蛋白激酶 C 在肺部疾病中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陈杨 ¹ , 李经历 ² , 苏珊珊 ¹ , 林鹏程 ¹ , 徐含烟 ¹ ,  李玉苹 ¹

1. ;
2. ;

Corresponding author：

李玉苹, Email: wzliyp@163.com

Keywords：

DOI：

10.7507/1671-6205.202103060

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Citation： 陈杨, 李经历, 苏珊珊, 林鹏程, 徐含烟, 李玉苹. 蛋白激酶 C 在肺部疾病中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(6): 452-456. doi: 10.7507/1671-6205.202103060 Copy

1.	BommaReddy RR, Patel R, Smalley T, et al. Effects of atypical protein kinase C inhibitor (DNDA) on lung cancer proliferation and migration by PKC-ι/FAK ubiquitination through the Cbl-b pathway. Onco Targets Ther, 2020, 13: 1661-1676.
2.	Isakov N. Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. Semin Cancer Biol, 2018, 48: 36-52.
3.	Li M, Zhao Y, He J, et al. Protein kinase C theta inhibition attenuates lipopolysaccharide-induced acute lung injury through notch signaling pathway via suppressing Th17 cell response in mice. Inflammation, 2019, 42(6): 1980-1989.
4.	Tsai JY, Rédei D, Hohmann J, et al. 12-deoxyphorbol esters induce growth arrest and apoptosis in human lung cancer A549 cells via activation of PKC-δ/PKD/ERK signaling pathway. Int J Mol Sci, 2020, 21(20): 7579.
5.	Leskow FC, Krasnapolski MA, Urtreger AJ. The pros and cons of targeting protein kinase C (PKC) in the management of cancer patients. Curr Pharm Biotechnol, 2011, 12(11): 1961-73.
6.	Mondrinos MJ, Kennedy PA, Lyons M, et al. Protein kinase C and acute respiratory distress syndrome. Shock, 2013, 39(6): 467-479.
7.	Newton AC. Protein kinase C: perfectly balanced. Crit Rev Biochem Mol Biol, 2018, 53(2): 208-230.
8.	Reyland ME, Jones DN. Multifunctional roles of PKCδ: opportunities for targeted therapy in human disease. Pharmacol Ther, 2016, 165: 1-13.
9.	Singh RM, Cummings E, Pantos C, et al. Protein kinase C and cardiac dysfunction: a review. Heart Fail Rev, 2017, 22(6): 843-859.
10.	Basu A. The enigmatic protein kinase C-eta. Cancers (Basel), 2019, 11(2): 214.
11.	Fan CF, Li Y, Jia J. Protein kinase Cs in lung cancer: a promising target for therapies. J Cancer Res Ther, 2013, 9 Suppl 2: S74-S79.
12.	Kim H, Zhao J, Zhang Q, et al. δV1-1 reduces pulmonary ischemia reperfusion-induced lung injury by inhibiting necrosis and mitochondrial localization of PKCδ and p53. Am J Transplant, 2016, 16(1): 83-98.
13.	Wang SB, Ye Q, Tu JW, et al. Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression. Int J Clin Exp Pathol, 2018, 11(7): 3487-3493.
14.	Shologu N, Scully M, Laffey JG, et al. Human mesenchymal stem cell secretome from bone marrow or adipose-derived tissue sources for treatment of hypoxia-induced pulmonary epithelial injury. Int J Mol Sci, 2018, 19(10): 2996.
15.	Magnani ND, Dada LA, Queisser MA, et al. HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na, K-ATPase to protect against hypoxia-induced lung injury. Proc Natl Acad Sci U S A, 2017, 114(47): E10178-E10186.
16.	Kilpatrick LE, Standage SW, Li H, et al. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC). J Leukoc Biol, 2011, 89(1): 3-10.
17.	Liverani E, Mondrinos MJ, Sun S, et al. Role of protein kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. PLoS One, 2018, 13(4): e0195379.
18.	Zhou HS, Li M, Sui BD, et al. Lipopolysaccharide impairs permeability of pulmonary microvascular endothelial cells via Connexin40. Microvasc Res, 2018, 115: 58-67.
