- Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
Citation: LI Yi'na, LIU Chuntao. Diagnostic value of exhaled nitric oxide in adult asthma: a systemic review and meta-analysis. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(6): 416-423. doi: 10.7507/1671-6205.202105010 Copy
1. | Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy, 2004, 59(5): 469-478. |
2. | Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet, 2019, 394(10196): 407-418. |
3. | Brigham EP, West NE. Diagnosis of asthma: diagnostic testing. Int Forum Allergy Rhinol, 2015, 5 Suppl 1: S27-S30. |
4. | Reddel HK, Taylor DR, Bateman ED, et al. An official American thoracic society/European respiratory society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med, 2009, 180(1): 59-99. |
5. | Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS board of directors, July 1999. Am J Respir Crit Care Med, 2000, 161(1): 309-329. |
6. | Holz O, Buhl R, Hausen T, et al. Measuring airway inflammation in clinical practise - application and interpretation. Pneumologie, 2007, 61(3): 194-201. |
7. | National institute for health and care excellence: clinical guidelines[M]. Asthma: Diagnosis, monitoring and chronic asthma management. London; National Institute for Health and Care Excellence (UK) Copyright © NICE 2020.2020. |
8. | Karrasch S, Linde K, Rücker G, et al. Accuracy of FENO for diagnosing asthma: a systematic review. Thorax, 2017, 72(2): 109-116. |
9. | Lluncor M, Barranco P, Amaya ED, et al. Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine. J Asthma, 2019, 56(1): 53-60. |
10. | Liu J, Xu R, Zhan C, et al. Clinical utility of ultrahigh fractional exhaled nitric oxide in predicting bronchial hyperresponsiveness in patients with suspected asthma. Postgrad Med J, 2019, 95(1128): 541-546. |
11. | Chen FJ, Huang XY, Lin GP, et al. Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. J Asthma, 2018, 55(7): 750-755. |
12. | Porpodis K, Domvri K, Kontakiotis T, et al. Comparison of diagnostic validity of mannitol and methacholine challenges and relationship to clinical status and airway inflammation in steroid-naïve asthmatic patients. J Asthma, 2017, 54(5): 520-529. |
13. | Nickels AS, Lim KG. Evaluation of exhaled nitric oxide's ability to predict methacholine challenge in adults with nonobstructive spirometry. Ann Allergy Asthma Immunol, 2016, 117(4): 365-369. |
14. | Wang Y, Li L, Han R, et al. Diagnostic value and influencing factors of fractional exhaled nitric oxide in suspected asthma patients. Int J Clin Exp Pathol, 2015, 8(5): 5570-5576. |
15. | He L, Wei M, Luo J, et al. Re-evaluation of the diagnostic value of fractional exhaled nitric oxide & its impact in patients with asthma. Indian J Med Res, 2018, 148(4): 441-448. |
16. | Beretta C, Rifflart C, Evrard G, et al. Assessment of eosinophilic airway inflammation as a contribution to the diagnosis of occupational asthma. Allergy, 2018, 73(1): 206-213. |
17. | 方思, 陈树煜, 何熹, 等. 呼出气一氧化氮与脉冲振荡技术对亚急性咳嗽患者筛查咳嗽变异性哮喘的价值. 中华医学杂志, 2017, 97(30): 2338-2343. |
18. | Arora R, Thornblade CE, Dauby PA, et al. Exhaled nitric oxide levels in military recruits with new onset asthma. Allergy Asthma Proc, 2006, 27(6): 493-498. |
19. | ElHalawani SM, Ly NT, Mahon RT, et al. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest, 2003, 124(2): 639-643. |
