Primary tracheobronchial lymphoma: two cases report and literature review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

YANG Xia ¹ , RUAN Yuying ¹ , LI Qiulian ¹ , LV Zili ² ,  BAI Jing ¹

1. Department of Respiratory Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R.China;
2. Department of Pathology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R.China;

Corresponding author：

BAI Jing, Email: bj1312002@aliyun.com

Keywords：

Lymphoma; Trachea; Bronchus

DOI：

10.7507/1671-6205.201611017

Video：

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ObjectiveTo improve the knowledge of primary tracheobronchial lymphoma.MethodsTwo patients with primary tracheobronchial lymphoma admitted to First Affiliated Hospital Guangxi Medical University in 2013 and in 2016 were analyzed retrospectively, and related literatures were reviewed. Chinese National Knowledge Infrastructure, Wanfang database and VIP database were searched by using " trachea lymphoma” or " bronchus lymphoma” as keywords. Meanwhile, databases including PubMed, Ovid Medline and Embase database were retrieved with " Trachea” or " Bronchus” AND " Lymphoma” as keywords. Seventy-two cases of primary tracheobronchial lymphoma were reported, the clinical feature, imaging feature, pathological feature, treatment and prognosis of 72 cases were analyzed.ResultsThe two patients were both females. The chief complaints included cough and dyspnea. The tissue biopsy under bronchoscope was the main diagnostic method. On histopathology, one case was diagnosed grade B cell lymphoma, another was diagnosed mantle cell lymphomas. After chemotherapy, the symptoms were relieved and never relapsed in the follow-up period until October 2016. Literature review found 72 patients with primary tracheobronchial lymphoma with women being the majority (47 cases, 65.28%). The patients aged from16 to 82 years with a median age of 51 years, and nine cases (12.5%) of the patients aged from 16 to 30 years. The specific clinical symptoms were cough and dyspnea. Pulmonary function prompted obstructive dysfunction of pulmonary ventilation. The chest CT scan showed consolidation shadow in trachea and bronchus with or without pulmonary atelectasis. Neoplasms could be found by bronchoscopy. Mucosa-associated lymphoid tissue (MALT) lymphoma was the most common pathological characteristic (36.11%). Mantle cell lymphomas has not been reported currently.ConclusionsPrimary tracheobronchial lymphoma is one of the rare airway tumors. Its clinical features, imaging examinations and bronchoscopic characteristics are not specific, which can be easily confused with lung cancer. It also can cause life-threatening airway obstruction. The bronchoscopy play an important role in diagnosis of primary tracheobronchial lymphoma, while the diagnosis is confirmed by histopathological examination. The main pathology type is MALT lymphoma. The prognosis is good.

Citation： YANG Xia, RUAN Yuying, LI Qiulian, LV Zili, BAI Jing. Primary tracheobronchial lymphoma: two cases report and literature review. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 254-259. doi: 10.7507/1671-6205.201611017 Copy

1.	Hoerbelt R, Padberg W. Primary tracheal tumors of the neck and mediastinum: resection and reconstruction procedures. Chirurg, 2011, 82(2): 125-133.
2.	Huang CL, Chen HC, Huang HC, et al. Tracheomediastinal fistula caused by non-Hodgkin’s lymphoma. Ann Thorac Cardiovasc Surg, 2014, 20 Suppl: 599-601.
3.	Gill MT, Cotelingam JD, Lowery-Nordberg M, et al. Tracheal non-Hodgkin’s lymphoma masquerading as benign granulation tissue: a report of two cases. Ann Otol Rhinol Laryngol, 2010, 119(7): 431-435.
4.	De Giacomo T, Venuta F, Anile M, et al. Non-Hodgkin’s lymphoma, presenting as an isolated endobronchial mass after bilateral lung transplantation: a case report. Transplant Proc, 2007, (10): 3541-3544.
5.	William J, Variakojis D, Yeldandi A, et al. Lymphoproliferative neoplasms of the lung: a review. Arch Pathol Lab Med, 2013, 137: 382-391.
6.	Thieblemont C, de la Fouchardière A, Coiffier B. Nongastric mucosa-associated lymphoid tissue lymphomas. Clin Lymphoma Myeloma Leukemia, 2003, 3(4): 212-224.
7.	Graham BB, Mathlsen DJ, Mark EJ, et al. Primary pulmonary lymphoma. Ann Thorac Surg, 2005, 80(4): 1248-1253.
8.	Gibson M, Hansell DM. Lymphocytic disorders of the chest: pathology and imaging. Clin Radiol, 1998, 53(7): 469-480.
9.	吕品, 尹金植, 刘晶. 纤维支气管镜下氩等离子凝固及冷冻治疗气管黏膜相关淋巴组织淋巴瘤 1 例及文献复习. 吉林大学学报(医学版), 2016, 42(1): 152-153.
10.	孙江平, 俞锐敏. 气管支气管黏膜相关淋巴组织淋巴瘤一例. 中国呼吸与危重监护杂志, 2016, 15(3): 298-302.
11.	徐峰, 徐作军. 原发性气管非何杰金氏淋巴瘤一例并文献复习. 中华全科医师杂志, 2006, 5(2): 119-121.
12.	Yang FF, Gao R, Miao Y, et al. Primary tracheobronchial non-Hodgkin lymphoma causing life-threatening airway obstruction: a case report. J Thorac Dis, 2015, 7(12): E667-E671.
13.	Matsumoto S, Fujimoto N, Fuchimoto Y, et al. Endobronchial T-cell lymphoma in a patient with chronic pyothorax. Respirol Case Rep, 2015, 3(2): 44-47.
14.	Kadota N, Shinohara T, Machida H, et al. Asymptomatic tracheal MALT lymphoma discovered on spirometric findings presenting with elevated respiratory resistance. BMC Res Notes, 2015, 8: 223-224.
15.	Wang AY, Wang JT, Shen Y, et al. Relapse of Non-Hodgkin’s Lymphoma Involving the Trachea: Acute Subglottic Obstruction. Case Rep Otolaryngol, 2014, 2014: 230682.
16.	张波, 姚国忠. 原发于主支气管腔内淋巴瘤 1 例. 临床肺科杂志, 2014, 19(5): 968-969.
17.	Qin J, Liu J, Axiotis CA. Cytological diagnosis of adult T-cell leukemia/lymphoma in sputum. Diagn Cytopathol, 2016, 44(5): 416-418.
18.	韦荣干, 王庆国, 莫祥兰. 纤维支气管镜细胞学诊断肺原发性非霍奇金淋巴瘤 1 例. 诊断病理学杂志, 2008, 15(3): 250-251.
19.	刘伟, 郭思佳, 魏葆琳, 等. EBUSTBNA 联合纵隔镜诊断 B 细胞淋巴瘤 1 例. 现代肿瘤医学, 2016, 24(7): 1129-1131.
20.	Gutiérrez L, Fernandez L, Sua LF. Malignant obstruction of the central airway by an EBV(+) diffuse large B-cell lymphoma: an unusual presentation: track: bronchoscopy. J Thorac Oncol, 2016, 11(10S): S228-S231.

