Citation: 徐婉婷, 江晓琴, 朱涛. 肺动脉高压的治疗进展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(4): 287-292. doi: 10.7507/1671-6205.202311023 Copy
1. | Maron BA, Hess E, Maddox TM, et al. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation, 2016, 133(13): 1240-1248. |
2. | Wissmüller M, Dohr J, Adler J, et al. Pulmonary hypertension associated with left heart disease. Herz, 2023, 48(4): 266-273. |
3. | Lang IM, Delcroix M. Novel acquisitions in chronic thromboembolic pulmonary hypertension. Eur Heart J, 2023, 44(27): 2417-2419. |
4. | Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J, 2019, 53(1): 1801913. |
5. | Humbert M, Sitbon O, Guignabert C, et al. Treatment of pulmonary arterial hypertension: recent progress and a look to the future. Lancet Respir Med, 2023, 11(9): 804-819. |
6. | Sitbon O, Humbert M, Jaïs X, et al. Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension. Circulation, 2005, 111(23): 3105-3111. |
7. | Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J, 2023, 61(1): 2200879. |
8. | Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study. Lancet, 2001, 358(9288): 1119-1123. |
9. | Galiè N, Olschewski H, Oudiz RJ, et al. Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation, 2008, 117(23): 3010-3019. |
10. | Pulido T, Adzerikho I, Channick RN, et al. Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension. N Engl J Med, 2013, 369(9): 809-818. |
11. | Shi Q, Wang Z, Yang N, et al. Sildenafil for adult Asian patients with pulmonary arterial hypertension: a systematic review and meta-analysis. Ann Palliat Med, 2022, 11(1): 339-351. |
12. | Ghofrani H-A, Galiè N, Grimminger F, et al. Riociguat for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2013, 369(4): 330-340. |
13. | Nakamura K, Saito Y, Akagi S, et al. Epoprostenol sodium for treatment of pulmonary arterial hypertension. Vasc Health Risk Manag, 2015: 265. |
14. | Sitbon O, Channick R, Chin KM, et al. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2015, 373(26): 2522-2533. |
15. | Lajoie AC, Lauzière G, Lega JC, et al. Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis. Lancet Respir Med, 2016, 4(4): 291-305. |
16. | Galiè N, Barberà JA, Frost AE, et al. Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension. N Engl J Med, 2015, 373(9): 834-844. |
17. | Chin KM, Sitbon O, Doelberg M, et al. Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension. J Am Coll Cardiol, 2021, 78(14): 1393-1403. |
18. | Zhang Q, Zhu F, Shi G, et al. Maternal Outcomes Among Pregnant Women With Congenital Heart Disease-Associated Pulmonary Hypertension. Circulation, 2023, 147(7): 549-561. |
19. | Luna-Lopez R, Segura De La Cal T, Sarnago Cebada F, et al. Triple vasodilator therapy in pulmonary arterial hypertension associated with congenital heart disease. Heart, 2023: heartjnl-2023-323015. |
20. | Humbert M, McLaughlin V, Gibbs J S R, et al. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2021, 384(13): 1204-1215. |
21. | Hoeper MM, Badesch DB, Ghofrani HA, et al. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2023, 388(16): 1478-1490. |
22. | Carvalho T. Merck bets on sotatercept in pulmonary arterial hypertension. Nat Med, 2023, 29(1): 2-3. |
23. | Olsson KM, Fuge J, Park DH, et al. Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension. Eur Respir J, 2023, 62(2): 2301070. |
24. | Souza R, Badesch DB, Ghofrani HA, et al. Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial. Eur Respir J, 2023, 62(3): 2301107. |
25. | Zheng R, Xu T, Wang X, et al. Stem cell therapy in pulmonary hypertension: current practice and future opportunities. Eur Respir Rev, 2023, 32(169): 230112. |
26. | Granton J, Langleben D, Kutryk MB, et al. Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial. Circ Res, 2015, 117(7): 645-654. |
