哮喘-慢性阻塞性肺疾病重叠的临床研究和诊断标准进展_Chinese Journal of Respiratory and Critical Care Medicine

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嵇华夏 ¹ , 周勤 ¹ ,  孙书明 ²

1. ;
2. ;

Corresponding author：

孙书明, Email: zhh1314jhx@163.com

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DOI：

10.7507/1671-6205.201610030

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Citation： 嵇华夏, 周勤, 孙书明. 哮喘-慢性阻塞性肺疾病重叠的临床研究和诊断标准进展. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(4): 407-413. doi: 10.7507/1671-6205.201610030 Copy

1.	Global strategy for asthma management and prevention[R/OL]. Global Initiative for Asthma (GINA). [2015-04-13]. Available at: http://ginasthma.org/.
2.	Global strategy for the diagnosis, management, and prevention of COPD[R/OL]. Global Initiative for Chronic Obstructive Lung Disease (GOLD). [2015-04-13]. Available at: http://goldcopd.org/.
3.	Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc, 2004, 1(3): 176-183.
4.	Global Strategy for Asthma Management and Prevention, 2017[R/OL]. Global Initiative for Asthma. [2017-04-13]. Available at: http://ginasthma.org/.
5.	Postma DS, Reddel HK, ten Hacken NH, et al. Asthma and chronic obstructive pulmonary disease: similarities and differences. Clin. Chest Med, 2014, 63(5-6): 332.
6.	Kim TB, Oh YM, Chang YS, et al. The reality of an intermediate type between asthma and COPD in practice. Respir Care, 2012, 57(8): 1248-1253.
7.	Miravitlles M, Andreu I, Romero Y, et al. Difficulties in differential diagnosis of COPD and asthma in primary care. Br J Gen Pract, 2012, 62(595): e68-75.
8.	Braman SS. The chronic obstructive pulmonary disease-asthma overlap syndrome. Allergy Asthma Proc, 2015, 36(36): 11.
9.	申景文, 王绪飞. 哮喘和慢性阻塞性肺疾病重叠的治疗策略]. 世界最新医学信息文摘, 2015, 15(16): 92-93.
10.	Kauppi P, Kupiainen H, Lindqvist A, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma, 2011, 48(3): 279-285.
11.	Miravitlles M, Soler-Cataluna JJ, Calle M, et al. Spanish guideline for COPD (GesEPOC). Update 2014. Arch. Bronconeumol, 2014, 50(Suppl.1): 1-16.
12.	Diaz-Guzman E, Khosravi M, Mannino DM. Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population. COPD, 2011, 8(6): 400-407.
13.	de Marco R, Pesce G, Marcon A, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middleaged and elderly people from the general population. PLoS ONE, 2013, 8(5): e62985.
14.	张弘, 蔡柏蔷. 支气管哮喘慢性阻塞性肺疾病重叠综合征简介. 中华结核和呼吸杂志, 2014, 37(9): 713-715.
15.	Milanese M, Di Marco F, Corsico AG, et al. Asthma control in elderly asthmatics. An Italian observational study. Respir. Med, 2014, 108(8): 1091-1099.
16.	Golpe R, Sanjuan Lopez P, Cano Jimenez E, et al. Distribution of clinical phenotypes in patients with chronic obstructive pulmonary disease caused by biomass and tobacco smoke. Arch. Bronconeumol, 2014, 50(8): 318-324.
17.	Miravitlles M, Huerta A, Fernandez-Villar JA, et al. Generic utilities in chronic obstructive pulmonary disease patients stratified according to different staging systems. Health Qual. Life Outcomes, 2014, 12(1): 120.
18.	Kitaguchi Y, Komatsu Y, Fujimoto K, et al. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int. J. Chron. Obstruct. Pulmon. Dis, 2012, 7(1): 283-289.
19.	Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir. Res, 2011, 12(1): 1-8.
20.	Marsh SE, Travers J, Weatherall M, et al. Proportional classifications of COPD phenotypes. Thorax, 2008, 63(9): 761-767.
