阻塞性睡眠呼吸暂停低通气综合征的流行病学及临床研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

程建琴 ¹ , 赵丹 ^2,3 ,  张湘燕 ^2,3

1. ;
2. ;
3. ;

Corresponding author：

张湘燕, Email: zxy35762@126.com

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DOI：

10.7507/1671-6205.202211021

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Citation： 程建琴, 赵丹, 张湘燕. 阻塞性睡眠呼吸暂停低通气综合征的流行病学及临床研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(12): 899-903. doi: 10.7507/1671-6205.202211021 Copy

1.	何权瀛, 王莞尔. 阻塞性睡眠呼吸暂停低通气综合征诊治指南 (基层版). 中国呼吸与危重监护杂志, 2015, 14(4): 398-405.
2.	Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
3.	苏小凤, 刘霖, 仲琳, 等. 中国阻塞性睡眠呼吸暂停综合征患病率的 Meta 分析. 中国循证医学杂志, 2021, 21(10): 1187-1194.
4.	Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med, 2019, 7(8): 687-698.
5.	李学忠, 刘洪英, 蔡晓岚. 阻塞性睡眠呼吸暂停低通气综合征疾病管理认知度调查. 山东大学耳鼻喉眼学报, 2014, 28(4): 11-15.
6.	胡庆磊, 杜翠萍, 杨扬, 等. 上海市普陀区 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中国眼耳鼻喉科杂志, 2017, 17(1): 49-54.
7.	苏轶, 徐伟伟, 王向云, 等. 东营市东营区老年人阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 临床耳鼻咽喉头颈外科杂志, 2016, 30(4): 299-305.
8.	马恒杰, 吴京波, 张静, 等. 蓬莱市人群睡眠呼吸暂停综合征流行病学调查的研究. 中国卫生产业, 2017, 14(21): 1-2.
9.	邹小量, 朱胜华, 李多洛, 等. 邵阳市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征的流行病学调查. 中国现代医学杂志, 2007(8): 956-959.
10.	穆娅沙·塔衣尔, 曹媛媛, 朱晴, 等. 肥胖相关基因多态性与阻塞性睡眠呼吸暂停低通气综合征遗传易感性的关系. 医学研究杂志, 2022, 51(3): 62-68.
11.	郭娟. 分析阻塞性睡眠呼吸暂停低通气综合征与甲状腺功能减退症的关系. 世界睡眠医学杂志, 2022, 9(1): 158-160.
12.	Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation, 2021, 144(3): e56-e67.
13.	耿燕, 陈伟军, 徐锦, 等. 阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病相关性 Meta 分析. 浙江中西医结合杂志, 2021, 31(7): 660-663.
14.	吴丹, 余红, 张程, 等. 贵阳市567名驾驶员阻塞性睡眠呼吸暂停低通气综合征的流行病学调查. 医学信息, 2016, 29(32): 30-32.
15.	Shah AJ, Quek E, Alqahtani JS, et al. Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101627.
16.	Shawon MSR, Perret JL, Senaratna CV, et al. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev, 2017, 32: 58-68.
17.	张晓雷, 张慧, 高博, 等. 慢性阻塞性肺疾病与致纤维化型间质性肺疾病患者阻塞性睡眠呼吸暂停对比研究. 中国实用内科杂志, 2020, 40(4): 300-305.
18.	Lancaster LH, Mason WR, Parnell JA, et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 2009, 136(3): 772-778.
19.	Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med, 2011, 183(6): 788-824.
20.	Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis, 2009, 51(5): 363-370.
21.	Adir Y, Humbert M, Chaouat A. Sleep-related breathing disorders and pulmonary hypertension. Eur Respir , 2021, 57: 2002258.
22.	Alonso-Fernández A, de la Peña M, Romero D, et al. Association between obstructive sleep apnea and pulmonary embolism. Mayo Clin Proc, 2013, 88(6): 579-587.
23.	Peng YH, Liao WC, Chung WS, et al. Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res, 2014, 134(2): 340-345.
24.	Varol E, Ozturk O, Yucel H, et al. The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets, 2011, 22(7): 552-556.
25.	Prasad B, Nyenhuis SM, Imayama I, et al. Asthma and obstructive sleep apnea overlap: what has the evidence taught us? Am J Respir Crit Care Med, 2020, 201(11): 1345-1357.
26.	Cabezas E, Pérez-Warnisher MT, Troncoso MF, et al. Sleep disordered breathing is highly prevalent in patients with lung cancer: results of the sleep apnea in lung cancer study. Respiration, 2019, 97(2): 119-124.
27.	Kendzerska T, Leung RS, Hawker G, et al. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ, 2014, 186(13): 985-992.
