Association between Plasma Homocysteine Level and the Prevalence of Coronary Heart Disease: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

SU Jian , LU Yiping ,  FENG Ercui , GAO Suqin , LIU Yanqing , WEI Shimin , LIU Qizhan

Public Health School, Nanjing Medical University, Nanjing 210029, China;

Corresponding author：

FENG Ercui, Email: ercuifeng@163.com

Keywords：

Plasma homocysteine; Coronary heart disease; Meta-analysis

DOI：

10.7507/1672-2531.20090152

Video：

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Objective 　To evaluate the association between coronary heart disease (CHD) and plasma homocysteine level, and to provide additional information for prevention and management of CHD.
Methods 　We searched CBM, CNKI, WanFang, and VIP databases. Case-control studies about the association between CHD and plasma homocysteine level published in China were identified. Meta-analysis was performed using RevMan 4.2 software.
Results 　The result of meta-analysis showed the plasma homocysteine level in the CHD group was higher than that of the control group (WMD=4.88, 95%CI 4.40 to 5.35, P lt;0.000 01), and the loss of safety coefficient was 1 339.
Conclusion 　High plasma homocysteine level is associated with increasing morbidity of CHD.

Citation： SU Jian,LU Yiping,FENG Ercui,GAO Suqin,LIU Yanqing,WEI Shimin,LIU Qizhan. Association between Plasma Homocysteine Level and the Prevalence of Coronary Heart Disease: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2009, 09(8): 862-865. doi: 10.7507/1672-2531.20090152 Copy

1.	薛莉, 陈树兰, 贾绍斌, 等. 同型半胱氨酸与冠心病的相关性及其机制探讨. 中华心血管病杂志, 2002, 30(9): 520-524.
2.	惠汝太. 炎症反应与动动脉粥样硬化及急性冠状动脉综合征. 中国循环杂志, 2000, 15: 259-260.
3.	曹国良, 乔永芳, 俞建华, 等. 轻中度高血压及合并冠心病患者血HCY与颈动脉IMT的关系. 中国新医药杂志, 2003, 2(8): 45.
4.	赵宁, 俞顺章. Meta-analysis: 一种新的定量综合方法. 中国慢性病预防与控制, 1993, 1(6): 277-281.
5.	the Joint International Society and Federation of Cardiology/World Health Organization. Nomenclature and criteria for diagnosis of ischemic heart disease. Circulation, 1979, 59: 607-609.
6.	鄢盛恺, 宋耀虹, 张春玲, 等. 荧光偏振免疫法检测血浆同型半胱氨酸水平的临床评价. 中华检验医学杂志, 2001, 24(1): 12-15.
7.	方理刚, 朱文玲, 朱广瑾, 等. 亚甲基四氢叶酸还原酶基因多态性及血中同型半胱氨酸和叶酸水平与冠心病的关系. 中华心血管病杂志, 2002, 30(9): 515-519.
8.	马淑梅, 李晓东, 孙亚清, 等. 冠心病患者血浆同型半胱氨酸与氧化低密度脂蛋白水平测定及其关系的探讨. 中华医学全科杂志, 2003,2(1): 23-24.
9.	王战坤, 郑良荣, 王兴祥, 等. 同型半胱氨酸与冠状动脉病变的相关性. 中华急诊医学杂志, 2003, 12(l1): 752-754.
10.	范海荣, 何青, 孙福成, 等. 同型半胱氨酸水平与冠心病的关系. 中华老年心脑血管病杂志, 2004, 6(4): 223-225.
11.	刘传红, 王玉桥, 解青, 等. 冠心病患者血浆同型半胱氨酸水平的变化及护理干预的作用. 郑州大学学报, 2005, 40(4): 713-716.
12.	胡勉, 李怀军, 王勇杰. 高同型半胱氨酸血症与冠心病的关系. 滨州医学院学报, 2006, 29(2): 99-100.
13.	蔺瑞兰, 崔卫东. 冠心病患者同型半胱氨酸测定的临床意义. 海南医学, 2007, 18(12): 153-154.
14.	武玲, 孙广宏, 焦海燕, 等. 同型半胱氨酸与冠心病及传统危险因素的关系探讨. 宁夏医学院学报, 2008, 30(1): 19-22.
15.	Boushey CJ, Beresford SA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk fact or for vascular disease. Probable benefits of increasing folic acid intakes. JAMA, 1995, 274: 1049-1057.
16.	Refsum H, Ueland PM, Nygård O, et al. Homocysteine and cardiovascular disease. Annu Rev Med, 1998, 49: 31-62.
17.	Verhoef P, Kok FJ, Kruyssen DA, et al. Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol, 1997, 17(5): 989-995.
18.	Evans RW, Shaten BJ, Hempel JD, et al. Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. Arterioscler Thromb Vasc Biol, 1997, 17(10): 1947-1953.
19.	Verhoef P, Hennekens CH, Allen RH, et al. Plasma total homocysteine and risk of angina pectoris with subsequent coronary artery bypass surgery. Am J Cardiol, 1997, 79(6): 799-801.
20.	Ford ES, Smith SJ, Stroup DF, et al. Homocysteine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol, 2002, 31: 59-70.
21.	Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA, 2002, 288: 2015-2022.
22.	黄宇彬. 高同型半胱氨酸血症与冠心病关系的研究进展. 心血管病学进展, 2008, 29(1): 73-76.
23.	Faraci FM, Lentz SR. Hyperhomocysteinemia, Oxidative Stress, and Cerebral Vascular Dysfunction. Stroke, 2004, 35: 345-347.
24.	谢志娟, 谭小进. 同型半胱氨酸与冠心病相关性研究进展. 中国心血管病研究, 2007, 5(9): 701-704.
25.	Franken DG, Boers GH, Blom HJ, et al. Treatment of mild hyperhomocysteinemia in vascular disease patient. Arterioscler. Thromb. Vasc. Biol, 1994, 14(3): 465-470.

