Correlation of treatment compliance analysis with lung function and control level in asthma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Wenya ¹ ,  LIN Jiangtao ¹ , LIU Chuntao ² , TANG Huaping ³ , HUO Jianmin ⁴ , GU Yuhai ⁵ , LIU Rongyu ⁶ , CHEN Ping ⁷ , YUAN Yadong ⁸ , YANG Xiaohong ⁹ , XU Jianying ¹⁰ , SUN Dejun ¹¹ , LI Najia ¹² , JIANG Shujuan ¹³ , CHEN Yiqiang ¹⁴ , WANG Changzheng ¹⁵ , YANG Lan ¹⁶ , LIU Xiaoju ¹⁷ , YANG Dong ¹⁸ , ZHANG Wei ¹⁹ , CHEN Zhuochang ²⁰ , LIN Qichang ²¹ , ZHOU Jianying ²² , ZHOU Xin ²³ , HU Chengping ²⁴ , JIANG Ping ²⁵ , ZHOU Wei ²⁶ , ZHANG Jie ²⁷ , CAI Shaoxi ²⁸ , QIU Chen ²⁹ , HUANG Mao ³⁰ , HUANG Yijiang ³¹ , LIU Huiguo ³² , 中国哮喘研究协作组

1. Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center of Respiratory Disease, Beijing 100029, P. R. China;
2. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P. R. China;
4. Department of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P. R. China;
5. Department of Respiratory Medicine, Qinghai Provincial People’s Hospital, Xi’ning, Qinghai 810007, P. R. China;
6. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P. R. China;
7. Department of Respiratory Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P. R. China;
8. Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050004, P. R. China;
9. Department of Pulmonary and Critical Care Medicine, Xinjiang Uiger Municipal People’s Hospital, Urumqi, Xinjiang 830001, P. R. China;
10. Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, Shanxi 030032, P. R. China;
11. Department of Pulmonary and Critical Care Medicine, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia 010017, P. R. China;
12. Department of Respiratory Medicine, Daqing Oilfield General Hospital, Daqing, Helongjiang 163311, P. R. China;
13. Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Ji’nan, Shandong 251411, P. R. China;
14. Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;
15. Department of Respiratory Medicine, Xinqiao Hospital of Army Medical University, Chongqing 410037, P. R. China;
16. Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, P. R. China;
17. Department of Geriatric Respiration, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P. R. China;
18. Department of Respiration, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
19. Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P. R. China;
20. Department of Respiratory Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan 450003, P. R. China;
21. Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujiang 350005, P. R. China;
22. Department of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, The First Hospital of Zhejiang Province, Hangzhou, Zhejiang 310003, P. R. China;
23. Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, P. R. China;
24. Department of Pulmonary and Critical Care Medicine, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P. R. China;
25. Department of Respiratory Medicine, Tianjin First Central Hospital, Tianjin 300192, P. R. China;
26. Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750003, P. R. China;
27. Department of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041, P. R. China;
28. Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern University of Science and Technology, Guangzhou, Guangdong 510515, P. R. China;
29. Department of Pulmonary and Critical Care Medicine, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, Guangdong 518020, P. R. China;
30. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 211103, P. R. China;
31. Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Haikou, Hainan 570031, P. R. China;
32. Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China;

Corresponding author：

LIN Jiangtao, Email: jiangtao_l@263.net

Keywords：

Bronchial asthma; treatment adherence; asthma control; quality of life; lung function

DOI：

10.7507/1671-6205.202201015

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the relationship between medication compliance of patients with uncontrolled asthma and lung function,airway inflammation level, asthma control level and quality of life so as to obtain important references for improving patient compliance and asthma control level in the future. Methods Questionnaires were performed in asthma patients who did not achieve asthma control and had poor compliance in 32 third-class hospitals in 28 provinces of China mainland. All patients were tested for lung function and airway inflammation levels. So the relevant data of asthma compliance was investigated and analyzed. Results A total of 923 patients were investigated and the questionnaire recovery rate was 100%. Two hundred and forty-three (26.33%) answered cognitive related questions about asthma completely correctly. Treatment compliance in asthma patients was positively correlated with lung function and significantly negatively correlated with exhaled nitric oxide. Better treatment compliance in asthma has higher level of asthma control and quality of life. Poor compliance in asthma patients will lead to decreased lung function and elevated levels of airway inflammation, resulting in decreased asthma control and quality of life. Conclusion Asthma treatment compliance is related to lung function, airway inflammation, asthma control level and quality of life.

