Objective To investigate the application value of fibrinogen and other serological indicators in the management of patients with bronchiectasis. Methods  Basic information, serological indicators such as blood routine items, biochemical, blood coagulation, and inflammation index of 121 patients with bronchiectasis in Nanjing Jinling Hospital and Nanjing Drum Tower Hospital from July 2021 to June 2023 were collected. The value of fibrinogen and other serological indicators in identifying patients with acute exacerbation and severely impaired lung function (FEV₁%pred<60%) was evaluated. Results  The levels of leukocytes, neutrophils, platelets, C-reactive protein and fibrinogen were higher in the patients with acute exacerbation and in the FEV₁%pred<60% group, negatively correlated with FEV₁%pred. While the level of albumin was higher in the patients of the stable group and FEV₁%pred≥60% group, and positively correlated with FEV₁%pred. Compared with leukocytes, neutrophils, platelets, C-reactive protein and albumin, fibrinogen demonstrated the best recognition ability for the patients with FEV₁%pred<60% (AUC=0.839). The sensitivity of identifying patients with FEV₁%pred<60% was 91.18% and the specificity was 71.26% when the level of fibrinogen was over 3.35 g/L. Conclusions  Leukocytes, neutrophils, platelets, C-reactive protein, albumin and fibrinogen have shown certain application value in recognition of patients with bronchiectasis in acute exacerbation stage and FEV₁%pred<60%. These serological indicators may be helpful in precision treatment and individual management of patients with bronchiectasis.

Citation： LI Yuanyuan, ZHAO Tingting, SU Xin. The application value of fibrinogen and other serological indicators in the management of patients with bronchiectasis. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(11): 777-783. doi: 10.7507/1671-6205.202403059 Copy