慢性阻塞性肺疾病与干细胞的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

宋庆 ¹ , 林铃 ¹ , 李雪杉 ¹ , 成玮 ¹ , 刘聪 ¹ , 周爱媛 ² ,  陈平 ¹

1. ;
2. ;

Corresponding author：

陈平, Email: pingchen0731@csu.edu.cn

Keywords：

DOI：

10.7507/1671-6205.202202044

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Citation： 宋庆, 林铃, 李雪杉, 成玮, 刘聪, 周爱媛, 陈平. 慢性阻塞性肺疾病与干细胞的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(10): 745-750. doi: 10.7507/1671-6205.202202044 Copy

1.	Obling N, Backer V, Hurst JR, et al. Nasal and systemic inflammation in chronic obstructive pulmonary disease (COPD). Respir Med, 2022, 195: 106774.
2.	GBD 2017 Oesophageal Cancer Collaborators. The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol, 2020, 5(6): 582-597.
3.	GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med, 2020, 8(6): 585-596.
4.	Global Initiative for Chronic Obstructive Lung Disease Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease Global Initiative for Chronic Obstructive Lung Disease, 2022[EB/OL]. [2021-10-17]. Available from: http://www.goldcopd.org/.
5.	Saba JA, Liakath Ali K, Green R, et al. Translational control of stem cell function. Nat Rev Mol Cell Biol, 2021, 22(10): 671-690.
6.	Chen YT, Miao K, Zhou LF, et al. Stem cell therapy for chronic obstructive pulmonary disease. Chin Med J (Engl), 2021, 134(13): 1535-1545.
7.	Coppolino I, Ruggeri P, Nucera F, et al. Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema. COPD, 2018, 15(5): 536-556.
8.	杨悦, 曹君, 陈平. 小鼠内皮祖细胞的培养和移植. 中国组织工程研究与临床康复, 2009, 13(41): 8109-8113.
9.	Song Q, Chen P, Liu XM. The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD. Respir Res, 2021, 22(1): 39.
10.	Liu XR, Liu YL, Huang XY, et al. Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease. Mol Med Rep, 2017, 16(4): 5294-5302.
11.	He ZH, Peng HH, Gao M, et al. p300/Sp1-mediated high expression of p16 promotes endothelial progenitor cell senescence leading to the occurrence of chronic obstructive pulmonary disease. Mediators Inflamm, 2021, 2021: 5599364.
12.	He ZH, Chen P, Chen Y, et al. Dual effects of cigarette smoke extract on proliferation of endothelial progenitor cells and the protective effect of 5-aza-2'-deoxycytidine on EPCs against the damage caused by CSE. BioMed Res Int, 2014, 2014: 640752.
13.	He Z, Chen Y, Hou C, et al. Cigarette smoke extract changes expression of endothelial nitric oxide synthase (eNOS) and p16 (INK4a) and is related to endothelial progenitor cell dysfunction. Med Sci Monit, 2017, 23: 3224-3231.
14.	He ZH, Chen Y, Chen P, et al. Cigarette smoke extract affects methylation status and attenuates Sca-1 expression of mouse endothelial progenitor cell in vitro. Tob Induc Dis, 2021, 19: 8.
15.	Pei CZ, Wang XY, Lin YJ, et al. Inhibition of galectin-3 alleviates cigarette smoke extract-induced autophagy and dysfunction in endothelial progenitor cells. Oxid Med Cell Longev, 2019, 2019: 7252943.
16.	He ZH, Chen Y, Chen P, et al. 5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16^Ink4a expression in lung tissue. Int J Chron Obstruct Pulmon Dis, 2017, 12: 3149-3158.
17.	He ZH, Chen Y, Chen P, et al. Decitabine enhances stem cell antigen-1 expression in cigarette smoke extract-induced emphysema in animal model. Exp Biol Med (Maywood), 2016, 241(2): 131-139.
18.	Shi ZH, Chen Y, Cao J, et al. Intratracheal transplantation of endothelial progenitor cells attenuates smoking-induced COPD in mice. Int J Chron Obstruct Pulmon Dis, 2017, 12: 947-960.