Citation： WANG Wenya, LIN Jiangtao, LIU Chuntao, TANG Huaping, HUO Jianmin, GU Yuhai, LIU Rongyu, CHEN Ping, YUAN Yadong, YANG Xiaohong, XU Jianying, SUN Dejun, LI Najia, JIANG Shujuan, CHEN Yiqiang, WANG Changzheng, YANG Lan, LIU Xiaoju, YANG Dong, ZHANG Wei, CHEN Zhuochang, LIN Qichang, ZHOU Jianying, ZHOU Xin, HU Chengping, JIANG Ping, ZHOU Wei, ZHANG Jie, CAI Shaoxi, QIU Chen, HUANG Mao, HUANG Yijiang, LIU Huiguo. Correlation of treatment compliance analysis with lung function and control level in asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(11): 761-767. doi: 10.7507/1671-6205.202201015 Copy

1.	Lin JT, Wang WY, Chen P, et al. Prevalence and risk factors of asthma in mainland China: The CARE study. Respir Med, 2018, 137: 48-54.
2.	Song WJ, Kang MG, Chang YS, et al. Epidemiology of adult asthma in Asia: toward a better understanding. Asia Pac Allergy, 2014, 4(2): 75-85.
3.	Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention: NHLBI/WHO Workshop report. Bethesda: National Heart, Lung and Blood Institue. National Institute of Health, 2006.
4.	Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control Study. Am J Respir Crit Care Med, 2004, 170(8): 836-844.
5.	林江涛, 王文巧, 周新, 等. 我国30个省市城区门诊支气管哮喘患者控制水平的调查结果. 中华结核和呼吸杂志, 2017, 40(7): 494-498.
6.	Dalcin PTR, Menegotto DM, Zanonato A, et al. Factors associated with uncontrolled asthma in Porto Alegre, Brazil. Braz J Med Biol Res, 2009, 42(11): 1097-1103.
7.	中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2016年版). 中华结核和呼吸杂志, 2016, 39(9): 675-697.
8.	中华医学会呼吸病学分会肺功能专业组. 肺功能检查指南 (第二部分)—肺量计检查. 中华结核和呼吸杂志, 2014, 37(7): 481-486.
9.	Dweik RA, Boggs PB, Erzurum SC, et al. An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. Am J Respir Crit Care Med, 2011, 184(5): 602-615.
10.	Neugaard BI, Priest JL, Burch SP, et al. Quality of care for veterans with  chronic diseases: performance on quality indicators, medication use and adherence, and health care utilization. Popul Health Manag, 2011, 14(2): 99-106.
11.	裘若帆, 林江涛. 支气管哮喘患者依从性的影响因素及改善策略. 中华医学杂志, 2018, 98(46): 3795-3798.
12.	Jochmann A, Artusio L, Jamalzadeh A, et al. Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children. Eur Respir J, 2017, 50(6): 1700910.
13.	Bonini M, Usmani OS. Novel methods for device and adherence monitoring in asthma. Curr Opin Pulm Med, 2018, 24(1): 63-69.
14.	Heaney LG, Busby J, Bradding P, et al. Remotely monitored therapy and nitric oxide suppression identifies nonadherence in severe asthma. Am J Respir Crit Care Med, 2019, 199(4): 454-464.
15.	Donaire JG, Pérez DD, Hernández C, et al. Study to evaluate satisfaction with the inhalation device used by patients with asthma or chronic obstructive pulmonary disease and the association with adherence and disease control. J Aerosol Med Pulm Drug Deliv, 2020, 33(3): 153-160.
16.	Devillier P, Ghasarossian C, Terrioux P, et al. Persistent asthma: chronic therapy quantitative compliance in daily practice. Rev Mal Respir, 2018, 35(3): 269-278.
17.	Sureehein SKA, Haddad RM, Alsamen GA. Poor Adherence to inhaler therapy in patients with bronchial asthma: rates and causes. Middle East J Intern Med, 2015, 8(3): 3-6.
18.	Sinha R, Lahiry S, Ghosh S. Suboptimal compliance to aerosol therapy in pediatric asthma: a prospective cohort study from Eastern India. Lung India, 2019, 36(6): 512-518.
19.	Wahyuni AS, Hamid RZ, Syafiuddin T, et al. The correlation between adherence and asthma patients quality of life in Medan, Indonesia. Open Access Maced J Med Sci, 2018, 6(11): 2198-2205.

