The detection and clinical role of periostin in BLAF of patients with dermatomyositis- and rheumatoid arthritis-related interstitial lung disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

HE Xinwei ^1,2 , LUO Qiongzhen ¹ , SHANG Ying ¹ ,  GAO Zhancheng ¹

1. Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, P. R. China;
2. Department of Internal Medicine, Xicheng District Zhanlanlu Hospital, Beijing 100044, P. R. China;

Corresponding author：

GAO Zhancheng, Email: zcgao@bjmu.edu.cn

Keywords：

Connective tissue disease-related interstitial lung disease; Bronchoalveolar lavage fluid; Periostin; Krebs von den Lungen-6

DOI：

10.7507/1671-6205.201802025

Video：

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ObjectiveTo explore the expression of periostin in bronchoalveolar lavage fluid (BALF) of patients with dermatomyositis-related interstitial lung disease (DM-ILD) and rheumatoid arthritis-related interstitial lung disease (RA-ILD).MethodsA total of 44 patients with DM-ILD and 28 patients with RA-ILD were underwent bronchoalveolar lavage. Cells in BALF were collected and analyzed by absolute different cell counts. The level of periostin and Krebs von den Lungen-6 (KL-6) were tested by enzyme linked immunosorbent assay. Results of high resolution CT of patients were scored. Thirty patients without interstitial lung disease (ILD) served as a control group.ResultsLevels of periostin and KL-6 were significantly increased in BALF of patients with DM-ILD and RA-ILD compared with control group (all P<0.05). Levels of periostin were positively correlated with lymphocyte counts and levels of KL-6 in BALF (allP<0.05). Furthermore, levels of periostin were significantly correlated with high resolution CT scores (P<0.05).ConclusionsLevels of periostin are increased in patients with DM-ILD and RA-ILD. Periostin might be served as an indicator of CTD-ILD.

Citation： HE Xinwei, LUO Qiongzhen, SHANG Ying, GAO Zhancheng. The detection and clinical role of periostin in BLAF of patients with dermatomyositis- and rheumatoid arthritis-related interstitial lung disease. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(5): 465-469. doi: 10.7507/1671-6205.201802025 Copy

1.	Demoruelle MK, Mittoo S, Solomon JJ. Connective tissue disease-related interstitial lung disease. Best Pract Res Clin Rheumatol, 2016, 30(1): 39-52.
2.	Nurmi HM, Kettunen HP, Suoranta SK, et al. Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease. Respir Med, 2018, 134: 24-30.
3.	Fujisawa T, Hozumi H, Kono M, et al. Predictive factors for long-term outcome in polymyositis/dermatomyositis-associated interstitial lung diseases. Respir Investig, 2017, 55(2): 130-137.
4.	Okamoto M, Hoshino T, Kitasato Y, et al. Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J, 2011, 37(5): 1119-1127.
5.	Yamaguchi Y, Ono J, Masuoka M, et al. Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. Br J Dermatol, 2013, 168(4): 717-725.
6.	中华医学会风湿病学分会. 多发性肌炎和皮肌炎诊断及治疗指南. 中华风湿病学杂志, 2010, 14(12): 8828-8831.
7.	Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum, 1988, 31(3): 315-324.
8.	Jee AS, Adelstein S, Bleasel J, et al. Role of autoantibodies in the diagnosis of connective-tissue disease ILD (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF). J Clin Med, 2017, 6(5): E51.
9.	Oda K, Ishimoto H, Yatera K, et al. High-resolution CT scoring system-based grading scale predicts the clinical outcomes in patients with idiopathic pulmonary fibrosis. Respir Res, 2014, 15: 10.
10.	Kudo A, Kii I. Periostin function in communication with extracellular matrices. J Cell Commun Signal, 2018, 12(1): 301-308.
11.	Mino M, Kanno K, Okimoto K, et al. Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatol Commun, 2017, 1(10): 1099-1109.
12.	Izuhara K, Nunomura S, Nanri Y, et al. Periostin in inflammation and allergy. Cell Mol Life Sci, 2017, 74(23): 4293-4303.
13.	Ohta S, Okamoto M, Fujimoto K, et al. The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis. PLoS One, 2017, 12(3): e0174547.
14.	Samara KD, Trachalaki A, Tsitoura E, et al. Upregulation of citrullination pathway: from autoimmune to idiopathic lung fibrosis. Respir Res, 2017, 18(1): 218.
15.	Wakamatsu K, Nagata N, Kumazoe H, et al. Prognostic value of serial serum KL-6 measurements in patients with idiopathic pulmonary fibrosis. Respir Investig, 2017, 55(1): 16-23.
16.	Oguz EO, Kucuksahin O, Turgay M, et al. Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. Clin Rheumatol, 2016, 35(3): 663-666.
17.	Meyer KC, Raghu G. Bronchoalveolar lavage for the evaluation of interstitial lung disease: is it clinically useful?. Eur Respir J, 2011, 38(4): 761-769.
18.	Atzeni F, Gerardi MC, Barilaro G, et al. Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review. Expert Rev Clin Immunol, 2018, 4(1): 69-82.
19.	Kotani T, Takeuchi T, Yoshimatsu Y, et al. Initial limited three-level thin-section computed tomography scorings predict the prognosis of acute/subacute interstitial pneumonia in patients with dermatomyositis. Mod Rheumatol, 2016, 26(5): 738-743.
20.	Ito Y, Arita M, Kumagai S, et al. Radiological fibrosis score is strongly associated with worse survival in rheumatoid arthritis-related interstitial lung disease. Mod Rheumatol, 2018, 15: 1-21.
21.	Yamakawa H, Hagiwara E, Kitamura H, et al. Serum KL-6 and surfactant protein-D as monitoring and predictive markers of interstitial lung disease in patients with systemic sclerosis and mixed connective tissue disease. J Thorac Dis, 2017, 9(2): 362-371.
22.	Sugiyama Y, Yoshimi R, Tamura M, et al. The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease. Arthritis Res Ther, 2018, 20(1): 7.