20. | Florentin A, Acouetey DS, Remen T, et al. Exhaled nitric oxide and screening for occupational asthma in two at-risk sectors: bakery and hairdressing. Int J Tuberc Lung Dis, 2014, 18(6): 744-750. |
21. | Fortuna AM, Feixas T, González M, et al. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med, 2007, 101(11): 2416-2421. |
22. | Fukuhara A, Saito J, Sato S, et al. Validation study of asthma screening criteria based on subjective symptoms and fractional exhaled nitric oxide. Ann Allergy Asthma Immunol, 2011, 107(6): 480-486. |
23. | Heffler E, Guida G, Marsico P, et al. Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respir Med, 2006, 100(11): 1981-1987. |
24. | Katsoulis K, Ganavias L, Michailopoulos P, et al. Exhaled nitric oxide as screening tool in subjects with suspected asthma without reversibility. Int Arch Allergy Immunol, 2013, 162(1): 58-64. |
25. | Kostikas K, Papaioannou AI, Tanou K, et al. Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season. Chest, 2008, 133(4): 906-913. |
26. | Kowal K, Bodzenta-Lukaszyk A, Zukowski S. Exhaled nitric oxide in evaluation of young adults with chronic cough. J Asthma, 2009, 46(7): 692-698. |
27. | Malinovschi A, Backer V, Harving H, et al. The value of exhaled nitric oxide to identify asthma in smoking patients with asthma-like symptoms. Respir Med, 2012, 106(6): 794-801. |
28. | Pedrosa M, Cancelliere N, Barranco P, et al. Usefulness of exhaled nitric oxide for diagnosing asthma. J Asthma, 2010, 47(7): 817-821. |
29. | Sato S, Saito J, Sato Y, et al. Clinical usefulness of fractional exhaled nitric oxide for diagnosing prolonged cough. Respir Med, 2008, 102(10): 1452-1459. |
30. | Schleich FN, Asandei R, Manise M, et al. Is FENO50 useful diagnostic tool in suspected asthma?. Int J Clin Pract, 2012, 66(2): 158-165. |
31. | Schneider A, Schwarzbach J, Faderl B, et al. FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respir Med, 2013, 107(2): 209-216. |
32. | Smith AD, Cowan JO, Brassett KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med, 2005, 172(4): 453-459. |
33. | Tilemann L, Gindner L, Meyer F, et al. Differences in local and systemic inflammatory markers in patients with obstructive airways disease. Prim Care Respir J, 2011, 20(4): 407-414. |
34. | Voutilainen M, Malmberg LP, Vasankari T, et al. Exhaled nitric oxide indicates poorly athlete's asthma. Clin Respir J, 2013, 7(4): 347-353. |
35. | 张永明, 林江涛, 苏楠, 等. 呼出气一氧化氮检测在慢性咳嗽病因诊断中的价值. 中华医学杂志, 2011, 91(18): 1254-1258. |
36. | 敖敏, 郭述良, 税莉莉, 等. 呼出气一氧化氮在咳嗽变异性哮喘诊断中的价值. 重庆医科大学学报, 2019, 44(3): 322-326. |
37. | 陈凤佳, 严英硕, 周燕斌. 呼出气一氧化氮监测对支气管哮喘的诊断及治疗评估价值研究. 中国全科医学, 2014, 17(29): 3430-3434. |
38. | 陈洁, 李秀. 呼出气一氧化氮诊断支气管哮喘的临床价值. 临床肺科杂志, 2015, 20(9): 1706-1708. |
39. | 邓海燕, 彭丽慈, 王海潮. 呼出气一氧化氮检测在咳嗽变异性哮喘中的诊断意义. 中外医疗, 2017, 36(2): 1-4+9. |
40. | 杜丽艳, 庞桂芬, 于国云, 等. 呼出气一氧化氮与肺功能联合检测对于慢性咳嗽病因的诊断价值. 临床肺科杂志, 2018, 23(6): 1081-1084. |
41. | 黄金华, 许浦生, 黎教武, 等. 支气管激发试验、FENO 及诱导痰 ECP 在哮喘中的相关性及 FENO、诱导痰 ECP 诊断价值. 临床肺科杂志, 2016, 21(7): 1177-1181. |
42. | 江银玲, 杨万春, 沈欣. 呼出气一氧化氮与支气管哮喘患者外周血嗜酸性粒细胞相关性及联合检测价值. 分子诊断与治疗杂志, 2020, 12(8): 1115-1118+1132. |
43. | 姜箜鸣, 陈国忠. 呼出气一氧化氮检测在慢性咳嗽病因诊断中的临床意义. 武汉大学学报(医学版), 2018, 39(5): 793-796. |
44. | 刘莉, 张红梅, 王伟霞, 等. 呼出气一氧化氮在老年咳嗽变异性哮喘鉴别诊断中的应用. 检验医学与临床, 2018, 15(15): 2325-2328. |