21.	Fu JJ, Gibson PG, Simpson JL, et al. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration, 2014, 87(1): 63-74.
22.	Andersen H, Lampela P, Nevanlinna A, et al. High hospital burden in overlap syndrome of asthma and COPD. Clin. Respir. J, 2013, 7(4): 342-346.
23.	Menezes AM, Montes de Oca M, Perez-Padilla R, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest, 2014, 145(2): 297-304.
24.	Chung JW, Kong KA, Lee JH, et al. Characteristics and self-rated health of overlap syndrome. Int. J. Chron. Obstruct. Pulmon. Dis, 2014, 9(1): 795-804.
25.	Toy EL, Gallagher KF, Stanley EL, et al. The economic impact of exacerbations of chronic obstructive pulmonary disease and exacerbation definition: a review. COPD, 2010, 7(3): 214-228.
26.	Blanchette CM, Gutierrez B, Ory C, et al. Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population. J. Manag. Care Pharm, 2008, 14(2): 176-185.
27.	Rhee CK, Yoon HK, Yoo KH, et al. Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma. COPD, 2014, 11(2): 163-170.
28.	Shaya FT, Dongyi D, Akazawa MO, et al. Burden of concomitant asthma and COPD in a Medicaid population. Chest, 2008, 134(1): 14-19.
29.	钱小顺, 李天志, 王俊锋. 老年人慢性阻塞性肺病的临床特点分析. 中华老年多器官疾病杂志. 2008, 7(6): 485-488.
30.	Hardin M, Cho M, McDonald ML, et al. The clinical and genetic features of COPD-asthma overlap syndrome. Eur. Respir. J, 2014, 44(2): 341-350.
31.	Miravitlles M, Soriano JB, Ancochea J, et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status. Respir. Med, 2013, 107(7): 1053-1060.
32.	Fattahi F, ten Hacken NH, Lofdahl CG, et al. Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study. Respir. Res, 2013, 14(1): 10.
33.	Christenson SA, Steiling K, van den Berge M, et al. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med, 2015, 191(7): 758-766.
34.	Mauad T, Dolhnikoff M. Pathologic similarities and differences between asthma and chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med, 2008, 14(14): 31-38.
35.	Guerra S, Martinez FD. Epidemiology of the origins of airflow limitation in asthma. Proc. Am. Thorac. Soc, 2009, 6(8): 707-711.
36.	Postma DS, Kerkhof M, Boezen HM, et al. Asthma and chronic obstructive pulmonary disease: common genes, common environments? Am. J. Respir. Crit. Care Med, 2011, 183(12): 1588-1594.
37.	Shirtcliffe P, Marsh S, Travers J, et al. Childhood asthma and GOLD-defined chronic obstructive pulmonary disease. Intern. Med. J, 2012, 42(1): 83-88.
38.	Aanerud M, Carsin AE, Sunyer J, et al. Interaction between asthma and smoking increases the risk of adult airway obstruction. Eur. Respir. J, 2015, 45(3): 635-643.
39.	James AL, Palmer LJ, Kicic E, et al. Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking. Am. J. Respir. Crit. Care Med, 2005, 171(2): 109-114.
40.	Perret JL, Dharmage SC, Matheson MC, et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age. Am. J. Respir. Crit. Care Med, 2013, 187(1): 42-48.
41.	孙永昌. 慢性阻塞性肺疾病与支气管哮喘并存的诊治问题. 中华结核和呼吸杂志, 2012, 35(4): 297-299.
42.	Broekema M, ten Hacken NH, Volbeda F, et al. Airway epithelial changes in smokers but not in ex-smokers with asthma. Am J Respir Crit Care Med, 2009, 180(12): 1170-1178.
43.	Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet, 2010, 376: 803-813.
44.	van Schayck CP, Levy ML, Chen JC, et al. Coordinated diagnostic approach for adult obstructive lung disease in primary care. Prim Care Respir J. 2004, 13(4): 218-221.
