肠道菌群及其代谢物在哮喘中的作用研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

廖万忠 ¹ , 蒋伟哲 ¹ , 何碧钻 ¹ , 覃久芸 ¹ ,  刘雪萍 ² ,  付书婕 ¹

1. ;
2. ;

Corresponding author：

刘雪萍, Email: 562782029@qq.com; 付书婕, Email: 370034@sr.gxmu.edu.cn

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DOI：

10.7507/1671-6205.202305029

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Citation： 廖万忠, 蒋伟哲, 何碧钻, 覃久芸, 刘雪萍, 付书婕. 肠道菌群及其代谢物在哮喘中的作用研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(9): 666-672. doi: 10.7507/1671-6205.202305029 Copy

1.	Miller RL, Grayson MH, Strothman K. Advances in asthma: new understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol, 2021, 148(6): 1430-1441.
2.	Papi A, Brightling C, Pedersen SE, et al. Asthma. Lancet, 2018, 391(10122): 783-800.
3.	Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr, 2002, 22: 283-307.
4.	Hillman ET, Lu H, Yao T, et al. Microbial ecology along the gastrointestinal tract. Microbes Environ, 2017, 32(4): 300-313.
5.	He Y, Wen Q, Yao F, et al. Gut-lung axis: the microbial contributions and clinical implications. Crit Rev Microbiol, 2017, 43(1): 81-95.
6.	Hauptmann M, Schaible UE. Linking microbiota and respiratory disease. FEBS Lett, 2016, 590(21): 3721-3738.
7.	Russell SL, Gold MJ, Hartmann M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep, 2012, 13(5): 440-447.
8.	McGovern N, Shin A, Low G, et al. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature, 2017, 546(7660): 662-666.
9.	Mishra A, Lai GC, Yao LJ, et al. Microbial exposure during early human development primes fetal immune cells. Cell, 2021, 184(13): 3394-3409. e20.
10.	Rackaityte E, Halkias J, Fukui EM, et al. Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med, 2020, 26(4): 599-607.
11.	Depner M, Taft DH, Kirjavainen PV, et al. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med, 2020, 26(11): 1766-1775.
12.	Stokholm J, Blaser MJ, Thorsen J, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun, 2018, 9(1): 141.
13.	Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med, 2016, 22(10): 1187-1191.
14.	康树敏. 生命早期不同环境对小鼠肠道菌群定植以对哮喘模型Th1/Th2平衡的影响[D]. 东南大学, 2016.
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19.	Valverde-Molina J, García-Marcos L. Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma. Nutrients, 2023, 15(3): 486.
20.	Hasegawa K, Linnemann RW, Mansbach JM, et al. The fecal microbiota profile and bronchiolitis in infants. Pediatrics, 2016, 138(1): e20160218.
21.	Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med, 2015, 7(307): 307ra152.
22.	Arrieta MC, Arévalo A, Stiemsma L, et al. Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting. J Allergy Clin Immunol, 2018, 142(2): 424-434.
23.	van Nimwegen FA, Penders J, Stobberingh EE, et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol, 2011, 128(5): 948-955. e553.
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26.	Ashique S, De Rubis G, Sirohi E, et al. Short chain fatty acids: fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases. Chem Biol Interact, 2022, 368: 110231.
27.	Li M, van Esch BCAM, Wagenaar GTM, et al. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. Eur J Pharmacol, 2018, 831: 52-59.
28.	Thio CL, Chi PY, Lai AC, et al. Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. J Allergy Clin Immunol, 2018, 142(6): 1867-1883.
29.	Aoyama M, Kotani J, Usami M. Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. Nutrition, 2010, 26(6): 653- 661.
30.	Liu Q, Tian XL, Maruyama D, et al. Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression. Am J Physiol Lung Cell Mol Physiol, 2021, 321(1): L65-L78.
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33.	Manni ML, Heinrich VA, Buchan GJ, et al. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep, 2021, 11(1): 17788.
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36.	Gürdeniz G, Ernst M, Rago D, et al. Neonatal metabolome of caesarean section and risk of childhood asthma. Eur Respir J, 2022, 59(6): 2102406.
37.	Chang YD, Li CH, Tsai CH, et al. Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. FASEB J, 2020, 34(11): 15300-15313.