45. | 刘敏, 许西琳, 刘冬, 等. 呼出气一氧化氮和外周血嗜酸性粒细胞百分率对支气管哮喘诊断和病情评估价值. 中华实用诊断与治疗杂志, 2017, 31(8): 769-771. |
46. | 买智涛, 姜明明, 万善志. FENO 联合血清 ECP、IgE 检测对支气管哮喘的临床诊断价值. 分子诊断与治疗杂志, 2020, 12(5): 625-628+633. |
47. | 任旭斌, 刘春涛, 黄玉芳, 等. 呼出气一氧化氮检测对支气管哮喘的诊断价值. 中国呼吸与危重监护杂志, 2009, 8(4): 322-326. |
48. | 谭晓媚, 于化鹏, 刘洁露, 等. 呼出气一氧化氮测定在支气管哮喘诊断中的应用. 山东医药, 2016, 56(23): 65-67. |
49. | 吐逊姑力·麦麦提, 克丽别娜·吐尔逊, 王惠妩, 等. FeNO、Dmin、FEV1%pred 相关性及其在支气管哮喘诊断中的价值. 新疆医科大学学报, 2018, 41(3): 295-299. |
50. | 徐迎莉, 马希涛, 杨志刚. 呼出气一氧化氮检测对支气管哮喘的诊断意义. 河南医学研究, 2014, 23(1): 23-25. |
51. | 姚慧娟, 张悦鸣, 李志奎. 呼出气一氧化氮检测诊断支气管哮喘. 国际呼吸杂志, 2013, 33(7): 508-512. |
52. | 张连莲, 刘洋, 赵尔为, 等. 呼出气一氧化氮在支气管哮喘诊断中的价值. 中国实验诊断学, 2015, 19(8): 1287-1289. |
53. | Guo Z, Wang Y, Xing G, et al. Diagnostic accuracy of fractional exhaled nitric oxide in asthma: a systematic review and meta-analysis of prospective studies. J Asthma, 2016, 53(4): 404-412. |
54. | Fahy JV. Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol, 2015, 15(1): 57-65. |
55. | Uryasjev MO, Ponomareva IV, Bhar M, et al. The cough variant asthma. Ter Arkh, 2020, 92(3): 98-101. |
56. | Onadeko BO, Khadadah ME, Ezeamnzie CI, et al. Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma. East Afr Med J, 2004, 81(1): 27-33. |
57. | Lemiere C, Chaboillez S, Welman M, et al. Outcome of occupational asthma after removal from exposure: a follow-up study. Can Respir J, 2010, 17(2): 61-66. |
58. | Pacheco A, Faro V, Cobeta I, et al. Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology, 2011, 16(6): 994-999. |
59. | Song WJ, Kim HJ, Shim JS, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: a systematic review and meta-analysis. J Allergy Clin Immunol, 2017, 140(3): 701-709. |
60. | Wang D, Wang Y, Liang H, et al. Race and ethnicity have significant influence on fractional exhaled nitric oxide. Ann Allergy Asthma Immunol, 2018, 120(3): 272-277. |
61. | Ahovuo-Saloranta A, Csonka P, Lehtimäki L. Basic characteristics and clinical value of FENO in smoking asthmatics-a systematic review. J Breath Res, 2019, 13(3): 034003. |
62. | Brussee JE, Smit HA, Kerkhof M, et al. Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy. Eur Respir J, 2005, 25(3): 455-461. |
63. | Boot JD, de Ridder L, de Kam ML, et al. Comparison of exhaled nitric oxide measurements between niox mino electrochemical and ecomedics chemiluminescence analyzer. Respir Med, 2008, 102(11): 1667-1671. |
64. | Cloutier MM, Dixon AE, Krishnan JA, et al. Managing asthma in adolescents and adults: 2020 asthma guideline update from the national asthma education and prevention program. JAMA, 2020, 324(22): 2301-2317. |
65. | 彭晓琴, 刘明心, 戴维, 等. 早期肺癌患者呼出气特征性挥发性有机化合物及其诊断价值研究. 中国胸心血管外科临床杂志, 2020, 27(12): 1429-1435. |
- 1. Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy, 2004, 59(5): 469-478.
- 2. Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet, 2019, 394(10196): 407-418.
- 3. Brigham EP, West NE. Diagnosis of asthma: diagnostic testing. Int Forum Allergy Rhinol, 2015, 5 Suppl 1: S27-S30.
- 4. Reddel HK, Taylor DR, Bateman ED, et al. An official American thoracic society/European respiratory society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med, 2009, 180(1): 59-99.
- 5. Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS board of directors, July 1999. Am J Respir Crit Care Med, 2000, 161(1): 309-329.
