氢气对肺移植保护机制的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

张梦荻 ,  周华成

哈尔滨医科大学第四附属医院（黑龙江哈尔滨 150001）;

Corresponding author：

周华成, Email: zhouhuacheng@163.com

Keywords：

DOI：

10.7507/1671-6205.201706034

Video：

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Citation： 张梦荻, 周华成. 氢气对肺移植保护机制的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 219-222. doi: 10.7507/1671-6205.201706034 Copy

1.	Liu R, Fang X, Meng C, et al. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015, 240(9): 1214-1222.
2.	Zhao M, Fernandez LG, Doctor A, et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol, 2006, 291(5): L1018-1026.
3.	Nakagiri T, Warnecke G, Avsar M, et al. Lung function early after lung transplantation is correlated with the frequency of regulatory T cells. Surg Today, 2012, 42(3): 250-258.
4.	Kawamura T, Huang C-S, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 2011, 150(2): 240-249.
5.	Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12): 1344-1351.
6.	Noda K, Tanaka Y, Shigemura N, et al. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int, 2012, 25(12): 1213-1222.
7.	Takahashi M, Chen-Yoshikawa TF, Saito M, et al. Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injurydagger. Eur J Cardiothorac Surg, 2017, 51(3): 442-448.
8.	Zhai Y, Zhou X, Dai Q, et al. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015, 98(2): 268-276.
9.	Meng C, Ma L, Niu L, et al. Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. Life Sci, 2016, 151: 199-206.
10.	Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1): 41-49.
11.	Chen X, Liu Q, Wang D, et al. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev, 2015, 2015: 106836.
12.	Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2): 399-407.
13.	Liu Q, Li BS, Song YJ, et al. Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. Mol Med Rep, 2016, 13(4): 3588-3596.
14.	Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell, 2011, 21(1): 92-101.
15.	Bai X, Liu S, Yuan L, et al. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016, 1646: 410-417.
16.	Gao Y, Gui Q, Jin L, et al. Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats. Neurosci Lett, 2017, 640: 29-36.
17.	Chian CF, Chiang CH, Chuang CH, et al. SN50, a Cell-Permeable Inhibitor of Nuclear Factor-kappaB, Attenuates Ventilator-Induced Lung Injury in an Isolated and Perfused Rat Lung Model. Shock, 2016, 46(2): 194-201.
18.	Xie K, Yu Y, Huang Y, et al. Molecular Hydrogen Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice through Reducing Inflammation and Apoptosis. Shock, 2012, 37(5): 548-55.
19.	Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2): 253-258.
20.	Liu Q, Shen WF, Sun HY, et al. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver Int, 2010, 30(7): 958-968.
21.	Liu H, Chen X, Han Y, et al. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomed Pharmacother, 2014, 68(3): 267-275.
22.	Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10): L646-656.
23.	Diao M, Zhang S, Wu L, et al. Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. Inflammation, 2016, 39(6): 2029-2039.
24.	Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12): 2130-2137.
25.	Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016, 15(1): DOI http://dx.doi.org/10.4238/gmr.15016050.
26.	Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2): 291-298.

1. Liu R, Fang X, Meng C, et al. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015, 240(9): 1214-1222.
2. Zhao M, Fernandez LG, Doctor A, et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol, 2006, 291(5): L1018-1026.
3. Nakagiri T, Warnecke G, Avsar M, et al. Lung function early after lung transplantation is correlated with the frequency of regulatory T cells. Surg Today, 2012, 42(3): 250-258.
4. Kawamura T, Huang C-S, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 2011, 150(2): 240-249.
5. Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12): 1344-1351.
6. Noda K, Tanaka Y, Shigemura N, et al. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int, 2012, 25(12): 1213-1222.
7. Takahashi M, Chen-Yoshikawa TF, Saito M, et al. Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injurydagger. Eur J Cardiothorac Surg, 2017, 51(3): 442-448.
8. Zhai Y, Zhou X, Dai Q, et al. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015, 98(2): 268-276.
9. Meng C, Ma L, Niu L, et al. Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. Life Sci, 2016, 151: 199-206.
10. Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1): 41-49.
11. Chen X, Liu Q, Wang D, et al. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev, 2015, 2015: 106836.
12. Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2): 399-407.
13. Liu Q, Li BS, Song YJ, et al. Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. Mol Med Rep, 2016, 13(4): 3588-3596.
14. Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell, 2011, 21(1): 92-101.
15. Bai X, Liu S, Yuan L, et al. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016, 1646: 410-417.
16. Gao Y, Gui Q, Jin L, et al. Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats. Neurosci Lett, 2017, 640: 29-36.
17. Chian CF, Chiang CH, Chuang CH, et al. SN50, a Cell-Permeable Inhibitor of Nuclear Factor-kappaB, Attenuates Ventilator-Induced Lung Injury in an Isolated and Perfused Rat Lung Model. Shock, 2016, 46(2): 194-201.
18. Xie K, Yu Y, Huang Y, et al. Molecular Hydrogen Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice through Reducing Inflammation and Apoptosis. Shock, 2012, 37(5): 548-55.
19. Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2): 253-258.
20. Liu Q, Shen WF, Sun HY, et al. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver Int, 2010, 30(7): 958-968.
21. Liu H, Chen X, Han Y, et al. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomed Pharmacother, 2014, 68(3): 267-275.
22. Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10): L646-656.
23. Diao M, Zhang S, Wu L, et al. Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. Inflammation, 2016, 39(6): 2029-2039.
24. Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12): 2130-2137.
25. Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016, 15(1): DOI http://dx.doi.org/10.4238/gmr.15016050.
26. Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2): 291-298.

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