促红细胞生成素对急性肺损伤保护作用机制的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

周玲玲 ¹ ,  夏国际 ¹ , 罗萍 ² , 潘烨 ³

1. ;
2. ;
3. ;

Corresponding author：

夏国际, Email: xiagj1966@163.com

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DOI：

10.7507/1671-6205.201704016

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Citation： 周玲玲, 夏国际, 罗萍, 潘烨. 促红细胞生成素对急性肺损伤保护作用机制的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(1): 105-108. doi: 10.7507/1671-6205.201704016 Copy

1.	马晓春, 王辰, 方强, 等. 急性肺损伤/急性呼吸窘迫综合征诊断和治疗指南. 中国危重病急救医学, 2006, 18(12): 706-710.
2.	Zhang DX, Zhang LM, Zhao XC, et al. Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Biomed Pharmacother, 2017, 87: 332-341.
3.	Miljus N, Massih B, Weis MA, et al. Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems. J Neurochem, 2017, 141(1): 63-74.
4.	Rezaee MA, Mohammadpour AH, Imenshahidi M, et al. Protective effect of erythropoietin on myocardial apoptosis in rats exposed to carbon monoxide. Life Sci , 2016, 148: 118-124.
5.	Alempijevic T, Zec S, Nikolic V, et al. Erythropoietin in predicting prognosis in patient with acute-on-chronic liver failure. J Gastrointestin Liver Dis, 2016, 25(4): 473-479.
6.	Ranjbaran M, Kadkhodaee M, Seifi B, et al. Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS-dependent mechanism in male Wistar rats. Injury, 2017, 48(2): 262-269.
7.	Cui H, He J, Chen H, et al. Erythropoietin attenuates hyperoxia-induced lung injury by upregulating epidermal growth factor-like domain 7 in newborn rats. Biomed Rep, 2017, 6(1): 32-38.
8.	石芸萍. 促红细胞生成素的研究进展. 疾病监测与控制杂志, 2016, 10(3): 202-203.
9.	Wu H, Dong G, Liu H, et al. Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression. Eur J Pharmacol, 2009, 602(2-3): 406-412.
10.	Vollmar B, Eipel C, Menger MD, Therapeutic effects of erythropoietin in murine models of endotoxin shock. Crit Care Med, 2009, 37(3): 889-898.
11.	Fiordaliso F, Chimenti S, Staszewsky L, et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A, 2005, 102(6): 2046-2051.
12.	Brines M, Grasso G, Fiordaliso F, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A, 2004, 101(41): 14907-14912.
13.	Maiese K, Chong ZZ, Shang YC, et al. Raves and risks for erythropoietin. Cytokine Growth Factor Rev, 2008, 19(2): 145-155.
14.	Ravikumar P, Menon JU, Punnakitikashem P, et al. Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine, 2016, 12(3): 811-821.
15.	Aggarwal S, Gross CM, Kumar S, et al. Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. Am J Respir Cell Mol Biol, 2014, 50 (3): 614-625.
16.	Liu Y, Lu J, Chen L, et al. Erythropoietin-derived petide protects against acute lung injury after rat traumatic brain injury . Cell Physiol Biochem, 2017, 41(5): 2037-2044.
17.	Tascilar O, Cakmak GK, Tekin IO, et al. Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis. World J Gastroenterol, 2007, 13(46): 6172-6182.
18.	Korkmaz T, Kahramansoy N, Kilicgun A, et al. The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis. BMC Research Notes, 2014, 7(1): 1-6.
