肥胖急性呼吸窘迫综合征患者的临床特点_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

张书娟 , 韩丽丽 ,  万献尧

大连医科大学重症医学研究所/附属一院重症医学科（辽宁大连 116011）;

Corresponding author：

万献尧, Email: 13322210199@163.com

Keywords：

DOI：

10.7507/1671-6205.201609014

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Citation： 张书娟, 韩丽丽, 万献尧. 肥胖急性呼吸窘迫综合征患者的临床特点. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(4): 421-424. doi: 10.7507/1671-6205.201609014 Copy

1.	徐赫男. 从中国居民营养与慢性病状况报告看到了什么. 糖尿病临床, 2016, 10(4): 142-145.
2.	胡雪, 陈月, 邹大进. 肥胖、糖尿病与肿瘤: 病理生理机制新进展. 中华糖尿病杂志, 2010, 2(5): 321-324.
3.	Smits A, Lopes A, Das N, et al. Surgical morbidity and clinical outcomes in ovarian cancer the role of obesity. BJOG, 2016, 123(2): 300-308.
4.	杨毅, 邱海波. 急性呼吸窘迫综合征救治: 需要遵循的十大原则. 中华重症医学电子杂志, 2015, 1(1): 33-38.
5.	Villar J, Blanco J, Kacmarek RM. Current incidence and outcome of the acute respiratory distress syndrome. Curr Opin Crit Care, 2016, 22(1): 1-6.
6.	Morgan OW, Bramley A, Fowlkes A, et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A (H1N1) disease. PLoS One, 2010, 5(3): e9694.
7.	Bautista E, Chotpitayasunondh T, Gao Z, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med, 2010, 362(18): 1708-1719.
8.	杨胜富, 吴东波. 肥胖的流行病学病理生理及治疗的研究进展. 中国临床医学, 2016, 9(4): 358-362.
9.	Littleton SW. Impact of obesity on respiratory function. Respirology, 2012, 17(1): 43-49.
10.	Hibbert K, Rice M, Malhotra A. Obesity and ARDS. Chest, 2012, 142(3): 785-790.
11.	Ilavská S, Horváthová M, Szabová M, et al. Association between the human immune response and body mass index. Hum Immunol, 2012, 73(5): 480-485.
12.	Lu Y, Van Bever HP, Lim TK, et al. Obesity, asthma prevalence and IL-4: roles of inflammatory cytokines, adiponectin and neuropeptide Y. Pediatr Allergy Immunol, 2015, 26(6): 530-536.
13.	van Harmelen V, Eriksson A, Aström G, et al. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes, 2008, 57(2): 378-386.
14.	Stapleton RD, Dixon AE, Parsons PE, et al. The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest, 2010, 138(3): 568-577.
15.	Gong MN, Bajwa EK, Thompson BT, et al. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax, 2010, 65(1): 44-50.
16.	Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol, 2005, 115(5): 911-919; quiz 920.
17.	La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol, 2004, 4(5): 371-379.
18.	Ubags ND, Vernooy JH, Burg E, et al. The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med, 2014, 42(2): e143-151.
19.	Wosu AC, Vélez JC, Barbosa C, et al. The relationship between high risk for obstructive sleep apnea and general and central obesity: findings from a sample of Chilean College Students. ISRN Obes, 2014, 2014: 871681.
