嗜酸性粒细胞在急性呼吸窘迫综合征中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陈刚 , 李毅 , LU Rongli ,  PAN Pinhua

中南大学湘雅医院呼吸内科，国家呼吸系统疾病临床医学研究中心分中心（湖南长沙 410008）;

Corresponding author：

PAN Pinhua, Email: pinhuapan668@csu.edu.cn

Keywords：

DOI：

10.7507/1671-6205.202205053

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Citation： LU Rongli, PAN Pinhua. 嗜酸性粒细胞在急性呼吸窘迫综合征中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(3): 218-222. doi: 10.7507/1671-6205.202205053 Copy

1.	Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet, 2022, 400(10358): 1145-1156.
2.	Bellani G, Laffey J G, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
3.	Zhu C, Weng QY, Zhou LR, et al. Homeostatic and early-recruited CD101 - eosinophils suppress endotoxin-induced acute lung injury. Eur Respir J, 2020, 56(5): 1902354.
4.	Grisaru-Tal S, Itan M, Klion AD, et al. A new dawn for eosinophils in the tumour microenvironment. Nat Rev Cancer, 2020, 20(10): 594-607.
5.	Klion AD, Ackerman SJ, Bochner BS. Contributions of eosinophils to human health and disease. Annu Rev Pathol, 2020, 15: 179-209.
6.	Aoki A, Hirahara K, Kiuchi M, et al. Eosinophils: Cells known for over 140 years with broad and new functions. Allergol Int, 2021, 70(1): 3-8.
7.	廖新, 陈林, 况九龙. 嗜酸性粒细胞与慢性阻塞性肺疾病的临床研究进展. 中国呼吸与危重监护杂志, 2020, 19(1): 84-87.
8.	Al Duhailib Z, Farooqi M, Piticaru J, et al. The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Can J Anaesth, 2021, 68(5): 715-726.
9.	Valent P, Degenfeld-Schonburg L, Sadovnik I, et al. Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity. Semin Immunopathol, 2021, 43(3): 423-438.
10.	Manohar M, Kandikattu HK, Upparahalli Venkateshaiah S, et al. Eosinophils in the pathogenesis of pancreatic disorders. Semin Immunopathol, 2021, 43(3): 411-422.
11.	Linch SN, Kelly AM, Danielson ET, et al. Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun, 2009, 77(11): 4976-4982.
12.	Percopo CM, Dyer KD, Ochkur SI, et al. Activated mouse eosinophils protect against lethal respiratory virus infection. Blood, 2014, 123(5): 743-752.
13.	赵新成, 史家欣, 梁程程, 等. 嗜酸性粒细胞作为生物标志物在慢性阻塞性肺疾病中的研究进展. 中国呼吸与危重监护杂志, 2018, 17(6): 624-628.
14.	李小平, 欧阳辉, 袁浩, 等. 血嗜酸性粒细胞在慢性阻塞性肺疾病的临床研究进展. 中国呼吸与危重监护杂志, 2019, 18(4): 396-399.
15.	Hallgren R, Borg T, Venge P, et al. Signs of neutrophil and eosinophil activation in adult respiratory distress syndrome. Crit Care Med, 1984, 12(1): 14-18.
16.	Willetts L, Parker K, Wesselius L J, et al. Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res, 2011, 12(1): 116.
17.	Zein JG, Love TE, Erzurum SC. Asthma is associated with a lower risk of sepsis and sepsis-related mortality. Am J Respir Crit Care Med, 2017, 196(6): 787-790.
18.	Verhoef PA, Bhavani SV, Carey KA, et al. Allergic immune diseases and the risk of mortality among patients hospitalized for acute infection. Crit Care Med, 2019, 47(12): 1735-1742.