19.	Ji MH, Tong JH, Tan YH, et al. Erythropoietin pretreatment attenuates seawater aspiration-induced acute lung injury in rats. Inflammation, 2016, 39(1): 447-456.
20.	王晓蕾, 岳冬梅, 陈宁, 等. 促红细胞生成素对高体积分数氧肺损伤新生大鼠单核细胞趋化蛋白-1表达的影响. 实用儿科临床杂志, 2010, 25(2): 92-95.
21.	Shang Y, Jiang YX, Xu SP, et al. Reduction of pulmonary inflammatory response by erythropoietin in a rat model of endotoxaemia . Chin Med J, 2009, 122(7): 834-838.
22.	Rocha J, Eduardo-Figueira M, Barateiro A, et al. Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat. Inflammation, 2015, 38(1): 312-326.
23.	Yuksel IO, Cagirci G, Koklu E, et al. Erythropoietin stimulates the coronary collateral development in patients with coronary chronic total occlusion. Neth Heart J, 2016, 24(10): 609-616.
24.	韩新鹏, 张方琪. 重组人促红细胞生成素对内毒素诱导的ALI/ARDS大鼠的干预作用. 国际呼吸杂志, 2016, 36(22): 1723-1726.
25.	Heitrich M, García DM, Stoyanoff TR, et al. Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R, VEGF and VEGF-R2 modulation. Biomed Pharmacother, 2016, 82: 606-613.
26.	Yu DF, Zhu LH, Jiang L, et al. Recombinant human erythropoietin augments neovascularization responses in a neonatal rat model of premature brain damage by phosphatidylinositol 3 kinase/Akt pathway. Chin Med J (Engl), 2017, 130(7): 854-858.
27.	Hu R, Cheng Y, Jing H, et al. Erythropoietin promotes the protective properties of transplanted endothelial progenitor cells against acute lung injury via PI3K/AKT pathway. Shock, 2014, 42(4): 327-336.
28.	刘庆辉, 刘长庭, 石敏, 等. 重组人促红细胞生成素对成年大鼠高氧肺损伤Bax和Bcl-2蛋白表达的影响. 中国呼吸与危重监护杂志, 10(4): 345-349.
29.	丁璐, 吴本清, 黄进洁, 等. 促红细胞生成素对新生大鼠高氧肺损伤细胞凋亡的影响. 中国当代儿科杂志, 2010, 12(7): 576-579.
30.	MacRedmond R, Singhera GK, Dorscheid DR, et al. Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of acute lung injury. Eur Respir J, 2009, 33(6): 1403-1414.
31.	金晓盛, 许先荣, 李国平, 等. 促红细胞生成素后处理减轻大鼠再灌注损伤肺细胞凋亡中的作用及机制. 浙江医学, 2016, 38(1): 17-21.
32.	Szabó C. Multiple pathways of peroxynitrite cytotnxicity. Toxicol Lett, 2003, 140-141: 105-112.
33.	Kakavass S, Demestiha T, Vasileiou P, et al. Erythropoetin as a novel agent with pleiotropic effects against acute lung injury . Eur J Clin Pharmacol, 2011, 67(1): 1-9.
34.	Bakan V, Kurutas EB, Çıralık H, et al. Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma-induced pulmonary contusion. Ulus Travma Acil Cerrahi Derg, 2016, 22(4): 322-327.
35.	Ardalan MR, Estakhri R, Hajipour B, et al. Erythropoietin ameliorates oxidative stress and tissue injury following renal ischemia/reperfusion in rat kidney and lung. Med Princ Pract, 2013, 22(1): 70-74.
36.	Jang W, Kim HJ, Li H, et al. The neuroprotective effect of erythropoietin on rotenone-induced neurotoxicity in SH-SY5Y cells through the induction of autophagy. Mol Neurobiol, 2016, 53(6): 3812-3821.
37.	Luan Y, Zhang L, Chao S, et al. Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling. Oncotarget, 2016, 7(30): 47082-47094.
38.	Li R, Zhang LM, Sun WB. Erythropoietin rescues primary rat cortical neurons from pyroptosis and apoptosis via Erk1/2-Nrf2/Bach1 signal pathway. Brain Res Bull, 2017, 130: 236-244.