19.	Ma YM, He X, Liu XM, et al. Endothelial microparticles derived from primary pulmonary microvascular endothelial cells mediate lung inflammation in chronic obstructive pulmonary disease by transferring microRNA-126. J Inflamm Res, 2022, 15: 1399-1411.
20.	Hisata S, Racanelli AC, Kermani P, et al. Reversal of emphysema by restoration of pulmonary endothelial cells. J Exp Med, 2021, 218(8): e20200938.
21.	Yoshida M, Minagawa S, Araya J, et al. Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis. Nat Commun, 2019, 10(1): 3145.
22.	Choi J, Jang YJ, Dabrowska C, et al. Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration. Nat Cell Biol, 2021, 23(9): 953-966.
23.	Alysandratos KD, Herriges MJ, Kotton DN. Epithelial stem and progenitor cells in lung repair and regeneration. Annu Rev Physiol, 2021, 83: 529-550.
24.	Rock JR, Onaitis MW, Rawlins EL, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA, 2009, 106(31): 12771-12775.
25.	Ghosh M, Miller YE, Nakachi I, et al. Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2018, 197(7): 885-896.
26.	Stoyanova T, Goldstein AS, Cai HJ, et al. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev, 2012, 26: 2271-2285.
27.	Liu QX, Li HJ, Wang Q, et al. Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease. Respir Res, 2016, 17(1): 159.
28.	Li HJ, Cui LW, Liu QX, et al. Ginsenoside Rb3 alleviates CSE-induced TROP2 Upregulation through p38 MAPK and NF-κB pathways in basal cells. Am J Respir Cell Mol Biol, 2021, 64(6): 747-759.
29.	Yang J, Zuo WL, Fukui T, et al. Smoking-dependent distal-to-proximal repatterning of the adult human small airway epithelium. Am J Respir Crit Care Med, 2017, 196(3): 340-352.
30.	Zuo WL, Yang J, Gomi K, et al. EGF-amphiregulin interplay in airway stem/progenitor cells links the pathogenesis of smoking-induced lesions in the human airway epithelium. Stem Cells, 2017, 35(3): 824-837.
31.	Zuo WL, Yang J, Strulovici-Barel Y, et al. Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes. Eur Respir J, 2019, 53(5): 1702553.
32.	Hegab AE, Ha VL, Gilbert JL, et al. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells, 2011, 29(8): 1283-1293.
33.	Tata A, Kobayashi Y, Chow RD, et al. Myoepithelial cells of submucosal glands can function as reserve stem cells to regenerate airways after injury. Cell Stem Cell, 2018, 22(5): 668-683. e6.
34.	Kim CFB, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell, 2005, 121(6): 823-835.
35.	Salwig I, Spitznagel B, Vazquez-Armendariz AI, et al. Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo. EMBO J, 2019, 38(12): e102099.
36.	Kawakita N, Toba H, Miyoshi K, et al. Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration. Stem Cell Res Ther, 2020, 11(1): 430.
37.	Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature, 2014, 507(7491): 190-194.
38.	Tanosaki T, Mikami Y, Shindou H, et al. Lysophosphatidylcholine acyltransferase 1 deficiency promotes pulmonary emphysema via apoptosis of alveolar epithelial cells. Inflammation, 2022, 45(4): 1765-1779.
39.	Tsutsumi A, Ozaki M, Chubachi S, et al. Exposure to cigarette smoke enhances the stemness of alveolar type 2 cells. Am J Respir Cell Mol Biol, 2020, 63(3): 293-305.
40.	Hu Y, Ng-Blichfeldt JP, Ota C, et al. Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. Stem Cells, 2020, 38(11): 1467-1478.
41.	Weiss ARR, Dahlke MH. Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs. Front Immunol, 2019, 10: 1191.
42.	Antunes MA, Abreu SC, Cruz FF, et al. Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema. Respir Res, 2014, 15(1): 118.
43.	Rolandsson Enes S, Andersson Sjöland A, Skog I, et al. MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC. Sci Rep, 2016, 6: 29160.
44.	Hoffman AM, Paxson JA, Mazan MR, et al. Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells Dev, 2011, 20(10): 1779-1792.
