Chest CT study in patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Xueren ¹ , LIU Bin ¹ , DING Mengjiang ² ,  PENG Shouchun ¹ , WEI Luqing ¹

1. Department of Respiratory and Critical Care Medicine, Pingjin Hospital, Logistics University of the Chinese People’s Armed Police Forces, Tianjing 300162, P. R. China;
2. Tianjin Provincal Corps Hospital of Chinese People’s Armed Police Force, Tianjing 300162, P. R. China;

Corresponding author：

PENG Shouchun, Email: pengshouchun@163.com

Keywords：

Interstitial pneumonia; Positive myeloperoxidase antineutrophil cytoplasmic antibody; Idiopathic pulmonary fibrosis; Emphysema; Chest high-resolution computed tomography

DOI：

10.7507/1671-6205.201611025

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Objective To investigate the characteristics on chest high-resolution computed tomography (HRCT) of patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody (MPO-IP). Methods The extent of fibrosis and subtypes of emphysema on HRCT of MPO-IP patients were retrospectively analyzed and compared with idiopathic pulmonary fibrosis (IPF) cases admitted in the same period. Results From July 2014 to March 2016, 10 patients was diagnosed with IPF and 10 patients was diagnosed with MPO-IP. Emphysema was not different between two groups. Among the MPO-IP patients, 8 patients presented with a usual interstitial pneumonia (UIP) pattern. There existed statistical difference in the bronchial bifurcation level, the fibrosis score of lungs in the MPO-IP patients presented with UIP was lower than that in the IPF patients. Conclusions UIP is the predominant radiologic type of MPO-IP patients. Fibrosis in IPF is more serious than that in MPO-IP with UIP. Paraseptal and centrilobular emphysema are main forms in MPO-IP patients.

Citation： LI Xueren, LIU Bin, DING Mengjiang, PENG Shouchun, WEI Luqing. Chest CT study in patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 183-186. doi: 10.7507/1671-6205.201611025 Copy

1.	Hosoda C, Baba T, Hagiwara E, et al. Clinical features of usual interstitial pneumonia with anti-neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis. Respirology. 2016. 21(5): 920-926.
2.	Jacob J, Hansell DM. HRCT of fibrosing lung disease. Respirology. 2015. 20(6): 859-872.
3.	Lynch DA, Godwin JD, Safrin S, et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med. 2005. 172(4): 488-493.
4.	Bradley B, Branley HM, Egan JJ, et al. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008. 63 Suppl 5: v1-v58.
5.	Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011. 183(6): 788-824.
6.	蔡后荣. 2011 年特发性肺纤维化诊断和治疗循证新指南解读. 中国呼吸与危重监护杂志. 2011. 10(4): 313-316.
7.	Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013. 188(6): 733-748.
8.	Fischer A, du Bois R. Interstitial lung disease in connective tissue disorders. Lancet. 2012. 380(9842): 689-698.
9.	陈露露, 张德平, 苗立云. 合并肺部损害的显微镜下多血管炎的临床特征及与特发性肺纤维化的比较分析. 中国呼吸与危重监护杂志. 2011. 10(5): 437-441.
10.	Smith M, Dalurzo M, Panse P, Parish J, Leslie K. Usual interstitial pneumonia-pattern fibrosis in surgical lung biopsies. Clinical, radiological and histopathological clues to aetiology. J Clin Pathol. 2013. 66(10): 896-903.
11.	Kitaguchi Y, Fujimoto K, Hanaoka M, Kawakami S, Honda T, Kubo K. Clinical characteristics of combined pulmonary fibrosis and emphysema. Respirology. 2010. 15(2): 265-271.

1. Hosoda C, Baba T, Hagiwara E, et al. Clinical features of usual interstitial pneumonia with anti-neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis. Respirology. 2016. 21(5): 920-926.
2. Jacob J, Hansell DM. HRCT of fibrosing lung disease. Respirology. 2015. 20(6): 859-872.
3. Lynch DA, Godwin JD, Safrin S, et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med. 2005. 172(4): 488-493.
4. Bradley B, Branley HM, Egan JJ, et al. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008. 63 Suppl 5: v1-v58.
5. Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011. 183(6): 788-824.
6. 蔡后荣. 2011 年特发性肺纤维化诊断和治疗循证新指南解读. 中国呼吸与危重监护杂志. 2011. 10(4): 313-316.
7. Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013. 188(6): 733-748.
8. Fischer A, du Bois R. Interstitial lung disease in connective tissue disorders. Lancet. 2012. 380(9842): 689-698.
9. 陈露露, 张德平, 苗立云. 合并肺部损害的显微镜下多血管炎的临床特征及与特发性肺纤维化的比较分析. 中国呼吸与危重监护杂志. 2011. 10(5): 437-441.
10. Smith M, Dalurzo M, Panse P, Parish J, Leslie K. Usual interstitial pneumonia-pattern fibrosis in surgical lung biopsies. Clinical, radiological and histopathological clues to aetiology. J Clin Pathol. 2013. 66(10): 896-903.
11. Kitaguchi Y, Fujimoto K, Hanaoka M, Kawakami S, Honda T, Kubo K. Clinical characteristics of combined pulmonary fibrosis and emphysema. Respirology. 2010. 15(2): 265-271.

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Chest CT study in patients with interstitial pneumonia with positive myeloperoxidase antineutrophil cytoplasmic antibody

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