Prognosis of Cerebral Venous Sinus Thrombosis_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Zhiqin , HAO Zilong ,  LIU Ming , WU Bo

Neurology Department,West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIU Ming, Email: docterqing@163.com

Keywords：

Cerebral vein sinus thrombosis; Prognosis; Multivariable analysis

DOI：

10.7507/1672-2531.20080039

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Objective　 To investigate the long-term prognosis of cerebral venous sinus thrombosis (CVST) and to identify the early predictors of poor outcome.
Methods　 We performed a prospective register study on the prognosis of CVST patients. All patients were followed up continuously. The primary endpoint was death or dependence as assessed by the modified Rankin Scale (mRS) score gt;2 at month 6. A multivariable logistic regression model was applied to identify the predictors of outcome.
Results　 A total of 52 CVST patients were included. The rates of recurrence and death at month 6 were 13.5% and 7.7%, respectively, and 29.9% of the patients were dead or dependent at month 6. The multivariable logistic regression analysis revealed that the predictors of death or dependence at month 6 were intracranial parenchymal lesion (OR=14.62, 95%CI 2.36 to 90.36) and delayed diagnosis (OR=13.14, 95%CI 1.90 to 90.84).
Conclusion　 In China, CVST is still a disease that may lead to death or dependence. Its long-term prognosis is relatively poor compared to that reported in western patients. This difference may due to the delayed diagnosis of CVST in China.

Citation： LIU Zhiqin,HAO Zilong,LIU Ming,WU Bo. Prognosis of Cerebral Venous Sinus Thrombosis. Chinese Journal of Evidence-Based Medicine, 2008, 08(3): 170-173. doi: 10.7507/1672-2531.20080039 Copy

1.	Einhaupl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol, 2006, 13(6): 553-559.
2.	Ferro JM, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke, 2004, 35(3): 664-670.
3.	Bousser MG. Cerebral venous thrombosis: diagnosis and management. Journal of Neurology, 2000, 247(4): 252-258.
4.	Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurology, 2007, 6(2): 162-170.
5.	王建祯, 凌锋, 吉训明, 等. 老年人脑静脉窦血栓形成26例临床分析. 中国老年学杂志, 2007, 27(5): 876-877.
6.	魏东宁, 陈玉萍. 中国人脑静脉及静脉窦血栓形成的临床特点. 中国卒中杂志, 2007, 2(9): 729-733.
7.	支兴龙, 王建祯, 凌锋, 等. 影响脑静脉窦血栓预后的相关因素分析(附87例报告). 山东医药, 2007, 47(23): 77-78.
8.	Canhão P, Ferro JM, Lindgren AG, et al. Causes and predictors of death in cerebral venous thrombosis. Stroke, 2005, 36(8): 1720-1725.
9.	Einhaupl KM, Villringer A, Meister W, et al. Heparin treatment in sinus venous thrombosis. Lancet, 1991, 338(8767): 597-600.
10.	De Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke, 1999, 30(3): 484-488.
11.	Ferro JM, Lopes MG, Rosas MJ, et al. Long-term prognosis of cerebral vein and dural sinus thrombosis. results of the VENOPORT study.Cerebrovascular Diseases (Basel, Switzerland), 2002, 13(4): 272-278.
12.	Breteau G, Mounier-Vehier F, Godefroy O, et al. Cerebral venous thrombosis 3-year clinical outcome in 55 consecutive patients. J Neurol, 2003, 250(1): 29-35.

1. Einhaupl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol, 2006, 13(6): 553-559.
2. Ferro JM, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke, 2004, 35(3): 664-670.
3. Bousser MG. Cerebral venous thrombosis: diagnosis and management. Journal of Neurology, 2000, 247(4): 252-258.
4. Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurology, 2007, 6(2): 162-170.
5. 王建祯, 凌锋, 吉训明, 等. 老年人脑静脉窦血栓形成26例临床分析. 中国老年学杂志, 2007, 27(5): 876-877.
6. 魏东宁, 陈玉萍. 中国人脑静脉及静脉窦血栓形成的临床特点. 中国卒中杂志, 2007, 2(9): 729-733.
7. 支兴龙, 王建祯, 凌锋, 等. 影响脑静脉窦血栓预后的相关因素分析(附87例报告). 山东医药, 2007, 47(23): 77-78.
8. Canhão P, Ferro JM, Lindgren AG, et al. Causes and predictors of death in cerebral venous thrombosis. Stroke, 2005, 36(8): 1720-1725.
9. Einhaupl KM, Villringer A, Meister W, et al. Heparin treatment in sinus venous thrombosis. Lancet, 1991, 338(8767): 597-600.
10. De Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke, 1999, 30(3): 484-488.
11. Ferro JM, Lopes MG, Rosas MJ, et al. Long-term prognosis of cerebral vein and dural sinus thrombosis. results of the VENOPORT study.Cerebrovascular Diseases (Basel, Switzerland), 2002, 13(4): 272-278.
12. Breteau G, Mounier-Vehier F, Godefroy O, et al. Cerebral venous thrombosis 3-year clinical outcome in 55 consecutive patients. J Neurol, 2003, 250(1): 29-35.

Chinese Journal of Evidence-Based Medicine

Prognosis of Cerebral Venous Sinus Thrombosis

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