Objective  To explore the predictive value of Charlson comorbidity index(CCI)in the prognosis of aged chronic obstructive pulmonary disease (COPD)patients. Methods  A retrospective review was performed for 350 hospitalized aged COPD patients who admitted in Xuanwu Hospital of Capital Medical University from January 2010 to January 2015.The clinical data were recorded including age,body mass index (BMI),comorbidities (CCI score),FEV₁%pred,the times of acute exacerbation of COPD a year before admission,and in-hospital mortality.The risk factors of acute exacerbation and in-hospital mortality were analyzed by multivariable logistic regression. Results  There were 177 patients who had experienced acute exacerbation more than 2 times per year and 173 patients who had experienced acute exacerbation less than 2 times per year.Multivariable logistic regression analysis showed that CCI [OR=1.559,95% CI(1.309,1.856),P=0.000] and FEV₁%pred [OR=0.979,95% CI(0.964,0.994),P=0.006] were the independent predictors for acute exacerbation of COPD.The in-hospital mortality rate was 10.3%(36/314). Multivariable logistic regression analysis showed that CCI [OR＝1.894,95% CI (1.422,2.523),P=0.000],age [OR=1.153,95% CI(1.063,1.251),P=0.001],FEV₁%pred [OR=0.916,95% CI(0.878,0.955),P=0.000],BMI [OR=0.849,95% CI(0.749,0.962),P=0.011],acute exacerbation more than 2 times per year [OR=6.340,95% CI(1.469,27.366),P=0.013] were the independent predictors for mortality. Conclusion  CCI is an independent risk factor associated with in-hospital mortality and acute exacerbation of COPD.

Citation： ZhangLin, PiChunmei, NieXiuhong. Predictive Value of Charlson Comorbidity Index in Prognosis of Aged Chronic Obstructive Pulmonary Disease Patients. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(4): 333-336. doi: 10.7507/1671-6205.2016079 Copy