- 6. Holz O, Buhl R, Hausen T, et al. Measuring airway inflammation in clinical practise - application and interpretation. Pneumologie, 2007, 61(3): 194-201.
- 7. National institute for health and care excellence: clinical guidelines[M]. Asthma: Diagnosis, monitoring and chronic asthma management. London; National Institute for Health and Care Excellence (UK) Copyright © NICE 2020.2020.
- 8. Karrasch S, Linde K, Rücker G, et al. Accuracy of FENO for diagnosing asthma: a systematic review. Thorax, 2017, 72(2): 109-116.
- 9. Lluncor M, Barranco P, Amaya ED, et al. Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine. J Asthma, 2019, 56(1): 53-60.
- 10. Liu J, Xu R, Zhan C, et al. Clinical utility of ultrahigh fractional exhaled nitric oxide in predicting bronchial hyperresponsiveness in patients with suspected asthma. Postgrad Med J, 2019, 95(1128): 541-546.
- 11. Chen FJ, Huang XY, Lin GP, et al. Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. J Asthma, 2018, 55(7): 750-755.
- 12. Porpodis K, Domvri K, Kontakiotis T, et al. Comparison of diagnostic validity of mannitol and methacholine challenges and relationship to clinical status and airway inflammation in steroid-naïve asthmatic patients. J Asthma, 2017, 54(5): 520-529.
- 13. Nickels AS, Lim KG. Evaluation of exhaled nitric oxide's ability to predict methacholine challenge in adults with nonobstructive spirometry. Ann Allergy Asthma Immunol, 2016, 117(4): 365-369.
- 14. Wang Y, Li L, Han R, et al. Diagnostic value and influencing factors of fractional exhaled nitric oxide in suspected asthma patients. Int J Clin Exp Pathol, 2015, 8(5): 5570-5576.
- 15. He L, Wei M, Luo J, et al. Re-evaluation of the diagnostic value of fractional exhaled nitric oxide & its impact in patients with asthma. Indian J Med Res, 2018, 148(4): 441-448.
- 16. Beretta C, Rifflart C, Evrard G, et al. Assessment of eosinophilic airway inflammation as a contribution to the diagnosis of occupational asthma. Allergy, 2018, 73(1): 206-213.
- 17. 方思, 陈树煜, 何熹, 等. 呼出气一氧化氮与脉冲振荡技术对亚急性咳嗽患者筛查咳嗽变异性哮喘的价值. 中华医学杂志, 2017, 97(30): 2338-2343.
- 18. Arora R, Thornblade CE, Dauby PA, et al. Exhaled nitric oxide levels in military recruits with new onset asthma. Allergy Asthma Proc, 2006, 27(6): 493-498.
- 19. ElHalawani SM, Ly NT, Mahon RT, et al. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest, 2003, 124(2): 639-643.
- 20. Florentin A, Acouetey DS, Remen T, et al. Exhaled nitric oxide and screening for occupational asthma in two at-risk sectors: bakery and hairdressing. Int J Tuberc Lung Dis, 2014, 18(6): 744-750.
- 21. Fortuna AM, Feixas T, González M, et al. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med, 2007, 101(11): 2416-2421.
- 22. Fukuhara A, Saito J, Sato S, et al. Validation study of asthma screening criteria based on subjective symptoms and fractional exhaled nitric oxide. Ann Allergy Asthma Immunol, 2011, 107(6): 480-486.
- 23. Heffler E, Guida G, Marsico P, et al. Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respir Med, 2006, 100(11): 1981-1987.
- 24. Katsoulis K, Ganavias L, Michailopoulos P, et al. Exhaled nitric oxide as screening tool in subjects with suspected asthma without reversibility. Int Arch Allergy Immunol, 2013, 162(1): 58-64.
- 25. Kostikas K, Papaioannou AI, Tanou K, et al. Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season. Chest, 2008, 133(4): 906-913.
- 26. Kowal K, Bodzenta-Lukaszyk A, Zukowski S. Exhaled nitric oxide in evaluation of young adults with chronic cough. J Asthma, 2009, 46(7): 692-698.
- 27. Malinovschi A, Backer V, Harving H, et al. The value of exhaled nitric oxide to identify asthma in smoking patients with asthma-like symptoms. Respir Med, 2012, 106(6): 794-801.
- 28. Pedrosa M, Cancelliere N, Barranco P, et al. Usefulness of exhaled nitric oxide for diagnosing asthma. J Asthma, 2010, 47(7): 817-821.