27. | Samaranayake CB, Kempny A, Naeije R, et al. Beta-blockade improves right ventricular diastolic function in exercising pulmonary arterial hypertension. Eur Respir J, 2023, 61(5): 2300144. |
28. | Ryanto GRT, Suraya R, Nagano T. Mitochondrial Dysfunction in Pulmonary Hypertension. Antioxidants, 2023, 12(2): 372. |
29. | Galkin A, Sitapara R, Clemons B, et al. Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension. Eur Respir J, 2022, 60(6): 2102356. |
30. | Cullivan S, Gaine S, Sitbon O. New trends in pulmonary hypertension. Eur Respir Rev, 2023, 32(167): 220211. |
31. | Morris NR, Kermeen FD, Jones AW, et al. Exercise-based rehabilitation programmes for pulmonary hypertension. Cochrane Airways Group. Cochrane Database Syst Rev, 2023, 2023(3). |
32. | Mocumbi A, Humbert M, Saxena A, et al. Pulmonary hypertension. Nat Rev Dis Primers. 2024 Jan 4;10(1): 1. |
33. | Bermejo J, Yotti R, García-Orta R, et al. Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial. Eur Heart J, 2018 Apr 14;39(15): 1255-1264. |
34. | Purvey M, Allen G. Managing acute pulmonary oedema. Aust Prescr, 2017, 40(2): 59-63. |
35. | Ciarka A, Doan V, Velez-Roa S, et al. Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension. Am J Respir Crit Care Med, 2010, 181(11): 1269-1275. |
36. | Zhang H, Kan J, Zhang J, et al. 3-Year Outcome in Patients With Combined Precapillary and Postcapillary Pulmonary Hypertension: Results From PADN-5 Trial. JACC Heart Fail. 2023 Jun 12: S2213-1779(23)00252-4. |
37. | Zhang H, Wei Y, Zhang C, et al. Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomized PADN-CFDA Trial. JACC Cardiovasc Interv. 2022 Dec 12;15(23): 2412-2423. |
38. | Shi Y, Liu J, Zhang R, et al. Targeting Endothelial ENO1 (Alpha-Enolase) -PI3K-Akt-mTOR Axis Alleviates Hypoxic Pulmonary Hypertension. Hypertension, 2023, 80(5): 1035-1047. |
39. | Sugarman J, Weatherald J. Management of Pulmonary Hypertension Due to Chronic Lung Disease. Methodist Debakey Cardiovasc J. 2021 Jul 1;17(2): 124-133. |
40. | Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J. 2008 Nov;32(5): 1371-85. |
41. | Vitulo P, Stanziola A, Confalonieri M, et al. Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial. J Heart Lung Transplant. 2017 Feb;36(2): 166-174. |
42. | Raghu G, Behr J, Brown KK, et al. Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med. 2013 May 7;158(9): 641-9. |
43. | Nathan SD, Behr J, Collard HR, et al. Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study. Lancet Respir Med. 2019 Sep;7(9): 780-790. |
44. | Barnes H, Brown Z, Burns A, et al. Phosphodiesterase 5 inhibitors for pulmonary hypertension. Cochrane Database Syst Rev. 2019 Jan 31;1(1): CD012621. |
45. | Waxman A, Restrepo-Jaramillo R, Thenappan T, et al. Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease. N Engl J Med. 2021 Jan 28;384(4): 325-334. |
46. | Hsieh WC, Jansa P, Huang WC, et al. Residual pulmonary hypertension after pulmonary endarterectomy: A meta-analysis. J Thorac Cardiovasc Surg. 2018 Sep;156(3): 1275-1287. |
47. | Humbert M, Simonneau G, Pittrow D, et al. Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant. 2022 Jun;41(6): 716-721. |
48. | Simonneau G, D'Armini AM, Ghofrani HA, et al. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2). Eur Respir J. 2015 May;45(5): 1293-302. |
49. | Sadushi-Kolici R, Jansa P, Kopec G, et al. Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial. Lancet Respir Med. 2019 Mar;7(3): 239-248. |
50. | Ghofrani HA, Simonneau G, D'Armini AM, et al. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. Lancet Respir Med. 2017 Oct;5(10): 785-794. |
- 1. Maron BA, Hess E, Maddox TM, et al. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation, 2016, 133(13): 1240-1248.
