Effect of Epristeride on Gross Hematuria Secondary to Transurethral Resection of Prostate_Chinese Journal of Evidence-Based Medicine

Authors：

DENG Hua , GUO Zhiming , GONG Chunyu , LAI Fei

Department of Urology, The Second People’s Hospital of Chengdu, Chengdu 610017, China;

Corresponding author：

Keywords：

Hematuria; Transurethral resection of prostate; Epristeride

DOI：

10.7507/1672-2531.20080233

Video：

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Objective 　To evaluate the effect of epristeride on gross hematuria secondary to transurethral resection of prostate (TURP).
Methods 　A total of 50 patients with gross hematuria secondary to TURP were divided into two groups: 25 patients were treated with routine treatment plus 5 mg epristeride, twice a day for 3 months, while the other 25 only received routine treatment.
Results 　At the 6-month follow-up visit, gross hematuria recurred in 63% of patients in the control group, but in only 30% of patients in the epristeride group. The difference was statistically significant (P lt;0.05). Moreover, the grade of gross hematuria was significantly lower in the epristeride group (P lt;0.05).
Conclusion 　 Epristeride appears to be effective in treating gross hematuria secondary to TURP.

Citation： DENG Hua,GUO Zhiming,GONG Chunyu,LAI Fei. Effect of Epristeride on Gross Hematuria Secondary to Transurethral Resection of Prostate. Chinese Journal of Evidence-Based Medicine, 2008, 08(12): 1051-1052. doi: 10.7507/1672-2531.20080233 Copy

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2.	Donohue JF, Hayne D, Karnik U, et al. Randomized, placebocontrolled trial showing that finasteride reduces prostatic vascularity rapidly within 2 weeks. BJU International, 2005, 96(9): 1319-1322.
3.	Foley SJ, Soloman LZ, Wedderburn AW, et al. A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride.[see comment]. J Urol, 2000, 163(2): 496-498.
4.	陈向新, 尹杰, 麦能斌, 等. 非那雄胺在经尿道前列腺电切术后镜下血尿阴转中的作用. 新医学, 2003, 34(11): 679-680.
5.	张鲜利, 崔敏. 依立雄胺片. 中国新药杂志, 2001, 10(1): 64.
6.	薛兆英, 韩文科, 金杰, 等. 爱普列特治疗良性前列腺增生Ⅱ期临床研究. 中国临床药理学杂志, 2000, 16(6): 432-435.
7.	Puchner PJ, Miller MI. The effects of finasteride on hematuria associated with benign prostatic hyperplasia: a preliminary report. J Urol, 1995, 154(5): 1779-1782.
8.	Franck-Lissbrant I, Haggstrom S, Damber JE, et al. Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology, 1998, 139(2): 451-456.
9.	邓华, 魏强, 李涛, 等. 术前使用依立雄胺对经尿道前列腺切除术中出血的预防作用. 中国循证医学杂志, 2007, 7(6): 415-419.

1. 刘孝东, 杨宇如, 卢一平, 等. 非那雄胺减少TURP术中出血的机理研究. 中华泌尿外科杂志. 2003, 24(10): 694-696.
2. Donohue JF, Hayne D, Karnik U, et al. Randomized, placebocontrolled trial showing that finasteride reduces prostatic vascularity rapidly within 2 weeks. BJU International, 2005, 96(9): 1319-1322.
3. Foley SJ, Soloman LZ, Wedderburn AW, et al. A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride.[see comment]. J Urol, 2000, 163(2): 496-498.
4. 陈向新, 尹杰, 麦能斌, 等. 非那雄胺在经尿道前列腺电切术后镜下血尿阴转中的作用. 新医学, 2003, 34(11): 679-680.
5. 张鲜利, 崔敏. 依立雄胺片. 中国新药杂志, 2001, 10(1): 64.
6. 薛兆英, 韩文科, 金杰, 等. 爱普列特治疗良性前列腺增生Ⅱ期临床研究. 中国临床药理学杂志, 2000, 16(6): 432-435.
7. Puchner PJ, Miller MI. The effects of finasteride on hematuria associated with benign prostatic hyperplasia: a preliminary report. J Urol, 1995, 154(5): 1779-1782.
8. Franck-Lissbrant I, Haggstrom S, Damber JE, et al. Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology, 1998, 139(2): 451-456.
9. 邓华, 魏强, 李涛, 等. 术前使用依立雄胺对经尿道前列腺切除术中出血的预防作用. 中国循证医学杂志, 2007, 7(6): 415-419.

Chinese Journal of Evidence-Based Medicine

Effect of Epristeride on Gross Hematuria Secondary to Transurethral Resection of Prostate

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