高海拔旅行相关静脉血栓栓塞症研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

程渊 ^1,2 , 赤列群措 ¹ , PUBU Zhuoga ¹ , BIAN Qiongda ¹ ,  MMEILANG Chutso ¹ , CHEN Huailei ¹ , BIANMA Cuo ¹

1. ;
2. ;

Corresponding author：

MMEILANG Chutso, Email: meilang2008@126.com

Keywords：

DOI：

10.7507/1671-6205.202210066

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Citation： PUBU Zhuoga, BIAN Qiongda, MMEILANG Chutso, CHEN Huailei, BIANMA Cuo. 高海拔旅行相关静脉血栓栓塞症研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(2): 142-147. doi: 10.7507/1671-6205.202210066 Copy

1.	Luks AM, Hackett PH. Medical conditions and high-altitude travel. N Engl J Med, 2022, 386(4): 364-373.
2.	Cymerman A, Rock PB. Medical Problems in High Mountain Environments. A Handbook for Medical Officers. National Academies Press (US): Washington (DC), 1994.
3.	马四清, 吴天一, 张雪峰, 主编. 急性重症高原病与多器官功能障碍综合征. 人民卫生出版社: 北京, 2014.
4.	周语嫣, 梁斌苗, 梁宗安. 高空、高原、地下空间环境对呼吸功能的影响. 中国呼吸与危重监护杂志, 2020, 19(2): 198-202.
5.	Higgins JP, Tuttle T, Higgins JA. Altitude and the heart: is going high safe for your cardiac patient?. Am Heart J, 2010, 159(1): 25-32.
6.	Richalet JP, Larmignat P, Poitrine E, et al. Physiological risk factors for severe high-altitude illness: a prospective cohort study. Am J Respir Crit Care Med, 2012, 185(2): 192-198.
7.	Anand AC, Saha A, Kumar R, et al. Portal system thrombosis: a new dimension of high altitude illnesses. Trop Gastroenterol, 2000, 21(4): 172-173.
8.	Ashraf HM, Javed A, Ashraf S. Pulmonary embolism at high altitude and hyperhomocysteinemia. J Coll Physicians Surg Pak, 2006, 16(1): 71-73.
9.	Anand AC, Jha SK, Saha A, et al. Thrombosis as a complication of extended stay at high altitude. Natl Med J India, 2001, 14(4): 197-201.
10.	Smallman DP, McBratney CM, Olsen CH, et al. Quantification of the 5-year incidence of thromboembolic events in U. S. Air Force Academy cadets in comparison to the U. S. Naval and Military Academies. Mil Med, 2011, 176(2): 209-213.
11.	Cancienne JM, Diduch DR, Werner BC. High altitude is an independent risk factor for postoperative symptomatic venous thromboembolism after knee arthroscopy: a matched case-control study of medicare patients. Arthroscopy, 2017, 33(2): 422-427.
12.	Yang HH, Yang G, Xu ML, et al. Impact of high altitude on the incidence of postoperative venous thromboembolism and its genetic susceptibility: a meta-analysis and systematic review. Sci Total Environ, 2022, 838(Pt 4): 156632.
13.	Presti B, Berthrong M, Sherwin RM. Chronic thrombosis of major pulmonary arteries. Hum Pathol, 1990, 21(6): 601-606.
14.	Dutta V, Singh R, Kumar S, et al. Profile of pulmonary embolism in service personnel posted at high altitude area. Indian Heart J, 2018, 70(3): 427-429.
15.	Khalil KF, Saeed W. Pulmonary embolism in soldiers serving at high altitude. J Coll Physicians Surg Pak, 2010, 20(7): 468-471.
16.	Khan DA, Hashim R, Mirza TM, et al. Differentiation of pulmonary embolism from high altitude pulmonary edema. J Coll Physicians Surg Pak, 2003, 13(5): 267-270.
17.	Wu JL, Han XB, Ke HW, et al. Pulmonary embolism at extreme high altitude: a study of seven cases. High Alt Med Biol, 2022, 23(3): 209-214.
18.	Chandra D, Parisini E, Mozaffarian D. Meta-analysis: travel and risk for venous thromboembolism. Ann Intern Med, 2009, 151(3): 180-190.
19.	Schreijer AJ, Cannegieter SC, Doggen CJ, et al. The effect of flight-related behaviour on the risk of venous thrombosis after air travel. Br J Haematol, 2009, 144(3): 425-429.
20.	Belcaro G, Geroulakos G, Nicolaides AN, et al. Venous thromboembolism from air travel: the LONFLIT study. Angiology, 2001, 52(6): 369-374.
21.	Schreijer AJ, Cannegieter SC, Meijers JC, et al. Activation of coagulation system during air travel: a crossover study. Lancet, 2006, 367(9513): 832-838.
22.	Toff WD, Jones CI, Ford I, et al. Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation. JAMA, 2006, 295(19): 2251-2261.
23.	Watson HG, Baglin TP. Guidelines on travel-related venous thrombosis. Br J Haematol, 2011, 152(1): 31-34.
