CHEN Xiaobo 1 , YAO Yao 1 , YE Yongshun 1 , ZHONG Nanshan 1 , LI Shiyue 1 , LU Liya 2
  • 1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P. R. China;
  • 2. Department of Anesthesia, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P. R. China;
LI Shiyue, Email: lishiyue@188.com; LU Liya, Email: 2412183636@qq.com
Anesthesia; Tracheal intubation; Rigid bronchoscopy; Transbronchial cryobiopsy; Arterial blood gas
10.7507/1671-6205.201911025
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To evaluate the difference between the tracheal intubation connected to conventional ventilation (TI-CV) and rigid bronchoscopy connected to high frequency ventilation (RB-HFV) under general anesthesia on patients with transbronchial cryobiopsy (TBCB).Method A prospective, randomized, controlled trial was conducted in interstitial lung disease patients with TBCB from August 2018 to February 2019 in the First Affiliated Hospital of Guangzhou Medical University. According to the different methods of intubation, the patients were divided to a TI-CV group and a RB-HFV group randomly. The operating duration, extubation duration, total anesthesia time, heart rate, blood pressure and arterial blood gas analysis were collected and analyzed.Results Sixty-five patients were enrolled. There were 33 patients with an average age of (48.0±15.0) years in TI-CV group and 32 patients with an average age of (48.8±10.8) years in RB-HFV group. The basic line of body mass index, pulmonary function (FEV1, FVC and DLCO), arterial blood gas (pH, PaO2 and PaCO2) and heart rate (HR), mean arterial pressure (MAP) had no significant differences between two groups. At the first 5 minutes of operation, the pH was (7.34±0.06) and (7.26±0.06), and the PaCO2 was (48.82±9.53) and (62.76±9.80) mm Hg in TI-CV group and RB-HFV group respectively, with significant differences (P=0.000). At the end of operation, the pH was (7.33±0.06) and (7.21±0.08), the PaCO2 was (48.91±10.49) and (70.93±14.83) mm Hg, the HR were (79.6±21.1) and (93.8±18.7) bpm, the MAP were (72.15±13.03) and (82.63±15.65) mm Hg in TI-CV group and RB-HFV group respectively, with significant differences (P<0.05). There were no differences in the operating duration and extubation duration between two groups. The total anesthesia time was (47.4±8.8) and (53.3±11.6) min with significant difference (P=0.017). Five minutes after the extubation, there were no significant difference in the pH, PaO2, PaCO2, HR and MAP between two groups. No serious complications occurred in either group.Conclusions Compared with rigid bronchoscopy, TI-CV under general anesthesia is more conducive to maintain effective ventilation, and maintain the HR and MAP stable during the TBCB procedure. TBCB procedure should be performed by TI-CV under general anesthesia in patients with poor cardiopulmonary function.

Citation： CHEN Xiaobo, YAO Yao, YE Yongshun, ZHONG Nanshan, LI Shiyue, LU Liya. The impacts of the different ventilation methods on patients with transbronchial cryobiopsy: a prospective randomized controlled trial. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(2): 123-127. doi: 10.7507/1671-6205.201911025 Copy

  • Previous Article

    The predictive value of diaphragmatic rapid shallow breathing index during the spontaneous breathing trial for weaning outcome

  • Next Article

    支气管乳突状瘤一例并文献复习