咳嗽变异性哮喘的争议问题_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

张利 ,  邱忠民

同济大学附属同济医院呼吸与危重症医学科（上海 200065）;

Corresponding author：

邱忠民, Email: qiuzhongmin@tongji.edu.cn

Keywords：

DOI：

10.7507/1671-6205.202108047

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Citation： 张利, 邱忠民. 咳嗽变异性哮喘的争议问题. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(9): 609-612. doi: 10.7507/1671-6205.202108047 Copy

1.	中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015). 中华结核与呼吸杂志, 2016, 39(5): 323-354.
2.	Lai K, Chen R, Lin J, et al. A prospective, multicenter survey on causes of chronic cough in China. Chest, 2013, 143(3): 613-620.
3.	Ding H, Xu X, Wen S, et al. Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China. J Thorac Dis, 2019, 11(8): 3482-3489.
4.	Côté A, Russell RJ, Boulet LP, et al. Managing chronic cough due to asthma and NAEB in adults and adolescents: CHEST Guideline and Expert Panel Report. Chest, 2020, 158(1): 68-96.
5.	Niimi A, Amitani R, Suzuki K, et al. Eosinophilic inflammation in cough variant asthma. Eur Respir J, 1998, 11(5): 1064-1069.
6.	Niimi A, Chung KF. Airway inflammation and remodeling changes in patients with chronic cough: do they tell us about the cause of cough?. Pulm Pharmacol Ther, 2004, 17(6): 441-446.
7.	Corrao WM, Braman SS, Irwin RS. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med, 1979, 300(12): 633-637.
8.	O'Connell EJ, Rojas AR, Sachs MI. Cough-type asthma: a review. Ann Allergy, 1991, 66(4): 278-282, 285.
9.	Glauser FL. Variant asthma. Ann Allergy, 1972, 30(8): 457-459.
10.	McFadden ER Jr. Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. N Engl J Med, 1975, 292(11): 555-559.
11.	Mukae H, Kaneko T, Obase Y, et al. The Japanese Respiratory Society Guidelines for the Management of Cough and Sputum (Digest Edition). Respir Investig, 2021, 59(3): 270-290.
12.	林江涛, 张晓岩. 勿将感染后咳嗽诊断为咳嗽变异性哮喘. 中华结核与呼吸杂志, 2019, 42(3): 167-169.
13.	Enseki M, Nukaga M, Tadaki H, et al. A breath sound analysis in children with cough variant asthma. Allergol Int, 2019, 68(1): 33-38.
14.	Koh YY, Chae SA, Min KU. Cough variant asthma is associated with a higher wheezing threshold than classic asthma. Clin Exp Allergy, 1993, 23(8): 696-701.
15.	中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2020 年版). 中华结核和呼吸杂志, 2020, 43(12): 1023-1048.
16.	Fujimura M, Ogawa H, Nishizawa Y, et al. Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?. Thorax, 2003, 58(1): 14-18.
17.	赵婷, 邱志宏, 王岚, 等. 简化咳嗽积分临床应用价值的研究. 中华全科医师杂志, 2012, 11(4): 273-276.
18.	Smith J, Alman D, Budri H, et al. The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough Results From a Phase 2 Pilot Study (VOLCANO-1). Chest, 2020, 157(1): 111-118.
19.	Canning BJ, Chang AB, Bolser DC, et al. Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report. Chest, 2014, 146(6): 1633-1648.
20.	Irwin RS, French CT, Smyrnios NA, et al. Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch Intern Med, 1997, 157(17): 1981-1987.
21.	中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2009). 中华结核和呼吸杂志, 2009, 32(6): 407-413.
22.	李馨, 魏为利, 余莉, 等. 支气管扩张剂治疗有效和无效咳嗽变异性哮喘的比较研究. 同济大学学报(医学版), 2011, 32(1): 95-100.
23.	Yi F, Han LN, Liu BJ, et al. Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study. Pulm Pharmacol Ther, 2020, 61: 101903.
24.	Campbell M, Eliraz A, Johansson G, et al. Formoterol for maintenance and as needed treatment of chronic obstructive pulmonary disease. Respir Med, 2005, 99(12): 1511-1520.
25.	Wei W, Yu L, Wang Y, et al. Efficacy and safety of modified sequential three-step empirical therapy for chronic cough. Respirology, 2010, 15(5): 830-836.
26.	Chummun D, Lü H, Qiu Z. Empiric treatment of chronic cough in adults. Allergy Asthma Proc, 2011, 32(3): 193-197.
27.	Matsumoto H, Niimi A, Takemura M, et al. Prognosis of cough variant asthma: a retrospective analysis. J Asthma, 2006, 43(2): 131-135.
28.	Nakajima T, Nishimura Y, Nishiuma T, et al. Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. Respiration, 2005, 72(6): 606-611.
29.	O'Byrne PM, FitzGerald JM, Bateman ED, et al. Inhaled combined budesonide-formoterol as needed in mild asthma. N Engl J Med, 2018, 378(20): 1865-1876.
30.	O'Byrne PM, FitzGerald JM, Bateman ED, et al. Effect of a single day of increased as-needed budesonide-formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study. Lancet Respir Med, 2021, 9(2): 149-158.
31.	Kim CK, Kim JT, Kang H, et al. Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. Clin Exp Allergy, 2003, 33(10): 1409-1414.
32.	Todokoro M, Mochizuki H, Tokuyama K, et al. Childhood cough variant asthma and its relationship to classic asthma. Ann Allergy Asthma Immunol, 2003, 90(6): 652-659.

