活动性结核 γ 干扰素释放试验假阴性结果影响因素的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

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 何胜东 ^1,2 , 林云 ² , 严茂文 ¹

1. ;
2. ;

Corresponding author：

何胜东, Email: hsd1979@sina.com

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DOI：

10.7507/1671-6205.202002116

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Citation： 何胜东, 林云, 严茂文. 活动性结核 γ 干扰素释放试验假阴性结果影响因素的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(3): 224-228. doi: 10.7507/1671-6205.202002116 Copy

1.	高静韬, 刘宇红. 2019 年世界卫生组织全球结核病报告要点解读. 国际呼吸杂志, 2020, 40(3): 161-166.
2.	邓国防, 路希维. 肺结核活动性判断规范及临床应用专家共识. 中国防痨杂志, 2020, 42(4): 301-307.
3.	Takwoingi Y, Whitworth H, Rees-Roberts M, et al. Interferon gamma release assays for diagnostic evaluation of active tuberculosis (IDEA): test accuracy study and economic evaluation. Health Technol Assess, 2019, 23(23): 1-152.
4.	Santin M, García-García JM, Domínguez J, et al. Guidelines for the use of interferon-γ release assays in the diagnosis of tuberculosis infection. Enferm Infecc Microbiol Clin, 2016, 34(5): 303. e1-13.
5.	Nguyen DT, Teeter LD, Graves J, et al. Characteristics associated with negative interferon-γ release assay results in culture-confirmed tuberculosis patients, Texas, USA, 2013-2015. Emerg Infect Dis, 2018, 24(3): 534-540.
6.	Bae W, Park KU, Song EY, et al. Comparison of the sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB according to patient age. PLoS One, 2016, 11(6): e0156917.
7.	Kwon YS, Kim YH, Jeon K, et al. Factors that predict negative results of QuantiFERON-TB Gold In-Tube test in patients with culture-confirmed tuberculosis: a multicenter retrospective cohort study. PLoS One, 2015, 10(6): e0129792.
8.	de Visser V, Sotgiu G, Lange C, et al. False-negative interferon-γ release assay results in active tuberculosis: a TBNET study. Eur Respir J, 2015, 45(1): 279-283.
9.	Yang C, Zhang S, Yao L, et al. Evaluation of risk factors for false-negative results with an antigen-specific peripheral blood-based quantitative T cell assay (T-SPOT®. TB) in the diagnosis of active tuberculosis: a large-scale retrospective study in China. J Int Med Res, 2018, 46(5): 1815-1825.
10.	Pan LP, Jia HY, Liu F, et al. Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB. J Infect, 2015, 70(4): 367-380.
11.	Wang MS, Liu XJ. Risk factors for false-negative interferon-γ release assay results in culture-confirmed childhood TB. Am J Trop Med Hyg, 2019, 101(6): 1303-1307.
12.	Hang NT, Lien LT, Kobayashi N, et al. Analysis of factors lowering sensitivity of interferon-γ release assay for tuberculosis. PLoS One, 2011, 6(8): e23806.
13.	Yan L, Shen H, Xiao H. Characteristics of peripheral Vγ2Vδ2 T cells in interferon-γ release assay negative pulmonary tuberculosis patients. BMC Infect Dis, 2018, 18(1): 453.
14.	Santos JA, Duarte R, Nunes C. Host factors associated to false negative and indeterminate results in an interferon-γ release assay in patients with active tuberculosis. Pulmonology, 2020, 26(6): 353-362.
15.	Basu-Roy R, Thee S, Blázquez-Gamero D, et al. Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study. Eur Respir J, 2020, 56(1): 1902004.
16.	Di L, Li Y. The risk factor of false-negative and false-positive for T-SPOT.TB in active tuberculosis. J Clin Lab Anal, 2018, 32(2): e22273.
17.	Lee YM, Park KH, Kim SM, et al. Risk factors for false-negative results of T-SPOT.TB and tuberculin skin test in extrapulmonary tuberculosis. Infection, 2013, 41(6): 1089-1095.
