). Thorax, 2015, 70:451-457.
52.	Mehta AA, Agrawal AD, Appanna V. Vitamin D improves corticosteroid efficacy and attenuates its side-effects in an animal model of asthma. Can J Physiol Pharmacol, 2015, 93:53-61.
53.	Li W, Dong H, Zhao H, et al. 1, 25-Dihydroxyvitamin D3 prevents toluene diisocyanate-induced airway epithelial barrier disruption. Int J Mol Med, 2015, 36:263-270.
54.	Zhang RH, Zhao HJ, Dong HM, et al. 1α, 25-dihydroxyvitamin D₃ counteracts the effects of cigarette smoke in airway epithelial cells. Cell Immunol, 2015, 295:137-143.
55.	周丽芹, 董航明, 赵海金, 等.活性维生素D3下调屋尘螨诱导的气道上皮细胞胸腺基质淋巴生成素蛋白释放.南方医科大学学报, 2014, 34:492-496.

1. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol, 2009, 19:73-78.
2. Holick MF. Vitamin D deficiency. N Engl J Med, 2007, 357:266-281.
3. Kerley CP, Elnazir B, Faul J, et al. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulm Pharmacol Ther, 2015, 32:60-74.
4. Hansdottir S, Monick MM, Hinde SL, et al. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol, 2008, 181:7090-7099.
5. Adorini L, Penna G, Giarratana N. Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands. J Steroid Biochem Mol Biol, 2004, 89-90(1-5):437-441.
6. Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol, 2012, 188:2127-2135.
7. Keating P, Munim A, Hartmann JX. Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol, 2014, 112:154-162.
8. Drozdenko G, Heine G, Worm M. Oral vitamin D increases the frequencies of CD38⁺ human B cells and ameliorates IL-17-producing T cells. Exp Dermatol, 2014, 23:107-112.
9. Agrawal T, Gupta GK, Agrawal DK. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. Clin Exp Allergy, 2013, 43:672-683.
10. Vasiliou JE, Lui S, Walker SA, et al. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease. Allergy, 2014, 69:1380-1389.
11. Boonstra A, Barrat FJ, Crain C, et al. 1α, 25-Dihydroxyvitamin D3 has a direct effect on naive CD4⁺ T cells to enhance the development of Th2 cells. J Immunol, 2001, 167:4974-4980.
12. Zosky GR, Hart PH, Whitehouse AJ, et al. Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age. Ann Am Thorac Soc, 2014, 11:571-577.
13. Camargo CA Jr, Ingham T, Wickens K, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics, 2011, 127:180-187.
14. Allan KM, Prabhu N, Craig LC, et al. Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. Eur Respir J, 2015, 45:1027-1036.
15. Erkkola M, Kaila M, Nwaru BI, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy, 2009, 39:875-882.
16. Miyake Y, Sasaki S, Tanaka K, et al. Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J, 2010, 35:1228-1234.
17. Gale CR, Robinson SM, Harvey NC, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr, 2008, 62:68-77.
18. Hansen S, Maslova E, Strøm M, et al. The long-term programming effect of maternal 25-hydroxyvitamin D in pregnancy on allergic airway disease and lung function in offspring after 20 to 25 years of follow-up. J Allergy Clin Immunol, 2015, 136:169-176.
19. Pike KC, Inskip HM, Robinson S, et al. Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 2012, 67:950-956.
20. Wills AK, Shaheen SO, Granell R, et al. Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function. Clin Exp Allergy, 2013, 43:1180-1188.
21. Gazibara T, den Dekker HT, de Jongste JC, et al. Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: The Generation R Study. Clin Exp Allergy, 2016, 46:337-346.
22. Baïz N, Dargent-Molina P, Wark JD, et al. Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J Allergy Clin Immunol, 2014, 133:147-153.
23. van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma:the PIAMA birth cohort study. Pediatr Allergy Immunol, 2011, 22:784-793.
24. Hollams EM, Hart PH, Holt BJ, et al. Vitamin D and atopy and asthma phenotypes in children:a longitudinal cohort study. Eur Respir J, 2011, 38:1320-1327.
25. Mai XM, Langhammer A, Camargo CA Jr, et al. Serum 25-hydroxyvitamin D levels and incident asthma in adults:the HUNT Study. Am J Epidemiol, 2012, 176:1169-1176.
26. Thuesen BH, Heede NG, Tang L, et al. No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults. Allergy, 2015, 70:1501-1504.
