Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WU Yuan ¹ , CHEN Xueru ¹ , WU Siyi ¹ , CHEN Jiankun ² , ZHENG Aifang ⁴ ,  LI Li ⁴ ,  LI Jiqiang ² ,  CHEN Hai ³

1. The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P. R. China;
2. The Third General Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong 510006, P. R. China;
3. Department of Otolaryngology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong 510006, P. R. China;
4. Department of Respiratory and Critical Care Medicine, Kashi First People's Hospital, Kashi, Xinjiang 844000, P. R. China;

Corresponding author：

LI Li, Email: 811346876@qq.com; LI Jiqiang, Email: lijiqiangjizhen@163.com; CHEN Hai, Email: chaitcm@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Han nationality; Uygur nationality; disease characteristics

DOI：

10.7507/1671-6205.202304042

Video：

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Objective To study the differences of obstructive sleep apnea hypopnea syndrome (OSAHS)-related indexes between Uyghur and Han, and to provide evidence for the development of individualized treatment measures for different ethnic groups. Methods 224 Han OSAHS patients were collected from Guangdong Provincial Hospital of Chinese Medicine, and 178 Uygur OSAHS patients were collected from The First People’s Hospital of Kashi between January 2018 and December 2019. The collected data information included age, sex, nationality, body mass index (BMI), apnea hypopnea index (AHI), lowest oxygen saturation (LSaO₂), OSAHS stage, mean corpuscular hemoglobin concentration (MCHC), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), and glycosylated hemoglobin (HbAlc). After using propensity matching scores to reduce confounding factors, differences in above indicators between different nationalities were compared. Results The mean values of MCHC, TC and HDL in Uygur OSAHS patients were lower than those in Han patients at the same stage, and the mean values of LSaO₂ and LDL in mild and severe Uygur OSAHS patients were lower than those in Han patients at the same stage, with statistically significant differences (all P<0.05). There were no significant differences in AHI, TG, FBG or HbAlc between Uygur and Han patients with OSAHS. Conclusion There are significant differences in LSaO₂, LDL, MCHC, TC and HDL between Uygur and Han Chinese patients with OSAHS.

Citation： WU Yuan, CHEN Xueru, WU Siyi, CHEN Jiankun, ZHENG Aifang, LI Li, LI Jiqiang, CHEN Hai. Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(6): 424-430. doi: 10.7507/1671-6205.202304042 Copy

1.	伍瑜, 佘笠, 黄东海. 阻塞性睡眠呼吸暂停低通气综合征患者相关免疫功能变化的研究进展. 中华耳鼻咽喉头颈外科杂志, 2022, 57(5): 649-655.
2.	Malhotra A, White DP. Obstructive sleep apnoea. Lancet, 2002, 360(9328): 237-245.
3.	Lu XX, Wang X, Xu T, et al. Circulating C3 and glucose metabolism abnormalities in patients with OSAHS. Sleep Breath, 2018, 22(2): 345-351.
4.	White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med, 2005, 172(11): 1363-1370.
5.	游振宁, 杨青岩. 阻塞性睡眠呼吸暂停综合征与动脉粥样硬化研究进展. 临床医学进展, 2022, 12(8): 7284-7291.
6.	Parikh MP, Gupta NM, Mccullough AJ. Obstructive sleep apnea and the liver. Clin Liver Dis, 2019, 23(2): 363-382.
7.	Franklin KA, Lindberg E. Obstructive sleep apnea is a common disorder in the population - a review on the epidemiology of sleep apnea. J Thorac Dis, 2015, 7(8): 1311-1322.
8.	Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med, 2012, 8(5): 597-619.
9.	Lévy P, Pépin JL, Arnaud C, et al. Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Respir J, 2008, 32(4): 1082-1095.
10.	Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
11.	Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA, 2004, 291(16): 2013-2016.
12.	李海洲, 李巍, 那学武, 等. 成人阻塞性睡眠呼吸暂停低通气综合征患者的人格特征分析. 中国耳鼻咽喉头颈外科, 2021, 28(1): 49-52.
13.	Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008, 5(2): 136-143.
14.	何忠明, 韩芳, 宋镇, 等. 克拉玛依市区35岁以上人群鼾症发生率调查及危险因素分析. 中国呼吸与危重监护杂志, 2010, 9(4): 404-408.
15.	Aurora RN, Punjabi NM. Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association. Lancet Respir Med, 2013, 1(4): 329-338.
16.	杨晰珺, 关建, 吴海莺. 阻塞性睡眠呼吸暂停低通气综合征与血脂紊乱关系的研究进展. 山东大学耳鼻喉眼学报, 2022, 36(2): 133-138.
17.	董文平, 任寿安. 血清核转录因子红系2相关因子2、血红素加氧酶-1水平与阻塞性睡眠呼吸暂停患者认知障碍的相关性研究. 中国呼吸与危重监护杂志, 2022, 21(7): 478-483.
18.	刘颐轩, 宋桉, 王芸, 等. 氧化应激在肥胖及胰岛素抵抗中的作用研究进展. 解放军医药杂志, 2014, 26(1): 99-101.
19.	周骁, 杨会笃, 苏叶馨, 等. 氧化应激促进AGT-REN双转基因高血压小鼠心肌中电导钙激活钾离子通道表达. 中国病理生理杂志, 2016, 32(5): 869-873.
20.	姜良征, 欧阳松云, 苏皎. p22phox C242T基因多态性与阻塞性睡眠呼吸暂停并认知功能障碍的关系探讨. 中国呼吸与危重监护杂志, 2018, 17(4): 373-376.
21.	王伟. 新疆巴州地区维吾尔族和中原汉族成人下颌部测量分析[D]. 郑州大学, 2019.
22.	Liak C, Fitzpatrick M. Coagulability in obstructive sleep apnea. Can Respir J, 2011, 18(6): 338-348.
23.	玛依拉·阿布都克力木. 胆固醇吸收关键基因Numb与冠心病及血脂水平的关联分析研究[D]. 新疆医科大学, 2016.

