慢性阻塞性肺疾病稳定期和急性加重期血浆和诱导痰中 S100A8/A9 变化及其意义_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 陈小菊 ¹ , 向小均 ² , 张文波 ¹ , 冷长燕 ¹ , 周智 ¹

1. ;
2. ;

Corresponding author：

陈小菊, Email: cxj9592@163.com

Keywords：

慢性阻塞性肺疾病; S100A8/A9; 白细胞介素-1β; 白细胞介素-8; 肿瘤坏死因子-ɑ

DOI：

10.7507/1671-6205.201702025

Video：

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目的通过观察 S100A8/A9 在不同分期慢性阻塞性肺疾病（简称慢阻肺）患者血浆和诱导痰中的水平及其与患者肺功能和血浆中炎症介质的相关性分析，探讨 S100A8/A9 在慢阻肺发病机制中的作用。方法收集 2013 年 8 月至 2014 年 1 月于川北医学院附属医院门诊就诊的稳定期和住院的急性加重期慢阻肺患者以及门诊健康体检者各 30 例。采用 ELISA 法检测三组研究对象血浆和诱导痰中 S100A8/A9 及血浆白细胞介素（IL）-1β、IL-8 和肿瘤坏死因子-ɑ （TNF-ɑ）的浓度。应用相关分析法对慢阻肺患者血浆、诱导痰中 S100A8/A9 与肺功能及血浆中炎症介质的相关性进行分析。结果慢阻肺急性加重期和稳定期组患者血浆及诱导痰中 S100A8/A9、血浆 IL-1β、IL-8、TNF-ɑ 的浓度均较健康对照组显著增高（P<0.01），而慢阻肺急性加重期组患者血浆及诱导痰中 S100A8/A9、血浆 IL-1β、IL-8、TNF-ɑ的浓度又较慢阻肺稳定期组显著增高（P<0.01）。慢阻肺患者血浆和诱导痰中 S100A8/A9 水平与 FEV ₁%pred 呈负相关。慢阻肺患者血浆和诱导痰中 S100A8/A9 水平与血浆中 IL-1β、IL-8、TNF-α 的水平均呈正相关。结论慢阻肺患者体内 S100A8/A9 合成和释放显著增多，其 S100A8/A9 水平与气流受限严重程度和血浆炎症介质水平相关。提示 S100A8/A9 参与了慢阻肺的发生发展，可能主要参与慢阻肺的炎症机制。

Citation： 陈小菊, 向小均, 张文波, 冷长燕, 周智. 慢性阻塞性肺疾病稳定期和急性加重期血浆和诱导痰中 S100A8/A9 变化及其意义. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(5): 509-512. doi: 10.7507/1671-6205.201702025 Copy

1.	Lozano R, Naghavi M, Foreman K. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2095-2128.
2.	中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013 年修订版).中华结核和呼吸杂志, 2013, 36(4): 255-264.0.
3.	Vogl T, Leukert N, Barczyk K, et al. Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochm Biophys Acta, 2006, 1763(11): 1298-1306.
4.	Roth J, Vogl T, Sorg C, et al. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol, 2003, 24(4): 155-158.
5.	Vogl T, Gharibyan AL, Morozova-Roche LA. Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes. Int J Mol Sci, 2012, 13 (3): 2893-2917.
6.	Halayko AJ, Sharma P. S100A8/A9 as a Pro-inflammatory Cytokine in Obstructive Airway Disease Via the Multi-Ligand Receptor, RAGE. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 2009, 8(4): 306-317.
7.	Rammes A, Roth J, Goebeler M, et al. Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem, 1997, 272(14): 9496-9502.
8.	Merkel D, Rist W, Seither P, et al. Proteomic study of human bronchoalveolar lavage fluids from smokers with chronic obstructive pulmonary disease by combining surface-enhanced laser desorption/ionization-mass spectrometry profiling with mass spectrometric protein identification. Proteomics, 2005, 5(11): 2972-2980.
9.	RivaM, Kallberg E, Bjork P, et al. Induction of nuclear factorkappaB responses by the S100A9 protein is Toll-like receptor-4- dependent.Immunology, 2012, 137(2): 172-182.

1. Lozano R, Naghavi M, Foreman K. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2095-2128.
2. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013 年修订版).中华结核和呼吸杂志, 2013, 36(4): 255-264.0.
3. Vogl T, Leukert N, Barczyk K, et al. Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochm Biophys Acta, 2006, 1763(11): 1298-1306.
4. Roth J, Vogl T, Sorg C, et al. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol, 2003, 24(4): 155-158.
5. Vogl T, Gharibyan AL, Morozova-Roche LA. Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes. Int J Mol Sci, 2012, 13 (3): 2893-2917.
6. Halayko AJ, Sharma P. S100A8/A9 as a Pro-inflammatory Cytokine in Obstructive Airway Disease Via the Multi-Ligand Receptor, RAGE. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 2009, 8(4): 306-317.
7. Rammes A, Roth J, Goebeler M, et al. Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem, 1997, 272(14): 9496-9502.
8. Merkel D, Rist W, Seither P, et al. Proteomic study of human bronchoalveolar lavage fluids from smokers with chronic obstructive pulmonary disease by combining surface-enhanced laser desorption/ionization-mass spectrometry profiling with mass spectrometric protein identification. Proteomics, 2005, 5(11): 2972-2980.
9. RivaM, Kallberg E, Bjork P, et al. Induction of nuclear factorkappaB responses by the S100A9 protein is Toll-like receptor-4- dependent.Immunology, 2012, 137(2): 172-182.

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慢性阻塞性肺疾病稳定期和急性加重期血浆和诱导痰中 S100A8/A9 变化及其意义

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