45.	Cappetta D, De Angelis A, Spaziano G, et al. Lung mesenchymal stem cells ameliorate elastase-induced damage in an animal model of emphysema. Stem Cells Int, 2018, 2018: 9492038.
46.	Kruk DMLW, Wisman M, Noordhoek JA, et al. Paracrine regulation of alveolar epithelial damage and repair responses by human lung-resident mesenchymal stromal cells. Cells, 2021, 10(11): 2860.
47.	Kruk DMLW, Wisman M, Bruin HG, et al. Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema. Am J Physiol Lung Cell Mol Physiol, 2021, 320(5): L832-L844.
48.	Bi H, He J, He X, et al. Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease-obstructive sleep apnea overlap syndrome rat model. Mol Med Rep, 2021, 23(1): 69.
49.	Liu HM, Liu YT, Zhang J, et al. Bone marrow mesenchymal stem cells ameliorate lung injury through anti-inflammatory and antibacterial effect in COPD mice. J Huazhong Univ Sci Technolog Med Sci, 2017, 37(4): 496-504.
50.	Maremanda KP, Sundar IK, Rahman I. Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicol Appl Pharmacol, 2019, 385: 114788.
51.	杨莉颖. 小鼠BMSC外泌体减轻CSE诱导的肺微血管内皮细胞凋亡. 湖南:中南大学, 2019: 43-44.
52.	Ridzuan N, Zakaria N, Widera D, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Res Ther, 2021, 12(1): 54.
53.	Cho JW, Park KS, Bae JY. Effects of Wharton's jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease. Regen Ther, 2019, 11: 207-211.
54.	Song L, Peng J, Guo XJ. Exosomal lncRNA TCONS_00064356 derived from injured alveolar epithelial type Ⅱ cells affects the biological characteristics of mesenchymal stem cells. Life Sci, 2021, 278: 119568.
55.	Cho RJ, Kim YS, Kim JY, et al. Human adipose-derived mesenchymal stem cell spheroids improve recovery in a mouse model of elastase-induced emphysema. BMB Rep, 2017, 50(2): 79-84.
56.	郝术安, 吴琦, 王茂均. 脂肪间充质干细胞移植治疗慢性阻塞性肺疾病. 中国组织工程研究, 2016, 20(41): 6177-6182.
57.	Hong Y, Kim YS, Hong SH, et al. Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model. Exp Mol Med, 2016, 21,48(10): e266.
58.	Fujioka N, Kitabatake M, Ouji-Sageshima N, et al. Human adipose-derived mesenchymal stem cells ameliorate elastase-induced emphysema in mice by mesenchymal-epithelial transition. Int J Chron Obstruct Pulmon Dis, 2021, 16: 2783-2793.
59.	Chen TY, Liu CH, Chen TH, et al. Conditioned media of adipose-derived stem cells suppresses sidestream cigarette smoke extract induced cell death and epithelial-mesenchymal transition in lung epithelial cells. Int J Mol Sci, 2021, 22(21): 12069.
60.	Arruda de Faria C, Silva Júnior WA, Caetano Andrade Coelho KB, et al. Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: simvastatin as a potential adjuvant in cellular homing. Pulm Pharmacol Ther, 2021, 70: 102075.
61.	Li X, Zhang YL, Liang YM, et al. iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells. J Cell Mol Med, 2017, 21(2): 265-277.
62.	Michaeloudes C, Li X, Mak JCW, et al. Study of mesenchymal stem cell-mediated mitochondrial transfer in in vitro models of oxidant-mediated airway epithelial and smooth muscle cell injury. Methods Mol Biol, 2021, 2269: 93-105.
63.	Chen XY, Chen YY, Lin W, et al. Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in recovering from murine pulmonary emphysema under cigarette smoke exposure. Front Med (Lausanne), 2021, 8: 713824.
64.	Chen Q, Lv L, Zheng CJ, et al. Human umbilical cord-derived mesenchymal stem cells repair SU5416-injured emphysema by inhibiting apoptosis via rescuing VEGF-VEGFR2-AKT pathway in rats. Int J Stem Cells, 2022, 15(4): 395-404.
