Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHANG Panpan ¹ , WANG Yanhui ² , HAN Xiaoqing ¹ , MENG Qingling ³ , WNAG Ling ¹ , LIU Chen ¹ , WANG Yuan ¹ , HUANG Chao ¹ ,  WANG Hongyang ¹

1. Department of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P. R. China;
2. College of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei 063210, P. R. China;
3. Internal medicine, People Hospitsal of Qianxi, Qianxi, Heibei 063005, P. R. China;

Corresponding author：

WANG Hongyang, Email: tsmywhy@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Elderly; Edaravone; Interleukin-6; Tumor necrosis factor-α; Intercellular adhesion molecule-1

DOI：

10.7507/1671-6205.201903047

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Objective To investigate the effects and clinical significance of edaravone on serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 90 elderly patients with moderate to severe OSAHS confirmed by polysomnography were recruited from North China University of Science and Technology Affiliated Hospital in February 2016 to October 2017. According to random number table method the OSAHS patients were randomly divided into group A (n=30), group B (n=30) and group C (n=30). Group A received continuous positive airway pressure treatment for six months, group B received edaravone therapy and continuous positive airway pressure treatment for six months, and group C only received edaravone therapy for six months. The changes of serum TNF-α, IL-6 and ICAM-1 were detected by enzyme-linked immunosorbent assay before and after treatment.Results The differences of serum TNF-α, IL-6 and ICAM-1 before treatment in the three groups were not statistically significant (P>0.05). Compared with before treatment, the levels of serum TNF-α, IL-6 and ICAM-1 decreased in the three groups (P<0.05). After six months of treatment, the levels of serum TNF-α, IL-6 and ICAM-1 decreased in group A and group B compared with group C (P<0.05), and decreased significantly in group B compared with group A (P<0.05).Conclusion Edaravone can inhibit the expressions of serum TNF-α, IL-6 and ICAM-1 in elderly patients with moderate to severe OSAHS, and thereby reduce vascular endothelial dysfunction and injury.

Citation： ZHANG Panpan, WANG Yanhui, HAN Xiaoqing, MENG Qingling, WNAG Ling, LIU Chen, WANG Yuan, HUANG Chao, WANG Hongyang. Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(1): 32-35. doi: 10.7507/1671-6205.201903047 Copy

1.	李蓉, 杨爱荣, 杨发满, 等. 老年睡眠呼吸暂停低通气综合征患者血清 HIF-1α、VEGF、hs-CRP、NT-proBNP 的水平. 中国老年学杂志, 2015, 35(23): 6814-6815.
2.	Ryan CM, Battisti-Charbonney A, Sobczyk O, et al. Evaluation of cerebrovascular reactivity in subjects with and without obstructive sleep apnea. J Stroke Cerebrovasc Dis, 2018, 27(1): 162-168.
3.	Floras JS. Sleep apnea and cardiovascular disease: an enigmatic risk factor. Circ Res, 2018, 122(12): 1741-1764.
4.	Rowley JA, Chowdhuri S. Leukocytes: a potential link between obstructive sleep apnea and cardiovascular disease?. Ann Am Thorac Soc, 2018, 15(8): 918-919.
5.	Jin F, Liu JN, Zhang XW, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
6.	徐彦飞, 刘露, 周舟, 等. 持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征合并难治性高血压患者血压及相关炎性因子的影响. 中国呼吸与危重监护杂志, 2019, 18(4): 322-326.
7.	张盼盼, 韩晓庆, 王红阳, 等. 持续气道正压通气对中重度阻塞性睡眠呼吸暂停综合征患者血清 S100β 及 NSE 的影响. 临床耳鼻咽喉头颈外科杂志, 2015, 29(6): 509-511.
8.	张盼盼, 韩晓庆, 王红阳, 等. 持续气道正压通气对老年睡眠呼吸暂停患者神经损伤因子的影响. 中华老年心脑血管病杂志, 2015, 17(7): 739-741.
9.	韩晓庆, 张盼盼, 王红阳, 等. 双水平气道正压通气治疗对老年阻塞性睡眠呼吸暂停低通气综合征患者认知功能及血清 5-羟色胺的影响. 中国老年学杂志, 2017, 37(3): 636-637.
10.	马勋龙, 刘洋贝, 刘荣雁, 等. 依达拉奉联合阿托伐他汀钙对老年血管性痴呆者血液流变学及颈动脉硬化斑块的影响. 解放军医药杂志, 2017, 29(7): 77-81.
11.	何权瀛, 陈宝元. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011 年修订版)解读. 中华结核和呼吸杂志, 2012, 35(1): 7-8.
12.	王锦华, 陈强, 汪东良. 老年急性脑梗死患者依达拉奉联合神经节苷脂治疗的临床效果及对炎症因子的影响. 中华医院感染学杂志, 2015, 25(10): 2179-2181.
13.	Kikuchi K, Tancharoen S, Takeshige N, et al. The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci, 2013, 14(7): 13909-13930.
14.	郭华, 陈炅, 索冬卫. 依达拉奉对急性脑梗死患者炎症因子、6-酮-前列腺素 F1α、血栓素 B2、血管内皮功能和肽素及 N 末端脑钠素原的影响. 中国生化药物杂志, 2015, 35(4): 77-80.
15.	李立群, 张嘉宾, 王红阳, 等. 依达拉奉对重叠综合征伴认知障碍患者认知功能的影响. 实用心脑肺血管病杂志, 2015, 23(11): 74-76.
16.	韩晓庆, 张盼盼, 李琳. 依达拉奉对重度间歇低氧大鼠认知功能及 Nogo-A 表达的影响. 中国中西医结合急救杂志, 2017, 24(6): 570-574.
17.	Taylor CT, Kent BD, Crinion SJ, et al. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem Biophys Res Commun, 2014, 447(4): 660-665.
18.	边丽丽, 谷小芳, 刘芳, 等. 依达拉奉联合丹红对急性脑梗死患者炎症反应及氧化应激的影响. 医学临床研究, 2017, 34(3): 558-560.
19.	王雁冰, 苏梅, 张希龙. 持续气道正压通气对重叠综合征患者血清中相关炎症因子水平的影响. 中华医学杂志, 2014, 94(6): 416-419.
20.	Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation, 2008, 117(17): 2270-2278.
21.	Fotis L, Agrogiannis G, Vlachosi S, et al. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model. Vivo, 2012, 26(2): 243.
22.	Chang YT, Lin HC, Chang WN, et al. Impact of inflammation and oxidative stress on carotid intima-media thickness in obstructive sleep apnea patients without metabolic syndrome. J Sleep Res, 2017, 26(2): 151-158.

