Treatment of ventricular septal defect with pulmonary hypertension with entricular septal defect repair and lung allograft: a case report_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Fengke ¹ , WANG Yuebin ¹ , DING Zhidan ¹ , FANG Zeming ¹ , ZHAO Kai ¹ , FENG Min ² , CHANG Siyuan ² , CHANG Wei ² , LIU Gang ² , WANG Yong ³ , JIN Feng ³ , LI Jun ⁴ , HUANG Mingjun ⁴ , ZHANG Xin ⁵ , LUO Hong ⁵ , ZHANG Liang ⁵ ,  ZHAO Gaofeng ¹

1. Department of Thoracic Surgery/Lung Transplantation Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China;
2. Surgical ICU of The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China;
3. Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China;
4. Invitro Support Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China;
5. Department of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China;

Corresponding author：

ZHAO Gaofeng, Email: 18437122911@163.com

Keywords：

Lung Transplan; pulmonary arterial hypertension; ventricular septal defect

DOI：

10.7507/1671-6205.202208066

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Objective To explore the clinical effect of ventricular septal defect repair and lung allograft (simply as "heart repair and lung transplant") in the treatment of ventricular septal defect complicated with severe pulmonary hypertension. Methods A 21-year-old female patient with ventricular septal defect and severe pulmonary hypertension was treated with cardiopulmonary bypass (CPB) under general anesthesia, and then right lung transplantation was performed, and then left lung transplantation was performed after changing body position. Results The operation was conducted successively. The intraoperative CPB support time was 90 minutes, and the blood loss was 2000 mL. Extracorporeal membrane oxygenation was removed on the second day after operation, the ventilator was evacuated on the third day, and the patient recovered and discharged on the 38th day. Postoperative echocardiography showed significant improvement in pulmonary artery pressure. Conclusion For patients with simple congenital heart disease complicated with severe pulmonary hypertension, "heart repair and lung transplant" can improve their quality of life.

Citation： LI Fengke, WANG Yuebin, DING Zhidan, FANG Zeming, ZHAO Kai, FENG Min, CHANG Siyuan, CHANG Wei, LIU Gang, WANG Yong, JIN Feng, LI Jun, HUANG Mingjun, ZHANG Xin, LUO Hong, ZHANG Liang, ZHAO Gaofeng. Treatment of ventricular septal defect with pulmonary hypertension with entricular septal defect repair and lung allograft: a case report. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(8): 577-580. doi: 10.7507/1671-6205.202208066 Copy

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2.	朱少金, 陈静瑜, 吴波, 等. 双肺移植治疗重症特发性肺动脉高压18例临床分析. 中华医学杂志, 2016, 96(36): 2909-2911.
3.	杨盛春, 周其文, 来永强, 等. 室间隔缺损合并重度肺动脉高压围手术期处理. 心肺血管病杂志, 2002, 21(4): 204-206.
4.	胡盛寿, 朱晓东, 郭嘉强, 等. 艾森曼格综合征的外科治疗. 中国循环杂志, 1991, 6(1): 30-33.
5.	Trulock EP, Edwards LB, Taylor DO, et al. Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart—lung transplant report-2005. J Heart Lung Transplant, 2005, 24: 956-967.
6.	刘磊, 叶书高, 郑明峰, 等. 动脉导管结扎同期双肺移植治疗动脉导管未闭合并艾森曼格综合征. 器官移植, 2016, 7(3): 210-214.
7.	陈静瑜, 张庆广, 荆朝辉, 等. 肺或心肺联合移植治疗艾森曼格综合征的初探. 中华医学杂志, 2007, 87(17): 1165-1168.
8.	Khan IY, Singer LG, de Perrot M, et al. Survival after lung transplantation in systemic sclerosis. A systematic review. Respir Med, 2013, 107(12): 2081-2087.

1. 杨媛华, 马瑞晓, 庞文翼, 等. ESC/ERS《肺动脉高压诊断和治疗指南》解读之治疗策略. 中华医学杂志, 2016, 96(22): 1793-1795.
2. 朱少金, 陈静瑜, 吴波, 等. 双肺移植治疗重症特发性肺动脉高压18例临床分析. 中华医学杂志, 2016, 96(36): 2909-2911.
3. 杨盛春, 周其文, 来永强, 等. 室间隔缺损合并重度肺动脉高压围手术期处理. 心肺血管病杂志, 2002, 21(4): 204-206.
4. 胡盛寿, 朱晓东, 郭嘉强, 等. 艾森曼格综合征的外科治疗. 中国循环杂志, 1991, 6(1): 30-33.
5. Trulock EP, Edwards LB, Taylor DO, et al. Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart—lung transplant report-2005. J Heart Lung Transplant, 2005, 24: 956-967.
6. 刘磊, 叶书高, 郑明峰, 等. 动脉导管结扎同期双肺移植治疗动脉导管未闭合并艾森曼格综合征. 器官移植, 2016, 7(3): 210-214.
7. 陈静瑜, 张庆广, 荆朝辉, 等. 肺或心肺联合移植治疗艾森曼格综合征的初探. 中华医学杂志, 2007, 87(17): 1165-1168.
8. Khan IY, Singer LG, de Perrot M, et al. Survival after lung transplantation in systemic sclerosis. A systematic review. Respir Med, 2013, 107(12): 2081-2087.

Chinese Journal of Respiratory and Critical Care Medicine

Treatment of ventricular septal defect with pulmonary hypertension with entricular septal defect repair and lung allograft: a case report

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