1. 伍瑜, 佘笠, 黄东海. 阻塞性睡眠呼吸暂停低通气综合征患者相关免疫功能变化的研究进展. 中华耳鼻咽喉头颈外科杂志, 2022, 57(5): 649-655.
2. Malhotra A, White DP. Obstructive sleep apnoea. Lancet, 2002, 360(9328): 237-245.
3. Lu XX, Wang X, Xu T, et al. Circulating C3 and glucose metabolism abnormalities in patients with OSAHS. Sleep Breath, 2018, 22(2): 345-351.
4. White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med, 2005, 172(11): 1363-1370.
5. 游振宁, 杨青岩. 阻塞性睡眠呼吸暂停综合征与动脉粥样硬化研究进展. 临床医学进展, 2022, 12(8): 7284-7291.
6. Parikh MP, Gupta NM, Mccullough AJ. Obstructive sleep apnea and the liver. Clin Liver Dis, 2019, 23(2): 363-382.
7. Franklin KA, Lindberg E. Obstructive sleep apnea is a common disorder in the population - a review on the epidemiology of sleep apnea. J Thorac Dis, 2015, 7(8): 1311-1322.
8. Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med, 2012, 8(5): 597-619.
9. Lévy P, Pépin JL, Arnaud C, et al. Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Respir J, 2008, 32(4): 1082-1095.
10. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
11. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA, 2004, 291(16): 2013-2016.
12. 李海洲, 李巍, 那学武, 等. 成人阻塞性睡眠呼吸暂停低通气综合征患者的人格特征分析. 中国耳鼻咽喉头颈外科, 2021, 28(1): 49-52.
13. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008, 5(2): 136-143.
14. 何忠明, 韩芳, 宋镇, 等. 克拉玛依市区35岁以上人群鼾症发生率调查及危险因素分析. 中国呼吸与危重监护杂志, 2010, 9(4): 404-408.
15. Aurora RN, Punjabi NM. Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association. Lancet Respir Med, 2013, 1(4): 329-338.
16. 杨晰珺, 关建, 吴海莺. 阻塞性睡眠呼吸暂停低通气综合征与血脂紊乱关系的研究进展. 山东大学耳鼻喉眼学报, 2022, 36(2): 133-138.
17. 董文平, 任寿安. 血清核转录因子红系2相关因子2、血红素加氧酶-1水平与阻塞性睡眠呼吸暂停患者认知障碍的相关性研究. 中国呼吸与危重监护杂志, 2022, 21(7): 478-483.
18. 刘颐轩, 宋桉, 王芸, 等. 氧化应激在肥胖及胰岛素抵抗中的作用研究进展. 解放军医药杂志, 2014, 26(1): 99-101.
19. 周骁, 杨会笃, 苏叶馨, 等. 氧化应激促进AGT-REN双转基因高血压小鼠心肌中电导钙激活钾离子通道表达. 中国病理生理杂志, 2016, 32(5): 869-873.
20. 姜良征, 欧阳松云, 苏皎. p22phox C242T基因多态性与阻塞性睡眠呼吸暂停并认知功能障碍的关系探讨. 中国呼吸与危重监护杂志, 2018, 17(4): 373-376.
21. 王伟. 新疆巴州地区维吾尔族和中原汉族成人下颌部测量分析[D]. 郑州大学, 2019.
22. Liak C, Fitzpatrick M. Coagulability in obstructive sleep apnea. Can Respir J, 2011, 18(6): 338-348.
23. 玛依拉·阿布都克力木. 胆固醇吸收关键基因Numb与冠心病及血脂水平的关联分析研究[D]. 新疆医科大学, 2016.

Chinese Journal of Respiratory and Critical Care Medicine

Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients

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