19.	Verhoef PA, Constantinides MG, McDonald BD, et al. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol, 2016, 137(2): 591-600.
20.	Krishack PA, Hollinger MK, Kuzel TG, et al. IL-33–mediated eosinophilia protects against acute lung injury. Am J Respir Cell Mol Biol, 2021, 64(5): 569-578.
21.	Laffey JG, Madotto F, Bellani G, et al. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med, 2017, 5(8): 627-638.
22.	Pavord ID, Lettis S, Anzueto A, et al. Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis. Lancet Respir Med, 2016, 4(9): 731-741.
23.	Vedel-Krogh S, Nordestgaard BG, Lange P, et al. Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD. Eur Respir J, 2018, 51(5): 1800120.
24.	Rosenberg HF, Dyer KD, Domachowske JB. Respiratory viruses and eosinophils: exploring the connections. Antiviral Res, 2009, 83(1): 1-9.
25.	Du YZ, Tu L, Zhu PJ, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan. A retrospective observational study. Am J Respir Crit Care Med, 2020, 201(11): 1372-1379.
26.	Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 2020, 75(7): 1730-1741.
27.	Li XC, Xu SY, Yu MQ, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol, 2020, 146(1): 110-118.
28.	Liao DY, Zhou F, Luo LL, et al. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study. Lancet Haematol, 2020, 7(9): e671-e678.
29.	Xie GG, Ding FM, Han L, et al. The role of peripheral blood eosinophil counts in COVID-19 patients. Allergy, 2021, 76(2): 471-482.
30.	Liu F, Xu AF, Zhang Y, et al. Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis, 2020, 95: 183-191.
31.	Beurnier A, Jutant E, Jevnikar M, et al. Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation. Eur Respir J, 2020, 56(5): 2001875.
32.	Auriemma CL, Zhuo H, Delucchi K, et al. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med, 2020, 46(6): 1222-1231.
33.	Krishack PA, Wang K, Rzhetsky A, et al. Preexisting type 2 immune activation protects against the development of sepsis. Am J Respir Cell Mol Biol, 2017, 57(5): 628-630.
34.	Lavoignet C, Le Borgne P, Chabrier S, et al. White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED. Eur J Clin Microbiol Infect Dis, 2019, 38(8): 1523-1532.
35.	Krishack PA, Louviere TJ, Decker TS, et al. Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils. JCI insight, 2019, 4(6): e124168.
36.	Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res, 2011, 343(1): 57-83.
37.	Liu J, Zhang S, Dong X, et al. Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome. J Clin Invest, 2020, 130(12): 6417-6428.
38.	Matthay MA, Wick KD. Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome. J Clin Invest, 2020, 130(12): 6218-6221.
39.	David B, Bafadhel M, Koenderman L, et al. Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait. Thorax, 2021, 76(2): 188-195.
40.	Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease, 2022. Available at: https://goldcopd.org/2022-gold-reports-2/.

1. Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet, 2022, 400(10358): 1145-1156.
2. Bellani G, Laffey J G, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
3. Zhu C, Weng QY, Zhou LR, et al. Homeostatic and early-recruited CD101 - eosinophils suppress endotoxin-induced acute lung injury. Eur Respir J, 2020, 56(5): 1902354.
4. Grisaru-Tal S, Itan M, Klion AD, et al. A new dawn for eosinophils in the tumour microenvironment. Nat Rev Cancer, 2020, 20(10): 594-607.
5. Klion AD, Ackerman SJ, Bochner BS. Contributions of eosinophils to human health and disease. Annu Rev Pathol, 2020, 15: 179-209.
6. Aoki A, Hirahara K, Kiuchi M, et al. Eosinophils: Cells known for over 140 years with broad and new functions. Allergol Int, 2021, 70(1): 3-8.
7. 廖新, 陈林, 况九龙. 嗜酸性粒细胞与慢性阻塞性肺疾病的临床研究进展. 中国呼吸与危重监护杂志, 2020, 19(1): 84-87.
8. Al Duhailib Z, Farooqi M, Piticaru J, et al. The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Can J Anaesth, 2021, 68(5): 715-726.
9. Valent P, Degenfeld-Schonburg L, Sadovnik I, et al. Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity. Semin Immunopathol, 2021, 43(3): 423-438.
10. Manohar M, Kandikattu HK, Upparahalli Venkateshaiah S, et al. Eosinophils in the pathogenesis of pancreatic disorders. Semin Immunopathol, 2021, 43(3): 411-422.
11. Linch SN, Kelly AM, Danielson ET, et al. Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun, 2009, 77(11): 4976-4982.
12. Percopo CM, Dyer KD, Ochkur SI, et al. Activated mouse eosinophils protect against lethal respiratory virus infection. Blood, 2014, 123(5): 743-752.
13. 赵新成, 史家欣, 梁程程, 等. 嗜酸性粒细胞作为生物标志物在慢性阻塞性肺疾病中的研究进展. 中国呼吸与危重监护杂志, 2018, 17(6): 624-628.
14. 李小平, 欧阳辉, 袁浩, 等. 血嗜酸性粒细胞在慢性阻塞性肺疾病的临床研究进展. 中国呼吸与危重监护杂志, 2019, 18(4): 396-399.
15. Hallgren R, Borg T, Venge P, et al. Signs of neutrophil and eosinophil activation in adult respiratory distress syndrome. Crit Care Med, 1984, 12(1): 14-18.
16. Willetts L, Parker K, Wesselius L J, et al. Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res, 2011, 12(1): 116.
17. Zein JG, Love TE, Erzurum SC. Asthma is associated with a lower risk of sepsis and sepsis-related mortality. Am J Respir Crit Care Med, 2017, 196(6): 787-790.
18. Verhoef PA, Bhavani SV, Carey KA, et al. Allergic immune diseases and the risk of mortality among patients hospitalized for acute infection. Crit Care Med, 2019, 47(12): 1735-1742.
19. Verhoef PA, Constantinides MG, McDonald BD, et al. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol, 2016, 137(2): 591-600.
20. Krishack PA, Hollinger MK, Kuzel TG, et al. IL-33–mediated eosinophilia protects against acute lung injury. Am J Respir Cell Mol Biol, 2021, 64(5): 569-578.
21. Laffey JG, Madotto F, Bellani G, et al. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med, 2017, 5(8): 627-638.
22. Pavord ID, Lettis S, Anzueto A, et al. Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis. Lancet Respir Med, 2016, 4(9): 731-741.
23. Vedel-Krogh S, Nordestgaard BG, Lange P, et al. Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD. Eur Respir J, 2018, 51(5): 1800120.
24. Rosenberg HF, Dyer KD, Domachowske JB. Respiratory viruses and eosinophils: exploring the connections. Antiviral Res, 2009, 83(1): 1-9.
25. Du YZ, Tu L, Zhu PJ, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan. A retrospective observational study. Am J Respir Crit Care Med, 2020, 201(11): 1372-1379.
26. Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 2020, 75(7): 1730-1741.
27. Li XC, Xu SY, Yu MQ, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol, 2020, 146(1): 110-118.
28. Liao DY, Zhou F, Luo LL, et al. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study. Lancet Haematol, 2020, 7(9): e671-e678.
29. Xie GG, Ding FM, Han L, et al. The role of peripheral blood eosinophil counts in COVID-19 patients. Allergy, 2021, 76(2): 471-482.
30. Liu F, Xu AF, Zhang Y, et al. Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis, 2020, 95: 183-191.
31. Beurnier A, Jutant E, Jevnikar M, et al. Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation. Eur Respir J, 2020, 56(5): 2001875.
32. Auriemma CL, Zhuo H, Delucchi K, et al. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med, 2020, 46(6): 1222-1231.
33. Krishack PA, Wang K, Rzhetsky A, et al. Preexisting type 2 immune activation protects against the development of sepsis. Am J Respir Cell Mol Biol, 2017, 57(5): 628-630.
34. Lavoignet C, Le Borgne P, Chabrier S, et al. White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED. Eur J Clin Microbiol Infect Dis, 2019, 38(8): 1523-1532.
35. Krishack PA, Louviere TJ, Decker TS, et al. Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils. JCI insight, 2019, 4(6): e124168.
36. Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res, 2011, 343(1): 57-83.
37. Liu J, Zhang S, Dong X, et al. Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome. J Clin Invest, 2020, 130(12): 6417-6428.
38. Matthay MA, Wick KD. Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome. J Clin Invest, 2020, 130(12): 6218-6221.
39. David B, Bafadhel M, Koenderman L, et al. Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait. Thorax, 2021, 76(2): 188-195.
40. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease, 2022. Available at: https://goldcopd.org/2022-gold-reports-2/.

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嗜酸性粒细胞在急性呼吸窘迫综合征中的研究进展

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