环状 RNA 与呼吸系统疾病_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

徐康乔 ¹ ,  夏世金 ¹ , 王坚 ² , 周敏 ³ ,  双晓萍 ⁴

1. ;
2. ;
3. ;
4. ;

Corresponding author：

夏世金, Email: xiashijinhd@163.com; 双晓萍, Email: 997413146@qq.com

Keywords：

DOI：

10.7507/1671-6205.201909009

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Citation： 徐康乔, 夏世金, 王坚, 周敏, 双晓萍. 环状 RNA 与呼吸系统疾病. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(6): 611-616. doi: 10.7507/1671-6205.201909009 Copy

1.	Barrett SP, Salzman J. Circular RNAs: analysis, expression and potential functions. Development, 2016, 143(11): 1838-1847.
2.	Liu L, Wang J, Khanabdali R, et al. Circular RNAs: isolation, characterisation and their potential role in diseases. RNA Biol, 2017, 14(12): 1715-1721.
3.	Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA, 1976, 73(11): 3852-3856.
4.	Nigro JM, Cho KR, Fearon ER, et al. Scrambled exons. Cell, 1991, 64(3): 607-613.
5.	Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One, 2012, 7(2): e30733.
6.	Chen X, Han P, Zhou T, et al. circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations. Sci Rep, 2016, 6(1): 34985.
7.	Vicens Q, Westhof E. Biogenesis of circular RNAs. Cell, 2014, 159(1): 13-14.
8.	Wilusz JE, Sharp PA. A circuitous route to noncoding RNA. Science, 2013, 340(6131): 440-441.
9.	Yao T, Chen Q, Fu L, et al. Circular RNAs: biogenesis, properties, roles, and their relationships with liver diseases. Hepatol Res, 2017, 47(6): 497-504.
10.	Gao Y, Wang J, Zheng Y, et al. Comprehensive identification of internal structure and alternative splicing events in circular RNAs. Nat Commun, 2016, 7: 12060.
11.	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
12.	Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015, 160(6): 1125-1134.
13.	Meng S, Zhou H, Feng Z, et al. CircRNA: functions and properties of a novel potential biomarker for cancer. Mol Cancer, 2017, 16(1): 94.
14.	Liu J, Liu T, Wang XM, et al. Circles reshaping the RNA world: from waste to treasure. Mol Cancer, 2017, 16(1): 58.
15.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
16.	Panda AC. Circular RNAs act as miRNA sponges. Adv Exp Med Biol, 2018, 1087: 67-79.
17.	Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
18.	Capel B, Swain A, Nicolis SK, et al. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell, 1993, 73(5): 1019-1030.
19.	Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
20.	Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2016, 38(18): 1402-1412.
21.	Chen CY, Sarnow P. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science, 1995, 268(5209): 415-417.
22.	Legnini I, Timoteo GD, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
23.	Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3): 304-315.
24.	Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
25.	Li Y, Hu J, Li L, et al. Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. Biochem Biophys Res Commun, 2018, 503(3): 2089-2094.
26.	Su C, Han Y, Zhang H, et al. CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signalling. J Cell Mol Med, 2018, 22(6): 3097-3107.
27.	Wang X, Zhu X, Zhang H, et al. Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation. Biochem Biophys Res Commun, 2018, 496(4): 1069-1075.
28.	Wan L, Zhang L, Fan K, et al. Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-Catenin pathway. Biomed Res Int, 2016: 1579490.
29.	Xie H, Ren X, Xin S, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget, 2016, 7(18): 26680-26691.
30.	Han J, Zhao G, Ma X, et al. CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. Biochem Biophys Res Commun, 2018, 503(4): 2429-2435.
31.	Zhao F, Han Y, Liu Z, et al. circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498. Biosci Rep, 2018, 38(4): BSR20180570.
32.	Hang D, Zhou J, Qin N, et al. A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. Cancer Med, 2018, 7(6): 2783-2791.
33.	Qiu BQ, Wu YB, Xiong D, et al. CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non‐small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling. J Cell Physiol, 2019, 234(7): 11256-11264.
34.	Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