- 2. Wissmüller M, Dohr J, Adler J, et al. Pulmonary hypertension associated with left heart disease. Herz, 2023, 48(4): 266-273.
- 3. Lang IM, Delcroix M. Novel acquisitions in chronic thromboembolic pulmonary hypertension. Eur Heart J, 2023, 44(27): 2417-2419.
- 4. Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J, 2019, 53(1): 1801913.
- 5. Humbert M, Sitbon O, Guignabert C, et al. Treatment of pulmonary arterial hypertension: recent progress and a look to the future. Lancet Respir Med, 2023, 11(9): 804-819.
- 6. Sitbon O, Humbert M, Jaïs X, et al. Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension. Circulation, 2005, 111(23): 3105-3111.
- 7. Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J, 2023, 61(1): 2200879.
- 8. Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study. Lancet, 2001, 358(9288): 1119-1123.
- 9. Galiè N, Olschewski H, Oudiz RJ, et al. Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2. Circulation, 2008, 117(23): 3010-3019.
- 10. Pulido T, Adzerikho I, Channick RN, et al. Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension. N Engl J Med, 2013, 369(9): 809-818.
- 11. Shi Q, Wang Z, Yang N, et al. Sildenafil for adult Asian patients with pulmonary arterial hypertension: a systematic review and meta-analysis. Ann Palliat Med, 2022, 11(1): 339-351.
- 12. Ghofrani H-A, Galiè N, Grimminger F, et al. Riociguat for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2013, 369(4): 330-340.
- 13. Nakamura K, Saito Y, Akagi S, et al. Epoprostenol sodium for treatment of pulmonary arterial hypertension. Vasc Health Risk Manag, 2015: 265.
- 14. Sitbon O, Channick R, Chin KM, et al. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2015, 373(26): 2522-2533.
- 15. Lajoie AC, Lauzière G, Lega JC, et al. Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis. Lancet Respir Med, 2016, 4(4): 291-305.
- 16. Galiè N, Barberà JA, Frost AE, et al. Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension. N Engl J Med, 2015, 373(9): 834-844.
- 17. Chin KM, Sitbon O, Doelberg M, et al. Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension. J Am Coll Cardiol, 2021, 78(14): 1393-1403.
- 18. Zhang Q, Zhu F, Shi G, et al. Maternal Outcomes Among Pregnant Women With Congenital Heart Disease-Associated Pulmonary Hypertension. Circulation, 2023, 147(7): 549-561.
- 19. Luna-Lopez R, Segura De La Cal T, Sarnago Cebada F, et al. Triple vasodilator therapy in pulmonary arterial hypertension associated with congenital heart disease. Heart, 2023: heartjnl-2023-323015.
- 20. Humbert M, McLaughlin V, Gibbs J S R, et al. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2021, 384(13): 1204-1215.
- 21. Hoeper MM, Badesch DB, Ghofrani HA, et al. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension. N Engl J Med, 2023, 388(16): 1478-1490.
- 22. Carvalho T. Merck bets on sotatercept in pulmonary arterial hypertension. Nat Med, 2023, 29(1): 2-3.
- 23. Olsson KM, Fuge J, Park DH, et al. Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension. Eur Respir J, 2023, 62(2): 2301070.
- 24. Souza R, Badesch DB, Ghofrani HA, et al. Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial. Eur Respir J, 2023, 62(3): 2301107.
- 25. Zheng R, Xu T, Wang X, et al. Stem cell therapy in pulmonary hypertension: current practice and future opportunities. Eur Respir Rev, 2023, 32(169): 230112.
- 26. Granton J, Langleben D, Kutryk MB, et al. Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial. Circ Res, 2015, 117(7): 645-654.
- 27. Samaranayake CB, Kempny A, Naeije R, et al. Beta-blockade improves right ventricular diastolic function in exercising pulmonary arterial hypertension. Eur Respir J, 2023, 61(5): 2300144.