27. Thuesen BH, Skaaby T, Husemoen LL, et al. The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults. Clin Exp Allergy, 2015, 45:265-272.
28. Bener A, Ehlayel MS, Tulic MK, et al. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol, 2012, 157:168-175.
29. Freishtat RJ, Iqbal SF, Pillai DK, et al. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr, 2010, 156:948-952.
30. Niruban SJ, Alagiakrishnan K, Beach J, et al. Association between vitamin D and respiratory outcomes in Canadian adolescents and adults. J Asthma, 2015, 52:653-661.
31. Checkley W, Robinson CL, Baumann LM, et al. 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru. Clin Exp Allergy, 2015, 45:273-282.
32. Niruban SJ, Alagiakrishnan K, Beach J, et al. Association of vitamin D with respiratory outcomes in Canadian children. Eur J Clin Nutr, 2014, 68:1334-1340.
33. Wawro N, Heinrich J, Thiering E, et al. Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies. BMC Pediatr, 2014, 14:286.
34. Salas NM, Luo L, Harkins MS, et al. Vitamin D deficiency and adult asthma exacerbations. J Asthma, 2014, 51:950-955.
35. Brehm JM, Acosta-Pérez E, Klei L, et al. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med, 2012, 186:140-146.
36. Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from costa rica. Allergy Asthma Immunol Res, 2013, 5:283-288.
37. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol, 2010, 126:52-58.
38. Samrah S, Khatib I, Omari M, et al. Vitamin D deficiency and level of asthma control in women from North of Jordan: a case-control study. J Asthma, 2014, 51:832-838.
39. Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis, 2013, 57:392-397.
40. Confino-Cohen R, Brufman I, Goldberg A, et al. Vitamin D, asthma prevalence and asthma exacerbations:a large adult population-based study. Allergy, 2014, 69:1673-1680.
41. Arikoglu T, Kuyucu S, Karaismailoglu E, et al. The association of vitamin D, cathelicidin, and vitamin D binding protein with acute asthma attacks in children. Allergy Asthma Proc, 2015, 36:51-58.
42. Sutherland ER, Goleva E, Jackson LP, et al. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med, 2010, 181:699-704.
43. Brehm JM, Celedón JC, Soto-Quiros ME, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med, 2009, 179:765-771.
44. Korn S, Hübner M, Jung M, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res, 2013, 14:25.
45. Gupta A, Sjoukes A, Richards D, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med, 2011, 184:1342-1349.
46. Arshi S, Fallahpour M, Nabavi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol, 2014, 113:404-409.
47. de Groot JC, van Roon EN, Storm, et al. Vitamin D reduces eosinophilic airway inflammationin nonatopic asthma. J Allergy Clin Immunol, 2015, 135:670-675.
48. Majak P, Olszowiec-Chlebna M, Smejda K, et al. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol, 2011, 127:1294-1296.
49. Tachimoto H, Mezawa H, Segawa T, et al. Improved control of childhood asthma with low-dose, short-term vitamin D supplementation: a randomized, double-blind, placebo-controlled trial. Allergy, 2016 Feb 3.doi:10.1111/all.12856.[Epub ahead of print].
50. Castro M, King TS, Kunselman SJ, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA, 2014, 311:2083-2091.
51. Martineau AR, MacLaughlin BD, Hooper RL, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma(ViDiAs). Thorax, 2015, 70:451-457.
52. Mehta AA, Agrawal AD, Appanna V. Vitamin D improves corticosteroid efficacy and attenuates its side-effects in an animal model of asthma. Can J Physiol Pharmacol, 2015, 93:53-61.
53. Li W, Dong H, Zhao H, et al. 1, 25-Dihydroxyvitamin D3 prevents toluene diisocyanate-induced airway epithelial barrier disruption. Int J Mol Med, 2015, 36:263-270.
54. Zhang RH, Zhao HJ, Dong HM, et al. 1α, 25-dihydroxyvitamin D₃ counteracts the effects of cigarette smoke in airway epithelial cells. Cell Immunol, 2015, 295:137-143.
55. 周丽芹, 董航明, 赵海金, 等.活性维生素D3下调屋尘螨诱导的气道上皮细胞胸腺基质淋巴生成素蛋白释放.南方医科大学学报, 2014, 34:492-496.

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补充维生素D:哮喘治疗新手段?

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