吸烟相关间质性肺疾病的对比分析_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

桂贤华 ¹ , 黄妹 ¹ , 曹敏 ¹ , 陈婷婷 ² , 孟凡青 ² , 蔡后荣 ¹ ,  肖永龙 ¹

1. ;
2. ;

Corresponding author：

肖永龙, Email: xiaoyonglong@hotmail.com

Keywords：

呼吸性细支气管炎伴间质性肺疾病; 脱屑性间质性肺炎; 肺朗格汉斯组织细胞增生症

DOI：

10.7507/1671-6205.201904094

Video：

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目的提高对不同类型的吸烟相关间质性肺疾病的临床、影像及病理学特点的认识。方法对诊断为呼吸性细支气管炎伴间质性肺疾病（RB-ILD）、脱屑性间质性肺炎（DIP）、肺朗格汉斯组织细胞增生症（PLCH）患者的临床表现、影像学和组织病理学特点进行分析比较。结果 3 例患者，男 2 例，女 1 例，年龄 21～71 岁，吸烟史为 4～50 年，均为慢性起病，主要临床表现为咳嗽、咳痰、活动后气促。胸部高分辨 CT 的主要表现为小叶中央型微结节影、网格影、囊状影。病理学表现：RB-ILD 呼吸性细支气管周围少许炎症渗出、管腔中有少许巨噬细胞；DIP 肺泡腔内巨噬细胞聚集；PLCH 以朗格汉斯细胞组成为主的星状结节，朗格汉斯组织细胞表达 CD1α。结论吸烟相关的间质性肺疾病临床及影像表现各异，增强对这类疾病的认识，结合组织病理学检查有利于及早诊断这类疾病。

Citation： 桂贤华, 黄妹, 曹敏, 陈婷婷, 孟凡青, 蔡后荣, 肖永龙. 吸烟相关间质性肺疾病的对比分析. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(5): 495-499. doi: 10.7507/1671-6205.201904094 Copy

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2.	Caminati A, Cavazza A, Sverzellati N, et al. An integrated approach in the diagnosis of smoking-related interstitial lung diseases. Eur Respir Rev, 2012, 21(125): 207-217.
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9.	Ryu JH, Myers JL, Capizzi SA, et al. Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. Chest, 2005, 127(1): 178-184.
10.	Mueller-Mang C, Grosse C, Schmid K, et al. What every radiologist should know about idiopathic interstitial pneumonias. Radiographics, 2007, 27(3): 595-615.
11.	Hidalgo A, Franquet T, Giménez A, et al. Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol, 2006, 16(11): 2463-2470.
12.	Hartman TE, Primack SL, Kang EY, et al. Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: assessment with serial CT. Chest, 1996, 110(2): 378-382.
13.	Caminati A, Harari S. Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis. Pro Am Thorac Soc, 2006, 3(4): 299-306.
14.	Flaherty KR, Fell C, Aubry MC, et al. Smoking-related idiopathic interstitial pneumonia. Eur Respir J, 2014, 44(3): 594-602.
15.	Knyazhitskiy A, Masson RG, Corkey R, et al. Beneficial response to macrolide antibiotic in a patient with desquamative interstitial pneumonia refractory to corticosteroid therapy. Chest, 2008, 134(1): 185-187.
16.	Tazi A. Adult pulmonary Langerhans’ cell histiocytosis. Eur Respir J, 2006, 27(6): 1272-1285.
17.	Mason RH, Foley NM, Branley HM, et al. Pulmonary Langerhans cell histiocytosis (PLCH): a new UK register. Thorax, 2014, 69(8): 766-767.
18.	Vassallo R, Ryu J H, Colby T V, et al. Pulmonary Langerhans'-cell histiocytosis. N Engl J Med, 2000, 342(26): 1969-1978.
19.	Mogulkoc N, Veral A, Bishop PW, et al. Pulmonary Langerhans’ cell histiocytosis: radiologic resolution following smoking cessation. Chest, 1999, 115(5): 1452-1455.
20.	Roden AC, Hu X, Kip S, et al. BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases. Am J Surg Pathol, 2014, 38(4): 548-551.
21.	Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte‐derived dendritic cells. Clin Exp Immunol, 2013, 173(2): 288-297.

1. Balbi B, Cottin V, Singh S, et al. Smoking-related lung diseases: a clinical perspective. Eur Respir J, 2010, 35(2): 231-233.
2. Caminati A, Cavazza A, Sverzellati N, et al. An integrated approach in the diagnosis of smoking-related interstitial lung diseases. Eur Respir Rev, 2012, 21(125): 207-217.
3. Myers JL, Veal Jr CF, Shin MS, et al. Respiratory bronchiolitis causing interstitial lung disease: a clinicopathologic study of six cases. Am Rev Respir Dis, 1987, 135(4): 880-884.
4. Wells AU, Nicholson AG, Hansell DM. Challenges in pulmonary fibrosis. 4: Smoking-induced diffuse interstitial lung diseases. Thorax, 2007, 62(10): 904-910.
5. Moon J, du Bois RM, Colby TV, et al. Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax, 1999, 54: 1009-1014.
6. Woo OH, Yong HS, Oh YW, et al. Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. AJR Am J Roentgenol, 2007, 188(5): W412-W414.
7. Ryu JH, Colby TV, Hartman TE, et al. Smoking-related interstitial lung diseases: a concise review. Eur Respir J, 2001, 17(1): 122-132.
8. Attili AK, Kazerooni EA, Gross BH, et al. Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics, 2008, 28(5): 1383-1396.
9. Ryu JH, Myers JL, Capizzi SA, et al. Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. Chest, 2005, 127(1): 178-184.
10. Mueller-Mang C, Grosse C, Schmid K, et al. What every radiologist should know about idiopathic interstitial pneumonias. Radiographics, 2007, 27(3): 595-615.
11. Hidalgo A, Franquet T, Giménez A, et al. Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol, 2006, 16(11): 2463-2470.
12. Hartman TE, Primack SL, Kang EY, et al. Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: assessment with serial CT. Chest, 1996, 110(2): 378-382.
13. Caminati A, Harari S. Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis. Pro Am Thorac Soc, 2006, 3(4): 299-306.
14. Flaherty KR, Fell C, Aubry MC, et al. Smoking-related idiopathic interstitial pneumonia. Eur Respir J, 2014, 44(3): 594-602.
15. Knyazhitskiy A, Masson RG, Corkey R, et al. Beneficial response to macrolide antibiotic in a patient with desquamative interstitial pneumonia refractory to corticosteroid therapy. Chest, 2008, 134(1): 185-187.
16. Tazi A. Adult pulmonary Langerhans’ cell histiocytosis. Eur Respir J, 2006, 27(6): 1272-1285.
17. Mason RH, Foley NM, Branley HM, et al. Pulmonary Langerhans cell histiocytosis (PLCH): a new UK register. Thorax, 2014, 69(8): 766-767.
18. Vassallo R, Ryu J H, Colby T V, et al. Pulmonary Langerhans'-cell histiocytosis. N Engl J Med, 2000, 342(26): 1969-1978.
19. Mogulkoc N, Veral A, Bishop PW, et al. Pulmonary Langerhans’ cell histiocytosis: radiologic resolution following smoking cessation. Chest, 1999, 115(5): 1452-1455.
20. Roden AC, Hu X, Kip S, et al. BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases. Am J Surg Pathol, 2014, 38(4): 548-551.
21. Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte‐derived dendritic cells. Clin Exp Immunol, 2013, 173(2): 288-297.

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Chinese Journal of Respiratory and Critical Care Medicine

吸烟相关间质性肺疾病的对比分析

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