35.	Zhang Y, Zhao H, Zhang L, et al. Identification of the tumor-suppressive function of circular RNA FOXO3 in non-small cell lung cancer through sponging miR-155. Mol Med Rep, 2018, 17(6): 7692-7700.
36.	Ma X, Yang X, Bao W, et al. Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. Biochem Biophys Res Commun, 2018, 498(4): 1009-1015.
37.	Qiu M, Xia W, Chen R, et al. The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma. Cancer Res, 2018, 78(11): 2839-2851.
38.	Li L, Li W, Chen N, et al. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Clin Cancer Res, 2019, 25(4): 1302-1317.
39.	Luo YH, Zhu XZ, Huang KW, et al. Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. Biomed Pharmacother, 2017, 96: 892-898.
40.	Yu W, Jiang H, Zhang H, et al. Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer. Onco Targets Ther, 2018, 11: 5569-5577.
41.	Zhou Y, Zheng X, Xu B, et al. Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non- small cell lung cancer by miR-1183/PDPK1 signaling pathway. Biochem Biophys Res Commun, 2019, 508(2): 527-535.
42.	Jiang MM, Mai ZT, Wan SZ, et al. Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. J Cancer Res Clin Oncol, 2018, 144(4): 667-674.
43.	Zhu X, Wang X, Wei S, et al. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. FEBS J, 2017, 284(14): 2170-2182.
44.	Qu D, Yan B, Xin R, et al. A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer. Am J Cancer Res, 2018, 8(8): 1387-1402.
45.	Liu W, Ma W, Yuan Y, et al. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. Biochem Biophys Res Commun, 2018, 500(4): 846-851.
46.	Liu T, Song Z, Gai Y. Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p. Biochem Biophys Res Commun, 2018, 503(3): 1503-1509.
47.	Wang L, Tong X, Zhou Z, et al. Circular RNA hsa-circ-0008305(circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer. Mol Cancer, 2018, 17(1): 140.
48.	Gu X, Wang G, Shen H, et al. Hsa_circ_0033155: a potential novel biomarker for non-small cell lung cancer. Exp Ther Med, 2018, 16(4): 3220-3226.
49.	Chen D, Ma W, Ke Z, et al. CircRNA hsa_circ_100395 regulates miR-1228/ TCF21 pathway to inhibit lung cancer progression. Cell Cycle, 2018, 17(16): 2080-2090.
50.	Zhang X, Zhu M, Yang R, et al. Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Oncotarget, 2017, 8(69): 113571-113582.
51.	Qian Z, Liu H, Li M, et al. Potential diagnostic power of blood circular RNA expression in active pulmonary tuberculosis. EBioMedicine, 2018, 27: 18-26.
52.	Zhuang ZG, Zhang JA, Luo HL, et al. The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Mol Immunol, 2017, 90: 264-272.
53.	Huang ZK, Yao FY, Xu JQ, et al. Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from active tuberculosis patients. Cell Physiol Biochem, 2018, 45(3): 1230-1240.
54.	Wan QQ, Wu D, Ye QF. The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: a microarray study. Biochem Biophys Res Commun, 2017, 493(1): 684-689.
55.	Li X, Yuan Z, Chen J, et al. Microarray analysis reveals the changes of circular RNA expression and molecular mechanism in acute lung injury mouse model. J Cell Biochem, 2019, 120(10): 16658-16667.
56.	Gu S, Li G, Zhang X, et al. Aberrant expression of long noncoding RNAs in chronic thromboembolic pulmonary hypertension. Mol Med Rep, 2015, 11(4): 2631-2643.
57.	Wang J, Zhu MC, Kalionis B, et al. Characteristics of circular RNA expression in lung tissues from mice with hypoxia-induced pulmonary hypertension. Int J Mol Med, 2018, 42(3): 1353-1366.
58.	王坚, 胡明冬, 唐晓丹, 等. 慢病毒介导环状RNA mmu-circ-0001033过表达抑制低氧性小鼠肺动脉平滑肌细胞增殖的实验研究. 中华肺部疾病杂志(电子版), 2018, 11(1): 39-43.
59.	Miao R, Wang Y, Wan J, et al. Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. Medicine (Baltimore), 2017, 96(27): e7354.
60.	Fang S, Guo H, Cheng Y, et al. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis, 2018, 9(3): 396.
61.	Cheng Y, Luo W, Li Z, et al. CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress and autophagy. Am J Respir Cell Mol Biol, 2019, 61(3): 380-391.
62.	王坚, 黄嘉楠, 宋元林, 等. 环状RNA的研究新进展. 生命科学, 2017, 29(11): 1141-1148.
63.	Wang J, Zhu M, Pan J, et al. Circular RNAs: a rising star in respiratory diseases. Respir Res, 2019, 20(1): 3.
64.	Haque S, Harries LW. Circular RNAs (circRNAs) in health and disease. Genes (Basel), 2017, 8(12): pii E353.

