烟草相关性慢性阻塞性肺疾病气道炎症研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

杨添文 ¹ , YANG Lifen ¹ , REN Chaofeng ¹ , 杨艳霞 ¹ , 郑勤玲 ¹ , 刘姝 ² , 曾小艺 ¹ , 黄倩 ¹ ,  李梅华 ¹

1. ;
2. ;

Corresponding author：

李梅华, Email: limeihuakm2009@163.com

Keywords：

DOI：

10.7507/1671-6205.201909028

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Citation： YANG Lifen, REN Chaofeng. 烟草相关性慢性阻塞性肺疾病气道炎症研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(6): 621-625. doi: 10.7507/1671-6205.201909028 Copy

1.	Anderson GP. Advances in understanding COPD. F1000Res, 2016, 5: F1000 Faculty Rev-2392.
2.	Nakayama T, Church DF, Pryor WA. Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. Free Radic Biol Med, 1989, 7(1): 9-15.
3.	Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol, 2016, 138(1): 16-27.
4.	Bucher H, Mang S, Keck M, et al. Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice. Pulm Pharmacol Ther, 2017, 44: 96-105.
5.	Yi G, Liang M, Li M, et al. A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. Inflamm Res, 2018, 67(6): 539-551.
6.	Yanagisawa H, Hashimoto M, Minagawa S, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol, 2017, 312(1): L122-L130.
7.	Roos AB, Stampfli MR. Targeting Interleukin-17 signalling in cigarette smoke-induced lung disease: Mechanistic concepts and therapeutic opportunities. Pharmacol Ther, 2017, 178: 123-131.
8.	Dudakov JA, Hanash AM, van den Brink MR. Interleukin-22: immunobiology and pathology. Annu Rev Immunol, 2015, 33: 747-785.
9.	Starkey MR, Plank MW, Casolari P, et al. IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis. Eur Respir J, 2019, 54(1): 1800174.
10.	Jing HY, Liu LY, Zhou JF, et al. Inhibition of C-X-C motif chemokine 10 (CXCL10) protects mice from cigarette smoke-induced chronic obstructive pulmonary disease. Med Sci Monit, 2018, 24: 5748-5753.
11.	Chen J, Dai LQ, Wang T, et al. The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD. Ann Med, 2019, 51(5-6): 314-329.
12.	Gabryelska A, Kuna P, Antczak A, et al. IL-33 mediated inflammation in chronic respiratory diseases-understanding the role of the member of IL-1 superfamily. Front Immunol, 2019, 10: 692.
13.	Lee JH, Hailey KL, Vitorino SA, et al. Cigarette smoke triggers IL-33-associated inflammation in a model of late-stage chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 2019, 61(5): 567-574.
14.	Perincek G, Avcı S. Evaluation of alpha-1-antitrypsin levels in blood serum of patients with chronic obstructive pulmonary disease. Acta Biomed, 2018, 90(1): 37-43.
15.	Senn O, Russi EW, Schindler C, et al. Circulating alpha1-antitrypsin in the general population: determinants and association with lung function. Respir Res, 2008, 9(1): 35.
16.	Sclar DA, Evans MA, Robison LM, et al. α1-Proteinase inhibitor (human) in the treatment of hereditary emphysema secondary to α1-antitrypsin deficiency: number and costs of years of life gained. Clin Drug Investig, 2012, 32(5): 353-360.
17.	Ferrarotti I, Thun GA, Zorzetto M, et al. Serum levels and genotype distribution of α1-antitrypsin in the general population. Thorax, 2012, 67(8): 669-674.
18.	Owen CA, Hu Z, Barrick B, et al. Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol, 2003, 29(3): 283-294.
19.	Manicone AM, Gharib SA, Gong KQ, et al. Matrix metalloproteinase-28 is a key contributor to emphysema pathogenesis. Am J Pathol, 2017, 187(6): 1288-1300.
