Diagnostic value and analysis of endobronchial ultrasonography with a guide sheath for pulmonary fungal disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

SUN Yunqing ¹ , CHENG Pengpeng ¹ , WANG Qian ¹ , WANG Yanmin ¹ , ZHANG Yue ¹ , GUAN Wenbin ² , GUO Xuejun ¹ ,  HAN Fengfeng ¹

1. Department of Respiratory Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P. R. China;
2. Department of Pathology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P. R. China;

Corresponding author：

HAN Fengfeng, Email: hanfengfeng@xinhuamed.com.cn

Keywords：

Pulmonary fungal disease; Endobronchial ultrasonography with a guide sheath; Diagnosis

DOI：

10.7507/1671-6205.201903017

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Objective To explore the diagnostic value of endobronchial ultrasonography with a guide sheath (EBUS-GS) for pulmonary fungal disease.Methods All patients were collected from January 2015 to December 2018. They were diagnosed with pulmonary fungal disease by tissue biopsy, body fluid or blood test, and without other diseases such as pneumonia, lung cancer, lung abscess, tuberculosis, or organizing pneumonia, etc. After clinical anti-fungal treatment, clinical symptoms were relieved, chest CT lesions were absorbed, laboratory-related checks were turned negative in these patients. All patients underwent bronchoscopy, bronchoalveolar lavage fluid/brush examination, and blood galactomannan antigen test/latex agglutination test. They were divided into an EBUS-GS group and a non-EBUS-GS group according to whether EBUS-GS check was performed. Non-parametric test was used to analyze the diagnostic value of EBUS-GS in pulmonary fungal diseases.Results Fifty-one patients were included and 20 patients in the EBUS-GS group and 31 patients in the non-EBUS-GS group. The EBUS-GS group had a higher positive rate of pulmonary fungal disease. The diagnostic rates of the EBUS-GS group and the non-EBUS-GS group were statistically different (90.0% vs. 48.4%, P<0.05).Conclusion EBUS-GS can improve the diagnosis rate of pulmonary fungal disease and provides further evidence for a clear diagnosis.

Citation： SUN Yunqing, CHENG Pengpeng, WANG Qian, WANG Yanmin, ZHANG Yue, GUAN Wenbin, GUO Xuejun, HAN Fengfeng. Diagnostic value and analysis of endobronchial ultrasonography with a guide sheath for pulmonary fungal disease. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(1): 28-31. doi: 10.7507/1671-6205.201903017 Copy

1.	Asano F, Matsuno Y, Tsuzuku A, et al. Diagnosis of peripheral pulmonary lesions using a bronchoscope insertion guidance system combined with endobronchial ultrasonography with a guide sheath. Lung Cancer, 2008, 60(3): 366-373.
2.	何小羊, 任秋霞, 杨英. 2008~2017 年我国深部真菌病原谱及流行特征国内文献系统分析. 中国真菌病学杂志, 2018, 13(4): 229-234.
3.	Enoch DA, Yang H, Aliyu SH, et al. The changing epidemiology of invasive fungal infections. Methods Mol Biol, 2017, 1508: 17-65.
4.	Yan X, Zong F, Kong H, et al. Pulmonary fungal diseases in immunocompetent hosts: a single-center retrospective analysis of 35 subjects. Mycopathologia, 2016, 181(7-8): 513-521.
5.	孙强, 王丽环. 糖尿病患者呼吸机相关性肺炎病原学分析. 中华医院感染学杂志, 2012, 22(23): 5230-5231.
6.	Knutsen AP, Slavin RG. Allergic bronchopulmonary Aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol, 2011, 2011: 843763.
7.	Overton NL, Simpson A, Bowyer P, et al. Genetic susceptibility to severe asthma with fungal sensitization. Int J Immunogenet, 2017, 44(3): 93-106.
8.	De Soyza A, Aliberti S. Bronchiectasis and Aspergillus: how are they linked?. Med Mycol, 2017, 55(1): 69-81.
9.	Zou M, Tang L, Zhao S, et al. Systematic review and meta-analysis of detecting galactomannan in broncho alveolar lavage fluid for diagosing invasive aspergillosis. PLoS One, 2012, 7(8): e4334.
10.	Garnacho-Montero J, Olaechea P, Alvarez-Lerma F, et al. Epidemiology diagnosis and treatment of fungal respiratory infections in the critically ill patient. Rev Esp Quimioter, 2013, 26(2): 173-188.
11.	Zhou W, Li H, Zhang Y, et al. Diagnostic value of galactomannan antigen test in serum and broncho alveolar lavage fluid samples from patients with nonneutropenic invasive pulmonary aspergillosis. J Clin Microbiol, 2017, 55(7): 2153-2161.
12.	牟向东, 李若瑜, 万喆, 等. 血清乳胶凝集试验诊断肺隐球菌病的临床对照研究. 中华结核和呼吸杂志, 2018, 31(5): 360-363.
13.	吕群. 乳胶凝集试验对肺隐球菌病诊断价值的 Meta 分析. 中华全科医学, 2017, 15(3): 521-523.
14.	Hazeki N, Tachihara M, Tsukamoto R, et al. Utility of cell blocks obtained by catheter aspiration via a guide sheath during endobronchial ultrasonography. Respir Investig, 2017, 55(2): 161-165.
15.	Izumo T, Matsumoto Y, Sasada S, et al. Utility of rapid on-site cytologic evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions. Jpn J Clin Oncol, 2017, 47(3): 221-225.
16.	Wang C, Li X, Zhou Z, et al. Endobronchial ultrasonography with guide sheath versus computed tomography guided transthoracic needle biopsy for peripheral pulmonary lesions: a propensity score matched analysis. J Thorac Dis, 2016, 8(10): 2758-2764.
17.	Izumo T, Sasada S, Chavez C, et al. The diagnostic value of histology and cytology samples during endobronchial ultrasound with a guide sheath. Jpn J Clin Oncol, 2015, 45(4): 362-366.
18.	Takai M, Izumo T, Chavez C, et al. Transbronchial needle aspiration through a guide sheath with endobronchial ultrasonography (GS-TBNA) for peripheral pulmonary lesions. Ann Thorac Cardiovasc Surg, 2014, 20(1): 19-25.
19.	Hayama M, Izumo T, Chavez C, et al. Additional transbronchial needle aspiration through a guide sheath for peripheral pulmonary lesions that cannot be detected by radial EBUS. Clin Respir J, 2017, 11(6): 757-764.

