Chronic cough and risk of cerebrovascular disease: a prospective cohort study_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Zhenbin ¹ , YANG Xiaoxia ² , CHEN Min ³ , LIU Tao ³ , TIAN Kunming ² ,  DENG Renli ⁴

1. Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P. R. China;
2. Department of Preventive Medicine, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563006, P. R. China;
3. Department of Chronic Disease Prevention and Control, Guiyang, Guizhou 550004, P. R. China;
4. Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 519000, P. R. China;

Corresponding author：

DENG Renli, Email: renli_deng@163.com

Keywords：

Chronic cough; cerebrovascular disease; risk; cohort study

DOI：

10.7507/1671-6205.202209065

Video：

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Objective To explore the association between cough patterns and cerebrovascular disease risk, and to provide epidemiological evidence for the early diagnosis and prevention of cerebrovascular disease. Methods During the period from 2010 to 2012 in Guizhou Province, a multi-stage proportional stratified cluster sampling method was used to recruit people with the inclusion criteria of the study into a cohort and a baseline questionnaire for demographic information, lifestyle, and disease history was administered. The incidence of cerebrovascular disease was followed up from 2016 to 2020. Results A total of 4804 subjects were followed up, and 4589 (53.5% were female) subjects were enrolled in final investigation. Compared with non-chronic cough group, there was no statistical significance in the risk of cerebrovascular diseases (P>0.05), however, chronic cough (the risk ratio was 2.00 and the 95% confidence interval ranged from 1.08 to 3.69) was twice as likely to develop cerebrovascular disease as non-cough. Conclusions People with chronic cough are more likely to develop cerebrovascular disease than people without cough. More attention to the management and control of cough should be paid to avoid chronic cough, so as to reduce the risk of cerebrovascular diseases.

Citation： ZHU Zhenbin, YANG Xiaoxia, CHEN Min, LIU Tao, TIAN Kunming, DENG Renli. Chronic cough and risk of cerebrovascular disease: a prospective cohort study. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(5): 343-348. doi: 10.7507/1671-6205.202209065 Copy

1.	金建秋, 李伟, 母艳蕾, 等. 脑血管病患者出现口腔黏膜病的调查分析. 中华流行病学杂志, 2019, 40(8): 1003-1005.
2.	中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑血管疾病分类2015. 中华神经科杂志, 2017, 50(3): 168-171.
3.	彭琴, 李海玲, 王媛, 等. 1990-2016年中国人群脑血管病疾病负担变化趋势. 中华流行病学杂志, 2019, 40(4): 400-405.
4.	钱丹, 潘华, 刘维洲, 等. 2016—2018年铜陵市心脑血管疾病死亡及潜在减寿情况分析. 中国公共卫生管理, 2021, 37(4): 494-497+505.
5.	The GBD 2016 Lifetime Risk of Stroke Collaborators; Feigin VL, Nguyen G, Cercy K, et al. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. N Engl J Med, 2018, 379(25): 2429-2437.
6.	Ma QF, Li R, Wang LJ, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 2021, 6(12): e897-e906.
7.	Wu SM, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394–405.
8.	Chao BH, Yan F, Hua Y, et al. Stroke prevention and control system in China: CSPPC-Stroke Program. Int J Stroke, 2021, 16(3): 265-272.
9.	王拥军, 李子孝, 谷鸿秋, 等. 中国卒中报告2019(中文版)(3). 中国卒中杂志, 2020, 15(12): 1251-1263.
10.	McGarvey L, Gibson PG. What is chronic cough? Terminology. J Allergy Clin Immunol Pract, 2019, 7(6): 1711-1714.
11.	刘英丽. 咳嗽性晕厥病因及发病机制探究[D]. 郑州大学, 2018.
12.	杨中华. Neurology: 咳嗽诱发持续性高颅压. 中国卒中杂志, 2019, 14(10): 1045-1046.
13.	Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax, 2010, 65(11): 956-962.
14.	Stavem K, Schirmer H, Gulsvik A. Respiratory symptoms and cardiovascular causes of deaths: a population-based study with 45 years of follow-up. PLoS One, 2022, 17(10): e0276560.
15.	吉宁飞, 蒋雄斌, 黄茂. 老年人慢性咳嗽的病因构成和临床分析. 实用老年医学, 2012, 26(5): 377-379.
16.	王丽敏, 张梅, 李镒冲, 等. 2013年中国慢性病及其危险因素监测总体方案. 中华预防医学杂志, 2018, 52(2): 191-194.
17.	赵文华, 宁光. 2010年中国慢性病监测项目的内容与方法. 中华预防医学杂志, 2012, 46(5): 477-479.
18.	《中国脑卒中防治报告2019》编写组. 《中国脑卒中防治报告2019》概要. 中国脑血管病杂志, 2020, 17(5): 272-281.
19.	《中国高血压防治指南》修订委员会. 中国高血压防治指南2018年修订版. 心脑血管病防治, 2019, 19(1): 1-44.
20.	中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版). 中华健康管理学杂志, 2017, 11(1): 7-28.
21.	De Torres JP, Cordoba-Lanus E, López-Aguilar C, et al. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. Eur Respir J, 2006, 27(5): 902-907.
22.	Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice?. Ther Adv Respir Dis, 2018, 12: 1753465817750524.
23.	Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic inflammation and oxidative stress the missing links?. Clin Sci (Lond), 2016, 130(13): 1039-1050.
24.	Swystun LL, Liaw PC. The role of leukocytes in thrombosis. Blood, 2016, 128(6): 753-762.
25.	陆子华. 高血压是怎么引起脑梗死的. 人人健康, 2021(23): 25.
26.	Imano H, Kitamura A, Sato S, et al. Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the Circulatory Risk in Communities Study (CIRCS). Stroke, 2009, 40(5): 1571-1577.
27.	Melbye H, Stylidis M, Solis JCA, et al. Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study. ESC Heart Fail, 2020, 7(6): 4139-4150.
28.	Lahousse L, Verhamme KM, Stricker BH, et al. Cardiac effects of current treatments of chronic obstructive pulmonary disease. Lancet Respir Med, 2016, 4(2): 149-164.
29.	张涵泊, 周卓星. 脑血管病诊治中血脂检验的应用效果研究. 微量元素与健康研究, 2022, 39(1): 71-72.