45.	Barrecheguren M, Esquinas C, Miravitlles M. The asthmachronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges. Curr Opin Pulm Med, 2015, 21(1): 74-79.
46.	Tzortzaki EG, Proklou A, Siafakas NM. Asthma in the elderly: can we distinguish it from COPD? J Allergy (Cairo) 2011, 2011(2011): 843543.
47.	Zeki AA, Schivo M, Chan A, et al. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo) 2011, 2011(6): 861926.
48.	侯超, 胡晓帆, 刘婷, 等. 哮喘长期管理方法的研究进展. 中华肺部疾病杂志电子版, 2013, 6(5): 55-59.
49.	Abramson MJ, Perret JL, Dharmage SC, et al. Distinguishing adult-onset asthma from COPD: a review and a new approach. Int J Chron Obstruct Pulmon Dis, 2014, 9: 945-962.
50.	Lee JH, Haselkorn T, Borish L, et al. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest, 2007, 132(6): 1882-1889.
51.	沈宁, 贺蓓. 应用噻托溴铵治疗成人未控制哮喘. 中华医学杂志, 2010, 90(42): 2955-2955.
52.	沈宁, 马洪明, 陈秋冬, 等. 白三烯受体拮抗剂作为哮喘控制一线或附加治疗药物的评价. 中华医学杂志, 2011, 91(28): 1960-1960.
53.	Korn D, Van den Brande P, Potvin E, et al. Efficacy of add-on montelukast in patients with non-controlled asthma: a Belgian open-label study. Curr Med Res Opin, 2009, 25(2): 489-497.
54.	Mirabelli MC, Beavers SF, Chatterjee AB. Active asthma and the prevalence of physician-diagnosed COPD. Lung, 2014, 192(5): 693-700.
55.	Tashkin DP. Is it asthma, COPD, or something in between, and does it matter? Respiratory Care, 2012, 57(8): 1354-1356.
56.	Tinkelman DG, Price DB, Nordyke RJ, et al. Misdiagnosis of COPD and asthma in primary care patients 40 years of age and over. J Asthma, 2006, 43(1): 75-80.
57.	Burgess JA, Walters EH, Byrnes GB, et al. Who remembers whether they had asthma as children? J Asthma, 2006, 43(10): 727-730.
58.	Tashkin DP, Celli B, Decramer M, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J. 2008, 31(4): 742-750.
59.	D’Silva L, Hassan N, Wang HY, et al. Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice. Can Respir J, 2011, 18(3): 144-148.
60.	Hancox RJ, Cowan DC, Aldridge RE, et al. Asthma phenotypes: consistency of classification using induced sputum. Respirology, 2012, 17(3): 461-466.
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1. Global strategy for asthma management and prevention[R/OL]. Global Initiative for Asthma (GINA). [2015-04-13]. Available at: http://ginasthma.org/.
2. Global strategy for the diagnosis, management, and prevention of COPD[R/OL]. Global Initiative for Chronic Obstructive Lung Disease (GOLD). [2015-04-13]. Available at: http://goldcopd.org/.
3. Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc, 2004, 1(3): 176-183.
4. Global Strategy for Asthma Management and Prevention, 2017[R/OL]. Global Initiative for Asthma. [2017-04-13]. Available at: http://ginasthma.org/.
5. Postma DS, Reddel HK, ten Hacken NH, et al. Asthma and chronic obstructive pulmonary disease: similarities and differences. Clin. Chest Med, 2014, 63(5-6): 332.
6. Kim TB, Oh YM, Chang YS, et al. The reality of an intermediate type between asthma and COPD in practice. Respir Care, 2012, 57(8): 1248-1253.
7. Miravitlles M, Andreu I, Romero Y, et al. Difficulties in differential diagnosis of COPD and asthma in primary care. Br J Gen Pract, 2012, 62(595): e68-75.
8. Braman SS. The chronic obstructive pulmonary disease-asthma overlap syndrome. Allergy Asthma Proc, 2015, 36(36): 11.
9. 申景文, 王绪飞. 哮喘和慢性阻塞性肺疾病重叠的治疗策略]. 世界最新医学信息文摘, 2015, 15(16): 92-93.
10. Kauppi P, Kupiainen H, Lindqvist A, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma, 2011, 48(3): 279-285.