19.	Xie L, Chiang ET, Wu X, et al. Regulation of thrombin-induced lung endothelial cell barrier disruption by protein kinase C Delta. PLoS One, 2016, 11(7): e0158865.
20.	Lee S, Ro H, In HJ, et al. Fisetin inhibits TNF-α/NF-κB-induced IL-8 expression by targeting PKCδ in human airway epithelial cells. Cytokine, 2018, 108: 247-254.
21.	Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res, 2012, 91(2): 142-149.
22.	Dianat M, Radan M, Badavi M, et al. Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress. Respir Res, 2018, 19(1): 58.
23.	Hsu HT, Tseng YT, Wong WJ, et al. Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. BMC Complement Altern Med, 2018, 18(1): 211.
24.	Wyatt TA, Slager RE, Heires AJ, et al. Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. Am J Respir Cell Mol Biol, 2010, 42(6): 706-715.
25.	Schneberger D, DeVasure JM, Kirychuk SA, et al. Organic barn dust inhibits surfactant protein D production through protein kinase-C alpha dependent increase of GPR116. PLoS One, 2018, 13(12): e0208597.
26.	Natarajan K, Gottipati KR, Berhane K, et al. Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells. Respir Res, 2016, 17(1): 137.
27.	Zhan X, Zhang W, Sun T, et al. Bulleyaconitine a effectively relieves allergic lung inflammation in a murine asthmatic model. Med Sci Monit, 2019, 25: 1656-1662.
28.	Qiao Y, Tam J, Tan S, et al. CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling. J Allergy Clin Immunol, 2017, 139(1): 82-92.e5.
29.	Madouri F, Chenuet P, Beuraud C, et al. Protein kinase C θ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. J Allergy Clin Immunol, 2017, 139(5): 1650-1666.
30.	Wang J, Sun L, Nie Y, et al. Protein kinase C δ (PKCδ) attenuates bleomycin induced pulmonary fibrosis via inhibiting NF-κB signaling pathway. Front Physiol, 2020, 11: 367.
31.	Garg R, Benedetti LG, Abera MB, et al. Protein kinase C and cancer: what we know and what we do not. Oncogene, 2014, 33(45): 5225-5237.
32.	Garg R, Cooke M, Benavides F, et al. PKCε is required for KRAS-driven lung tumorigenesis. Cancer Res, 2020, 80(23): 5166-5173.
33.	Casado-Medrano V, Barrio-Real L, Wang A, et al. Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. Oncogene, 2019, 38(27): 5396-5412.
34.	Tzeng HT, Li TH, Tang YA, et al. Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget, 2017, 8(65): 108556-108570.
35.	Arencibia JM, Fröhner W, Krupa M, et al. An allosteric inhibitor scaffold targeting the PIF-pocket of atypical protein kinase C isoforms. ACS Chem Biol, 2017, 12(2): 564-573.
36.	Lee PC, Fang YF, Yamaguchi H, et al. Targeting PKCδ as a therapeutic strategy against heterogeneous mechanisms of EGFR inhibitor resistance in EGFR-mutant lung cancer. Cancer Cell, 2018, 34(6): 954-969.e4.
37.	Antal CE, Hudson AM, Kang E, et al. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell, 2015, 160(3): 489-502.
38.	Zhou Q, Dai J, Chen T, et al. Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion. Cell Signal, 2017, 38: 49-59.
39.	Cai X, Zhu H, Li Y. PKCζ, MMP-2 and MMP-9 expression in lung adenocarcinoma and association with a metastatic phenotype. Mol Med Rep, 2017, 16(6): 8301-8306.
40.	Halvorsen AR, Haugen MH, Öjlert ÅK, et al. Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients. Front Oncol, 2020, 10: 590755.