24.	Kotwal J, Apte CV, Kotwal A, et al. High altitude: a hypercoagulable state: results of a prospective cohort study. Thromb Res, 2007, 120(3): 391-397.
25.	Bhatt VR. Secondary polycythemia and the risk of venous thromboembolism. J Clin Med Res, 2014, 6(5): 395-397.
26.	Gertler JP, Perry L, L'Italien G, et al. Ambient oxygen tension modulates endothelial fibrinolysis. J Vasc Surg, 1993, 18(6): 939-945; discussion 945-946.
27.	Pichler Hefti J, Risch L, Hefti U, et al. Changes of coagulation parameters during high altitude expedition. Swiss Med Wkly, 2010, 140(7-8): 111-117.
28.	DeLoughery TG, Robertson DG, Smith CA, et al. Moderate hypoxia suppresses exercise-induced procoagulant changes. Br J Haematol, 2004, 125(3): 369-372.
29.	Mercer JB, Østerud B, Tveita T. The effect of short-term cold exposure on risk factors for cardiovascular disease. Thromb Res, 1999, 95(2): 93-104.
30.	Nagelkirk PR, Hogan KB, Hoare JM. Ambient temperature affects thrombotic potential at rest and following exercise. Thromb Res, 2012, 130(2): 248-252.
31.	Johannesdottir SA, Horváth-Puhó E, Dekkers OM, et al. Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study. JAMA Intern Med, 2013, 173(9): 743-752.
32.	Cushman M, Tsai AW, White RH, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med, 2004, 117(1): 19-25.
33.	Jha PK, Sahu A, Prabhakar A, et al. Genome-wide expression analysis suggests hypoxia-triggered hyper-coagulation leading to venous thrombosis at high altitude. Thromb Haemost, 2018, 118(7): 1279-1295.
34.	Shang CX, Wuren T, Ga Q, et al. The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude. Platelets, 2020, 31(1): 33-42.
35.	Trunk AD, Rondina MT, Kaplan DA. Venous thromboembolism at high altitude: our approach to patients at risk. High Alt Med Biol, 2019, 20(4): 331-336.
36.	Tyagi T, Ahmad S, Gupta N, et al. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood, 2014, 123(8): 1250-1260.
37.	蔡婷婷, 达娃次仁, 周红恩, 等. 高原地区不同海拔高度急性肺栓塞临床特征分析. 中华结核和呼吸杂志, 2019, 42(10): 755-759.
38.	Zafren K, Feldman J, Becker RJ, et al. D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340 m: the Mount Everest Deep Venous Thrombosis Study (Ev-DVT). High Alt Med Biol, 2011, 12(3): 223-227.
39.	Gupta N, Sahu A, Prabhakar A, et al. Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci U S A, 2017, 114(18): 4763-4768.
40.	Gupta N, Ashraf MZ. Exposure to high altitude: a risk factor for venous thromboembolism?. Semin Thromb Hemost, 2012, 38(2): 156-163.
41.	Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2 Suppl): e195S-e226S.
42.	Lapostolle F, Le Toumelin P, Chassery C, et al. Gender as a risk factor for pulmonary embolism after air travel. Thromb Haemost, 2009, 102(6): 1165-1168.
43.	Kuipers S, Cannegieter SC, Middeldorp S, et al. The absolute risk of venous thrombosis after air travel: a cohort study of 8, 755 employees of international organisations. PLoS Med, 2007, 4(9): e290.
44.	Nair V, Mohapatro AK, Sreedhar M, et al. A case of hereditary protein S deficiency presenting with cerebral sinus venous thrombosis and deep vein thrombosis at high altitude. Acta Haematol, 2008, 119(3): 158-161.
45.	Ridker PM, Miletich JP, Hennekens CH, et al. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA, 1997, 277(16): 1305-1307.
46.	Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost, 1998, 79(4): 706-708.
47.	Zivelin A, Rosenberg N, Faier S, et al. A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene. Blood, 1998, 92(4): 1119-1124.
48.	Clarke M, Hopewell S, Juszczak E, et al. Compression stockings for preventing deep vein thrombosis in airline passengers. Cochrane Database Syst Rev, 2006, (2): CD004002.
49.	Cesarone MR, Belcaro G, Nicolaides AN, et al. Venous thrombosis from air travel: the LONFLIT3 study-prevention with aspirin vs low-molecular-weight heparin (LMWH) in high-risk subjects: a randomized trial. Angiology, 2002, 53(1): 1-6.
50.	Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J, 2019, 54(3): 1901647.
51.	Weitz JI, Lensing AWA, Prins MH, et al. Rivaroxaban or aspirin for extended treatment of venous thromboembolism. N Engl J Med, 2017, 376(13): 1211-1222.