11. Miravitlles M, Soler-Cataluna JJ, Calle M, et al. Spanish guideline for COPD (GesEPOC). Update 2014. Arch. Bronconeumol, 2014, 50(Suppl.1): 1-16.
12. Diaz-Guzman E, Khosravi M, Mannino DM. Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population. COPD, 2011, 8(6): 400-407.
13. de Marco R, Pesce G, Marcon A, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middleaged and elderly people from the general population. PLoS ONE, 2013, 8(5): e62985.
14. 张弘, 蔡柏蔷. 支气管哮喘慢性阻塞性肺疾病重叠综合征简介. 中华结核和呼吸杂志, 2014, 37(9): 713-715.
15. Milanese M, Di Marco F, Corsico AG, et al. Asthma control in elderly asthmatics. An Italian observational study. Respir. Med, 2014, 108(8): 1091-1099.
16. Golpe R, Sanjuan Lopez P, Cano Jimenez E, et al. Distribution of clinical phenotypes in patients with chronic obstructive pulmonary disease caused by biomass and tobacco smoke. Arch. Bronconeumol, 2014, 50(8): 318-324.
17. Miravitlles M, Huerta A, Fernandez-Villar JA, et al. Generic utilities in chronic obstructive pulmonary disease patients stratified according to different staging systems. Health Qual. Life Outcomes, 2014, 12(1): 120.
18. Kitaguchi Y, Komatsu Y, Fujimoto K, et al. Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int. J. Chron. Obstruct. Pulmon. Dis, 2012, 7(1): 283-289.
19. Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir. Res, 2011, 12(1): 1-8.
20. Marsh SE, Travers J, Weatherall M, et al. Proportional classifications of COPD phenotypes. Thorax, 2008, 63(9): 761-767.
21. Fu JJ, Gibson PG, Simpson JL, et al. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration, 2014, 87(1): 63-74.
22. Andersen H, Lampela P, Nevanlinna A, et al. High hospital burden in overlap syndrome of asthma and COPD. Clin. Respir. J, 2013, 7(4): 342-346.
23. Menezes AM, Montes de Oca M, Perez-Padilla R, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest, 2014, 145(2): 297-304.
24. Chung JW, Kong KA, Lee JH, et al. Characteristics and self-rated health of overlap syndrome. Int. J. Chron. Obstruct. Pulmon. Dis, 2014, 9(1): 795-804.
25. Toy EL, Gallagher KF, Stanley EL, et al. The economic impact of exacerbations of chronic obstructive pulmonary disease and exacerbation definition: a review. COPD, 2010, 7(3): 214-228.
26. Blanchette CM, Gutierrez B, Ory C, et al. Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population. J. Manag. Care Pharm, 2008, 14(2): 176-185.
27. Rhee CK, Yoon HK, Yoo KH, et al. Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma. COPD, 2014, 11(2): 163-170.
28. Shaya FT, Dongyi D, Akazawa MO, et al. Burden of concomitant asthma and COPD in a Medicaid population. Chest, 2008, 134(1): 14-19.
29. 钱小顺, 李天志, 王俊锋. 老年人慢性阻塞性肺病的临床特点分析. 中华老年多器官疾病杂志. 2008, 7(6): 485-488.
30. Hardin M, Cho M, McDonald ML, et al. The clinical and genetic features of COPD-asthma overlap syndrome. Eur. Respir. J, 2014, 44(2): 341-350.
31. Miravitlles M, Soriano JB, Ancochea J, et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status. Respir. Med, 2013, 107(7): 1053-1060.
32. Fattahi F, ten Hacken NH, Lofdahl CG, et al. Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study. Respir. Res, 2013, 14(1): 10.
33. Christenson SA, Steiling K, van den Berge M, et al. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med, 2015, 191(7): 758-766.
34. Mauad T, Dolhnikoff M. Pathologic similarities and differences between asthma and chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med, 2008, 14(14): 31-38.