65.	Stessuk T, Ribeiro-Paes JT. Comment on "Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study". Stem Cell Res Ther, 2020, 11(1): 340.
66.	Weiss DJ, Segal K, Casaburi R, et al. Effect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels. Respir Res, 2021, 22(1): 142.
67.	Armitage J, Tan DBA, Troedson R, et al. Mesenchymal stromal cell infusion modulates systemic immunological responses in stable COPD patients: a phase Ⅰ pilot study. Eur Respir J, 2018, 51: 1702369.
68.	Armitage JD, Tan DBA, Sturm M, et al. Transcriptional profiling of circulating mononuclear cells from patients with chronic obstructive pulmonary disease receiving mesenchymal stromal cell infusions. Stem Cells Transl Med, 2021, 10(11): 1470-1481.
69.	Harrell CR, Miloradovic D, Sadikot R, et al. Molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cell-derived product "Exo-d-MAPPS" in attenuation of chronic airway inflammation. Anal Cell Pathol (Amst), 2020, 2020: 3153891.
70.	Squassoni SD, Sekiya EJ, Fiss E, et al. Autologous infusion of bone marrow and mesenchymal stromal cells in patients with chronic obstructive pulmonary disease: phase Ⅰ randomized clinical trial. Int J Chron Obstruct Pulmon Dis, 2021, 16: 3561-3574.

1. Obling N, Backer V, Hurst JR, et al. Nasal and systemic inflammation in chronic obstructive pulmonary disease (COPD). Respir Med, 2022, 195: 106774.
2. GBD 2017 Oesophageal Cancer Collaborators. The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol, 2020, 5(6): 582-597.
3. GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med, 2020, 8(6): 585-596.
4. Global Initiative for Chronic Obstructive Lung Disease Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease Global Initiative for Chronic Obstructive Lung Disease, 2022[EB/OL]. [2021-10-17]. Available from: http://www.goldcopd.org/.
5. Saba JA, Liakath Ali K, Green R, et al. Translational control of stem cell function. Nat Rev Mol Cell Biol, 2021, 22(10): 671-690.
6. Chen YT, Miao K, Zhou LF, et al. Stem cell therapy for chronic obstructive pulmonary disease. Chin Med J (Engl), 2021, 134(13): 1535-1545.
7. Coppolino I, Ruggeri P, Nucera F, et al. Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema. COPD, 2018, 15(5): 536-556.
8. 杨悦, 曹君, 陈平. 小鼠内皮祖细胞的培养和移植. 中国组织工程研究与临床康复, 2009, 13(41): 8109-8113.
9. Song Q, Chen P, Liu XM. The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD. Respir Res, 2021, 22(1): 39.
10. Liu XR, Liu YL, Huang XY, et al. Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease. Mol Med Rep, 2017, 16(4): 5294-5302.
11. He ZH, Peng HH, Gao M, et al. p300/Sp1-mediated high expression of p16 promotes endothelial progenitor cell senescence leading to the occurrence of chronic obstructive pulmonary disease. Mediators Inflamm, 2021, 2021: 5599364.
12. He ZH, Chen P, Chen Y, et al. Dual effects of cigarette smoke extract on proliferation of endothelial progenitor cells and the protective effect of 5-aza-2'-deoxycytidine on EPCs against the damage caused by CSE. BioMed Res Int, 2014, 2014: 640752.
13. He Z, Chen Y, Hou C, et al. Cigarette smoke extract changes expression of endothelial nitric oxide synthase (eNOS) and p16 (INK4a) and is related to endothelial progenitor cell dysfunction. Med Sci Monit, 2017, 23: 3224-3231.
14. He ZH, Chen Y, Chen P, et al. Cigarette smoke extract affects methylation status and attenuates Sca-1 expression of mouse endothelial progenitor cell in vitro. Tob Induc Dis, 2021, 19: 8.
15. Pei CZ, Wang XY, Lin YJ, et al. Inhibition of galectin-3 alleviates cigarette smoke extract-induced autophagy and dysfunction in endothelial progenitor cells. Oxid Med Cell Longev, 2019, 2019: 7252943.