1. 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015). 中华结核与呼吸杂志, 2016, 39(5): 323-354.
2. Lai K, Chen R, Lin J, et al. A prospective, multicenter survey on causes of chronic cough in China. Chest, 2013, 143(3): 613-620.
3. Ding H, Xu X, Wen S, et al. Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China. J Thorac Dis, 2019, 11(8): 3482-3489.
4. Côté A, Russell RJ, Boulet LP, et al. Managing chronic cough due to asthma and NAEB in adults and adolescents: CHEST Guideline and Expert Panel Report. Chest, 2020, 158(1): 68-96.
5. Niimi A, Amitani R, Suzuki K, et al. Eosinophilic inflammation in cough variant asthma. Eur Respir J, 1998, 11(5): 1064-1069.
6. Niimi A, Chung KF. Airway inflammation and remodeling changes in patients with chronic cough: do they tell us about the cause of cough?. Pulm Pharmacol Ther, 2004, 17(6): 441-446.
7. Corrao WM, Braman SS, Irwin RS. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med, 1979, 300(12): 633-637.
8. O'Connell EJ, Rojas AR, Sachs MI. Cough-type asthma: a review. Ann Allergy, 1991, 66(4): 278-282, 285.
9. Glauser FL. Variant asthma. Ann Allergy, 1972, 30(8): 457-459.
10. McFadden ER Jr. Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. N Engl J Med, 1975, 292(11): 555-559.
11. Mukae H, Kaneko T, Obase Y, et al. The Japanese Respiratory Society Guidelines for the Management of Cough and Sputum (Digest Edition). Respir Investig, 2021, 59(3): 270-290.
12. 林江涛, 张晓岩. 勿将感染后咳嗽诊断为咳嗽变异性哮喘. 中华结核与呼吸杂志, 2019, 42(3): 167-169.
13. Enseki M, Nukaga M, Tadaki H, et al. A breath sound analysis in children with cough variant asthma. Allergol Int, 2019, 68(1): 33-38.
14. Koh YY, Chae SA, Min KU. Cough variant asthma is associated with a higher wheezing threshold than classic asthma. Clin Exp Allergy, 1993, 23(8): 696-701.
15. 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2020 年版). 中华结核和呼吸杂志, 2020, 43(12): 1023-1048.
16. Fujimura M, Ogawa H, Nishizawa Y, et al. Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?. Thorax, 2003, 58(1): 14-18.
17. 赵婷, 邱志宏, 王岚, 等. 简化咳嗽积分临床应用价值的研究. 中华全科医师杂志, 2012, 11(4): 273-276.
18. Smith J, Alman D, Budri H, et al. The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough Results From a Phase 2 Pilot Study (VOLCANO-1). Chest, 2020, 157(1): 111-118.
19. Canning BJ, Chang AB, Bolser DC, et al. Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report. Chest, 2014, 146(6): 1633-1648.
20. Irwin RS, French CT, Smyrnios NA, et al. Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch Intern Med, 1997, 157(17): 1981-1987.
21. 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2009). 中华结核和呼吸杂志, 2009, 32(6): 407-413.
22. 李馨, 魏为利, 余莉, 等. 支气管扩张剂治疗有效和无效咳嗽变异性哮喘的比较研究. 同济大学学报(医学版), 2011, 32(1): 95-100.
23. Yi F, Han LN, Liu BJ, et al. Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study. Pulm Pharmacol Ther, 2020, 61: 101903.
24. Campbell M, Eliraz A, Johansson G, et al. Formoterol for maintenance and as needed treatment of chronic obstructive pulmonary disease. Respir Med, 2005, 99(12): 1511-1520.
25. Wei W, Yu L, Wang Y, et al. Efficacy and safety of modified sequential three-step empirical therapy for chronic cough. Respirology, 2010, 15(5): 830-836.
26. Chummun D, Lü H, Qiu Z. Empiric treatment of chronic cough in adults. Allergy Asthma Proc, 2011, 32(3): 193-197.
27. Matsumoto H, Niimi A, Takemura M, et al. Prognosis of cough variant asthma: a retrospective analysis. J Asthma, 2006, 43(2): 131-135.
28. Nakajima T, Nishimura Y, Nishiuma T, et al. Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. Respiration, 2005, 72(6): 606-611.
29. O'Byrne PM, FitzGerald JM, Bateman ED, et al. Inhaled combined budesonide-formoterol as needed in mild asthma. N Engl J Med, 2018, 378(20): 1865-1876.
30. O'Byrne PM, FitzGerald JM, Bateman ED, et al. Effect of a single day of increased as-needed budesonide-formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study. Lancet Respir Med, 2021, 9(2): 149-158.
31. Kim CK, Kim JT, Kang H, et al. Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. Clin Exp Allergy, 2003, 33(10): 1409-1414.
32. Todokoro M, Mochizuki H, Tokuyama K, et al. Childhood cough variant asthma and its relationship to classic asthma. Ann Allergy Asthma Immunol, 2003, 90(6): 652-659.

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