28.	Gozal D, Farré R, Nieto F J. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest, 2015, 148(5): 1140-1147.
29.	Brenner R, Kivity S, Peker M, et al. Increased risk for cancer in young patients with severe obstructive sleep apnea. Respiration, 2019, 97(1): 15-23.
30.	Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med, 2009, 6(8): e1000132.
31.	Zinchuk A, Yaggi K, Wenlan Z, et al. Obstructive Sleep Apnea Increases the Risk of Diastolic Heart Failure: Results of a Large Population Study[M]//A77. EFFECT OF SLEEP DISORDERED BREATHING ON CARDIOMETABOLIC AND NEUROCOGNITIVE OUTCOMES. American Thoracic Society, 2018: A7694-A7694.
32.	苏小凤, 韩继明, 高莹卉, 等. 老年阻塞性睡眠呼吸暂停与代谢综合征各组分的相关性及其对远期不良心血管事件发生风险的影响. 南方医科大学学报, 2021, 41(11): 1592-1599.
33.	Traaen GM, Aakerøy L, Hunt TE, et al. Effect of continuous positive airway pressure on arrhythmia in atrial fibrillation and sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med, 2021, 204(5): 573-582.
34.	Baillieul S, Dekkers M, Brill AK, et al. Sleep apnoea and ischaemic stroke: current knowledge and future directions. Lancet Neurol, 2022, 21(1): 78-88.
35.	Seiler A, Camilo M, Korostovtseva L, et al. Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis. Neurology, 2019, 92(7): e648-e654.
36.	嵇朋, 孙根, 江利敏, 等. 阻塞性睡眠呼吸暂停低通气综合征与急性缺血性脑卒中预后的关系. 中华老年心脑血管病杂志, 2020, 22(12): 1297-1300.
37.	Owen JE, BenediktsdÓttir B, Gislason T, et al. Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea. Sleep, 2019, 42(1): zsy199.
38.	李东洙. 持续气道正压通气治疗2型糖尿病伴阻塞性睡眠呼吸暂停低通气综合征患者的疗效观察. 世界睡眠医学杂志, 2022, 9(3): 548-550.
39.	Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest, 2017, 152(5): 1070-1086.
40.	刘然, 陆菊明, 刘剑锋, 等. 2 型糖尿病患者阻塞性睡眠呼吸暂停综合征患病状况及相关因素分析. 中华老年心脑血管病杂志, 2013, 15(1): 29-31.
41.	李媛媛, 姚晓光, 蔡昕添, 等. 阻塞性睡眠呼吸暂停合并 2 型糖尿病患者 CAPA 治疗后对血糖影响的 meta 分析. 新疆医学, 2020, 50(3): 236-239.
42.	陈晶, 柯亭羽, 舒筠然, 等. 阻塞性睡眠呼吸暂停低通气综合征与甲状腺功能减退症的相关性研究进展. 医学综述, 2018, 24(23): 4705-4709.
43.	李友堂, 苏霞, 罗马长, 等. 阻塞性睡眠呼吸暂停综合征并胃食管反流病的分析及研究. 世界睡眠医学杂志, 2019, 6(10): 1455-1456.
44.	Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath, 2019, 23: 389-397.
45.	梁国良, 周志森, 杨智学, 等. 阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性研究. 中国医学创新, 2015, 12(29): 27-29.
46.	Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest, 2017, 152(2): 435-444.
47.	Zhang Y, Ren R, Lei F, et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med Rev, 2019, 45: 1-17.
48.	Edinger JD, Bonnet MH, Bootzin RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 2004, 27(8): 1567-1596.
49.	Luyster FS, Buysse DJ, Strollo Jr PJ. Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research. J Clin Sleep Med, 2010, 6(2): 196-204.
50.	Bertisch SM, Pollock BD, Mittleman MA, et al. Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study. Sleep, 2018, 41(6): zsy047.
51.	Kadono M, Hasegawa G. Insomnia disorder comorbid with diabetes. Nihon Rinsho, 2014, 72(5): 977-982.
52.	Smith S, Sullivan K, Hopkins W, et al. Frequency of insomnia report in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS). Sleep Med, 2004, 5(5): 449-456.
53.	Garbarino S, Bardwell WA, Guglielmi O, et al. Association of anxiety and depression in obstructive sleep apnea patients: a systematic review and meta-analysis. Behav Sleep Med, 2020, 18(1): 35-57.
54.	Saunamäki T, Jehkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review. Acta Neurol Scand, 2007, 116(5): 277-288.

