Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZhangXiuhong ¹ , LiLang ² ,  DongLiang ³ , GengXianlong ⁴

1. Department of Pharmacy, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214023, China;
2. ;
3. ;
4. ;

Corresponding author：

DongLiang, Email: 38395234@qq.com

Keywords：

Hospitalized pediatric patients; Respiratory tract infection; Pathogen; Drug resistance

DOI：

10.7507/1671-6205.2016131

Video：

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Objective To investigate the distribution and drug resistance of the pathogens isolated from hospitalized pediatric patients with respiratory tract infections, and to provide guidance for empiric therapy. Methods Respiratory tract specimens from hospitalized pediatric patients with respiratory tract infections from 2011 to 2015 were collected, and the strains were identified and the drug susceptibility was tested. Results A total of 1995 strains of pathogens, 1281 (64.21%) from boys and 714 (35.79%) from girls, were isolated from 6236 specimens and the detection rate was 31.99%. The mean age of the hospitalized pediatric patients was (1.22±2.05) years (ranged from 1 day to 14 years). 1393 (69.82%) pediatric patients were younger than 1 year. Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Candida albicans and Acinetobacter baumannii ranked the top five species, accounting for 29.82%, 15.09%, 13.18%, 12.73% and 5.91%, respectively. 1995 strains included gram-negative bacteria (50.93%), gram-positive bacteria (35.29%), and fungi (13.78%). The resistance rate of Staphylococcus aureus to oxacillin was 31.76%, but it was 100% sensitive to vancomycin and linezolid. The resistant rate of gram-negative bacteria to imipenem was ranged from 1.52% to 5.93%. The resistant rate of gram-negative bacteria to ceftazidime, cefepime, piperacillin tazobactam and tobramycin was less than 30.00%. Conclusions The infants whose age are younger than 1 year comprise the majority of the hospitalized pediatric patients with respiratory tract infections. The proportion of male is more than that of female. Staphylococcus aureus and enterobacteriaceae were the main isolated pathogens. There is difference in drug resistance between different pathogens, so antibiotics should be chosen according to the results of drug sensitivity testing.

Citation： ZhangXiuhong, LiLang, DongLiang, GengXianlong. Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 572-576. doi: 10.7507/1671-6205.2016131 Copy

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1. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality:an updated systematic analysis for 2010 with time trends since 2000. Lancet, 2012, 37:2151-261.
2. 郑辉, 彭亮, 卓广超.儿童呼吸道感染病原体IgM抗体检测结果分析.中华医院感染学杂志, 2015, 25:235-237.
3. 黄容, 黄梁镔, 田应敏, 等.连续3年儿科住院患者痰分离病原菌及耐药性变迁.中国感染控制杂志, 2015, 14:236-239.
4. 胡亚美, 江载芳, 诸福棠.实用儿科学.第7版.北京:人民卫生出版社, 2002, 1163-1199.
5. 葛均波, 徐永健, 主编.内科学.第8版.北京:人民卫生出版社, 2013, 9.
6. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; 24^th Informational Supplement, 2014, M100-S24.
7. 王晓丽, 俞赵军, 缪琪.儿科患儿医院呼吸道感染病原菌分布及耐药性分析.中华医院感染学杂志, 2014, 24:5673-5675.
8. 杨双丽, 汪红玲, 俞梅, 等.患儿下呼吸道感染病原菌的临床调查与耐药性分析.中华医院感染学杂志, 2015, 25:3805-3807.
9. 陈华, 赵华, 袁拥华, 等.患儿下呼吸道感染病原菌分布与药敏分析.中华医院感染学杂志, 2015, 25:3570-3571, 3591.
10. 张秀红, 董亮, 曹燕, 等.2011-2013年重症监护病房鲍曼不动杆菌和铜绿假单胞菌耐药性分析.现代预防医学, 2015, 42:4013-4015.
11. 《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则.2015年版.北京:人民卫生出版社, 2015, 7.
12. 崔战菊.儿童安全使用抗感染药物的临界年龄.临床医学, 2006, 26:81-82.
13. 陈洁, 李岩, 王晶, 等.耐甲氧西林金黄色葡萄球菌SCCmec基因分型及耐药谱分析.中华医院感染学杂志, 2012, 22:894-897.
14. 张艳, 王红梅, 马东礼.儿童感染肺炎链球菌的临床分布及耐药性分析.现代预防医学, 2015, 42:3899-3912.
15. 杨青, 俞云松, 孙自镛, 等.2011年中国CHINET呼吸道病原菌分布和耐药性监测.中国感染与化疗杂志, 2013, 13:357-364.
16. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; 18^th Informational Supplement, 2008, M100-S18.
17. 张玲玲, 李广起, 孙艳峰, 等.肿瘤住院患者感染病原菌与耐药性研究.中华医院感染学杂志, 2015, 25:3150-3152.

Chinese Journal of Respiratory and Critical Care Medicine

Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections

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