20.	Boehme SA, Franz-Bacon K, Ludka J, et al. MAP3K19 is overexpressed in COPD and is a central mediator of cigarette smoke-induced pulmonary inflammation and lower airway destruction. PLoS One, 2016, 11(12): e0167169.
21.	Boehme SA, Franz-Bacon K, DiTirro DN, et al. MAP3K19 is a novel regulator of TGF-β signaling that impacts bleomycin-induced lung injury and pulmonary fibrosis. PLoS One, 2016, 11(5): e0154874.
22.	Denney L, Byrne AJ, Shea TJ, et al. Pulmonary Epithelial cell-derived cytokine TGF-β1 is a critical cofactor for enhanced innate lymphoid cell function. Immunity, 2015, 43(5): 945-958.
23.	Kammerl IE, Dann A, Mossina A, et al. Impairment of immunoproteasome function by cigarette smoke and in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2016, 193(11): 1230-1241.
24.	Schmidt M, Finley D. Regulation of proteasome activity in health and disease. Biochim Biophys Acta, 2014, 1843(1): 13-25.
25.	Aghapour M, Raee P, Moghaddam SJ, et al. Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure. Am J Respir Cell Mol Biol, 2018, 58(2): 157-169.
26.	Sohal SS. Airway basal cell reprogramming and epithelial–mesenchymal transition: a potential key to understanding early chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2018, 197(12): 1644-1645.
27.	Shaykhiev R, Sackrowitz R, Fukui T, et al. Smoking-induced CXCL14 expression in the human airway epithelium links chronic obstructive pulmonary disease to lung cancer. Am J Respir Cell Mol Biol, 2013, 49(3): 418-425.
28.	Mahmood MQ, Reid D, Ward C, et al. Transforming growth factor (TGF) β1 and Smad signalling pathways: a likely key to EMT-associated COPD pathogenesis. Respirology, 2017, 22(1): 133-140.
29.	Jiang B, Guan Y, Shen HJ, et al. Akt/PKB signaling regulates cigarette smoke-induced pulmonary epithelial-mesenchymal transition. Lung Cancer, 2018, 122: 44-53.
30.	Eapen MS, Sharma P, Thompson IE, et al. Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Lab Invest, 2019, 99(2): 150-157.
31.	Eapen MS, Sharma P, Gaikwad AV, et al. Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1603-1610.
32.	Murray LA, Dunmore R, Camelo A, et al. Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium. Respir Res, 2017, 18(1): 82.
33.	Liao HD, Mao Y, Ying YG. The involvement of the laminin-integrin alpha7 beta1 signaling pathway in mechanical ventilation-induced pulmonary fibrosis. Thorac Dis, 2017, 9(10): 3961-3972.
34.	Feller D, Kun J, Ruzsics I, et al. Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines. Front Immunol, 2018, 9: 1724.
35.	Heijink IH, de Bruin HG, Dennebos R, et al. Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD. Eur Respir J, 2016, 48(2): 504-515.
36.	Zhou M, Jiao L, Liu Y. sFRP2 promotes airway inflammation and Th17/Treg imbalance in COPD via Wnt/β-catenin pathway. Respir Physiol Neurobiol, 2019, 270: 103282.
37.	Peng H, Guo T, Chen Z, et al. Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease. Exp Lung Res, 2019, 45(3-4): 101-111.
38.	Cloonan SM, Glass K, Laucho-Contreras ME, et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med, 2016, 22(2): 163-174.
39.	Li Y, Yu G, Yuan S, et al. Cigarette smoke-induced pulmonary inflammation and autophagy are attenuated in Ephx2-deficient mice. Inflammation, 2017, 40(2): 497-510.
40.	Selbach M, Schwanhäusser B, Thierfelder N, et al. Widespread changes in protein synthesis induced by microRNAs. Nature, 2008, 455(7209): 58-63.
41.	Du Y, Ding Y, Chen X, et al. MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression. Respir Res, 2017, 18(1): 155.