35. Guerra S, Martinez FD. Epidemiology of the origins of airflow limitation in asthma. Proc. Am. Thorac. Soc, 2009, 6(8): 707-711.
36. Postma DS, Kerkhof M, Boezen HM, et al. Asthma and chronic obstructive pulmonary disease: common genes, common environments? Am. J. Respir. Crit. Care Med, 2011, 183(12): 1588-1594.
37. Shirtcliffe P, Marsh S, Travers J, et al. Childhood asthma and GOLD-defined chronic obstructive pulmonary disease. Intern. Med. J, 2012, 42(1): 83-88.
38. Aanerud M, Carsin AE, Sunyer J, et al. Interaction between asthma and smoking increases the risk of adult airway obstruction. Eur. Respir. J, 2015, 45(3): 635-643.
39. James AL, Palmer LJ, Kicic E, et al. Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking. Am. J. Respir. Crit. Care Med, 2005, 171(2): 109-114.
40. Perret JL, Dharmage SC, Matheson MC, et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age. Am. J. Respir. Crit. Care Med, 2013, 187(1): 42-48.
41. 孙永昌. 慢性阻塞性肺疾病与支气管哮喘并存的诊治问题. 中华结核和呼吸杂志, 2012, 35(4): 297-299.
42. Broekema M, ten Hacken NH, Volbeda F, et al. Airway epithelial changes in smokers but not in ex-smokers with asthma. Am J Respir Crit Care Med, 2009, 180(12): 1170-1178.
43. Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet, 2010, 376: 803-813.
44. van Schayck CP, Levy ML, Chen JC, et al. Coordinated diagnostic approach for adult obstructive lung disease in primary care. Prim Care Respir J. 2004, 13(4): 218-221.
45. Barrecheguren M, Esquinas C, Miravitlles M. The asthmachronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges. Curr Opin Pulm Med, 2015, 21(1): 74-79.
46. Tzortzaki EG, Proklou A, Siafakas NM. Asthma in the elderly: can we distinguish it from COPD? J Allergy (Cairo) 2011, 2011(2011): 843543.
47. Zeki AA, Schivo M, Chan A, et al. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo) 2011, 2011(6): 861926.
48. 侯超, 胡晓帆, 刘婷, 等. 哮喘长期管理方法的研究进展. 中华肺部疾病杂志电子版, 2013, 6(5): 55-59.
49. Abramson MJ, Perret JL, Dharmage SC, et al. Distinguishing adult-onset asthma from COPD: a review and a new approach. Int J Chron Obstruct Pulmon Dis, 2014, 9: 945-962.
50. Lee JH, Haselkorn T, Borish L, et al. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest, 2007, 132(6): 1882-1889.
51. 沈宁, 贺蓓. 应用噻托溴铵治疗成人未控制哮喘. 中华医学杂志, 2010, 90(42): 2955-2955.
52. 沈宁, 马洪明, 陈秋冬, 等. 白三烯受体拮抗剂作为哮喘控制一线或附加治疗药物的评价. 中华医学杂志, 2011, 91(28): 1960-1960.
53. Korn D, Van den Brande P, Potvin E, et al. Efficacy of add-on montelukast in patients with non-controlled asthma: a Belgian open-label study. Curr Med Res Opin, 2009, 25(2): 489-497.
54. Mirabelli MC, Beavers SF, Chatterjee AB. Active asthma and the prevalence of physician-diagnosed COPD. Lung, 2014, 192(5): 693-700.
55. Tashkin DP. Is it asthma, COPD, or something in between, and does it matter? Respiratory Care, 2012, 57(8): 1354-1356.
56. Tinkelman DG, Price DB, Nordyke RJ, et al. Misdiagnosis of COPD and asthma in primary care patients 40 years of age and over. J Asthma, 2006, 43(1): 75-80.
57. Burgess JA, Walters EH, Byrnes GB, et al. Who remembers whether they had asthma as children? J Asthma, 2006, 43(10): 727-730.
58. Tashkin DP, Celli B, Decramer M, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J. 2008, 31(4): 742-750.
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哮喘-慢性阻塞性肺疾病重叠的临床研究和诊断标准进展

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