Changes of Bone on X-ray Photography in Preschool Children in Kashin-Beck Disease Endemic Area_Chinese Journal of Evidence-Based Medicine

Authors：

WU Taixiang ¹ ,  LI Youping ¹ , LIU Rongbo ² , PEI Fuxing ³ , YUAN Yong ⁴ , ZENG Xiaoqian ⁴ , YANG Xunzhe ⁴ , ZHUO Qi ⁴

1.Chinese Evidence-based Medicine Center, Chinese Clinical Trial Register, the Chinese Cochrane Centre, INCLEN, West China Hospital, Sichuan University, Chengdu 610041, China2.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China3.Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu 610041, China4.West China School of Medicine, Sichuan University, Chengdu 610041, China;

Corresponding author：

LI Youping, Email: txwutx@hotmail.com

Keywords：

Kasin-Beck disease; Etiological mechanism; Deiodinase activity decrease; X-ray changes? in bone metaphysis

DOI：

10.7507/1672-2531.20080021

Video：

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Objective 　To explore the etiological mechanism of Kashin-Beck disease (KBD) and? the changes of bone on X-ray photography in preschool children in the KBD endemic area.
Methods 　Children of 1-6 years old in Naidang village of Jinchuan county, Sichuan province, China were included; and their wrist and knee joints X-ray photos were collected. The photos were bl indly diagnosed.
Results 　Of the 22 children aged 1-6 years old in the village, 17 were included and another 3 aged 6-8 years old asked for examination. All children showed changes in bone metaphysis around wrist or/and knee joints based on the results of X-ray examination.
Conclusion 　The 20 children in mild type KBD area show common changes in bone metaphysis This result coincides with our hypothesis that hypoplastic cartilage should occur in the population of preschool children in the KBD endemic area.

Citation： WU Taixiang,LI Youping,LIU Rongbo,PEI Fuxing,YUAN Yong,ZENG Xiaoqian,YANG Xunzhe,ZHUO Qi. Changes of Bone on X-ray Photography in Preschool Children in Kashin-Beck Disease Endemic Area. Chinese Journal of Evidence-Based Medicine, 2008, 08(2): 82-85. doi: 10.7507/1672-2531.20080021 Copy

1.	吴泰相, 裴福兴, 李幼平, 等. 大骨节病病因机制的脱碘酶功能障碍新假说. 中国循证医学杂志, 2008, 8(1): 4-9.
2.	李富忠, 黄慧, 邓佳云, 等. 四川省儿童大骨节病新发病情况调查.预防医学情报杂志, 2007, 23(1): 28-30.
3.	黄慧, 李富忠, 邓佳云, 等. 2006年四川省大骨节病监测结果分析.地方病通报, 2007, 22(3): 56-57.
4.	杨建伯, 孙殿军. 大骨节病病区谷物镰刀菌培养物致雏鸡骺板软骨坏死的观察.中国地方病学杂志,1993,8(6):325-326.
5.	杨建伯, 孙殿军. 镰刀菌T-2毒素致鸡雏关节软骨病变观察. 中国地方病学杂志, 1994, 13(1): 1-2.
6.	周晓菲, 冯晓声, 张乃生, 等. T-2毒素及其对关节软骨和心肌毒性研究进展. 动物医学进展, 2006, 27(12): 49-53.
7.	赵志军, 李强. T2-毒素致大骨节病软骨损伤的研究进展. 中国地方病防治杂志, 2005, 20(1): 23-25.
8.	毕华银, 陈萍. 榆林病区水黄腐酸拟复制大骨节病动物模型的实验报告. 地方病通报, 1998, 13(3): 9-14.
9.	王子健, 马梅, 彭安. 大骨节病区黄腐酸对体外培养鸡胚软骨组织糖氨多糖代谢及脂质过氧化的影响. 中国地方病防治杂志, 1993, 8(6): 339-341.
10.	朱少华, Fietzek PP. 腐殖酸对NMRI鼠关节软骨粘弹性的影响. 中国地方病学杂志, 2004, 23(3): 221-222.
11.	应桂英, 贾勇, 栾荣生. 腐殖酸与软骨损伤关系的研究进展. 卫生研究, 2007, 36(2): 238-241.
12.	彭安, 杨春林. 大骨节病自由基制研究. 中国地方病防治杂志, 1990, 5(1): 28-31.
13.	鲍秉健, 苟改先, 鲍曼丽, 等. 河南省地甲病、克山病、大骨贡病病区不同人群发硒含量及全血GSH-Px活性的对比分析. 广东微量元素科学, 1997, 4(11): 16-18.
14.	Moreno-Reyes R, Suetens C, Mathieu F,et al. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and? iodine status. N Engl J Med, 1998, 339(16): 1112-1120.
15.	Pepene CE, Kasperk CH,Pfeilschifter J ,et al .Effects of triiodothyronine on the insulin-like growth factor system in primary human osteoblastic cells in vitro. Bone, 2001, 29(6): 540-546.
16.	Varga F, Rumpler M, Klaushofer K. Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3-E1. FEBS Lett, 1994, 345(1): 67-70.
17.	Will iams GR, Robson H, Shalet SM. Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol, 1998, 157(3): 391-403.
18.	Eriksen EF, Kassem M, Langdahl B. Growth hormone,? insulin-like growth factors and bone remodelling. Eur J Clin Invest, 1996, 26(7): 525-534.
19.	Cabello G, Wrutniak C. Thyroid hormone and growth: relationships with growth hormone effects and regulation. Reprod Nutr Dev, 1989, 29(4): 387-402.
20.	康龙丽, 郭雄, 左弘, 等. 大骨节病患者12号染色体7个STR位点基因频率分析. 中华流行病学杂志, 2005, 26(10): 790-793.