1. Anderson GP. Advances in understanding COPD. F1000Res, 2016, 5: F1000 Faculty Rev-2392.
2. Nakayama T, Church DF, Pryor WA. Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. Free Radic Biol Med, 1989, 7(1): 9-15.
3. Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol, 2016, 138(1): 16-27.
4. Bucher H, Mang S, Keck M, et al. Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice. Pulm Pharmacol Ther, 2017, 44: 96-105.
5. Yi G, Liang M, Li M, et al. A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. Inflamm Res, 2018, 67(6): 539-551.
6. Yanagisawa H, Hashimoto M, Minagawa S, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol, 2017, 312(1): L122-L130.
7. Roos AB, Stampfli MR. Targeting Interleukin-17 signalling in cigarette smoke-induced lung disease: Mechanistic concepts and therapeutic opportunities. Pharmacol Ther, 2017, 178: 123-131.
8. Dudakov JA, Hanash AM, van den Brink MR. Interleukin-22: immunobiology and pathology. Annu Rev Immunol, 2015, 33: 747-785.
9. Starkey MR, Plank MW, Casolari P, et al. IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis. Eur Respir J, 2019, 54(1): 1800174.
10. Jing HY, Liu LY, Zhou JF, et al. Inhibition of C-X-C motif chemokine 10 (CXCL10) protects mice from cigarette smoke-induced chronic obstructive pulmonary disease. Med Sci Monit, 2018, 24: 5748-5753.
11. Chen J, Dai LQ, Wang T, et al. The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD. Ann Med, 2019, 51(5-6): 314-329.
12. Gabryelska A, Kuna P, Antczak A, et al. IL-33 mediated inflammation in chronic respiratory diseases-understanding the role of the member of IL-1 superfamily. Front Immunol, 2019, 10: 692.
13. Lee JH, Hailey KL, Vitorino SA, et al. Cigarette smoke triggers IL-33-associated inflammation in a model of late-stage chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 2019, 61(5): 567-574.
14. Perincek G, Avcı S. Evaluation of alpha-1-antitrypsin levels in blood serum of patients with chronic obstructive pulmonary disease. Acta Biomed, 2018, 90(1): 37-43.
15. Senn O, Russi EW, Schindler C, et al. Circulating alpha1-antitrypsin in the general population: determinants and association with lung function. Respir Res, 2008, 9(1): 35.
16. Sclar DA, Evans MA, Robison LM, et al. α1-Proteinase inhibitor (human) in the treatment of hereditary emphysema secondary to α1-antitrypsin deficiency: number and costs of years of life gained. Clin Drug Investig, 2012, 32(5): 353-360.
17. Ferrarotti I, Thun GA, Zorzetto M, et al. Serum levels and genotype distribution of α1-antitrypsin in the general population. Thorax, 2012, 67(8): 669-674.
18. Owen CA, Hu Z, Barrick B, et al. Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol, 2003, 29(3): 283-294.
19. Manicone AM, Gharib SA, Gong KQ, et al. Matrix metalloproteinase-28 is a key contributor to emphysema pathogenesis. Am J Pathol, 2017, 187(6): 1288-1300.
20. Boehme SA, Franz-Bacon K, Ludka J, et al. MAP3K19 is overexpressed in COPD and is a central mediator of cigarette smoke-induced pulmonary inflammation and lower airway destruction. PLoS One, 2016, 11(12): e0167169.
21. Boehme SA, Franz-Bacon K, DiTirro DN, et al. MAP3K19 is a novel regulator of TGF-β signaling that impacts bleomycin-induced lung injury and pulmonary fibrosis. PLoS One, 2016, 11(5): e0154874.
22. Denney L, Byrne AJ, Shea TJ, et al. Pulmonary Epithelial cell-derived cytokine TGF-β1 is a critical cofactor for enhanced innate lymphoid cell function. Immunity, 2015, 43(5): 945-958.
23. Kammerl IE, Dann A, Mossina A, et al. Impairment of immunoproteasome function by cigarette smoke and in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2016, 193(11): 1230-1241.
24. Schmidt M, Finley D. Regulation of proteasome activity in health and disease. Biochim Biophys Acta, 2014, 1843(1): 13-25.
25. Aghapour M, Raee P, Moghaddam SJ, et al. Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure. Am J Respir Cell Mol Biol, 2018, 58(2): 157-169.
26. Sohal SS. Airway basal cell reprogramming and epithelial–mesenchymal transition: a potential key to understanding early chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2018, 197(12): 1644-1645.
27. Shaykhiev R, Sackrowitz R, Fukui T, et al. Smoking-induced CXCL14 expression in the human airway epithelium links chronic obstructive pulmonary disease to lung cancer. Am J Respir Cell Mol Biol, 2013, 49(3): 418-425.
28. Mahmood MQ, Reid D, Ward C, et al. Transforming growth factor (TGF) β1 and Smad signalling pathways: a likely key to EMT-associated COPD pathogenesis. Respirology, 2017, 22(1): 133-140.
29. Jiang B, Guan Y, Shen HJ, et al. Akt/PKB signaling regulates cigarette smoke-induced pulmonary epithelial-mesenchymal transition. Lung Cancer, 2018, 122: 44-53.
30. Eapen MS, Sharma P, Thompson IE, et al. Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Lab Invest, 2019, 99(2): 150-157.
31. Eapen MS, Sharma P, Gaikwad AV, et al. Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1603-1610.
32. Murray LA, Dunmore R, Camelo A, et al. Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium. Respir Res, 2017, 18(1): 82.
33. Liao HD, Mao Y, Ying YG. The involvement of the laminin-integrin alpha7 beta1 signaling pathway in mechanical ventilation-induced pulmonary fibrosis. Thorac Dis, 2017, 9(10): 3961-3972.
34. Feller D, Kun J, Ruzsics I, et al. Cigarette smoke-induced pulmonary inflammation becomes systemic by circulating extracellular vesicles containing Wnt5a and inflammatory cytokines. Front Immunol, 2018, 9: 1724.
35. Heijink IH, de Bruin HG, Dennebos R, et al. Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD. Eur Respir J, 2016, 48(2): 504-515.
36. Zhou M, Jiao L, Liu Y. sFRP2 promotes airway inflammation and Th17/Treg imbalance in COPD via Wnt/β-catenin pathway. Respir Physiol Neurobiol, 2019, 270: 103282.
37. Peng H, Guo T, Chen Z, et al. Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease. Exp Lung Res, 2019, 45(3-4): 101-111.
38. Cloonan SM, Glass K, Laucho-Contreras ME, et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med, 2016, 22(2): 163-174.
39. Li Y, Yu G, Yuan S, et al. Cigarette smoke-induced pulmonary inflammation and autophagy are attenuated in Ephx2-deficient mice. Inflammation, 2017, 40(2): 497-510.
40. Selbach M, Schwanhäusser B, Thierfelder N, et al. Widespread changes in protein synthesis induced by microRNAs. Nature, 2008, 455(7209): 58-63.
41. Du Y, Ding Y, Chen X, et al. MicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression. Respir Res, 2017, 18(1): 155.

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烟草相关性慢性阻塞性肺疾病气道炎症研究进展

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