18.	Lian G, Du F, Wu H, et al. Factors contributing to false-negative enzyme-linked immunospot assay for interferon-gamma results in active tuberculosis. Clin Lab, 2017, 63(4): 773-779.
19.	Cho K, Cho E, Kwon S, et al. Factors associated with indeterminate and false negative results of QuantiFERON-TB Gold In-Tube test in active tuberculosis. Tuberc Respir Dis (Seoul), 2012, 72(5): 416-425.
20.	Kim YJ, Kang JY, Kim SI, et al. Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis. BMC Infect Dis, 2018, 18(1): 457.
21.	Amelio P, Portevin D, Hella J, et al. HIV infection functionally impairs mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses. J Virol, 2019, 93(5): e01728-18.
22.	Crabtree-Ramírez B, Jenkins C, Jayathilake K, et al. HIV-related tuberculosis: mortality risk in persons without vs. with culture-confirmed disease. Int J Tuberc Lung Dis, 2019, 23(3): 306-314.
23.	Raby E, Moyo M, Devendra A, et al. The effects of HIV on the sensitivity of a whole blood IFN-gamma release assay in Zambian adults with active tuberculosis. PLoS One, 2008, 3(6): e2489.
24.	Kmeid J, Kulkarni PA, Batista MV, et al. Active mycobacterium tuberculosis infection at a comprehensive cancer center, 2006-2014. BMC Infect Dis, 2019, 19(1): 934.
25.	Workneh MH, Bjune GA, Yimer SA, et al. Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: a systematic review. PLoS One, 2017, 12(4): e0175925.
26.	Faurholt-Jepsen D, Aabye MG, Jensen AV, et al. Diabetes is associated with lower tuberculosis antigen-specific interferon gamma release in Tanzanian tuberculosis patients and non-tuberculosis controls. Scand J Infect Dis, 2014, 46(5): 384-391.
27.	Liao CH, Lai CC, Tan CK, et al. False-negative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis. J Infect, 2009, 59(6): 421-423.
28.	Bao L, Li T, Diao N, et al. Fluctuating behavior and influential factors in the performance of the QuantiFERON-TB Gold In-Tube assay in the diagnosis of tuberculosis. PLoS One, 2015, 10(8): e0103763.
29.	Bua A, Ruggeri M, Zanetti S, et al. Effect of teriflunomide on QuantiFERON-TB Gold results. Med Microbiol Immunol, 2017, 206(1): 73-75.
30.	Altet N, Latorre I3, Jiménez-Fuentes MÁ, et al. Assessment of the influence of direct tobacco smoke on infection and active TB management. PLoS One, 2017, 12(8): e0182998.
31.	Aabye MG, Hermansen TS, Ruhwald M, et al. Negative effect of smoking on the performance of the QuantiFERON TB gold in tube test. BMC Infect Dis, 2012, 12: 379.
32.	Huo ZY, Peng L. Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis. BMC Infect Dis, 2016, 16: 350.
33.	Doberne D, Gaur RL, Banaei N. Preanalytical delay reduces sensitivity of QuantiFERON-TB gold in-tube assay for detection of latent tuberculosis infection. J Clin Microbiol, 2011, 49(8): 3061-3064.
34.	Li JL, Liu Y, Ma LYM, et al. The performance of T-cell Xtend reagent in increasing blood storage times for interferon gamma release assays. J Clin Lab Anal, 2018, 32(2): e22253.
35.	Auld SC, Lee SH, Click ES, et al. IFN-γ release assay result is associated with disease site and death in active tuberculosis. Ann Am Thorac Soc, 2016, 13(12): 2151-2158.
36.	李楠, 邢志珩, 孙昕, 等. 胸部 CT 评分对 γ 干扰素释放试验阴性肺结核的诊断价值. 天津医药, 2019, 47(9): 953-957.
37.	Hu X, Liao S, Bai H, et al. Long noncoding RNA and predictive model to improve diagnosis of clinically diagnosed pulmonary tuberculosis. J Clin Microbiol, 2020, 58(7): e01973-19.