1. Barrett SP, Salzman J. Circular RNAs: analysis, expression and potential functions. Development, 2016, 143(11): 1838-1847.
2. Liu L, Wang J, Khanabdali R, et al. Circular RNAs: isolation, characterisation and their potential role in diseases. RNA Biol, 2017, 14(12): 1715-1721.
3. Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA, 1976, 73(11): 3852-3856.
4. Nigro JM, Cho KR, Fearon ER, et al. Scrambled exons. Cell, 1991, 64(3): 607-613.
5. Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One, 2012, 7(2): e30733.
6. Chen X, Han P, Zhou T, et al. circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations. Sci Rep, 2016, 6(1): 34985.
7. Vicens Q, Westhof E. Biogenesis of circular RNAs. Cell, 2014, 159(1): 13-14.
8. Wilusz JE, Sharp PA. A circuitous route to noncoding RNA. Science, 2013, 340(6131): 440-441.
9. Yao T, Chen Q, Fu L, et al. Circular RNAs: biogenesis, properties, roles, and their relationships with liver diseases. Hepatol Res, 2017, 47(6): 497-504.
10. Gao Y, Wang J, Zheng Y, et al. Comprehensive identification of internal structure and alternative splicing events in circular RNAs. Nat Commun, 2016, 7: 12060.
11. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
12. Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015, 160(6): 1125-1134.
13. Meng S, Zhou H, Feng Z, et al. CircRNA: functions and properties of a novel potential biomarker for cancer. Mol Cancer, 2017, 16(1): 94.
14. Liu J, Liu T, Wang XM, et al. Circles reshaping the RNA world: from waste to treasure. Mol Cancer, 2017, 16(1): 58.
15. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
16. Panda AC. Circular RNAs act as miRNA sponges. Adv Exp Med Biol, 2018, 1087: 67-79.
17. Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
18. Capel B, Swain A, Nicolis SK, et al. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell, 1993, 73(5): 1019-1030.
19. Abdelmohsen K, Panda AC, Munk R, et al. Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 2017, 14(3): 361-369.
20. Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J, 2016, 38(18): 1402-1412.
21. Chen CY, Sarnow P. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science, 1995, 268(5209): 415-417.
22. Legnini I, Timoteo GD, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
23. Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3): 304-315.
24. Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
25. Li Y, Hu J, Li L, et al. Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. Biochem Biophys Res Commun, 2018, 503(3): 2089-2094.
26. Su C, Han Y, Zhang H, et al. CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signalling. J Cell Mol Med, 2018, 22(6): 3097-3107.
27. Wang X, Zhu X, Zhang H, et al. Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation. Biochem Biophys Res Commun, 2018, 496(4): 1069-1075.
28. Wan L, Zhang L, Fan K, et al. Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-Catenin pathway. Biomed Res Int, 2016: 1579490.
29. Xie H, Ren X, Xin S, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget, 2016, 7(18): 26680-26691.
30. Han J, Zhao G, Ma X, et al. CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. Biochem Biophys Res Commun, 2018, 503(4): 2429-2435.
31. Zhao F, Han Y, Liu Z, et al. circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498. Biosci Rep, 2018, 38(4): BSR20180570.
32. Hang D, Zhou J, Qin N, et al. A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. Cancer Med, 2018, 7(6): 2783-2791.
33. Qiu BQ, Wu YB, Xiong D, et al. CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non‐small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling. J Cell Physiol, 2019, 234(7): 11256-11264.
34. Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
35. Zhang Y, Zhao H, Zhang L, et al. Identification of the tumor-suppressive function of circular RNA FOXO3 in non-small cell lung cancer through sponging miR-155. Mol Med Rep, 2018, 17(6): 7692-7700.
36. Ma X, Yang X, Bao W, et al. Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. Biochem Biophys Res Commun, 2018, 498(4): 1009-1015.
