The application of blood purification in lung transplantation_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

DING Shuo ¹ , CHEN Jingyu ^2,3 ,  HUANG Man ¹

1. Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310051, P. R. China;
2. Lung Transplant Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310051, P. R. China;
3. Wuxi Lung Transplant Center, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu 214000, P. R. China;

Corresponding author：

HUANG Man, Email: huangman@zju.edu.cn

Keywords：

Lung transplantation; blood purification; renal replacement therapy; plasmapheresis; Hemadsorption

DOI：

10.7507/1671-6205.202208068

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

With the deepening of current study and the innovation of perioperative management concept, there have been great advances in lung transplantation in recent years. The prognosis of patients has been significantly improved. At the same time, the role of various types of blood purification in the clinical monitoring and treatment of lung transplant patients is becoming increasingly prominent. This review aims to summarize the application and latest progress of in vitro blood purification such as renal replacement therapy, plasmapheresis and hemadsorption in the perioperative period of lung transplantation, and to provide a basis for further study.

Citation： DING Shuo, CHEN Jingyu, HUANG Man. The application of blood purification in lung transplantation. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(8): 556-560. doi: 10.7507/1671-6205.202208068 Copy

1.	Chambers DC, Perch M, Zuckermann A, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report-2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
2.	Puttarajappa CM, Bernardo JF, Kellum JA. Renal Complications Following Lung Transplantation and Heart Transplantation. Crit Care Clin, 2019, 35(1): 61-73.
3.	Benazzo A, Bajorek L, Morscher A, et al. Early implementation of renal replacement therapy after lung transplantation does not impair long-term kidney function in patients with idiopathic pulmonary arterial hypertension. J Thorac Cardiovasc Surg, 2022, 163(2): 524-535.e523.
4.	Di Nardo M, Tikkanen J, Husain S, et al. Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit. Anesthesiology, 2022, 136(3): 482-499.
5.	Lertjitbanjong P, Thongprayoon C, Cheungpasitporn W, et al. Acute kidney injury after lung transplantation: a systematic review and meta-analysis. J Clin Med, 2019, 8(10): 1713.
6.	Thongprayoon C, Lertjitbanjong P, Hansrivijit P, et al. Acute kidney injury in patients undergoing cardiac transplantation: a meta-analysis. Medicines (Basel), 2019, 6(4): 108.
7.	Egan TM, Edwards LB. Effect of the lung allocation score on lung transplantation in the United States. J Heart Lung Transplant, 2016, 35(4): 433-439.
8.	Jing L, Chen W, Guo L, et al. Acute kidney injury after lung transplantation: a narrative review. Ann Transl Med, 2021, 9(8): 717.
9.	Bihorac A, Delano MJ, Schold JD, et al. Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg, 2010, 252(1): 158-165.
10.	Nuis RJ, Rodes-Cabau J, Sinning JM, et al. Blood transfusion and the risk of acute kidney injury after transcatheter aortic valve implantation. Circ Cardiovasc Interv, 2012, 5(5): 680-688.
11.	Piffaretti G, Mariscalco G, Bonardelli S, et al. Predictors and outcomes of acute kidney injury after thoracic aortic endograft repair. J Vasc Surg, 2012, 56(6): 1527-1534.
12.	Kindzelski BA, Corcoran P, Siegenthaler MP, et al. Postoperative acute kidney injury following intraoperative blood product transfusions during cardiac surgery. Perfusion, 2018, 33(1): 62-70.
13.	Querrey M, Chiu S, Lecuona E, et al. CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation. J Clin Invest, 2022, 132(14): e157262.
14.	Ghaidan H, Stenlo M, Niroomand A, et al. Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation. Nat Commun, 2022, 13(1): 4173.
15.	Chen-Yoshikawa TF. Ischemia-reperfusion injury in lung transplantation. Cells, 2021, 10(6): 1333.