16. He ZH, Chen Y, Chen P, et al. 5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16^Ink4a expression in lung tissue. Int J Chron Obstruct Pulmon Dis, 2017, 12: 3149-3158.
17. He ZH, Chen Y, Chen P, et al. Decitabine enhances stem cell antigen-1 expression in cigarette smoke extract-induced emphysema in animal model. Exp Biol Med (Maywood), 2016, 241(2): 131-139.
18. Shi ZH, Chen Y, Cao J, et al. Intratracheal transplantation of endothelial progenitor cells attenuates smoking-induced COPD in mice. Int J Chron Obstruct Pulmon Dis, 2017, 12: 947-960.
19. Ma YM, He X, Liu XM, et al. Endothelial microparticles derived from primary pulmonary microvascular endothelial cells mediate lung inflammation in chronic obstructive pulmonary disease by transferring microRNA-126. J Inflamm Res, 2022, 15: 1399-1411.
20. Hisata S, Racanelli AC, Kermani P, et al. Reversal of emphysema by restoration of pulmonary endothelial cells. J Exp Med, 2021, 218(8): e20200938.
21. Yoshida M, Minagawa S, Araya J, et al. Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis. Nat Commun, 2019, 10(1): 3145.
22. Choi J, Jang YJ, Dabrowska C, et al. Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration. Nat Cell Biol, 2021, 23(9): 953-966.
23. Alysandratos KD, Herriges MJ, Kotton DN. Epithelial stem and progenitor cells in lung repair and regeneration. Annu Rev Physiol, 2021, 83: 529-550.
24. Rock JR, Onaitis MW, Rawlins EL, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA, 2009, 106(31): 12771-12775.
25. Ghosh M, Miller YE, Nakachi I, et al. Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2018, 197(7): 885-896.
26. Stoyanova T, Goldstein AS, Cai HJ, et al. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev, 2012, 26: 2271-2285.
27. Liu QX, Li HJ, Wang Q, et al. Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease. Respir Res, 2016, 17(1): 159.
28. Li HJ, Cui LW, Liu QX, et al. Ginsenoside Rb3 alleviates CSE-induced TROP2 Upregulation through p38 MAPK and NF-κB pathways in basal cells. Am J Respir Cell Mol Biol, 2021, 64(6): 747-759.
29. Yang J, Zuo WL, Fukui T, et al. Smoking-dependent distal-to-proximal repatterning of the adult human small airway epithelium. Am J Respir Crit Care Med, 2017, 196(3): 340-352.
30. Zuo WL, Yang J, Gomi K, et al. EGF-amphiregulin interplay in airway stem/progenitor cells links the pathogenesis of smoking-induced lesions in the human airway epithelium. Stem Cells, 2017, 35(3): 824-837.
31. Zuo WL, Yang J, Strulovici-Barel Y, et al. Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes. Eur Respir J, 2019, 53(5): 1702553.
32. Hegab AE, Ha VL, Gilbert JL, et al. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells, 2011, 29(8): 1283-1293.
33. Tata A, Kobayashi Y, Chow RD, et al. Myoepithelial cells of submucosal glands can function as reserve stem cells to regenerate airways after injury. Cell Stem Cell, 2018, 22(5): 668-683. e6.
34. Kim CFB, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell, 2005, 121(6): 823-835.
35. Salwig I, Spitznagel B, Vazquez-Armendariz AI, et al. Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo. EMBO J, 2019, 38(12): e102099.
36. Kawakita N, Toba H, Miyoshi K, et al. Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration. Stem Cell Res Ther, 2020, 11(1): 430.
37. Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature, 2014, 507(7491): 190-194.
38. Tanosaki T, Mikami Y, Shindou H, et al. Lysophosphatidylcholine acyltransferase 1 deficiency promotes pulmonary emphysema via apoptosis of alveolar epithelial cells. Inflammation, 2022, 45(4): 1765-1779.
39. Tsutsumi A, Ozaki M, Chubachi S, et al. Exposure to cigarette smoke enhances the stemness of alveolar type 2 cells. Am J Respir Cell Mol Biol, 2020, 63(3): 293-305.
40. Hu Y, Ng-Blichfeldt JP, Ota C, et al. Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. Stem Cells, 2020, 38(11): 1467-1478.