20.	El-Solh AA, Aquilina A, Pineda L, et al. Noninvasive ventilation for prevention of post-extubation respiratory failure in obese patients. Eur Respir J, 2006, 28(3): 588-595.
21.	Yoo JW, Synn A, Huh JW, et al. Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure. Korean J Intern Med, 2016, 31(1): 82-88.
22.	王四海. 压力-容积曲线低位转折点选择呼气末正压在 ARDS 应用价值. 临床肺科杂志, 2014, 19(3): 439-441.
23.	Yadam S, Bihler E, Balaan M. Acute respiratory distress syndrome. Crit Care Nurs Q, 2016, 39(2): 190-195.
24.	Fernandez R, Trenchs X, Klamburg J, et al. Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med, 2008, 34(8): 1487-1491.
25.	Sud S, Friedrich JO, Taccone P, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med, 2010, 36(4): 585-599.
26.	Schmidt M, Zogheib E, Rozé H, et al. The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med, 2013, 39(10): 1704-1713.
27.	Turner KL, Moore FA, Martindale R. Nutrition support for the acute lung injury/adult respiratory distress syndrome patient: a review. Nutr Clin Pract, 2011, 26(1): 14-25.
28.	Bihari S, Bailey M, Bersten AD. Steroids in ARDS: to be or not to be. Intensive Care Med, 2016, 42(5): 931-933.
29.	Bein T, Briegel J, Annane D. Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: yes. Intensive Care Med, 2016, 42(5): 918-920.
30.	周明. 糖皮质激素在重症社区获得性肺炎致急性呼吸窘迫综合征综合救治中的应用价值. 临床医学工程, 2015, 22(1): 57-58.
31.	郭献阳, 张明, 陈如杰, 等. 辛伐他汀治疗急性呼吸窘迫综合征的临床研究. 中国临床药理学杂志, 2015, 31(6): 406-408.
32.	喻文, 罗红敏. 辛伐他汀并不能改善急性呼吸窘迫综合征患者预后. 中华危重病急救医学, 2015, 27(3): 208-208.
33.	Truwit JD, Bernard GR, Steingrub J, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med, 2014, 370(23): 2191-2200.
34.	唐芳华, 黎艳. 体位护理对减少呼吸机相关性肺炎发生的效果观察. 中国临床新医学, 2015, (12): 1193-1195.
35.	O'Brien JM, Phillips GS, Ali NA, et al. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med, 2006, 34(3): 738-744.
36.	Soto GJ, Frank AJ, Christiani DC, et al. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med, 2012, 40(9): 2601-2608.
37.	O'Brien JM, Welsh CH, Fish RH, et al. Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med, 2004, 140(5): 338-345.
38.	Morris AE, Stapleton RD, Rubenfeld GD, et al. The association between body mass index and clinical outcomes in acute lung injury. Chest, 2007, 131(2): 342-348.
39.	Schell-Chaple HM, Puntillo KA, Matthay MA, et al. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care, 2015, 24(1): 15-23.
40.	李缺缺, 张久之, 万献尧. 老年急性呼吸窘迫综合征的特点. 中国呼吸与危重监护杂志, 2013, 12(5): 530-532.
41.	McIntyre LA, Moher D, Fergusson DA, et al. Efficacy of mesenchymal stromal cell therapy for acute lung injury in preclinical animal models: a systematic review. PLoS One, 2016, 11(1): e0147170.