16.	Sikma MA, Hunault CC, van de Graaf EA, et al. High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury. Eur J Clin Pharmacol, 2017, 73(5): 573-580.
17.	Mason DP, Solovera-Rozas M, Feng J, et al. Dialysis after lung transplantation: prevalence, risk factors and outcome. J Heart Lung Transplant, 2007, 26(11): 1155-1162.
18.	Issa N, Kukla A, Ibrahim HN. Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. Am J Nephrol, 2013, 37(6): 602-612.
19.	Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol, 2018, 14(4): 217-230.
20.	White LE, Hassoun HT. Inflammatory mechanisms of organ crosstalk during ischemic acute kidney injury. Int J Nephrol, 2012, 2012: 505197.
21.	Zahir H, McCaughan G, Gleeson M, et al. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br J Clin Pharmacol, 2004, 57(3): 298-309.
22.	Selewski DT, Wille KM. Continuous renal replacement therapy in patients treated with extracorporeal membrane oxygenation. Semin Dial, 2021, 34(6): 537-549.
23.	Askenazi DJ, Selewski DT, Paden ML, et al. Renal replacement therapy in critically ill patients receiving extracorporeal membrane oxygenation. Clin J Am Soc Nephrol, 2012, 7(8): 1328-1336.
24.	Cheng R, Hachamovitch R, Kittleson M, et al. Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: a meta-analysis of 1, 866 adult patients. Ann Thorac Surg, 2014, 97(2): 610-616.
25.	Deatrick KB, Mazzeffi MA, Galvagno SM Jr. , et al. Breathing life back into the kidney-continuous renal replacement therapy and veno-venous extracorporeal membrane oxygenation. ASAIO J, 2021, 67(2): 208-212.
26.	Fleming GM, Askenazi DJ, Bridges BC, et al. A multicenter international survey of renal supportive therapy during ECMO: the Kidney Intervention During Extracorporeal Membrane Oxygenation (KIDMO) group. ASAIO J, 2012, 58(4): 407-414.
27.	Damman K, van Deursen VM, Navis G, et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol, 2009, 53(7): 582-588.
28.	Vonk-Noordegraaf A, Marcus JT, Gan CT, et al. Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling. Chest, 2005, 128(6 Suppl): 628S-630S.
29.	Tudorache I, Sommer W, Kuhn C, et al. Lung transplantation for severe pulmonary hypertension-awake extracorporeal membrane oxygenation for postoperative left ventricular remodelling. Transplantation, 2015, 99(2): 451-458.
30.	Yusen RD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant, 2015, 34(10): 1264-1277.
31.	Bagshaw SM, Wald R. Strategies for the optimal timing to start renal replacement therapy in critically ill patients with acute kidney injury. Kidney Int, 2017, 91(5): 1022-1032.
32.	Kellum JA, Ronco C. The 17th Acute Disease Quality Initiative International Consensus Conference: Introducing Precision Renal Replacement Therapy. Blood Purif, 2016, 42(3): 221-223.
33.	Hadjiliadis D, Chaparro C, Reinsmoen NL, et al. Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study. J Heart Lung Transplant, 2005, 24(7 Suppl): S249-S254.
34.	Snyder LD, Gray AL, Reynolds JM, et al. Antibody desensitization therapy in highly sensitized lung transplant candidates. Am J Transplant, 2014, 14(4): 849-856.
35.	Krutsinger D, Pezzulo A, Blevins AE, et al. Idiopathic hyperammonemia after solid organ transplantation: Primarily a lung problem? A single-center experience and systematic review. Clin Transplant, 2017, 31(5): e12957.
36.	Chan PG, Kusztos A, Thorngren C, et al. Emergent plasmapheresis for hyperammonemia in a re-do double lung transplant patient. Ann Thorac Surg, 2021, 112(1): e45-e47.
37.	Larsen FS, Schmidt LE, Bernsmeier C, et al. High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial. J Hepatol, 2016, 64(1): 69-78.
38.	Iskender I, Arni S, Maeyashiki T, et al. Perfusate adsorption during ex vivo lung perfusion improves early post-transplant lung function. J Thorac Cardiovasc Surg, 2021, 161(2): e109-e121.
39.	Machuca TN, Cypel M, Yeung JC, et al. Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion. Ann Surg, 2015, 261(3): 591-597.