1. 高静韬, 刘宇红. 2019 年世界卫生组织全球结核病报告要点解读. 国际呼吸杂志, 2020, 40(3): 161-166.
2. 邓国防, 路希维. 肺结核活动性判断规范及临床应用专家共识. 中国防痨杂志, 2020, 42(4): 301-307.
3. Takwoingi Y, Whitworth H, Rees-Roberts M, et al. Interferon gamma release assays for diagnostic evaluation of active tuberculosis (IDEA): test accuracy study and economic evaluation. Health Technol Assess, 2019, 23(23): 1-152.
4. Santin M, García-García JM, Domínguez J, et al. Guidelines for the use of interferon-γ release assays in the diagnosis of tuberculosis infection. Enferm Infecc Microbiol Clin, 2016, 34(5): 303. e1-13.
5. Nguyen DT, Teeter LD, Graves J, et al. Characteristics associated with negative interferon-γ release assay results in culture-confirmed tuberculosis patients, Texas, USA, 2013-2015. Emerg Infect Dis, 2018, 24(3): 534-540.
6. Bae W, Park KU, Song EY, et al. Comparison of the sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB according to patient age. PLoS One, 2016, 11(6): e0156917.
7. Kwon YS, Kim YH, Jeon K, et al. Factors that predict negative results of QuantiFERON-TB Gold In-Tube test in patients with culture-confirmed tuberculosis: a multicenter retrospective cohort study. PLoS One, 2015, 10(6): e0129792.
8. de Visser V, Sotgiu G, Lange C, et al. False-negative interferon-γ release assay results in active tuberculosis: a TBNET study. Eur Respir J, 2015, 45(1): 279-283.
9. Yang C, Zhang S, Yao L, et al. Evaluation of risk factors for false-negative results with an antigen-specific peripheral blood-based quantitative T cell assay (T-SPOT®. TB) in the diagnosis of active tuberculosis: a large-scale retrospective study in China. J Int Med Res, 2018, 46(5): 1815-1825.
10. Pan LP, Jia HY, Liu F, et al. Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB. J Infect, 2015, 70(4): 367-380.
11. Wang MS, Liu XJ. Risk factors for false-negative interferon-γ release assay results in culture-confirmed childhood TB. Am J Trop Med Hyg, 2019, 101(6): 1303-1307.
12. Hang NT, Lien LT, Kobayashi N, et al. Analysis of factors lowering sensitivity of interferon-γ release assay for tuberculosis. PLoS One, 2011, 6(8): e23806.
13. Yan L, Shen H, Xiao H. Characteristics of peripheral Vγ2Vδ2 T cells in interferon-γ release assay negative pulmonary tuberculosis patients. BMC Infect Dis, 2018, 18(1): 453.
14. Santos JA, Duarte R, Nunes C. Host factors associated to false negative and indeterminate results in an interferon-γ release assay in patients with active tuberculosis. Pulmonology, 2020, 26(6): 353-362.
15. Basu-Roy R, Thee S, Blázquez-Gamero D, et al. Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study. Eur Respir J, 2020, 56(1): 1902004.
16. Di L, Li Y. The risk factor of false-negative and false-positive for T-SPOT.TB in active tuberculosis. J Clin Lab Anal, 2018, 32(2): e22273.
17. Lee YM, Park KH, Kim SM, et al. Risk factors for false-negative results of T-SPOT.TB and tuberculin skin test in extrapulmonary tuberculosis. Infection, 2013, 41(6): 1089-1095.
18. Lian G, Du F, Wu H, et al. Factors contributing to false-negative enzyme-linked immunospot assay for interferon-gamma results in active tuberculosis. Clin Lab, 2017, 63(4): 773-779.
19. Cho K, Cho E, Kwon S, et al. Factors associated with indeterminate and false negative results of QuantiFERON-TB Gold In-Tube test in active tuberculosis. Tuberc Respir Dis (Seoul), 2012, 72(5): 416-425.