1. Demoruelle MK, Mittoo S, Solomon JJ. Connective tissue disease-related interstitial lung disease. Best Pract Res Clin Rheumatol, 2016, 30(1): 39-52.
2. Nurmi HM, Kettunen HP, Suoranta SK, et al. Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease. Respir Med, 2018, 134: 24-30.
3. Fujisawa T, Hozumi H, Kono M, et al. Predictive factors for long-term outcome in polymyositis/dermatomyositis-associated interstitial lung diseases. Respir Investig, 2017, 55(2): 130-137.
4. Okamoto M, Hoshino T, Kitasato Y, et al. Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J, 2011, 37(5): 1119-1127.
5. Yamaguchi Y, Ono J, Masuoka M, et al. Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. Br J Dermatol, 2013, 168(4): 717-725.
6. 中华医学会风湿病学分会. 多发性肌炎和皮肌炎诊断及治疗指南. 中华风湿病学杂志, 2010, 14(12): 8828-8831.
7. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum, 1988, 31(3): 315-324.
8. Jee AS, Adelstein S, Bleasel J, et al. Role of autoantibodies in the diagnosis of connective-tissue disease ILD (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF). J Clin Med, 2017, 6(5): E51.
9. Oda K, Ishimoto H, Yatera K, et al. High-resolution CT scoring system-based grading scale predicts the clinical outcomes in patients with idiopathic pulmonary fibrosis. Respir Res, 2014, 15: 10.
10. Kudo A, Kii I. Periostin function in communication with extracellular matrices. J Cell Commun Signal, 2018, 12(1): 301-308.
11. Mino M, Kanno K, Okimoto K, et al. Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatol Commun, 2017, 1(10): 1099-1109.
12. Izuhara K, Nunomura S, Nanri Y, et al. Periostin in inflammation and allergy. Cell Mol Life Sci, 2017, 74(23): 4293-4303.
13. Ohta S, Okamoto M, Fujimoto K, et al. The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis. PLoS One, 2017, 12(3): e0174547.
14. Samara KD, Trachalaki A, Tsitoura E, et al. Upregulation of citrullination pathway: from autoimmune to idiopathic lung fibrosis. Respir Res, 2017, 18(1): 218.
15. Wakamatsu K, Nagata N, Kumazoe H, et al. Prognostic value of serial serum KL-6 measurements in patients with idiopathic pulmonary fibrosis. Respir Investig, 2017, 55(1): 16-23.
16. Oguz EO, Kucuksahin O, Turgay M, et al. Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. Clin Rheumatol, 2016, 35(3): 663-666.
17. Meyer KC, Raghu G. Bronchoalveolar lavage for the evaluation of interstitial lung disease: is it clinically useful?. Eur Respir J, 2011, 38(4): 761-769.
18. Atzeni F, Gerardi MC, Barilaro G, et al. Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review. Expert Rev Clin Immunol, 2018, 4(1): 69-82.
19. Kotani T, Takeuchi T, Yoshimatsu Y, et al. Initial limited three-level thin-section computed tomography scorings predict the prognosis of acute/subacute interstitial pneumonia in patients with dermatomyositis. Mod Rheumatol, 2016, 26(5): 738-743.
20. Ito Y, Arita M, Kumagai S, et al. Radiological fibrosis score is strongly associated with worse survival in rheumatoid arthritis-related interstitial lung disease. Mod Rheumatol, 2018, 15: 1-21.
21. Yamakawa H, Hagiwara E, Kitamura H, et al. Serum KL-6 and surfactant protein-D as monitoring and predictive markers of interstitial lung disease in patients with systemic sclerosis and mixed connective tissue disease. J Thorac Dis, 2017, 9(2): 362-371.
22. Sugiyama Y, Yoshimi R, Tamura M, et al. The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease. Arthritis Res Ther, 2018, 20(1): 7.

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The detection and clinical role of periostin in BLAF of patients with dermatomyositis- and rheumatoid arthritis-related interstitial lung disease

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