1. BommaReddy RR, Patel R, Smalley T, et al. Effects of atypical protein kinase C inhibitor (DNDA) on lung cancer proliferation and migration by PKC-ι/FAK ubiquitination through the Cbl-b pathway. Onco Targets Ther, 2020, 13: 1661-1676.
2. Isakov N. Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression. Semin Cancer Biol, 2018, 48: 36-52.
3. Li M, Zhao Y, He J, et al. Protein kinase C theta inhibition attenuates lipopolysaccharide-induced acute lung injury through notch signaling pathway via suppressing Th17 cell response in mice. Inflammation, 2019, 42(6): 1980-1989.
4. Tsai JY, Rédei D, Hohmann J, et al. 12-deoxyphorbol esters induce growth arrest and apoptosis in human lung cancer A549 cells via activation of PKC-δ/PKD/ERK signaling pathway. Int J Mol Sci, 2020, 21(20): 7579.
5. Leskow FC, Krasnapolski MA, Urtreger AJ. The pros and cons of targeting protein kinase C (PKC) in the management of cancer patients. Curr Pharm Biotechnol, 2011, 12(11): 1961-73.
6. Mondrinos MJ, Kennedy PA, Lyons M, et al. Protein kinase C and acute respiratory distress syndrome. Shock, 2013, 39(6): 467-479.
7. Newton AC. Protein kinase C: perfectly balanced. Crit Rev Biochem Mol Biol, 2018, 53(2): 208-230.
8. Reyland ME, Jones DN. Multifunctional roles of PKCδ: opportunities for targeted therapy in human disease. Pharmacol Ther, 2016, 165: 1-13.
9. Singh RM, Cummings E, Pantos C, et al. Protein kinase C and cardiac dysfunction: a review. Heart Fail Rev, 2017, 22(6): 843-859.
10. Basu A. The enigmatic protein kinase C-eta. Cancers (Basel), 2019, 11(2): 214.
11. Fan CF, Li Y, Jia J. Protein kinase Cs in lung cancer: a promising target for therapies. J Cancer Res Ther, 2013, 9 Suppl 2: S74-S79.
12. Kim H, Zhao J, Zhang Q, et al. δV1-1 reduces pulmonary ischemia reperfusion-induced lung injury by inhibiting necrosis and mitochondrial localization of PKCδ and p53. Am J Transplant, 2016, 16(1): 83-98.
13. Wang SB, Ye Q, Tu JW, et al. Transient cerebral ischemia/reperfusion-induced acute lung injury in rats associated with protein kinase C alpha expression. Int J Clin Exp Pathol, 2018, 11(7): 3487-3493.
14. Shologu N, Scully M, Laffey JG, et al. Human mesenchymal stem cell secretome from bone marrow or adipose-derived tissue sources for treatment of hypoxia-induced pulmonary epithelial injury. Int J Mol Sci, 2018, 19(10): 2996.
15. Magnani ND, Dada LA, Queisser MA, et al. HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na, K-ATPase to protect against hypoxia-induced lung injury. Proc Natl Acad Sci U S A, 2017, 114(47): E10178-E10186.
16. Kilpatrick LE, Standage SW, Li H, et al. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC). J Leukoc Biol, 2011, 89(1): 3-10.
17. Liverani E, Mondrinos MJ, Sun S, et al. Role of protein kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. PLoS One, 2018, 13(4): e0195379.
18. Zhou HS, Li M, Sui BD, et al. Lipopolysaccharide impairs permeability of pulmonary microvascular endothelial cells via Connexin40. Microvasc Res, 2018, 115: 58-67.
19. Xie L, Chiang ET, Wu X, et al. Regulation of thrombin-induced lung endothelial cell barrier disruption by protein kinase C Delta. PLoS One, 2016, 11(7): e0158865.
20. Lee S, Ro H, In HJ, et al. Fisetin inhibits TNF-α/NF-κB-induced IL-8 expression by targeting PKCδ in human airway epithelial cells. Cytokine, 2018, 108: 247-254.
21. Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res, 2012, 91(2): 142-149.
22. Dianat M, Radan M, Badavi M, et al. Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress. Respir Res, 2018, 19(1): 58.
23. Hsu HT, Tseng YT, Wong WJ, et al. Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. BMC Complement Altern Med, 2018, 18(1): 211.
24. Wyatt TA, Slager RE, Heires AJ, et al. Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. Am J Respir Cell Mol Biol, 2010, 42(6): 706-715.
25. Schneberger D, DeVasure JM, Kirychuk SA, et al. Organic barn dust inhibits surfactant protein D production through protein kinase-C alpha dependent increase of GPR116. PLoS One, 2018, 13(12): e0208597.
26. Natarajan K, Gottipati KR, Berhane K, et al. Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells. Respir Res, 2016, 17(1): 137.
27. Zhan X, Zhang W, Sun T, et al. Bulleyaconitine a effectively relieves allergic lung inflammation in a murine asthmatic model. Med Sci Monit, 2019, 25: 1656-1662.
28. Qiao Y, Tam J, Tan S, et al. CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling. J Allergy Clin Immunol, 2017, 139(1): 82-92.e5.
29. Madouri F, Chenuet P, Beuraud C, et al. Protein kinase C θ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. J Allergy Clin Immunol, 2017, 139(5): 1650-1666.
30. Wang J, Sun L, Nie Y, et al. Protein kinase C δ (PKCδ) attenuates bleomycin induced pulmonary fibrosis via inhibiting NF-κB signaling pathway. Front Physiol, 2020, 11: 367.
31. Garg R, Benedetti LG, Abera MB, et al. Protein kinase C and cancer: what we know and what we do not. Oncogene, 2014, 33(45): 5225-5237.
32. Garg R, Cooke M, Benavides F, et al. PKCε is required for KRAS-driven lung tumorigenesis. Cancer Res, 2020, 80(23): 5166-5173.
33. Casado-Medrano V, Barrio-Real L, Wang A, et al. Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. Oncogene, 2019, 38(27): 5396-5412.
34. Tzeng HT, Li TH, Tang YA, et al. Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget, 2017, 8(65): 108556-108570.
35. Arencibia JM, Fröhner W, Krupa M, et al. An allosteric inhibitor scaffold targeting the PIF-pocket of atypical protein kinase C isoforms. ACS Chem Biol, 2017, 12(2): 564-573.
36. Lee PC, Fang YF, Yamaguchi H, et al. Targeting PKCδ as a therapeutic strategy against heterogeneous mechanisms of EGFR inhibitor resistance in EGFR-mutant lung cancer. Cancer Cell, 2018, 34(6): 954-969.e4.
37. Antal CE, Hudson AM, Kang E, et al. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell, 2015, 160(3): 489-502.
38. Zhou Q, Dai J, Chen T, et al. Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion. Cell Signal, 2017, 38: 49-59.
39. Cai X, Zhu H, Li Y. PKCζ, MMP-2 and MMP-9 expression in lung adenocarcinoma and association with a metastatic phenotype. Mol Med Rep, 2017, 16(6): 8301-8306.
40. Halvorsen AR, Haugen MH, Öjlert ÅK, et al. Protein kinase C isozymes associated with relapse free survival in non-small cell lung cancer patients. Front Oncol, 2020, 10: 590755.

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蛋白激酶 C 在肺部疾病中的研究进展

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