20. Kim YJ, Kang JY, Kim SI, et al. Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis. BMC Infect Dis, 2018, 18(1): 457.
21. Amelio P, Portevin D, Hella J, et al. HIV infection functionally impairs mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses. J Virol, 2019, 93(5): e01728-18.
22. Crabtree-Ramírez B, Jenkins C, Jayathilake K, et al. HIV-related tuberculosis: mortality risk in persons without vs. with culture-confirmed disease. Int J Tuberc Lung Dis, 2019, 23(3): 306-314.
23. Raby E, Moyo M, Devendra A, et al. The effects of HIV on the sensitivity of a whole blood IFN-gamma release assay in Zambian adults with active tuberculosis. PLoS One, 2008, 3(6): e2489.
24. Kmeid J, Kulkarni PA, Batista MV, et al. Active mycobacterium tuberculosis infection at a comprehensive cancer center, 2006-2014. BMC Infect Dis, 2019, 19(1): 934.
25. Workneh MH, Bjune GA, Yimer SA, et al. Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: a systematic review. PLoS One, 2017, 12(4): e0175925.
26. Faurholt-Jepsen D, Aabye MG, Jensen AV, et al. Diabetes is associated with lower tuberculosis antigen-specific interferon gamma release in Tanzanian tuberculosis patients and non-tuberculosis controls. Scand J Infect Dis, 2014, 46(5): 384-391.
27. Liao CH, Lai CC, Tan CK, et al. False-negative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis. J Infect, 2009, 59(6): 421-423.
28. Bao L, Li T, Diao N, et al. Fluctuating behavior and influential factors in the performance of the QuantiFERON-TB Gold In-Tube assay in the diagnosis of tuberculosis. PLoS One, 2015, 10(8): e0103763.
29. Bua A, Ruggeri M, Zanetti S, et al. Effect of teriflunomide on QuantiFERON-TB Gold results. Med Microbiol Immunol, 2017, 206(1): 73-75.
30. Altet N, Latorre I3, Jiménez-Fuentes MÁ, et al. Assessment of the influence of direct tobacco smoke on infection and active TB management. PLoS One, 2017, 12(8): e0182998.
31. Aabye MG, Hermansen TS, Ruhwald M, et al. Negative effect of smoking on the performance of the QuantiFERON TB gold in tube test. BMC Infect Dis, 2012, 12: 379.
32. Huo ZY, Peng L. Accuracy of the interferon-γ release assay for the diagnosis of active tuberculosis among HIV-seropositive individuals: a systematic review and meta-analysis. BMC Infect Dis, 2016, 16: 350.
33. Doberne D, Gaur RL, Banaei N. Preanalytical delay reduces sensitivity of QuantiFERON-TB gold in-tube assay for detection of latent tuberculosis infection. J Clin Microbiol, 2011, 49(8): 3061-3064.
34. Li JL, Liu Y, Ma LYM, et al. The performance of T-cell Xtend reagent in increasing blood storage times for interferon gamma release assays. J Clin Lab Anal, 2018, 32(2): e22253.
35. Auld SC, Lee SH, Click ES, et al. IFN-γ release assay result is associated with disease site and death in active tuberculosis. Ann Am Thorac Soc, 2016, 13(12): 2151-2158.
36. 李楠, 邢志珩, 孙昕, 等. 胸部 CT 评分对 γ 干扰素释放试验阴性肺结核的诊断价值. 天津医药, 2019, 47(9): 953-957.
37. Hu X, Liao S, Bai H, et al. Long noncoding RNA and predictive model to improve diagnosis of clinically diagnosed pulmonary tuberculosis. J Clin Microbiol, 2020, 58(7): e01973-19.

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