- 29. Sato S, Saito J, Sato Y, et al. Clinical usefulness of fractional exhaled nitric oxide for diagnosing prolonged cough. Respir Med, 2008, 102(10): 1452-1459.
- 30. Schleich FN, Asandei R, Manise M, et al. Is FENO50 useful diagnostic tool in suspected asthma?. Int J Clin Pract, 2012, 66(2): 158-165.
- 31. Schneider A, Schwarzbach J, Faderl B, et al. FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respir Med, 2013, 107(2): 209-216.
- 32. Smith AD, Cowan JO, Brassett KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med, 2005, 172(4): 453-459.
- 33. Tilemann L, Gindner L, Meyer F, et al. Differences in local and systemic inflammatory markers in patients with obstructive airways disease. Prim Care Respir J, 2011, 20(4): 407-414.
- 34. Voutilainen M, Malmberg LP, Vasankari T, et al. Exhaled nitric oxide indicates poorly athlete's asthma. Clin Respir J, 2013, 7(4): 347-353.
- 35. 张永明, 林江涛, 苏楠, 等. 呼出气一氧化氮检测在慢性咳嗽病因诊断中的价值. 中华医学杂志, 2011, 91(18): 1254-1258.
- 36. 敖敏, 郭述良, 税莉莉, 等. 呼出气一氧化氮在咳嗽变异性哮喘诊断中的价值. 重庆医科大学学报, 2019, 44(3): 322-326.
- 37. 陈凤佳, 严英硕, 周燕斌. 呼出气一氧化氮监测对支气管哮喘的诊断及治疗评估价值研究. 中国全科医学, 2014, 17(29): 3430-3434.
- 38. 陈洁, 李秀. 呼出气一氧化氮诊断支气管哮喘的临床价值. 临床肺科杂志, 2015, 20(9): 1706-1708.
- 39. 邓海燕, 彭丽慈, 王海潮. 呼出气一氧化氮检测在咳嗽变异性哮喘中的诊断意义. 中外医疗, 2017, 36(2): 1-4+9.
- 40. 杜丽艳, 庞桂芬, 于国云, 等. 呼出气一氧化氮与肺功能联合检测对于慢性咳嗽病因的诊断价值. 临床肺科杂志, 2018, 23(6): 1081-1084.
- 41. 黄金华, 许浦生, 黎教武, 等. 支气管激发试验、FENO 及诱导痰 ECP 在哮喘中的相关性及 FENO、诱导痰 ECP 诊断价值. 临床肺科杂志, 2016, 21(7): 1177-1181.
- 42. 江银玲, 杨万春, 沈欣. 呼出气一氧化氮与支气管哮喘患者外周血嗜酸性粒细胞相关性及联合检测价值. 分子诊断与治疗杂志, 2020, 12(8): 1115-1118+1132.
- 43. 姜箜鸣, 陈国忠. 呼出气一氧化氮检测在慢性咳嗽病因诊断中的临床意义. 武汉大学学报(医学版), 2018, 39(5): 793-796.
- 44. 刘莉, 张红梅, 王伟霞, 等. 呼出气一氧化氮在老年咳嗽变异性哮喘鉴别诊断中的应用. 检验医学与临床, 2018, 15(15): 2325-2328.
- 45. 刘敏, 许西琳, 刘冬, 等. 呼出气一氧化氮和外周血嗜酸性粒细胞百分率对支气管哮喘诊断和病情评估价值. 中华实用诊断与治疗杂志, 2017, 31(8): 769-771.
- 46. 买智涛, 姜明明, 万善志. FENO 联合血清 ECP、IgE 检测对支气管哮喘的临床诊断价值. 分子诊断与治疗杂志, 2020, 12(5): 625-628+633.
- 47. 任旭斌, 刘春涛, 黄玉芳, 等. 呼出气一氧化氮检测对支气管哮喘的诊断价值. 中国呼吸与危重监护杂志, 2009, 8(4): 322-326.
- 48. 谭晓媚, 于化鹏, 刘洁露, 等. 呼出气一氧化氮测定在支气管哮喘诊断中的应用. 山东医药, 2016, 56(23): 65-67.
- 49. 吐逊姑力·麦麦提, 克丽别娜·吐尔逊, 王惠妩, 等. FeNO、Dmin、FEV1%pred 相关性及其在支气管哮喘诊断中的价值. 新疆医科大学学报, 2018, 41(3): 295-299.
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