1. 何权瀛, 王莞尔. 阻塞性睡眠呼吸暂停低通气综合征诊治指南 (基层版). 中国呼吸与危重监护杂志, 2015, 14(4): 398-405.
2. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med, 1993, 328(17): 1230-1235.
3. 苏小凤, 刘霖, 仲琳, 等. 中国阻塞性睡眠呼吸暂停综合征患病率的 Meta 分析. 中国循证医学杂志, 2021, 21(10): 1187-1194.
4. Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med, 2019, 7(8): 687-698.
5. 李学忠, 刘洪英, 蔡晓岚. 阻塞性睡眠呼吸暂停低通气综合征疾病管理认知度调查. 山东大学耳鼻喉眼学报, 2014, 28(4): 11-15.
6. 胡庆磊, 杜翠萍, 杨扬, 等. 上海市普陀区 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 中国眼耳鼻喉科杂志, 2017, 17(1): 49-54.
7. 苏轶, 徐伟伟, 王向云, 等. 东营市东营区老年人阻塞性睡眠呼吸暂停低通气综合征流行病学调查. 临床耳鼻咽喉头颈外科杂志, 2016, 30(4): 299-305.
8. 马恒杰, 吴京波, 张静, 等. 蓬莱市人群睡眠呼吸暂停综合征流行病学调查的研究. 中国卫生产业, 2017, 14(21): 1-2.
9. 邹小量, 朱胜华, 李多洛, 等. 邵阳市 20 岁以上人群阻塞性睡眠呼吸暂停低通气综合征的流行病学调查. 中国现代医学杂志, 2007(8): 956-959.
10. 穆娅沙·塔衣尔, 曹媛媛, 朱晴, 等. 肥胖相关基因多态性与阻塞性睡眠呼吸暂停低通气综合征遗传易感性的关系. 医学研究杂志, 2022, 51(3): 62-68.
11. 郭娟. 分析阻塞性睡眠呼吸暂停低通气综合征与甲状腺功能减退症的关系. 世界睡眠医学杂志, 2022, 9(1): 158-160.
12. Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation, 2021, 144(3): e56-e67.
13. 耿燕, 陈伟军, 徐锦, 等. 阻塞性睡眠呼吸暂停低通气综合征与胃食管反流病相关性 Meta 分析. 浙江中西医结合杂志, 2021, 31(7): 660-663.
14. 吴丹, 余红, 张程, 等. 贵阳市567名驾驶员阻塞性睡眠呼吸暂停低通气综合征的流行病学调查. 医学信息, 2016, 29(32): 30-32.
15. Shah AJ, Quek E, Alqahtani JS, et al. Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101627.
16. Shawon MSR, Perret JL, Senaratna CV, et al. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev, 2017, 32: 58-68.
17. 张晓雷, 张慧, 高博, 等. 慢性阻塞性肺疾病与致纤维化型间质性肺疾病患者阻塞性睡眠呼吸暂停对比研究. 中国实用内科杂志, 2020, 40(4): 300-305.
18. Lancaster LH, Mason WR, Parnell JA, et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 2009, 136(3): 772-778.
19. Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med, 2011, 183(6): 788-824.
20. Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis, 2009, 51(5): 363-370.
21. Adir Y, Humbert M, Chaouat A. Sleep-related breathing disorders and pulmonary hypertension. Eur Respir , 2021, 57: 2002258.
22. Alonso-Fernández A, de la Peña M, Romero D, et al. Association between obstructive sleep apnea and pulmonary embolism. Mayo Clin Proc, 2013, 88(6): 579-587.
23. Peng YH, Liao WC, Chung WS, et al. Association between obstructive sleep apnea and deep vein thrombosis/pulmonary embolism: a population-based retrospective cohort study. Thromb Res, 2014, 134(2): 340-345.
24. Varol E, Ozturk O, Yucel H, et al. The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets, 2011, 22(7): 552-556.
25. Prasad B, Nyenhuis SM, Imayama I, et al. Asthma and obstructive sleep apnea overlap: what has the evidence taught us? Am J Respir Crit Care Med, 2020, 201(11): 1345-1357.
26. Cabezas E, Pérez-Warnisher MT, Troncoso MF, et al. Sleep disordered breathing is highly prevalent in patients with lung cancer: results of the sleep apnea in lung cancer study. Respiration, 2019, 97(2): 119-124.
27. Kendzerska T, Leung RS, Hawker G, et al. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ, 2014, 186(13): 985-992.
28. Gozal D, Farré R, Nieto F J. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest, 2015, 148(5): 1140-1147.