1. Asano F, Matsuno Y, Tsuzuku A, et al. Diagnosis of peripheral pulmonary lesions using a bronchoscope insertion guidance system combined with endobronchial ultrasonography with a guide sheath. Lung Cancer, 2008, 60(3): 366-373.
2. 何小羊, 任秋霞, 杨英. 2008~2017 年我国深部真菌病原谱及流行特征国内文献系统分析. 中国真菌病学杂志, 2018, 13(4): 229-234.
3. Enoch DA, Yang H, Aliyu SH, et al. The changing epidemiology of invasive fungal infections. Methods Mol Biol, 2017, 1508: 17-65.
4. Yan X, Zong F, Kong H, et al. Pulmonary fungal diseases in immunocompetent hosts: a single-center retrospective analysis of 35 subjects. Mycopathologia, 2016, 181(7-8): 513-521.
5. 孙强, 王丽环. 糖尿病患者呼吸机相关性肺炎病原学分析. 中华医院感染学杂志, 2012, 22(23): 5230-5231.
6. Knutsen AP, Slavin RG. Allergic bronchopulmonary Aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol, 2011, 2011: 843763.
7. Overton NL, Simpson A, Bowyer P, et al. Genetic susceptibility to severe asthma with fungal sensitization. Int J Immunogenet, 2017, 44(3): 93-106.
8. De Soyza A, Aliberti S. Bronchiectasis and Aspergillus: how are they linked?. Med Mycol, 2017, 55(1): 69-81.
9. Zou M, Tang L, Zhao S, et al. Systematic review and meta-analysis of detecting galactomannan in broncho alveolar lavage fluid for diagosing invasive aspergillosis. PLoS One, 2012, 7(8): e4334.
10. Garnacho-Montero J, Olaechea P, Alvarez-Lerma F, et al. Epidemiology diagnosis and treatment of fungal respiratory infections in the critically ill patient. Rev Esp Quimioter, 2013, 26(2): 173-188.
11. Zhou W, Li H, Zhang Y, et al. Diagnostic value of galactomannan antigen test in serum and broncho alveolar lavage fluid samples from patients with nonneutropenic invasive pulmonary aspergillosis. J Clin Microbiol, 2017, 55(7): 2153-2161.
12. 牟向东, 李若瑜, 万喆, 等. 血清乳胶凝集试验诊断肺隐球菌病的临床对照研究. 中华结核和呼吸杂志, 2018, 31(5): 360-363.
13. 吕群. 乳胶凝集试验对肺隐球菌病诊断价值的 Meta 分析. 中华全科医学, 2017, 15(3): 521-523.
14. Hazeki N, Tachihara M, Tsukamoto R, et al. Utility of cell blocks obtained by catheter aspiration via a guide sheath during endobronchial ultrasonography. Respir Investig, 2017, 55(2): 161-165.
15. Izumo T, Matsumoto Y, Sasada S, et al. Utility of rapid on-site cytologic evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions. Jpn J Clin Oncol, 2017, 47(3): 221-225.
16. Wang C, Li X, Zhou Z, et al. Endobronchial ultrasonography with guide sheath versus computed tomography guided transthoracic needle biopsy for peripheral pulmonary lesions: a propensity score matched analysis. J Thorac Dis, 2016, 8(10): 2758-2764.
17. Izumo T, Sasada S, Chavez C, et al. The diagnostic value of histology and cytology samples during endobronchial ultrasound with a guide sheath. Jpn J Clin Oncol, 2015, 45(4): 362-366.
18. Takai M, Izumo T, Chavez C, et al. Transbronchial needle aspiration through a guide sheath with endobronchial ultrasonography (GS-TBNA) for peripheral pulmonary lesions. Ann Thorac Cardiovasc Surg, 2014, 20(1): 19-25.
19. Hayama M, Izumo T, Chavez C, et al. Additional transbronchial needle aspiration through a guide sheath for peripheral pulmonary lesions that cannot be detected by radial EBUS. Clin Respir J, 2017, 11(6): 757-764.

Chinese Journal of Respiratory and Critical Care Medicine

Diagnostic value and analysis of endobronchial ultrasonography with a guide sheath for pulmonary fungal disease

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