1. 吴泰相, 裴福兴, 李幼平, 等. 大骨节病病因机制的脱碘酶功能障碍新假说. 中国循证医学杂志, 2008, 8(1): 4-9.
2. 李富忠, 黄慧, 邓佳云, 等. 四川省儿童大骨节病新发病情况调查.预防医学情报杂志, 2007, 23(1): 28-30.
3. 黄慧, 李富忠, 邓佳云, 等. 2006年四川省大骨节病监测结果分析.地方病通报, 2007, 22(3): 56-57.
4. 杨建伯, 孙殿军. 大骨节病病区谷物镰刀菌培养物致雏鸡骺板软骨坏死的观察.中国地方病学杂志,1993,8(6):325-326.
5. 杨建伯, 孙殿军. 镰刀菌T-2毒素致鸡雏关节软骨病变观察. 中国地方病学杂志, 1994, 13(1): 1-2.
6. 周晓菲, 冯晓声, 张乃生, 等. T-2毒素及其对关节软骨和心肌毒性研究进展. 动物医学进展, 2006, 27(12): 49-53.
7. 赵志军, 李强. T2-毒素致大骨节病软骨损伤的研究进展. 中国地方病防治杂志, 2005, 20(1): 23-25.
8. 毕华银, 陈萍. 榆林病区水黄腐酸拟复制大骨节病动物模型的实验报告. 地方病通报, 1998, 13(3): 9-14.
9. 王子健, 马梅, 彭安. 大骨节病区黄腐酸对体外培养鸡胚软骨组织糖氨多糖代谢及脂质过氧化的影响. 中国地方病防治杂志, 1993, 8(6): 339-341.
10. 朱少华, Fietzek PP. 腐殖酸对NMRI鼠关节软骨粘弹性的影响. 中国地方病学杂志, 2004, 23(3): 221-222.
11. 应桂英, 贾勇, 栾荣生. 腐殖酸与软骨损伤关系的研究进展. 卫生研究, 2007, 36(2): 238-241.
12. 彭安, 杨春林. 大骨节病自由基制研究. 中国地方病防治杂志, 1990, 5(1): 28-31.
13. 鲍秉健, 苟改先, 鲍曼丽, 等. 河南省地甲病、克山病、大骨贡病病区不同人群发硒含量及全血GSH-Px活性的对比分析. 广东微量元素科学, 1997, 4(11): 16-18.
14. Moreno-Reyes R, Suetens C, Mathieu F,et al. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and? iodine status. N Engl J Med, 1998, 339(16): 1112-1120.
15. Pepene CE, Kasperk CH,Pfeilschifter J ,et al .Effects of triiodothyronine on the insulin-like growth factor system in primary human osteoblastic cells in vitro. Bone, 2001, 29(6): 540-546.
16. Varga F, Rumpler M, Klaushofer K. Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3-E1. FEBS Lett, 1994, 345(1): 67-70.
17. Will iams GR, Robson H, Shalet SM. Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol, 1998, 157(3): 391-403.
18. Eriksen EF, Kassem M, Langdahl B. Growth hormone,? insulin-like growth factors and bone remodelling. Eur J Clin Invest, 1996, 26(7): 525-534.
19. Cabello G, Wrutniak C. Thyroid hormone and growth: relationships with growth hormone effects and regulation. Reprod Nutr Dev, 1989, 29(4): 387-402.
20. 康龙丽, 郭雄, 左弘, 等. 大骨节病患者12号染色体7个STR位点基因频率分析. 中华流行病学杂志, 2005, 26(10): 790-793.

Chinese Journal of Evidence-Based Medicine

Changes of Bone on X-ray Photography in Preschool Children in Kashin-Beck Disease Endemic Area

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