41. Weiss ARR, Dahlke MH. Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs. Front Immunol, 2019, 10: 1191.
42. Antunes MA, Abreu SC, Cruz FF, et al. Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema. Respir Res, 2014, 15(1): 118.
43. Rolandsson Enes S, Andersson Sjöland A, Skog I, et al. MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC. Sci Rep, 2016, 6: 29160.
44. Hoffman AM, Paxson JA, Mazan MR, et al. Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells Dev, 2011, 20(10): 1779-1792.
45. Cappetta D, De Angelis A, Spaziano G, et al. Lung mesenchymal stem cells ameliorate elastase-induced damage in an animal model of emphysema. Stem Cells Int, 2018, 2018: 9492038.
46. Kruk DMLW, Wisman M, Noordhoek JA, et al. Paracrine regulation of alveolar epithelial damage and repair responses by human lung-resident mesenchymal stromal cells. Cells, 2021, 10(11): 2860.
47. Kruk DMLW, Wisman M, Bruin HG, et al. Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema. Am J Physiol Lung Cell Mol Physiol, 2021, 320(5): L832-L844.
48. Bi H, He J, He X, et al. Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease-obstructive sleep apnea overlap syndrome rat model. Mol Med Rep, 2021, 23(1): 69.
49. Liu HM, Liu YT, Zhang J, et al. Bone marrow mesenchymal stem cells ameliorate lung injury through anti-inflammatory and antibacterial effect in COPD mice. J Huazhong Univ Sci Technolog Med Sci, 2017, 37(4): 496-504.
50. Maremanda KP, Sundar IK, Rahman I. Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicol Appl Pharmacol, 2019, 385: 114788.
51. 杨莉颖. 小鼠BMSC外泌体减轻CSE诱导的肺微血管内皮细胞凋亡. 湖南:中南大学, 2019: 43-44.
52. Ridzuan N, Zakaria N, Widera D, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Res Ther, 2021, 12(1): 54.
53. Cho JW, Park KS, Bae JY. Effects of Wharton's jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease. Regen Ther, 2019, 11: 207-211.
54. Song L, Peng J, Guo XJ. Exosomal lncRNA TCONS_00064356 derived from injured alveolar epithelial type Ⅱ cells affects the biological characteristics of mesenchymal stem cells. Life Sci, 2021, 278: 119568.
55. Cho RJ, Kim YS, Kim JY, et al. Human adipose-derived mesenchymal stem cell spheroids improve recovery in a mouse model of elastase-induced emphysema. BMB Rep, 2017, 50(2): 79-84.
56. 郝术安, 吴琦, 王茂均. 脂肪间充质干细胞移植治疗慢性阻塞性肺疾病. 中国组织工程研究, 2016, 20(41): 6177-6182.
57. Hong Y, Kim YS, Hong SH, et al. Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model. Exp Mol Med, 2016, 21,48(10): e266.
58. Fujioka N, Kitabatake M, Ouji-Sageshima N, et al. Human adipose-derived mesenchymal stem cells ameliorate elastase-induced emphysema in mice by mesenchymal-epithelial transition. Int J Chron Obstruct Pulmon Dis, 2021, 16: 2783-2793.
59. Chen TY, Liu CH, Chen TH, et al. Conditioned media of adipose-derived stem cells suppresses sidestream cigarette smoke extract induced cell death and epithelial-mesenchymal transition in lung epithelial cells. Int J Mol Sci, 2021, 22(21): 12069.
60. Arruda de Faria C, Silva Júnior WA, Caetano Andrade Coelho KB, et al. Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: simvastatin as a potential adjuvant in cellular homing. Pulm Pharmacol Ther, 2021, 70: 102075.
61. Li X, Zhang YL, Liang YM, et al. iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells. J Cell Mol Med, 2017, 21(2): 265-277.
62. Michaeloudes C, Li X, Mak JCW, et al. Study of mesenchymal stem cell-mediated mitochondrial transfer in in vitro models of oxidant-mediated airway epithelial and smooth muscle cell injury. Methods Mol Biol, 2021, 2269: 93-105.
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