• 1. Tumor Center of West China Hospital, Sichuan University, Chengdu 610041, China2. The Second West China Hospital of Sichuan University, Chengdu 610041, China3. West China Hospital, Sichuan University, Chengdu 610041, China; Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China4. Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
WU Taixiang, Email: txwutx@hotmail.com
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Objective  To compare and evaluate the effectiveness and safety of irinotecan (IRI) versus oxaplatin (OXA), in combination with 5-FU/LV for patients with advanced colorectal cancer.
Methods  The literature search, study selection and assessment, data collection and analysis were undertaken by two reviewers according to the Cochrane Handbook for Systematic Reviews of Interventions. Randomised controlled trials (RCTs) or quasi-RCTs comparing IRI versus OXA, in combination with 5-FU/LV in the treatment of advanced colorectal cancer were collected.
Results  Seven studies involving 2107 patients were included. The OXA/5-FU/LV regimen was superior or at least equal to the IRI/5-FU/LV regimen in prolonging overall survival and time to progression. The OXA/5-FU/LV regimen showed a higher response rate and was associated with lower toxicities.
Conclusion  Compared with IRI, OXA is more appropriate for the treatment of advanced colorectal cancer when combined with 5-FU/LV.

Citation: WANG Ting,LUO Lili,ZHOU Qinghua,WU Taixiang. Irinotecan versus Oxaplatin in Combination with 5-FU/LV for \Advanced Colorectal Cancer: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2008, 08(1): 36-41. doi: 10.7507/1672-2531.20080009 Copy

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