Clinical characteristics of 96 hospitalized patients with coronavirus disease 2019_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Rong ¹ , XIE Lingli ¹ , DU Peng ² , FAN Huiqian ¹ ,  SONG Mingyu ³

1. Department of Gastroenterology, General Hospital of the Yangtse River Shipping, Wuhan, Hubei 430000, P. R. China;
2. Department of Respiratory Medicine, General Hospital of the Yangtse River Shipping, Wuhan, Hubei 430000, P. R. China;
3. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China;

Corresponding author：

SONG Mingyu, Email: langzhiwu126@126.com

Keywords：

Coronavirus disease 2019; Pneumonia; Clinical characteristics; Typing

DOI：

10.7507/1671-6205.202002066

Video：

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Objective To analyze the clinical characteristics of coronavirus disease 2019 (COVID-19), identify the high-risk factors which promoted the disease progression into severe or critical cases, and provide clinical guidance.Methods Ninety-six cases of clinically diagnosed coronavirus disease 2019 were collected and analyzed from General Hospital of the Yangtse River Shipping from January 20 to February 14, 2020. According to clinical classification, those cases were divided into two groups: mild group, including common and mild cases, and severe group including severe and critical cases.Results There were more than half of patients ages>60 years old and severe or critical illness (61.5%, 56.3%), and obese patients accounts for 45.8%, the complication of hypertension accounts for 52.1%. The average time from onset to hospitalization was (6.1±2.6) days, and the average hospitalization days were (15.7±6.3) days. Compared with the mild group, the number of male patients in the severe group was more (57.4% vs. 35.7%, P<0.05), the numbers of elderly patients were larger (77.8% vs. 40.5%, P<0.01), and more obese peoples (55.6% vs. 33.3%, P<0.05). Cough symptom was more common in clinical presentation in the severe group (81.5% vs. 61.9%, P< 0.05). Patients with the complication of hypertension or diabetes occupied a higher proportion in the severe group, which were 64.8% vs. 35.7% and 35.2% vs. 14.3% (P< 0.05), respectively. And the rate of hypoxemia in admission of the severe group was significantly higher (79.6% vs. 9.5%, P< 0.01).Conclusions The cases of ages>60 years old and severe or critical illness in coronavirus disease 2019 occupy a higher proportion, and the complication of hypertension accounts for high proportion. Men, ages>60 years old, obese, coughing symptoms, with hypertension and / or diabetes, hypoxemia upon admission are high risk factors for progression into severe and critical cases.

Citation： WANG Rong, XIE Lingli, DU Peng, FAN Huiqian, SONG Mingyu. Clinical characteristics of 96 hospitalized patients with coronavirus disease 2019. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(2): 144-147. doi: 10.7507/1671-6205.202002066 Copy

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1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223): 497-506.
2. Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia[J/OL]. N Engl J Med, 2020 Jan 29. [Epub ahead of print]. https://www.nejm.org/doi/10.1056/NEJMoa2001316.
3. Thompson RN. Novel coronavirus outbreak in Wuhan, China, 2020: Intense surveillance is vital for preventing sustained transmission in new locations. J Clin Med, 2020, 9(2): piiE498.
4. 国家卫生健康委办公厅国家中医药管理局办公室《新型冠状病毒感染的肺炎诊疗方案 (试行第五版)》[EB/OL].http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml[2020-02-04].
5. Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients[J/OL]. Can J Anaesth, 2020-02-12. [Epub ahead of print] https://link.springer.com/article/10.1007%2Fs12630-020-01591-x .
6. 宋元林, 白春学. 新型冠状病毒(2019-nCoV)肺炎流行期间呼吸科门诊质控上海专家共识[J/OL]. 复旦学报(医学版), 2020-02-13: 1-8, http://kns.cnki.net/kcms/detail/31.1885.r.20200212.1847.002.html.
7. 中华预防医学会新型冠状病毒肺炎防控专家组. 新型冠状病毒肺炎流行病学特征的最新认识. 中华流行病学杂志, 2020, 41(2): 139-144.
8. Wu YC, Chen CS, Chan YJ. Overview of the 2019 novel coronavirus (2019-nCoV): the pathogen of severe specific contagious pneumonia (SSCP)[J/OL]. J Chin Med Assoc, 2020-02-11. [Epub ahead of print] https://journals.lww.com/jcma/FullText/2020/03000/The_outbreak_of_COVID_19__An_overview.3.aspx .
9. Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China[J/OL]. Eur Radiol, 2020-02-13. [Epub ahead of print]. http://link.springer.com/10.1007/s00330-020-06731-x.
10. 史河水, 韩小雨, 樊艳青, 等. 新型冠状病毒(2019-nCoV)感染的肺炎临床特征及影像学表现[J/OL]. 临床放射学杂志, 2020-02-06: 1-8, https://doi.org/10.13437/j.cnki.jcr.20200206.002.
11. Shi HS, Han XY, Zheng CS. Evolution of CT Manifestations in a Patient Recovered from 2019 Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China[J/OL]. Radiology, 2020-02-07: 200269. [Epub ahead of print]. http://dx.doi.org/10.1148/radiol.2020200269.
12. 钟飞扬, 张寒菲, 王彬宸, 等. 新型冠状病毒肺炎的CT影像学表现[J/OL]. 武汉大学学报(医学版), 2020-02-13: 1-5. https://doi.org/10.14188/j.1671-8852.2020.0061.
13. Grasselli G, Castagna L, Bottino N, et al. Practical clinical application of an extracorporeal carbon Dioxide removal system in acute respiratory distress syndrome and acute on chronic respiratory failure[J/OL]. ASAIO J, 2019-08-06. [Epub ahead of print] http://dx.doi.org/10.1097/MAT.0000000000001050.
14. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China[J/OL]. JAMA, 2020-02-07. [Epub ahead of print] http://dx.doi.org/10.1001/jama.2020.1585.
15. 周灵, 刘辉国. 新型冠状病毒肺炎患者的早期识别和病情评估 [J/OL]. 中华结核和呼吸杂志, 2020, 43(2020-02-05). http://rs.yiigle.com/yufabiao/1179589.htm.
16. Fukumoto K, Taniguchi T, Usami N, et al. Preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer. Surg Today, 2015, 45(1): 63-67.
17. Duarte JC, Tavares e Castro A, Silva R, et al. Prognostic value of plasma D-dimer level in adults with community-acquired pneumonia: a prospective study. Rev Port Pneumol (2006), 2015, 21(4): 218-219.
18. Li N, Duan Q, Zhang W. Risk factors and coping strategies of severe community-acquired pneumonia in chemotherapy induction period of acute leukemia. Oncol Lett, 2018, 15: 3566-3571.
19. Kui L, Fang YY, Deng Y, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province[J/OL]. Chin Med J (Engl), 2020-02-07. [Epub ahead of print]. https://journals.lww.com/cmj/Abstract/publishahead/Clinical_characteristics_of_novel_coronavirus.99408.aspx.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical characteristics of 96 hospitalized patients with coronavirus disease 2019

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