37. Qiu M, Xia W, Chen R, et al. The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma. Cancer Res, 2018, 78(11): 2839-2851.
38. Li L, Li W, Chen N, et al. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Clin Cancer Res, 2019, 25(4): 1302-1317.
39. Luo YH, Zhu XZ, Huang KW, et al. Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. Biomed Pharmacother, 2017, 96: 892-898.
40. Yu W, Jiang H, Zhang H, et al. Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer. Onco Targets Ther, 2018, 11: 5569-5577.
41. Zhou Y, Zheng X, Xu B, et al. Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non- small cell lung cancer by miR-1183/PDPK1 signaling pathway. Biochem Biophys Res Commun, 2019, 508(2): 527-535.
42. Jiang MM, Mai ZT, Wan SZ, et al. Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. J Cancer Res Clin Oncol, 2018, 144(4): 667-674.
43. Zhu X, Wang X, Wei S, et al. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. FEBS J, 2017, 284(14): 2170-2182.
44. Qu D, Yan B, Xin R, et al. A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer. Am J Cancer Res, 2018, 8(8): 1387-1402.
45. Liu W, Ma W, Yuan Y, et al. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. Biochem Biophys Res Commun, 2018, 500(4): 846-851.
46. Liu T, Song Z, Gai Y. Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p. Biochem Biophys Res Commun, 2018, 503(3): 1503-1509.
47. Wang L, Tong X, Zhou Z, et al. Circular RNA hsa-circ-0008305(circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer. Mol Cancer, 2018, 17(1): 140.
48. Gu X, Wang G, Shen H, et al. Hsa_circ_0033155: a potential novel biomarker for non-small cell lung cancer. Exp Ther Med, 2018, 16(4): 3220-3226.
49. Chen D, Ma W, Ke Z, et al. CircRNA hsa_circ_100395 regulates miR-1228/ TCF21 pathway to inhibit lung cancer progression. Cell Cycle, 2018, 17(16): 2080-2090.
50. Zhang X, Zhu M, Yang R, et al. Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Oncotarget, 2017, 8(69): 113571-113582.
51. Qian Z, Liu H, Li M, et al. Potential diagnostic power of blood circular RNA expression in active pulmonary tuberculosis. EBioMedicine, 2018, 27: 18-26.
52. Zhuang ZG, Zhang JA, Luo HL, et al. The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Mol Immunol, 2017, 90: 264-272.
53. Huang ZK, Yao FY, Xu JQ, et al. Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from active tuberculosis patients. Cell Physiol Biochem, 2018, 45(3): 1230-1240.
54. Wan QQ, Wu D, Ye QF. The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: a microarray study. Biochem Biophys Res Commun, 2017, 493(1): 684-689.
55. Li X, Yuan Z, Chen J, et al. Microarray analysis reveals the changes of circular RNA expression and molecular mechanism in acute lung injury mouse model. J Cell Biochem, 2019, 120(10): 16658-16667.
56. Gu S, Li G, Zhang X, et al. Aberrant expression of long noncoding RNAs in chronic thromboembolic pulmonary hypertension. Mol Med Rep, 2015, 11(4): 2631-2643.
57. Wang J, Zhu MC, Kalionis B, et al. Characteristics of circular RNA expression in lung tissues from mice with hypoxia-induced pulmonary hypertension. Int J Mol Med, 2018, 42(3): 1353-1366.
58. 王坚, 胡明冬, 唐晓丹, 等. 慢病毒介导环状RNA mmu-circ-0001033过表达抑制低氧性小鼠肺动脉平滑肌细胞增殖的实验研究. 中华肺部疾病杂志(电子版), 2018, 11(1): 39-43.
59. Miao R, Wang Y, Wan J, et al. Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension. Medicine (Baltimore), 2017, 96(27): e7354.
60. Fang S, Guo H, Cheng Y, et al. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis, 2018, 9(3): 396.
61. Cheng Y, Luo W, Li Z, et al. CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress and autophagy. Am J Respir Cell Mol Biol, 2019, 61(3): 380-391.
62. 王坚, 黄嘉楠, 宋元林, 等. 环状RNA的研究新进展. 生命科学, 2017, 29(11): 1141-1148.
63. Wang J, Zhu M, Pan J, et al. Circular RNAs: a rising star in respiratory diseases. Respir Res, 2019, 20(1): 3.
64. Haque S, Harries LW. Circular RNAs (circRNAs) in health and disease. Genes (Basel), 2017, 8(12): pii E353.

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