1. Lin JT, Wang WY, Chen P, et al. Prevalence and risk factors of asthma in mainland China: The CARE study. Respir Med, 2018, 137: 48-54.
2. Song WJ, Kang MG, Chang YS, et al. Epidemiology of adult asthma in Asia: toward a better understanding. Asia Pac Allergy, 2014, 4(2): 75-85.
3. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention: NHLBI/WHO Workshop report. Bethesda: National Heart, Lung and Blood Institue. National Institute of Health, 2006.
4. Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control Study. Am J Respir Crit Care Med, 2004, 170(8): 836-844.
5. 林江涛, 王文巧, 周新, 等. 我国30个省市城区门诊支气管哮喘患者控制水平的调查结果. 中华结核和呼吸杂志, 2017, 40(7): 494-498.
6. Dalcin PTR, Menegotto DM, Zanonato A, et al. Factors associated with uncontrolled asthma in Porto Alegre, Brazil. Braz J Med Biol Res, 2009, 42(11): 1097-1103.
7. 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2016年版). 中华结核和呼吸杂志, 2016, 39(9): 675-697.
8. 中华医学会呼吸病学分会肺功能专业组. 肺功能检查指南 (第二部分)—肺量计检查. 中华结核和呼吸杂志, 2014, 37(7): 481-486.
9. Dweik RA, Boggs PB, Erzurum SC, et al. An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. Am J Respir Crit Care Med, 2011, 184(5): 602-615.
10. Neugaard BI, Priest JL, Burch SP, et al. Quality of care for veterans with  chronic diseases: performance on quality indicators, medication use and adherence, and health care utilization. Popul Health Manag, 2011, 14(2): 99-106.
11. 裘若帆, 林江涛. 支气管哮喘患者依从性的影响因素及改善策略. 中华医学杂志, 2018, 98(46): 3795-3798.
12. Jochmann A, Artusio L, Jamalzadeh A, et al. Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children. Eur Respir J, 2017, 50(6): 1700910.
13. Bonini M, Usmani OS. Novel methods for device and adherence monitoring in asthma. Curr Opin Pulm Med, 2018, 24(1): 63-69.
14. Heaney LG, Busby J, Bradding P, et al. Remotely monitored therapy and nitric oxide suppression identifies nonadherence in severe asthma. Am J Respir Crit Care Med, 2019, 199(4): 454-464.
15. Donaire JG, Pérez DD, Hernández C, et al. Study to evaluate satisfaction with the inhalation device used by patients with asthma or chronic obstructive pulmonary disease and the association with adherence and disease control. J Aerosol Med Pulm Drug Deliv, 2020, 33(3): 153-160.
16. Devillier P, Ghasarossian C, Terrioux P, et al. Persistent asthma: chronic therapy quantitative compliance in daily practice. Rev Mal Respir, 2018, 35(3): 269-278.
17. Sureehein SKA, Haddad RM, Alsamen GA. Poor Adherence to inhaler therapy in patients with bronchial asthma: rates and causes. Middle East J Intern Med, 2015, 8(3): 3-6.
18. Sinha R, Lahiry S, Ghosh S. Suboptimal compliance to aerosol therapy in pediatric asthma: a prospective cohort study from Eastern India. Lung India, 2019, 36(6): 512-518.
19. Wahyuni AS, Hamid RZ, Syafiuddin T, et al. The correlation between adherence and asthma patients quality of life in Medan, Indonesia. Open Access Maced J Med Sci, 2018, 6(11): 2198-2205.

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