1. Luks AM, Hackett PH. Medical conditions and high-altitude travel. N Engl J Med, 2022, 386(4): 364-373.
2. Cymerman A, Rock PB. Medical Problems in High Mountain Environments. A Handbook for Medical Officers. National Academies Press (US): Washington (DC), 1994.
3. 马四清, 吴天一, 张雪峰, 主编. 急性重症高原病与多器官功能障碍综合征. 人民卫生出版社: 北京, 2014.
4. 周语嫣, 梁斌苗, 梁宗安. 高空、高原、地下空间环境对呼吸功能的影响. 中国呼吸与危重监护杂志, 2020, 19(2): 198-202.
5. Higgins JP, Tuttle T, Higgins JA. Altitude and the heart: is going high safe for your cardiac patient?. Am Heart J, 2010, 159(1): 25-32.
6. Richalet JP, Larmignat P, Poitrine E, et al. Physiological risk factors for severe high-altitude illness: a prospective cohort study. Am J Respir Crit Care Med, 2012, 185(2): 192-198.
7. Anand AC, Saha A, Kumar R, et al. Portal system thrombosis: a new dimension of high altitude illnesses. Trop Gastroenterol, 2000, 21(4): 172-173.
8. Ashraf HM, Javed A, Ashraf S. Pulmonary embolism at high altitude and hyperhomocysteinemia. J Coll Physicians Surg Pak, 2006, 16(1): 71-73.
9. Anand AC, Jha SK, Saha A, et al. Thrombosis as a complication of extended stay at high altitude. Natl Med J India, 2001, 14(4): 197-201.
10. Smallman DP, McBratney CM, Olsen CH, et al. Quantification of the 5-year incidence of thromboembolic events in U. S. Air Force Academy cadets in comparison to the U. S. Naval and Military Academies. Mil Med, 2011, 176(2): 209-213.
11. Cancienne JM, Diduch DR, Werner BC. High altitude is an independent risk factor for postoperative symptomatic venous thromboembolism after knee arthroscopy: a matched case-control study of medicare patients. Arthroscopy, 2017, 33(2): 422-427.
12. Yang HH, Yang G, Xu ML, et al. Impact of high altitude on the incidence of postoperative venous thromboembolism and its genetic susceptibility: a meta-analysis and systematic review. Sci Total Environ, 2022, 838(Pt 4): 156632.
13. Presti B, Berthrong M, Sherwin RM. Chronic thrombosis of major pulmonary arteries. Hum Pathol, 1990, 21(6): 601-606.
14. Dutta V, Singh R, Kumar S, et al. Profile of pulmonary embolism in service personnel posted at high altitude area. Indian Heart J, 2018, 70(3): 427-429.
15. Khalil KF, Saeed W. Pulmonary embolism in soldiers serving at high altitude. J Coll Physicians Surg Pak, 2010, 20(7): 468-471.
16. Khan DA, Hashim R, Mirza TM, et al. Differentiation of pulmonary embolism from high altitude pulmonary edema. J Coll Physicians Surg Pak, 2003, 13(5): 267-270.
17. Wu JL, Han XB, Ke HW, et al. Pulmonary embolism at extreme high altitude: a study of seven cases. High Alt Med Biol, 2022, 23(3): 209-214.
18. Chandra D, Parisini E, Mozaffarian D. Meta-analysis: travel and risk for venous thromboembolism. Ann Intern Med, 2009, 151(3): 180-190.
19. Schreijer AJ, Cannegieter SC, Doggen CJ, et al. The effect of flight-related behaviour on the risk of venous thrombosis after air travel. Br J Haematol, 2009, 144(3): 425-429.
20. Belcaro G, Geroulakos G, Nicolaides AN, et al. Venous thromboembolism from air travel: the LONFLIT study. Angiology, 2001, 52(6): 369-374.
21. Schreijer AJ, Cannegieter SC, Meijers JC, et al. Activation of coagulation system during air travel: a crossover study. Lancet, 2006, 367(9513): 832-838.
22. Toff WD, Jones CI, Ford I, et al. Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation. JAMA, 2006, 295(19): 2251-2261.
23. Watson HG, Baglin TP. Guidelines on travel-related venous thrombosis. Br J Haematol, 2011, 152(1): 31-34.
24. Kotwal J, Apte CV, Kotwal A, et al. High altitude: a hypercoagulable state: results of a prospective cohort study. Thromb Res, 2007, 120(3): 391-397.
25. Bhatt VR. Secondary polycythemia and the risk of venous thromboembolism. J Clin Med Res, 2014, 6(5): 395-397.
26. Gertler JP, Perry L, L'Italien G, et al. Ambient oxygen tension modulates endothelial fibrinolysis. J Vasc Surg, 1993, 18(6): 939-945; discussion 945-946.
