浅析新型冠状病毒肺炎并发急性呼吸窘迫综合征的病理及病理生理_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

傅小云 ¹ , ZHOU Hourong ² , YE Xianwei ³ ,  ZHANG Xiangyan ³

1. ;
2. ;
3. ;

Corresponding author：

ZHANG Xiangyan, Email: zxy35762@126.com

Keywords：

DOI：

10.7507/1671-6205.202206042

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Citation： ZHOU Hourong, YE Xianwei, ZHANG Xiangyan. 浅析新型冠状病毒肺炎并发急性呼吸窘迫综合征的病理及病理生理. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(10): 756-760. doi: 10.7507/1671-6205.202206042 Copy

1.	Sweeney RM, McAuley DF. Acute respiratory distress syndrome. Lancet, 2016, 388(10058): 2416-2430.
2.	Li X, Ma XC. Acute respiratory failure in COVID-19: is it "typical" ARDS?. Crit Care, 2020, 24(1): 198.
3.	Batah SS, Fabro AT. Pulmonary pathology of ARDS in COVID-19: a pathological review for clinicians. Respir Med, 2021, 176: 106239.
4.	Wichmann D, Sperhake JP, Lütgehetmann M, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med, 2020, 173(4): 268-277.
5.	Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med, 2020, 383(2): 120-128.
6.	Navarro Conde P, Alemany Monraval P, Medina Medina C, et al. Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. Rev Esp Patol, 2020, 53(3): 188-192.
7.	Fox SE, Akmatbekov A, Harbert JL, et al. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med, 2020, 8(7): 681-686.
8.	Tian SF, Hu WD, Niu L, et al. Pulmonary pathology of early-phase 2019 Novel Coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol, 2020, 15(5): 700-704.
9.	Konopka KE, Wilson A, Myers JL. Postmortem lung findings in a patient with asthma and Coronavirus Disease 2019. Chest, 2020, 158(3): e99-e101.
10.	Barton LM, Duval EJ, Stroberg E, et al. COVID-19 autopsies, Oklahoma, USA. Am J Clin Pathol, 2020, 153(6): 725-733.
11.	Schwensen HF, Borreschmidt LK, Storgaard M, et al. Fatal pulmonary fibrosis: a post-COVID-19 autopsy case. J Clin Pathol, 2021, 74: 400-402.
12.	He Q, Mao QY, Zhang JL, et al. COVID-19 vaccines: current understanding on immunogenicity, safety, and further considerations. Front Immunol, 2021, 12: 669339.
13.	Parasher A. COVID-19: current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J, 2021, 97(1147): 312-320.
14.	Li WH, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 2003, 426(6965): 450-454.
15.	Barnes BJ, Adrover JM, Baxter-Stoltzfus A, et al. Targeting potential drivers of COVID-19: neutrophil extracellular traps. J Exp Med, 2020, 217(6): e20200652.
16.	Zuo Y, Yalavarthi S, Shi H, et al. Neutrophil extracellular traps in COVID-19. JCI Insight, 2020, 5(11): e138999.
17.	van Vught LA, Bos LDJ. COVID-19 pathophysiology: an opportunity to start appreciating time-dependent variation. Am J Respir Crit Care Med, 2022, 205(5): 483-485.
18.	Gheblawi M, Wang KM, Viveiros A, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th Anniversary of the Discovery of ACE2. Circ Res, 2020, 126(10): 1456-1474.
19.	Cargill RI, Lipworth BJ. Lisinopril attenuates acute hypoxic pulmonary vasoconstriction in humans. Chest, 1996, 109(2): 424-429.
20.	Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet, 2020, 395(10234): 1417-1418.
21.	Libby P, Lüscher T. COVID-19 is, in the end, an endothelial disease. Eur Heart J, 2020, 41(32): 3038-3044.
22.	Mangalmurti NS, Reilly JP, Cines DB, et al. COVID-19-associated acute respiratory distress syndrome clarified: a vascular endotype?. Am J Respir Crit Care Med, 2020, 202(5): 750-753.
23.	Damiani E, Carsetti A, Casarotta E, et al. Microvascular alterations in patients with SARS-COV-2 severe pneumonia. Ann Intensive Care, 2020, 10(1): 60.
24.	Lang M, Som A, Mendoza DP, et al. Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT. Lancet Infect Dis, 2020, 20(12): 1365-1366.
25.	Lang M, Som A, Carey D, et al. Pulmonary vascular manifestations of COVID-19 pneumonia. Radiol Cardiothorac Imaging, 2020, 2(3): e200277.
26.	Bonaventura A, Vecchié A, Dagna L, et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol, 2021, 21(5): 319-329.
27.	Gattinoni L, Chiumello D, Rossi S. COVID-19 pneumonia: ARDS or not?. Crit Care, 2020, 24(1): 154.
28.	Gattinoni L, Chiumello D, Caironi P, et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes?. Intensive Care Med, 2020, 46(6): 1099-1102.
29.	Panwar R, Madotto F, Laffey JG, et al. Compliance phenotypes in early acute respiratory distress syndrome before the COVID-19 pandemic. Am J Respir Crit Care Med, 2020, 202(9): 1244-1252.