29. Brenner R, Kivity S, Peker M, et al. Increased risk for cancer in young patients with severe obstructive sleep apnea. Respiration, 2019, 97(1): 15-23.
30. Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med, 2009, 6(8): e1000132.
31. Zinchuk A, Yaggi K, Wenlan Z, et al. Obstructive Sleep Apnea Increases the Risk of Diastolic Heart Failure: Results of a Large Population Study[M]//A77. EFFECT OF SLEEP DISORDERED BREATHING ON CARDIOMETABOLIC AND NEUROCOGNITIVE OUTCOMES. American Thoracic Society, 2018: A7694-A7694.
32. 苏小凤, 韩继明, 高莹卉, 等. 老年阻塞性睡眠呼吸暂停与代谢综合征各组分的相关性及其对远期不良心血管事件发生风险的影响. 南方医科大学学报, 2021, 41(11): 1592-1599.
33. Traaen GM, Aakerøy L, Hunt TE, et al. Effect of continuous positive airway pressure on arrhythmia in atrial fibrillation and sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med, 2021, 204(5): 573-582.
34. Baillieul S, Dekkers M, Brill AK, et al. Sleep apnoea and ischaemic stroke: current knowledge and future directions. Lancet Neurol, 2022, 21(1): 78-88.
35. Seiler A, Camilo M, Korostovtseva L, et al. Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis. Neurology, 2019, 92(7): e648-e654.
36. 嵇朋, 孙根, 江利敏, 等. 阻塞性睡眠呼吸暂停低通气综合征与急性缺血性脑卒中预后的关系. 中华老年心脑血管病杂志, 2020, 22(12): 1297-1300.
37. Owen JE, BenediktsdÓttir B, Gislason T, et al. Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea. Sleep, 2019, 42(1): zsy199.
38. 李东洙. 持续气道正压通气治疗2型糖尿病伴阻塞性睡眠呼吸暂停低通气综合征患者的疗效观察. 世界睡眠医学杂志, 2022, 9(3): 548-550.
39. Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest, 2017, 152(5): 1070-1086.
40. 刘然, 陆菊明, 刘剑锋, 等. 2 型糖尿病患者阻塞性睡眠呼吸暂停综合征患病状况及相关因素分析. 中华老年心脑血管病杂志, 2013, 15(1): 29-31.
41. 李媛媛, 姚晓光, 蔡昕添, 等. 阻塞性睡眠呼吸暂停合并 2 型糖尿病患者 CAPA 治疗后对血糖影响的 meta 分析. 新疆医学, 2020, 50(3): 236-239.
42. 陈晶, 柯亭羽, 舒筠然, 等. 阻塞性睡眠呼吸暂停低通气综合征与甲状腺功能减退症的相关性研究进展. 医学综述, 2018, 24(23): 4705-4709.
43. 李友堂, 苏霞, 罗马长, 等. 阻塞性睡眠呼吸暂停综合征并胃食管反流病的分析及研究. 世界睡眠医学杂志, 2019, 6(10): 1455-1456.
44. Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath, 2019, 23: 389-397.
45. 梁国良, 周志森, 杨智学, 等. 阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性研究. 中国医学创新, 2015, 12(29): 27-29.
46. Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest, 2017, 152(2): 435-444.
47. Zhang Y, Ren R, Lei F, et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med Rev, 2019, 45: 1-17.
48. Edinger JD, Bonnet MH, Bootzin RR, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 2004, 27(8): 1567-1596.
49. Luyster FS, Buysse DJ, Strollo Jr PJ. Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research. J Clin Sleep Med, 2010, 6(2): 196-204.
50. Bertisch SM, Pollock BD, Mittleman MA, et al. Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study. Sleep, 2018, 41(6): zsy047.
51. Kadono M, Hasegawa G. Insomnia disorder comorbid with diabetes. Nihon Rinsho, 2014, 72(5): 977-982.
52. Smith S, Sullivan K, Hopkins W, et al. Frequency of insomnia report in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS). Sleep Med, 2004, 5(5): 449-456.
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