1. Hoerbelt R, Padberg W. Primary tracheal tumors of the neck and mediastinum: resection and reconstruction procedures. Chirurg, 2011, 82(2): 125-133.
2. Huang CL, Chen HC, Huang HC, et al. Tracheomediastinal fistula caused by non-Hodgkin’s lymphoma. Ann Thorac Cardiovasc Surg, 2014, 20 Suppl: 599-601.
3. Gill MT, Cotelingam JD, Lowery-Nordberg M, et al. Tracheal non-Hodgkin’s lymphoma masquerading as benign granulation tissue: a report of two cases. Ann Otol Rhinol Laryngol, 2010, 119(7): 431-435.
4. De Giacomo T, Venuta F, Anile M, et al. Non-Hodgkin’s lymphoma, presenting as an isolated endobronchial mass after bilateral lung transplantation: a case report. Transplant Proc, 2007, (10): 3541-3544.
5. William J, Variakojis D, Yeldandi A, et al. Lymphoproliferative neoplasms of the lung: a review. Arch Pathol Lab Med, 2013, 137: 382-391.
6. Thieblemont C, de la Fouchardière A, Coiffier B. Nongastric mucosa-associated lymphoid tissue lymphomas. Clin Lymphoma Myeloma Leukemia, 2003, 3(4): 212-224.
7. Graham BB, Mathlsen DJ, Mark EJ, et al. Primary pulmonary lymphoma. Ann Thorac Surg, 2005, 80(4): 1248-1253.
8. Gibson M, Hansell DM. Lymphocytic disorders of the chest: pathology and imaging. Clin Radiol, 1998, 53(7): 469-480.
9. 吕品, 尹金植, 刘晶. 纤维支气管镜下氩等离子凝固及冷冻治疗气管黏膜相关淋巴组织淋巴瘤 1 例及文献复习. 吉林大学学报(医学版), 2016, 42(1): 152-153.
10. 孙江平, 俞锐敏. 气管支气管黏膜相关淋巴组织淋巴瘤一例. 中国呼吸与危重监护杂志, 2016, 15(3): 298-302.
11. 徐峰, 徐作军. 原发性气管非何杰金氏淋巴瘤一例并文献复习. 中华全科医师杂志, 2006, 5(2): 119-121.
12. Yang FF, Gao R, Miao Y, et al. Primary tracheobronchial non-Hodgkin lymphoma causing life-threatening airway obstruction: a case report. J Thorac Dis, 2015, 7(12): E667-E671.
13. Matsumoto S, Fujimoto N, Fuchimoto Y, et al. Endobronchial T-cell lymphoma in a patient with chronic pyothorax. Respirol Case Rep, 2015, 3(2): 44-47.
14. Kadota N, Shinohara T, Machida H, et al. Asymptomatic tracheal MALT lymphoma discovered on spirometric findings presenting with elevated respiratory resistance. BMC Res Notes, 2015, 8: 223-224.
15. Wang AY, Wang JT, Shen Y, et al. Relapse of Non-Hodgkin’s Lymphoma Involving the Trachea: Acute Subglottic Obstruction. Case Rep Otolaryngol, 2014, 2014: 230682.
16. 张波, 姚国忠. 原发于主支气管腔内淋巴瘤 1 例. 临床肺科杂志, 2014, 19(5): 968-969.
17. Qin J, Liu J, Axiotis CA. Cytological diagnosis of adult T-cell leukemia/lymphoma in sputum. Diagn Cytopathol, 2016, 44(5): 416-418.
18. 韦荣干, 王庆国, 莫祥兰. 纤维支气管镜细胞学诊断肺原发性非霍奇金淋巴瘤 1 例. 诊断病理学杂志, 2008, 15(3): 250-251.
19. 刘伟, 郭思佳, 魏葆琳, 等. EBUSTBNA 联合纵隔镜诊断 B 细胞淋巴瘤 1 例. 现代肿瘤医学, 2016, 24(7): 1129-1131.
20. Gutiérrez L, Fernandez L, Sua LF. Malignant obstruction of the central airway by an EBV(+) diffuse large B-cell lymphoma: an unusual presentation: track: bronchoscopy. J Thorac Oncol, 2016, 11(10S): S228-S231.

Chinese Journal of Respiratory and Critical Care Medicine

Primary tracheobronchial lymphoma: two cases report and literature review

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