1. Chambers DC, Perch M, Zuckermann A, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report-2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
2. Puttarajappa CM, Bernardo JF, Kellum JA. Renal Complications Following Lung Transplantation and Heart Transplantation. Crit Care Clin, 2019, 35(1): 61-73.
3. Benazzo A, Bajorek L, Morscher A, et al. Early implementation of renal replacement therapy after lung transplantation does not impair long-term kidney function in patients with idiopathic pulmonary arterial hypertension. J Thorac Cardiovasc Surg, 2022, 163(2): 524-535.e523.
4. Di Nardo M, Tikkanen J, Husain S, et al. Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit. Anesthesiology, 2022, 136(3): 482-499.
5. Lertjitbanjong P, Thongprayoon C, Cheungpasitporn W, et al. Acute kidney injury after lung transplantation: a systematic review and meta-analysis. J Clin Med, 2019, 8(10): 1713.
6. Thongprayoon C, Lertjitbanjong P, Hansrivijit P, et al. Acute kidney injury in patients undergoing cardiac transplantation: a meta-analysis. Medicines (Basel), 2019, 6(4): 108.
7. Egan TM, Edwards LB. Effect of the lung allocation score on lung transplantation in the United States. J Heart Lung Transplant, 2016, 35(4): 433-439.
8. Jing L, Chen W, Guo L, et al. Acute kidney injury after lung transplantation: a narrative review. Ann Transl Med, 2021, 9(8): 717.
9. Bihorac A, Delano MJ, Schold JD, et al. Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg, 2010, 252(1): 158-165.
10. Nuis RJ, Rodes-Cabau J, Sinning JM, et al. Blood transfusion and the risk of acute kidney injury after transcatheter aortic valve implantation. Circ Cardiovasc Interv, 2012, 5(5): 680-688.
11. Piffaretti G, Mariscalco G, Bonardelli S, et al. Predictors and outcomes of acute kidney injury after thoracic aortic endograft repair. J Vasc Surg, 2012, 56(6): 1527-1534.
12. Kindzelski BA, Corcoran P, Siegenthaler MP, et al. Postoperative acute kidney injury following intraoperative blood product transfusions during cardiac surgery. Perfusion, 2018, 33(1): 62-70.
13. Querrey M, Chiu S, Lecuona E, et al. CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation. J Clin Invest, 2022, 132(14): e157262.
14. Ghaidan H, Stenlo M, Niroomand A, et al. Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation. Nat Commun, 2022, 13(1): 4173.
15. Chen-Yoshikawa TF. Ischemia-reperfusion injury in lung transplantation. Cells, 2021, 10(6): 1333.
16. Sikma MA, Hunault CC, van de Graaf EA, et al. High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury. Eur J Clin Pharmacol, 2017, 73(5): 573-580.
17. Mason DP, Solovera-Rozas M, Feng J, et al. Dialysis after lung transplantation: prevalence, risk factors and outcome. J Heart Lung Transplant, 2007, 26(11): 1155-1162.
18. Issa N, Kukla A, Ibrahim HN. Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. Am J Nephrol, 2013, 37(6): 602-612.
19. Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol, 2018, 14(4): 217-230.
20. White LE, Hassoun HT. Inflammatory mechanisms of organ crosstalk during ischemic acute kidney injury. Int J Nephrol, 2012, 2012: 505197.
21. Zahir H, McCaughan G, Gleeson M, et al. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br J Clin Pharmacol, 2004, 57(3): 298-309.
22. Selewski DT, Wille KM. Continuous renal replacement therapy in patients treated with extracorporeal membrane oxygenation. Semin Dial, 2021, 34(6): 537-549.
23. Askenazi DJ, Selewski DT, Paden ML, et al. Renal replacement therapy in critically ill patients receiving extracorporeal membrane oxygenation. Clin J Am Soc Nephrol, 2012, 7(8): 1328-1336.
24. Cheng R, Hachamovitch R, Kittleson M, et al. Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: a meta-analysis of 1, 866 adult patients. Ann Thorac Surg, 2014, 97(2): 610-616.
25. Deatrick KB, Mazzeffi MA, Galvagno SM Jr. , et al. Breathing life back into the kidney-continuous renal replacement therapy and veno-venous extracorporeal membrane oxygenation. ASAIO J, 2021, 67(2): 208-212.
26. Fleming GM, Askenazi DJ, Bridges BC, et al. A multicenter international survey of renal supportive therapy during ECMO: the Kidney Intervention During Extracorporeal Membrane Oxygenation (KIDMO) group. ASAIO J, 2012, 58(4): 407-414.
27. Damman K, van Deursen VM, Navis G, et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol, 2009, 53(7): 582-588.
28. Vonk-Noordegraaf A, Marcus JT, Gan CT, et al. Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling. Chest, 2005, 128(6 Suppl): 628S-630S.
29. Tudorache I, Sommer W, Kuhn C, et al. Lung transplantation for severe pulmonary hypertension-awake extracorporeal membrane oxygenation for postoperative left ventricular remodelling. Transplantation, 2015, 99(2): 451-458.
30. Yusen RD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant, 2015, 34(10): 1264-1277.
31. Bagshaw SM, Wald R. Strategies for the optimal timing to start renal replacement therapy in critically ill patients with acute kidney injury. Kidney Int, 2017, 91(5): 1022-1032.
32. Kellum JA, Ronco C. The 17th Acute Disease Quality Initiative International Consensus Conference: Introducing Precision Renal Replacement Therapy. Blood Purif, 2016, 42(3): 221-223.
33. Hadjiliadis D, Chaparro C, Reinsmoen NL, et al. Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study. J Heart Lung Transplant, 2005, 24(7 Suppl): S249-S254.
34. Snyder LD, Gray AL, Reynolds JM, et al. Antibody desensitization therapy in highly sensitized lung transplant candidates. Am J Transplant, 2014, 14(4): 849-856.
35. Krutsinger D, Pezzulo A, Blevins AE, et al. Idiopathic hyperammonemia after solid organ transplantation: Primarily a lung problem? A single-center experience and systematic review. Clin Transplant, 2017, 31(5): e12957.
36. Chan PG, Kusztos A, Thorngren C, et al. Emergent plasmapheresis for hyperammonemia in a re-do double lung transplant patient. Ann Thorac Surg, 2021, 112(1): e45-e47.
37. Larsen FS, Schmidt LE, Bernsmeier C, et al. High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial. J Hepatol, 2016, 64(1): 69-78.
38. Iskender I, Arni S, Maeyashiki T, et al. Perfusate adsorption during ex vivo lung perfusion improves early post-transplant lung function. J Thorac Cardiovasc Surg, 2021, 161(2): e109-e121.
39. Machuca TN, Cypel M, Yeung JC, et al. Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion. Ann Surg, 2015, 261(3): 591-597.

Previous Article
The present research status on pulmonary infections after lung transplantation
Next Article
Rehabilitation experience of lung transplant patients with tracheostomy

Chinese Journal of Respiratory and Critical Care Medicine

The application of blood purification in lung transplantation

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content