- 28. Ryanto GRT, Suraya R, Nagano T. Mitochondrial Dysfunction in Pulmonary Hypertension. Antioxidants, 2023, 12(2): 372.
- 29. Galkin A, Sitapara R, Clemons B, et al. Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension. Eur Respir J, 2022, 60(6): 2102356.
- 30. Cullivan S, Gaine S, Sitbon O. New trends in pulmonary hypertension. Eur Respir Rev, 2023, 32(167): 220211.
- 31. Morris NR, Kermeen FD, Jones AW, et al. Exercise-based rehabilitation programmes for pulmonary hypertension. Cochrane Airways Group. Cochrane Database Syst Rev, 2023, 2023(3).
- 32. Mocumbi A, Humbert M, Saxena A, et al. Pulmonary hypertension. Nat Rev Dis Primers. 2024 Jan 4;10(1): 1.
- 33. Bermejo J, Yotti R, García-Orta R, et al. Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial. Eur Heart J, 2018 Apr 14;39(15): 1255-1264.
- 34. Purvey M, Allen G. Managing acute pulmonary oedema. Aust Prescr, 2017, 40(2): 59-63.
- 35. Ciarka A, Doan V, Velez-Roa S, et al. Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension. Am J Respir Crit Care Med, 2010, 181(11): 1269-1275.
- 36. Zhang H, Kan J, Zhang J, et al. 3-Year Outcome in Patients With Combined Precapillary and Postcapillary Pulmonary Hypertension: Results From PADN-5 Trial. JACC Heart Fail. 2023 Jun 12: S2213-1779(23)00252-4.
- 37. Zhang H, Wei Y, Zhang C, et al. Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomized PADN-CFDA Trial. JACC Cardiovasc Interv. 2022 Dec 12;15(23): 2412-2423.
- 38. Shi Y, Liu J, Zhang R, et al. Targeting Endothelial ENO1 (Alpha-Enolase) -PI3K-Akt-mTOR Axis Alleviates Hypoxic Pulmonary Hypertension. Hypertension, 2023, 80(5): 1035-1047.
- 39. Sugarman J, Weatherald J. Management of Pulmonary Hypertension Due to Chronic Lung Disease. Methodist Debakey Cardiovasc J. 2021 Jul 1;17(2): 124-133.
- 40. Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J. 2008 Nov;32(5): 1371-85.
- 41. Vitulo P, Stanziola A, Confalonieri M, et al. Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial. J Heart Lung Transplant. 2017 Feb;36(2): 166-174.
- 42. Raghu G, Behr J, Brown KK, et al. Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med. 2013 May 7;158(9): 641-9.
- 43. Nathan SD, Behr J, Collard HR, et al. Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study. Lancet Respir Med. 2019 Sep;7(9): 780-790.
- 44. Barnes H, Brown Z, Burns A, et al. Phosphodiesterase 5 inhibitors for pulmonary hypertension. Cochrane Database Syst Rev. 2019 Jan 31;1(1): CD012621.
- 45. Waxman A, Restrepo-Jaramillo R, Thenappan T, et al. Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease. N Engl J Med. 2021 Jan 28;384(4): 325-334.
- 46. Hsieh WC, Jansa P, Huang WC, et al. Residual pulmonary hypertension after pulmonary endarterectomy: A meta-analysis. J Thorac Cardiovasc Surg. 2018 Sep;156(3): 1275-1287.
- 47. Humbert M, Simonneau G, Pittrow D, et al. Oral anticoagulants (NOAC and VKA) in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant. 2022 Jun;41(6): 716-721.
- 48. Simonneau G, D'Armini AM, Ghofrani HA, et al. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2). Eur Respir J. 2015 May;45(5): 1293-302.
- 49. Sadushi-Kolici R, Jansa P, Kopec G, et al. Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial. Lancet Respir Med. 2019 Mar;7(3): 239-248.
- 50. Ghofrani HA, Simonneau G, D'Armini AM, et al. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. Lancet Respir Med. 2017 Oct;5(10): 785-794.
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