38.	van der Sluijs KF, van de Pol MA, Kulik W, et al. Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design. Thorax, 2013, 68(12): 1122-1130.
39.	范文婷, 钟世民, 胡琦, 等. 色氨酸代谢物调控Th17/Treg分化在小鼠哮喘变应原特异性免疫治疗中的作用及机制研究. 第三军医大学学报, 2018, 40(8): 658-665.
40.	Khan MA. Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint. J Transl Med, 2020, 18(1): 456.
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43.	Bunker JJ, Erickson SA, Flynn TM, et al. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science, 2017, 358(6361): eaan6619.
44.	Dzidic M, Abrahamsson TR, Artacho A, et al. Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development. J Allergy Clin Immunol, 2017, 139(3): 1017-1025. e14.
45.	Kau AL, Planer JD, Liu J, et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Transl Med, 2015, 7(276): 276ra24.
46.	Zhang XZ, Borbet TC, Fallegger A, et al. An antibiotic-impacted microbiota compromises the development of colonic regulatory T cells and predisposes to dysregulated immune responses. mBio, 2021, 12(1): e03335-20.
47.	Cait A, Hughes MR, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol, 2018, 11(3): 785-795.
48.	Bradley CP, Teng F, Felix KM, et al. Segmented Filamentous bacteria provoke lung autoimmunity by inducing gut-lung axis Th17 cells expressing dual TCRs. Cell Host Microbe, 2017, 22(5): 697-704, e4.
49.	李贱, 邹朋成, 杨莉容, 等. Th17细胞在哮喘发病中的作用研究进展. 中国呼吸与危重监护杂志, 2013, 12(3): 322-324.
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54.	Mamantopoulos M, Frising UC, Asaoka T, et al. El Tor Biotype Vibrio cholerae activates the caspase-11-independent canonical Nlrp3 and Pyrin inflammasomes. Front Immunol, 2019, 10: 2463.
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1. Miller RL, Grayson MH, Strothman K. Advances in asthma: new understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol, 2021, 148(6): 1430-1441.
2. Papi A, Brightling C, Pedersen SE, et al. Asthma. Lancet, 2018, 391(10122): 783-800.
3. Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr, 2002, 22: 283-307.
4. Hillman ET, Lu H, Yao T, et al. Microbial ecology along the gastrointestinal tract. Microbes Environ, 2017, 32(4): 300-313.
5. He Y, Wen Q, Yao F, et al. Gut-lung axis: the microbial contributions and clinical implications. Crit Rev Microbiol, 2017, 43(1): 81-95.
6. Hauptmann M, Schaible UE. Linking microbiota and respiratory disease. FEBS Lett, 2016, 590(21): 3721-3738.
7. Russell SL, Gold MJ, Hartmann M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep, 2012, 13(5): 440-447.
8. McGovern N, Shin A, Low G, et al. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature, 2017, 546(7660): 662-666.
9. Mishra A, Lai GC, Yao LJ, et al. Microbial exposure during early human development primes fetal immune cells. Cell, 2021, 184(13): 3394-3409. e20.
10. Rackaityte E, Halkias J, Fukui EM, et al. Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med, 2020, 26(4): 599-607.
11. Depner M, Taft DH, Kirjavainen PV, et al. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med, 2020, 26(11): 1766-1775.
12. Stokholm J, Blaser MJ, Thorsen J, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun, 2018, 9(1): 141.
13. Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med, 2016, 22(10): 1187-1191.
14. 康树敏. 生命早期不同环境对小鼠肠道菌群定植以对哮喘模型Th1/Th2平衡的影响[D]. 东南大学, 2016.
15. Qian LJ, Kang SM, Xie JL, et al. Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice. BMC Microbiol, 2017, 17(1): 135.
16. 杨玉婷, 倪吉祥, 徐彪, 等. 肠道菌群通过短链脂肪酸参与过敏性哮喘发病的相关机制研究进展. 山东医药, 2021, 61(23): 109-112.
17. Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature, 2013, 504(7480): 451-455.
18. Poulain-Godefroy O, Bouté M, Carrard J, et al. The aryl hydrocarbon receptor in asthma: friend or foe? Int J Mol Sci, 2020, 21(22): 8797.
19. Valverde-Molina J, García-Marcos L. Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma. Nutrients, 2023, 15(3): 486.
20. Hasegawa K, Linnemann RW, Mansbach JM, et al. The fecal microbiota profile and bronchiolitis in infants. Pediatrics, 2016, 138(1): e20160218.
21. Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med, 2015, 7(307): 307ra152.
22. Arrieta MC, Arévalo A, Stiemsma L, et al. Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting. J Allergy Clin Immunol, 2018, 142(2): 424-434.
23. van Nimwegen FA, Penders J, Stobberingh EE, et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol, 2011, 128(5): 948-955. e553.
24. Li YN, Huang F, Liu L, et al. Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice. Ann Allergy Asthma Immunol, 2012, 109(3): 201-207.
25. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science, 2012, 336(6086): 1268-1273.
26. Ashique S, De Rubis G, Sirohi E, et al. Short chain fatty acids: fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases. Chem Biol Interact, 2022, 368: 110231.
27. Li M, van Esch BCAM, Wagenaar GTM, et al. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. Eur J Pharmacol, 2018, 831: 52-59.
28. Thio CL, Chi PY, Lai AC, et al. Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. J Allergy Clin Immunol, 2018, 142(6): 1867-1883.
29. Aoyama M, Kotani J, Usami M. Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. Nutrition, 2010, 26(6): 653- 661.
30. Liu Q, Tian XL, Maruyama D, et al. Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression. Am J Physiol Lung Cell Mol Physiol, 2021, 321(1): L65-L78.
31. Kopf M, Schneider C, Nobs SP. The development and function of lung-resident macrophages and dendritic cells. Nat Immunol, 2015, 16(1): 36-44.
32. Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med, 2014, 20(2): 159-166.
33. Manni ML, Heinrich VA, Buchan GJ, et al. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep, 2021, 11(1): 17788.
34. Jia W, Xie GX, Jia WP. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol, 2018, 15(2): 111-128.
35. 张瀚文, 翁育清. 肥胖型哮喘发病机制及治疗进展. 岭南急诊医学杂志, 2022, 27(02): 200-202.
36. Gürdeniz G, Ernst M, Rago D, et al. Neonatal metabolome of caesarean section and risk of childhood asthma. Eur Respir J, 2022, 59(6): 2102406.
37. Chang YD, Li CH, Tsai CH, et al. Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. FASEB J, 2020, 34(11): 15300-15313.
38. van der Sluijs KF, van de Pol MA, Kulik W, et al. Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design. Thorax, 2013, 68(12): 1122-1130.
39. 范文婷, 钟世民, 胡琦, 等. 色氨酸代谢物调控Th17/Treg分化在小鼠哮喘变应原特异性免疫治疗中的作用及机制研究. 第三军医大学学报, 2018, 40(8): 658-665.
40. Khan MA. Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint. J Transl Med, 2020, 18(1): 456.
41. Cong YZ, Feng T, Fujihashi K, et al. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A, 2009, 106(46): 19256-19261.
42. Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol, 2012, 12(12): 821-832.
43. Bunker JJ, Erickson SA, Flynn TM, et al. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science, 2017, 358(6361): eaan6619.
44. Dzidic M, Abrahamsson TR, Artacho A, et al. Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development. J Allergy Clin Immunol, 2017, 139(3): 1017-1025. e14.
45. Kau AL, Planer JD, Liu J, et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Transl Med, 2015, 7(276): 276ra24.
46. Zhang XZ, Borbet TC, Fallegger A, et al. An antibiotic-impacted microbiota compromises the development of colonic regulatory T cells and predisposes to dysregulated immune responses. mBio, 2021, 12(1): e03335-20.
47. Cait A, Hughes MR, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol, 2018, 11(3): 785-795.
48. Bradley CP, Teng F, Felix KM, et al. Segmented Filamentous bacteria provoke lung autoimmunity by inducing gut-lung axis Th17 cells expressing dual TCRs. Cell Host Microbe, 2017, 22(5): 697-704, e4.
49. 李贱, 邹朋成, 杨莉容, 等. Th17细胞在哮喘发病中的作用研究进展. 中国呼吸与危重监护杂志, 2013, 12(3): 322-324.
50. Henrick BM, Rodriguez L, Lakshmikanth T, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell, 2021, 184(15): 3884-3898, e11.
51. Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell, 2009, 139(3): 485-498.
52. Li LZ, Fang ZF, Lee YK, et al. Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice. Food Funct, 2020, 11(10): 9272-9284.
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