1. 徐赫男. 从中国居民营养与慢性病状况报告看到了什么. 糖尿病临床, 2016, 10(4): 142-145.
2. 胡雪, 陈月, 邹大进. 肥胖、糖尿病与肿瘤: 病理生理机制新进展. 中华糖尿病杂志, 2010, 2(5): 321-324.
3. Smits A, Lopes A, Das N, et al. Surgical morbidity and clinical outcomes in ovarian cancer the role of obesity. BJOG, 2016, 123(2): 300-308.
4. 杨毅, 邱海波. 急性呼吸窘迫综合征救治: 需要遵循的十大原则. 中华重症医学电子杂志, 2015, 1(1): 33-38.
5. Villar J, Blanco J, Kacmarek RM. Current incidence and outcome of the acute respiratory distress syndrome. Curr Opin Crit Care, 2016, 22(1): 1-6.
6. Morgan OW, Bramley A, Fowlkes A, et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A (H1N1) disease. PLoS One, 2010, 5(3): e9694.
7. Bautista E, Chotpitayasunondh T, Gao Z, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med, 2010, 362(18): 1708-1719.
8. 杨胜富, 吴东波. 肥胖的流行病学病理生理及治疗的研究进展. 中国临床医学, 2016, 9(4): 358-362.
9. Littleton SW. Impact of obesity on respiratory function. Respirology, 2012, 17(1): 43-49.
10. Hibbert K, Rice M, Malhotra A. Obesity and ARDS. Chest, 2012, 142(3): 785-790.
11. Ilavská S, Horváthová M, Szabová M, et al. Association between the human immune response and body mass index. Hum Immunol, 2012, 73(5): 480-485.
12. Lu Y, Van Bever HP, Lim TK, et al. Obesity, asthma prevalence and IL-4: roles of inflammatory cytokines, adiponectin and neuropeptide Y. Pediatr Allergy Immunol, 2015, 26(6): 530-536.
13. van Harmelen V, Eriksson A, Aström G, et al. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes, 2008, 57(2): 378-386.
14. Stapleton RD, Dixon AE, Parsons PE, et al. The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest, 2010, 138(3): 568-577.
15. Gong MN, Bajwa EK, Thompson BT, et al. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax, 2010, 65(1): 44-50.
16. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol, 2005, 115(5): 911-919; quiz 920.
17. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol, 2004, 4(5): 371-379.
18. Ubags ND, Vernooy JH, Burg E, et al. The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med, 2014, 42(2): e143-151.
19. Wosu AC, Vélez JC, Barbosa C, et al. The relationship between high risk for obstructive sleep apnea and general and central obesity: findings from a sample of Chilean College Students. ISRN Obes, 2014, 2014: 871681.
20. El-Solh AA, Aquilina A, Pineda L, et al. Noninvasive ventilation for prevention of post-extubation respiratory failure in obese patients. Eur Respir J, 2006, 28(3): 588-595.
21. Yoo JW, Synn A, Huh JW, et al. Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure. Korean J Intern Med, 2016, 31(1): 82-88.
22. 王四海. 压力-容积曲线低位转折点选择呼气末正压在 ARDS 应用价值. 临床肺科杂志, 2014, 19(3): 439-441.
23. Yadam S, Bihler E, Balaan M. Acute respiratory distress syndrome. Crit Care Nurs Q, 2016, 39(2): 190-195.
24. Fernandez R, Trenchs X, Klamburg J, et al. Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med, 2008, 34(8): 1487-1491.
25. Sud S, Friedrich JO, Taccone P, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med, 2010, 36(4): 585-599.
26. Schmidt M, Zogheib E, Rozé H, et al. The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med, 2013, 39(10): 1704-1713.
27. Turner KL, Moore FA, Martindale R. Nutrition support for the acute lung injury/adult respiratory distress syndrome patient: a review. Nutr Clin Pract, 2011, 26(1): 14-25.
28. Bihari S, Bailey M, Bersten AD. Steroids in ARDS: to be or not to be. Intensive Care Med, 2016, 42(5): 931-933.
29. Bein T, Briegel J, Annane D. Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: yes. Intensive Care Med, 2016, 42(5): 918-920.
30. 周明. 糖皮质激素在重症社区获得性肺炎致急性呼吸窘迫综合征综合救治中的应用价值. 临床医学工程, 2015, 22(1): 57-58.
31. 郭献阳, 张明, 陈如杰, 等. 辛伐他汀治疗急性呼吸窘迫综合征的临床研究. 中国临床药理学杂志, 2015, 31(6): 406-408.
32. 喻文, 罗红敏. 辛伐他汀并不能改善急性呼吸窘迫综合征患者预后. 中华危重病急救医学, 2015, 27(3): 208-208.
33. Truwit JD, Bernard GR, Steingrub J, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med, 2014, 370(23): 2191-2200.
34. 唐芳华, 黎艳. 体位护理对减少呼吸机相关性肺炎发生的效果观察. 中国临床新医学, 2015, (12): 1193-1195.
35. O'Brien JM, Phillips GS, Ali NA, et al. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med, 2006, 34(3): 738-744.
36. Soto GJ, Frank AJ, Christiani DC, et al. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med, 2012, 40(9): 2601-2608.
37. O'Brien JM, Welsh CH, Fish RH, et al. Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med, 2004, 140(5): 338-345.
38. Morris AE, Stapleton RD, Rubenfeld GD, et al. The association between body mass index and clinical outcomes in acute lung injury. Chest, 2007, 131(2): 342-348.
39. Schell-Chaple HM, Puntillo KA, Matthay MA, et al. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care, 2015, 24(1): 15-23.
40. 李缺缺, 张久之, 万献尧. 老年急性呼吸窘迫综合征的特点. 中国呼吸与危重监护杂志, 2013, 12(5): 530-532.
41. McIntyre LA, Moher D, Fergusson DA, et al. Efficacy of mesenchymal stromal cell therapy for acute lung injury in preclinical animal models: a systematic review. PLoS One, 2016, 11(1): e0147170.

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