1. Sweeney RM, McAuley DF. Acute respiratory distress syndrome. Lancet, 2016, 388(10058): 2416-2430.
2. Li X, Ma XC. Acute respiratory failure in COVID-19: is it "typical" ARDS?. Crit Care, 2020, 24(1): 198.
3. Batah SS, Fabro AT. Pulmonary pathology of ARDS in COVID-19: a pathological review for clinicians. Respir Med, 2021, 176: 106239.
4. Wichmann D, Sperhake JP, Lütgehetmann M, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med, 2020, 173(4): 268-277.
5. Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med, 2020, 383(2): 120-128.
6. Navarro Conde P, Alemany Monraval P, Medina Medina C, et al. Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. Rev Esp Patol, 2020, 53(3): 188-192.
7. Fox SE, Akmatbekov A, Harbert JL, et al. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med, 2020, 8(7): 681-686.
8. Tian SF, Hu WD, Niu L, et al. Pulmonary pathology of early-phase 2019 Novel Coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol, 2020, 15(5): 700-704.
9. Konopka KE, Wilson A, Myers JL. Postmortem lung findings in a patient with asthma and Coronavirus Disease 2019. Chest, 2020, 158(3): e99-e101.
10. Barton LM, Duval EJ, Stroberg E, et al. COVID-19 autopsies, Oklahoma, USA. Am J Clin Pathol, 2020, 153(6): 725-733.
11. Schwensen HF, Borreschmidt LK, Storgaard M, et al. Fatal pulmonary fibrosis: a post-COVID-19 autopsy case. J Clin Pathol, 2021, 74: 400-402.
12. He Q, Mao QY, Zhang JL, et al. COVID-19 vaccines: current understanding on immunogenicity, safety, and further considerations. Front Immunol, 2021, 12: 669339.
13. Parasher A. COVID-19: current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J, 2021, 97(1147): 312-320.
14. Li WH, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 2003, 426(6965): 450-454.
15. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, et al. Targeting potential drivers of COVID-19: neutrophil extracellular traps. J Exp Med, 2020, 217(6): e20200652.
16. Zuo Y, Yalavarthi S, Shi H, et al. Neutrophil extracellular traps in COVID-19. JCI Insight, 2020, 5(11): e138999.
17. van Vught LA, Bos LDJ. COVID-19 pathophysiology: an opportunity to start appreciating time-dependent variation. Am J Respir Crit Care Med, 2022, 205(5): 483-485.
18. Gheblawi M, Wang KM, Viveiros A, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th Anniversary of the Discovery of ACE2. Circ Res, 2020, 126(10): 1456-1474.
19. Cargill RI, Lipworth BJ. Lisinopril attenuates acute hypoxic pulmonary vasoconstriction in humans. Chest, 1996, 109(2): 424-429.
20. Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet, 2020, 395(10234): 1417-1418.
21. Libby P, Lüscher T. COVID-19 is, in the end, an endothelial disease. Eur Heart J, 2020, 41(32): 3038-3044.
22. Mangalmurti NS, Reilly JP, Cines DB, et al. COVID-19-associated acute respiratory distress syndrome clarified: a vascular endotype?. Am J Respir Crit Care Med, 2020, 202(5): 750-753.
23. Damiani E, Carsetti A, Casarotta E, et al. Microvascular alterations in patients with SARS-COV-2 severe pneumonia. Ann Intensive Care, 2020, 10(1): 60.
24. Lang M, Som A, Mendoza DP, et al. Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT. Lancet Infect Dis, 2020, 20(12): 1365-1366.
25. Lang M, Som A, Carey D, et al. Pulmonary vascular manifestations of COVID-19 pneumonia. Radiol Cardiothorac Imaging, 2020, 2(3): e200277.
26. Bonaventura A, Vecchié A, Dagna L, et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol, 2021, 21(5): 319-329.
27. Gattinoni L, Chiumello D, Rossi S. COVID-19 pneumonia: ARDS or not?. Crit Care, 2020, 24(1): 154.
28. Gattinoni L, Chiumello D, Caironi P, et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes?. Intensive Care Med, 2020, 46(6): 1099-1102.
29. Panwar R, Madotto F, Laffey JG, et al. Compliance phenotypes in early acute respiratory distress syndrome before the COVID-19 pandemic. Am J Respir Crit Care Med, 2020, 202(9): 1244-1252.

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浅析新型冠状病毒肺炎并发急性呼吸窘迫综合征的病理及病理生理

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