27. Pichler Hefti J, Risch L, Hefti U, et al. Changes of coagulation parameters during high altitude expedition. Swiss Med Wkly, 2010, 140(7-8): 111-117.
28. DeLoughery TG, Robertson DG, Smith CA, et al. Moderate hypoxia suppresses exercise-induced procoagulant changes. Br J Haematol, 2004, 125(3): 369-372.
29. Mercer JB, Østerud B, Tveita T. The effect of short-term cold exposure on risk factors for cardiovascular disease. Thromb Res, 1999, 95(2): 93-104.
30. Nagelkirk PR, Hogan KB, Hoare JM. Ambient temperature affects thrombotic potential at rest and following exercise. Thromb Res, 2012, 130(2): 248-252.
31. Johannesdottir SA, Horváth-Puhó E, Dekkers OM, et al. Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study. JAMA Intern Med, 2013, 173(9): 743-752.
32. Cushman M, Tsai AW, White RH, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med, 2004, 117(1): 19-25.
33. Jha PK, Sahu A, Prabhakar A, et al. Genome-wide expression analysis suggests hypoxia-triggered hyper-coagulation leading to venous thrombosis at high altitude. Thromb Haemost, 2018, 118(7): 1279-1295.
34. Shang CX, Wuren T, Ga Q, et al. The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude. Platelets, 2020, 31(1): 33-42.
35. Trunk AD, Rondina MT, Kaplan DA. Venous thromboembolism at high altitude: our approach to patients at risk. High Alt Med Biol, 2019, 20(4): 331-336.
36. Tyagi T, Ahmad S, Gupta N, et al. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood, 2014, 123(8): 1250-1260.
37. 蔡婷婷, 达娃次仁, 周红恩, 等. 高原地区不同海拔高度急性肺栓塞临床特征分析. 中华结核和呼吸杂志, 2019, 42(10): 755-759.
38. Zafren K, Feldman J, Becker RJ, et al. D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340 m: the Mount Everest Deep Venous Thrombosis Study (Ev-DVT). High Alt Med Biol, 2011, 12(3): 223-227.
39. Gupta N, Sahu A, Prabhakar A, et al. Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci U S A, 2017, 114(18): 4763-4768.
40. Gupta N, Ashraf MZ. Exposure to high altitude: a risk factor for venous thromboembolism?. Semin Thromb Hemost, 2012, 38(2): 156-163.
41. Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2 Suppl): e195S-e226S.
42. Lapostolle F, Le Toumelin P, Chassery C, et al. Gender as a risk factor for pulmonary embolism after air travel. Thromb Haemost, 2009, 102(6): 1165-1168.
43. Kuipers S, Cannegieter SC, Middeldorp S, et al. The absolute risk of venous thrombosis after air travel: a cohort study of 8, 755 employees of international organisations. PLoS Med, 2007, 4(9): e290.
44. Nair V, Mohapatro AK, Sreedhar M, et al. A case of hereditary protein S deficiency presenting with cerebral sinus venous thrombosis and deep vein thrombosis at high altitude. Acta Haematol, 2008, 119(3): 158-161.
45. Ridker PM, Miletich JP, Hennekens CH, et al. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA, 1997, 277(16): 1305-1307.
46. Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost, 1998, 79(4): 706-708.
47. Zivelin A, Rosenberg N, Faier S, et al. A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene. Blood, 1998, 92(4): 1119-1124.
48. Clarke M, Hopewell S, Juszczak E, et al. Compression stockings for preventing deep vein thrombosis in airline passengers. Cochrane Database Syst Rev, 2006, (2): CD004002.
49. Cesarone MR, Belcaro G, Nicolaides AN, et al. Venous thrombosis from air travel: the LONFLIT3 study-prevention with aspirin vs low-molecular-weight heparin (LMWH) in high-risk subjects: a randomized trial. Angiology, 2002, 53(1): 1-6.
50. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J, 2019, 54(3): 1901647.
51. Weitz JI, Lensing AWA, Prins MH, et al. Rivaroxaban or aspirin for extended treatment of venous thromboembolism. N Engl J Med, 2017, 376(13): 1211-1222.

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高海拔旅行相关静脉血栓栓塞症研究进展

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