1. 金建秋, 李伟, 母艳蕾, 等. 脑血管病患者出现口腔黏膜病的调查分析. 中华流行病学杂志, 2019, 40(8): 1003-1005.
2. 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑血管疾病分类2015. 中华神经科杂志, 2017, 50(3): 168-171.
3. 彭琴, 李海玲, 王媛, 等. 1990-2016年中国人群脑血管病疾病负担变化趋势. 中华流行病学杂志, 2019, 40(4): 400-405.
4. 钱丹, 潘华, 刘维洲, 等. 2016—2018年铜陵市心脑血管疾病死亡及潜在减寿情况分析. 中国公共卫生管理, 2021, 37(4): 494-497+505.
5. The GBD 2016 Lifetime Risk of Stroke Collaborators; Feigin VL, Nguyen G, Cercy K, et al. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. N Engl J Med, 2018, 379(25): 2429-2437.
6. Ma QF, Li R, Wang LJ, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 2021, 6(12): e897-e906.
7. Wu SM, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394–405.
8. Chao BH, Yan F, Hua Y, et al. Stroke prevention and control system in China: CSPPC-Stroke Program. Int J Stroke, 2021, 16(3): 265-272.
9. 王拥军, 李子孝, 谷鸿秋, 等. 中国卒中报告2019(中文版)(3). 中国卒中杂志, 2020, 15(12): 1251-1263.
10. McGarvey L, Gibson PG. What is chronic cough? Terminology. J Allergy Clin Immunol Pract, 2019, 7(6): 1711-1714.
11. 刘英丽. 咳嗽性晕厥病因及发病机制探究[D]. 郑州大学, 2018.
12. 杨中华. Neurology: 咳嗽诱发持续性高颅压. 中国卒中杂志, 2019, 14(10): 1045-1046.
13. Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax, 2010, 65(11): 956-962.
14. Stavem K, Schirmer H, Gulsvik A. Respiratory symptoms and cardiovascular causes of deaths: a population-based study with 45 years of follow-up. PLoS One, 2022, 17(10): e0276560.
15. 吉宁飞, 蒋雄斌, 黄茂. 老年人慢性咳嗽的病因构成和临床分析. 实用老年医学, 2012, 26(5): 377-379.
16. 王丽敏, 张梅, 李镒冲, 等. 2013年中国慢性病及其危险因素监测总体方案. 中华预防医学杂志, 2018, 52(2): 191-194.
17. 赵文华, 宁光. 2010年中国慢性病监测项目的内容与方法. 中华预防医学杂志, 2012, 46(5): 477-479.
18. 《中国脑卒中防治报告2019》编写组. 《中国脑卒中防治报告2019》概要. 中国脑血管病杂志, 2020, 17(5): 272-281.
19. 《中国高血压防治指南》修订委员会. 中国高血压防治指南2018年修订版. 心脑血管病防治, 2019, 19(1): 1-44.
20. 中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版). 中华健康管理学杂志, 2017, 11(1): 7-28.
21. De Torres JP, Cordoba-Lanus E, López-Aguilar C, et al. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. Eur Respir J, 2006, 27(5): 902-907.
22. Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice?. Ther Adv Respir Dis, 2018, 12: 1753465817750524.
23. Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic inflammation and oxidative stress the missing links?. Clin Sci (Lond), 2016, 130(13): 1039-1050.
24. Swystun LL, Liaw PC. The role of leukocytes in thrombosis. Blood, 2016, 128(6): 753-762.
25. 陆子华. 高血压是怎么引起脑梗死的. 人人健康, 2021(23): 25.
26. Imano H, Kitamura A, Sato S, et al. Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the Circulatory Risk in Communities Study (CIRCS). Stroke, 2009, 40(5): 1571-1577.
27. Melbye H, Stylidis M, Solis JCA, et al. Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study. ESC Heart Fail, 2020, 7(6): 4139-4150.
28. Lahousse L, Verhamme KM, Stricker BH, et al. Cardiac effects of current treatments of chronic obstructive pulmonary disease. Lancet Respir Med, 2016, 4(2): 149-164.
29. 张涵泊, 周卓星. 脑血管病诊治中血脂检验的应用效果研究. 微量元素与健康研究, 2022, 39(1): 71-72.

Chinese Journal of Respiratory and Critical Care Medicine

Chronic cough and risk of cerebrovascular disease: a prospective cohort study

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