1. 李蓉, 杨爱荣, 杨发满, 等. 老年睡眠呼吸暂停低通气综合征患者血清 HIF-1α、VEGF、hs-CRP、NT-proBNP 的水平. 中国老年学杂志, 2015, 35(23): 6814-6815.
2. Ryan CM, Battisti-Charbonney A, Sobczyk O, et al. Evaluation of cerebrovascular reactivity in subjects with and without obstructive sleep apnea. J Stroke Cerebrovasc Dis, 2018, 27(1): 162-168.
3. Floras JS. Sleep apnea and cardiovascular disease: an enigmatic risk factor. Circ Res, 2018, 122(12): 1741-1764.
4. Rowley JA, Chowdhuri S. Leukocytes: a potential link between obstructive sleep apnea and cardiovascular disease?. Ann Am Thorac Soc, 2018, 15(8): 918-919.
5. Jin F, Liu JN, Zhang XW, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
6. 徐彦飞, 刘露, 周舟, 等. 持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征合并难治性高血压患者血压及相关炎性因子的影响. 中国呼吸与危重监护杂志, 2019, 18(4): 322-326.
7. 张盼盼, 韩晓庆, 王红阳, 等. 持续气道正压通气对中重度阻塞性睡眠呼吸暂停综合征患者血清 S100β 及 NSE 的影响. 临床耳鼻咽喉头颈外科杂志, 2015, 29(6): 509-511.
8. 张盼盼, 韩晓庆, 王红阳, 等. 持续气道正压通气对老年睡眠呼吸暂停患者神经损伤因子的影响. 中华老年心脑血管病杂志, 2015, 17(7): 739-741.
9. 韩晓庆, 张盼盼, 王红阳, 等. 双水平气道正压通气治疗对老年阻塞性睡眠呼吸暂停低通气综合征患者认知功能及血清 5-羟色胺的影响. 中国老年学杂志, 2017, 37(3): 636-637.
10. 马勋龙, 刘洋贝, 刘荣雁, 等. 依达拉奉联合阿托伐他汀钙对老年血管性痴呆者血液流变学及颈动脉硬化斑块的影响. 解放军医药杂志, 2017, 29(7): 77-81.
11. 何权瀛, 陈宝元. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011 年修订版)解读. 中华结核和呼吸杂志, 2012, 35(1): 7-8.
12. 王锦华, 陈强, 汪东良. 老年急性脑梗死患者依达拉奉联合神经节苷脂治疗的临床效果及对炎症因子的影响. 中华医院感染学杂志, 2015, 25(10): 2179-2181.
13. Kikuchi K, Tancharoen S, Takeshige N, et al. The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci, 2013, 14(7): 13909-13930.
14. 郭华, 陈炅, 索冬卫. 依达拉奉对急性脑梗死患者炎症因子、6-酮-前列腺素 F1α、血栓素 B2、血管内皮功能和肽素及 N 末端脑钠素原的影响. 中国生化药物杂志, 2015, 35(4): 77-80.
15. 李立群, 张嘉宾, 王红阳, 等. 依达拉奉对重叠综合征伴认知障碍患者认知功能的影响. 实用心脑肺血管病杂志, 2015, 23(11): 74-76.
16. 韩晓庆, 张盼盼, 李琳. 依达拉奉对重度间歇低氧大鼠认知功能及 Nogo-A 表达的影响. 中国中西医结合急救杂志, 2017, 24(6): 570-574.
17. Taylor CT, Kent BD, Crinion SJ, et al. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem Biophys Res Commun, 2014, 447(4): 660-665.
18. 边丽丽, 谷小芳, 刘芳, 等. 依达拉奉联合丹红对急性脑梗死患者炎症反应及氧化应激的影响. 医学临床研究, 2017, 34(3): 558-560.
19. 王雁冰, 苏梅, 张希龙. 持续气道正压通气对重叠综合征患者血清中相关炎症因子水平的影响. 中华医学杂志, 2014, 94(6): 416-419.
20. Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation, 2008, 117(17): 2270-2278.
21. Fotis L, Agrogiannis G, Vlachosi S, et al. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 at the early stages of atherosclerosis in a rat model. Vivo, 2012, 26(2): 243.
22. Chang YT, Lin HC, Chang WN, et al. Impact of inflammation and oxidative stress on carotid intima-media thickness in obstructive sleep apnea patients without metabolic syndrome. J Sleep Res, 2017, 26(2): 151-158.

Chinese Journal of Respiratory and Critical Care Medicine

Effects of edaravone on serum inflammatory factors and adhesion molecules in elderly OSAHS patients

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