1. 马晓春, 王辰, 方强, 等. 急性肺损伤/急性呼吸窘迫综合征诊断和治疗指南. 中国危重病急救医学, 2006, 18(12): 706-710.
2. Zhang DX, Zhang LM, Zhao XC, et al. Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Biomed Pharmacother, 2017, 87: 332-341.
3. Miljus N, Massih B, Weis MA, et al. Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems. J Neurochem, 2017, 141(1): 63-74.
4. Rezaee MA, Mohammadpour AH, Imenshahidi M, et al. Protective effect of erythropoietin on myocardial apoptosis in rats exposed to carbon monoxide. Life Sci , 2016, 148: 118-124.
5. Alempijevic T, Zec S, Nikolic V, et al. Erythropoietin in predicting prognosis in patient with acute-on-chronic liver failure. J Gastrointestin Liver Dis, 2016, 25(4): 473-479.
6. Ranjbaran M, Kadkhodaee M, Seifi B, et al. Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS-dependent mechanism in male Wistar rats. Injury, 2017, 48(2): 262-269.
7. Cui H, He J, Chen H, et al. Erythropoietin attenuates hyperoxia-induced lung injury by upregulating epidermal growth factor-like domain 7 in newborn rats. Biomed Rep, 2017, 6(1): 32-38.
8. 石芸萍. 促红细胞生成素的研究进展. 疾病监测与控制杂志, 2016, 10(3): 202-203.
9. Wu H, Dong G, Liu H, et al. Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression. Eur J Pharmacol, 2009, 602(2-3): 406-412.
10. Vollmar B, Eipel C, Menger MD, Therapeutic effects of erythropoietin in murine models of endotoxin shock. Crit Care Med, 2009, 37(3): 889-898.
11. Fiordaliso F, Chimenti S, Staszewsky L, et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A, 2005, 102(6): 2046-2051.
12. Brines M, Grasso G, Fiordaliso F, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A, 2004, 101(41): 14907-14912.
13. Maiese K, Chong ZZ, Shang YC, et al. Raves and risks for erythropoietin. Cytokine Growth Factor Rev, 2008, 19(2): 145-155.
14. Ravikumar P, Menon JU, Punnakitikashem P, et al. Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine, 2016, 12(3): 811-821.
15. Aggarwal S, Gross CM, Kumar S, et al. Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. Am J Respir Cell Mol Biol, 2014, 50 (3): 614-625.
16. Liu Y, Lu J, Chen L, et al. Erythropoietin-derived petide protects against acute lung injury after rat traumatic brain injury . Cell Physiol Biochem, 2017, 41(5): 2037-2044.
17. Tascilar O, Cakmak GK, Tekin IO, et al. Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis. World J Gastroenterol, 2007, 13(46): 6172-6182.
18. Korkmaz T, Kahramansoy N, Kilicgun A, et al. The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis. BMC Research Notes, 2014, 7(1): 1-6.
19. Ji MH, Tong JH, Tan YH, et al. Erythropoietin pretreatment attenuates seawater aspiration-induced acute lung injury in rats. Inflammation, 2016, 39(1): 447-456.
20. 王晓蕾, 岳冬梅, 陈宁, 等. 促红细胞生成素对高体积分数氧肺损伤新生大鼠单核细胞趋化蛋白-1表达的影响. 实用儿科临床杂志, 2010, 25(2): 92-95.
21. Shang Y, Jiang YX, Xu SP, et al. Reduction of pulmonary inflammatory response by erythropoietin in a rat model of endotoxaemia . Chin Med J, 2009, 122(7): 834-838.
22. Rocha J, Eduardo-Figueira M, Barateiro A, et al. Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat. Inflammation, 2015, 38(1): 312-326.
23. Yuksel IO, Cagirci G, Koklu E, et al. Erythropoietin stimulates the coronary collateral development in patients with coronary chronic total occlusion. Neth Heart J, 2016, 24(10): 609-616.
24. 韩新鹏, 张方琪. 重组人促红细胞生成素对内毒素诱导的ALI/ARDS大鼠的干预作用. 国际呼吸杂志, 2016, 36(22): 1723-1726.
25. Heitrich M, García DM, Stoyanoff TR, et al. Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R, VEGF and VEGF-R2 modulation. Biomed Pharmacother, 2016, 82: 606-613.
26. Yu DF, Zhu LH, Jiang L, et al. Recombinant human erythropoietin augments neovascularization responses in a neonatal rat model of premature brain damage by phosphatidylinositol 3 kinase/Akt pathway. Chin Med J (Engl), 2017, 130(7): 854-858.
27. Hu R, Cheng Y, Jing H, et al. Erythropoietin promotes the protective properties of transplanted endothelial progenitor cells against acute lung injury via PI3K/AKT pathway. Shock, 2014, 42(4): 327-336.
28. 刘庆辉, 刘长庭, 石敏, 等. 重组人促红细胞生成素对成年大鼠高氧肺损伤Bax和Bcl-2蛋白表达的影响. 中国呼吸与危重监护杂志, 10(4): 345-349.
29. 丁璐, 吴本清, 黄进洁, 等. 促红细胞生成素对新生大鼠高氧肺损伤细胞凋亡的影响. 中国当代儿科杂志, 2010, 12(7): 576-579.
30. MacRedmond R, Singhera GK, Dorscheid DR, et al. Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of acute lung injury. Eur Respir J, 2009, 33(6): 1403-1414.
31. 金晓盛, 许先荣, 李国平, 等. 促红细胞生成素后处理减轻大鼠再灌注损伤肺细胞凋亡中的作用及机制. 浙江医学, 2016, 38(1): 17-21.
32. Szabó C. Multiple pathways of peroxynitrite cytotnxicity. Toxicol Lett, 2003, 140-141: 105-112.
33. Kakavass S, Demestiha T, Vasileiou P, et al. Erythropoetin as a novel agent with pleiotropic effects against acute lung injury . Eur J Clin Pharmacol, 2011, 67(1): 1-9.
34. Bakan V, Kurutas EB, Çıralık H, et al. Endogenous erythropoietin level and effects of exogenous erythropoietin in a rat model of blunt chest trauma-induced pulmonary contusion. Ulus Travma Acil Cerrahi Derg, 2016, 22(4): 322-327.
35. Ardalan MR, Estakhri R, Hajipour B, et al. Erythropoietin ameliorates oxidative stress and tissue injury following renal ischemia/reperfusion in rat kidney and lung. Med Princ Pract, 2013, 22(1): 70-74.
36. Jang W, Kim HJ, Li H, et al. The neuroprotective effect of erythropoietin on rotenone-induced neurotoxicity in SH-SY5Y cells through the induction of autophagy. Mol Neurobiol, 2016, 53(6): 3812-3821.
37. Luan Y, Zhang L, Chao S, et al. Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling. Oncotarget, 2016, 7(30): 47082-47094.
38. Li R, Zhang LM, Sun WB. Erythropoietin rescues primary rat cortical neurons from pyroptosis and apoptosis via Erk1/2-Nrf2/Bach1 signal pathway. Brain Res Bull, 2017, 130: 236-244.

Chinese Journal of Respiratory and Critical Care Medicine

促红细胞生成素对急性肺损伤保护作用机制的研究进展

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