Objective To formulate an evidence-based treatment plan for a child patient with Asymptomatic Wolff-Parkinson-White (WPW) Syndrome.
Methods Based on the clinical problems whether the patients with asymptomatic WPW syndrome need prevent catheter ablation or not, we used “asymptomatic WPW syndrome” as the keywords and searched The Cochrane Library (Issue 3, 2007), MEDLINE (1981 to 2007), ACP Journal Club (1991 to 2007), BMJ Clinical Evidence (1999 to 2007) and NGC (1998 to 2007) for systematic reviews, randomized controlled trials (RCTs), controlled clinical trials and treatment guidelines. The methodological quality of the included studies was assessed to identify the current best evidence.
Results Two RCTs were retrieved in MEDLINE. The results showed arrhythmic events increased significantly in the high-risk control group than those in the ablation group, and in the patients with multi-pathways than those with only one pathway. Based on the current evidence, integrated with clinical expertise and the patients’ values, the patients underwent electrophysiologic test and the result showed the dominance pathway in the right side and the concealed accessory pathway in the left side. Then prevent catheter ablation was performed, and no cardiovascular complications occurred in the following 12 months, which confirmed that the plan was proved optimal.
Conclusion The findings of this study should reassure physicians and parents alike that in the children with the WPW syndrome who are at high risk for arrhythmias, ablation is an appropriate option.
Citation：
ZHANG Yan,YANG Bo,LIANG Jinjun,WAN Jun,TANG Yanhong,WU Gang,CAO Feng,JIANG Hong,HUANG Congxin. Evidence-Based Treatment for a Child with Asymptomatic
Wolff-Parkinson-White Syndrome. Chinese Journal of Evidence-Based Medicine, 2009, 09(2): 243-245. doi: 10.7507/1672-2531.20090047
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
| 1. |
Pappone C, Santielli V. Should catheter ablation be performed in asymptomatic patients with Wolff-Parkinson-White syndrome? Catheter ablation should be performed in asymptomatic patients with Wolff-Parkinson-White syndrome. Circulation, 2005, 112(14): 2207-2215.
|
| 2. |
Triedman J, Perry J, Van Hare G. Risk stratification for prophylactic in asymptomatic Wolff-Parkinson-White syndrome. N Engl J Med, 2005, 352(1): 92-93.
|
| 3. |
Niksch AL, Dubin AM. Risk stratification in the asymptomatic child with Wolff-Parkinson-White syndrome. Curr Opin Cardiol, 2006, 21(3): 205-207.
|
| 4. |
Pappone C, Santinelli V, Manguso F, et al. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome. N Engl J Med, 2003, 349(19): 1803-1811.
|
| 5. |
Pappone C, Manguso F, Santinelli R, et al. Radiofrequency ablation in children with asymptomatic Wolff-Parkinson–White syndrome. N Engl J Med, 2004, 351(12): 1197-1205.
|
| 6. |
Campbell RM, StrieperMJ, Frias PA, et al. Survey of current practice of pediatric electrophysiologists for asymptomatic Wolff -Parkinson - White syndrome. Pediatrics, 2003, 111:245–247.
|
| 7. |
Inoue K, Igarashi H, Fukushige J, et al. Long-term prospective study on the natural history of Wolff - Parkinson - white syndrome detected during a heart screening program at school. Acta Paediatr, 2000, 89(5): 542–545.
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- 1. Pappone C, Santielli V. Should catheter ablation be performed in asymptomatic patients with Wolff-Parkinson-White syndrome? Catheter ablation should be performed in asymptomatic patients with Wolff-Parkinson-White syndrome. Circulation, 2005, 112(14): 2207-2215.
- 2. Triedman J, Perry J, Van Hare G. Risk stratification for prophylactic in asymptomatic Wolff-Parkinson-White syndrome. N Engl J Med, 2005, 352(1): 92-93.
- 3. Niksch AL, Dubin AM. Risk stratification in the asymptomatic child with Wolff-Parkinson-White syndrome. Curr Opin Cardiol, 2006, 21(3): 205-207.
- 4. Pappone C, Santinelli V, Manguso F, et al. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome. N Engl J Med, 2003, 349(19): 1803-1811.
- 5. Pappone C, Manguso F, Santinelli R, et al. Radiofrequency ablation in children with asymptomatic Wolff-Parkinson–White syndrome. N Engl J Med, 2004, 351(12): 1197-1205.
- 6. Campbell RM, StrieperMJ, Frias PA, et al. Survey of current practice of pediatric electrophysiologists for asymptomatic Wolff -Parkinson - White syndrome. Pediatrics, 2003, 111:245–247.
- 7. Inoue K, Igarashi H, Fukushige J, et al. Long-term prospective study on the natural history of Wolff - Parkinson - white syndrome detected during a heart screening program at school. Acta Paediatr, 2000, 89(5): 542–545.
Journal type citation(1)
| 1. | 王旭，谢文鹏，张永奎. 铁死亡调控机制在骨肉瘤中的研究进展. 河北医药. 2024(23): 3637-3642 .  Baidu Scholar | |
Other types of references(3)
| 1. | 杨文笑. 养阴解毒方激活转录因子EGR1诱导肺癌细胞凋亡的分子机制研究[D]. 上海中医药大学. 2019. Baidu Scholar | |
| 2. | 陈伟妍. 基于PI3K/AKT/mTOR信号通路探讨熊果酸诱导胃癌细胞凋亡及自噬性死亡的机制研究[D]. 辽宁中医药大学. 2021. Baidu Scholar | |
| 3. | 曹宪姣. 熊果酸通过CAFs抑制甲状腺乳头状癌细胞的增殖、迁移和侵袭的研究[D]. 山东中医药大学. 2021. Baidu Scholar | |
