Comparison of cardiovascular risk factors in patients with chronic obstructive pulmonary disease of different severities_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 DU Fei , ZHANG Li , CHEN Daigang , YANG Huajun

Department of Respiratory Medicine, The First People’s Hospital of Zunyi, Institute of Respiratory Diseases, Zunyi, Guizhou 563000, P.R.China;

Corresponding author：

DU Fei, Email: fei632@163.com

Keywords：

Chronic obstructive pulmonary disease; Cardiovascular diseases; Risk factors

DOI：

10.7507/1671-6205.201702014

Video：

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Objectives To analyze the risk factors for cardiovascular disease (CVD) in patients with chronic obstructive pulmonary disease (COPD) of different severities. Methods The study included 50 patients with mild-to-moderate COPD and 50 with severe-to-very severe COPD admitted between January 2014 and January 2016. Comorbidities were recorded on the basis of data obtained from medical charts and clinical evaluations. The Charlson comorbidity index was calculated, and the Hospital Anxiety and Depression Scale (HADS) score was determined in each subject. Results There were more prevalences of smoking, depression and dyslipidemia in the patients with mild-to-moderate COPD than those with severe-to-very severe COPD (all P<0.001). The prevalences of high blood pressure, diabetes mellitus, alcoholism, and chronic heart failure were not different significantly between the two groups. The Charlson comorbidity index and HADS scores were not different between the two groups. Conclusions Comorbidities are fairly common in COPD regardless of its severity. Certain risk factors for CVD, as smoking, dyslipidemia, and depression, appear to be more prevalent in patients with mild-to-moderate COPD.

Citation： DU Fei, ZHANG Li, CHEN Daigang, YANG Huajun. Comparison of cardiovascular risk factors in patients with chronic obstructive pulmonary disease of different severities. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(4): 311-313. doi: 10.7507/1671-6205.201702014 Copy

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1. 中华医学会呼吸病分会慢性阻塞性肺部疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版). 中华结核和呼吸杂志, 2013, 36(4): 255-264.
2. 蔡柏蔷. 应重视慢性阻塞性肺疾病的合并症问题. 中华结核和呼吸杂志, 2013, 36(4): 245-247.
3. GOLD Executive Committee. Global Strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (Revised 2011). [EB/OL] [2015-09-16]. Available at: http://goldcopd.org.
4. Hillas G, Perlikos F, Tsiligianni I, et al. Managing comorbidities in COPD. Int J Chron Obstruct Pulmon Dis. 2015, 10(1): 95-109.
5. 边士淇, 寿松涛, 李望, 等. 查尔森合并症指数对脓毒症患者预后的评估价值. 中国全科医学, 2015, 18(14): 1637-1640.
6. Botega NJ, Bio MR, Zomignani MA, et al. Mood disorders among medical in-patients: a validation study of the hospital anxiety and depression scale (HAD). Rev Saude Publica. 1995, 29(5): 359-363.
7. 陈世谋, 刘少滨, 郭永明. 5年住院慢性阻塞性肺疾病患者合并症调查与死因分析. 中外医学研究, 2014, 12(26): 78-79.
8. Hanania NA, Mulleruva H, Locantore NW, et al. Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med, 2011, 183(5): 604-611.
9. 马芹, 陈哲. 慢性阻塞性肺疾病合并抑郁症对病情及预后的影响. 医学理论与实践, 2016, 29(11): 1452-1453.
10. Roversi SI, Roversi P. Coronary artery disease concomitant with chronic obstructive pulmonary disease. Eur J Clin Invest, 2014, 44(1): 93-102.
11. Liang BM, Xu ZB. Association of chronic obstructive pulmonary disease with coronary artery disease. Chin Med J, 2013, 126(17): 3205-3208.
12. Agarwal S, Rokadia H. Burden of cardiovascular disease in chronic obstructive pulmonary disease. Am J Prev Med, 2014, 47(2): 105-114.
13. Ferri C. Strategies for reducing the risk of cardiovascular disease in patients with chronic obstructive pulmonary disease. High Blood Press Cardiovasc Prev, 2015, 22(2): 103-111.
14. Guzik TJ, Grodzicki T. " Radical” link between chronic obstructive pulmonary disease and cardiovascular disease? Hypertension, 2014, 63: 444-446.
15. 王春娟, 熊彬. 慢性阻塞性肺疾病合并心血管疾病的治疗. 临床肺科杂志, 2016, 21(1): 149-151.

Chinese Journal of Respiratory and Critical Care Medicine

Comparison of cardiovascular risk factors in patients with chronic obstructive pulmonary disease of different severities

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