1. 薛莉, 陈树兰, 贾绍斌, 等. 同型半胱氨酸与冠心病的相关性及其机制探讨. 中华心血管病杂志, 2002, 30(9): 520-524.
2. 惠汝太. 炎症反应与动动脉粥样硬化及急性冠状动脉综合征. 中国循环杂志, 2000, 15: 259-260.
3. 曹国良, 乔永芳, 俞建华, 等. 轻中度高血压及合并冠心病患者血HCY与颈动脉IMT的关系. 中国新医药杂志, 2003, 2(8): 45.
4. 赵宁, 俞顺章. Meta-analysis: 一种新的定量综合方法. 中国慢性病预防与控制, 1993, 1(6): 277-281.
5. the Joint International Society and Federation of Cardiology/World Health Organization. Nomenclature and criteria for diagnosis of ischemic heart disease. Circulation, 1979, 59: 607-609.
6. 鄢盛恺, 宋耀虹, 张春玲, 等. 荧光偏振免疫法检测血浆同型半胱氨酸水平的临床评价. 中华检验医学杂志, 2001, 24(1): 12-15.
7. 方理刚, 朱文玲, 朱广瑾, 等. 亚甲基四氢叶酸还原酶基因多态性及血中同型半胱氨酸和叶酸水平与冠心病的关系. 中华心血管病杂志, 2002, 30(9): 515-519.
8. 马淑梅, 李晓东, 孙亚清, 等. 冠心病患者血浆同型半胱氨酸与氧化低密度脂蛋白水平测定及其关系的探讨. 中华医学全科杂志, 2003,2(1): 23-24.
9. 王战坤, 郑良荣, 王兴祥, 等. 同型半胱氨酸与冠状动脉病变的相关性. 中华急诊医学杂志, 2003, 12(l1): 752-754.
10. 范海荣, 何青, 孙福成, 等. 同型半胱氨酸水平与冠心病的关系. 中华老年心脑血管病杂志, 2004, 6(4): 223-225.
11. 刘传红, 王玉桥, 解青, 等. 冠心病患者血浆同型半胱氨酸水平的变化及护理干预的作用. 郑州大学学报, 2005, 40(4): 713-716.
12. 胡勉, 李怀军, 王勇杰. 高同型半胱氨酸血症与冠心病的关系. 滨州医学院学报, 2006, 29(2): 99-100.
13. 蔺瑞兰, 崔卫东. 冠心病患者同型半胱氨酸测定的临床意义. 海南医学, 2007, 18(12): 153-154.
14. 武玲, 孙广宏, 焦海燕, 等. 同型半胱氨酸与冠心病及传统危险因素的关系探讨. 宁夏医学院学报, 2008, 30(1): 19-22.
15. Boushey CJ, Beresford SA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk fact or for vascular disease. Probable benefits of increasing folic acid intakes. JAMA, 1995, 274: 1049-1057.
16. Refsum H, Ueland PM, Nygård O, et al. Homocysteine and cardiovascular disease. Annu Rev Med, 1998, 49: 31-62.
17. Verhoef P, Kok FJ, Kruyssen DA, et al. Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol, 1997, 17(5): 989-995.
18. Evans RW, Shaten BJ, Hempel JD, et al. Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. Arterioscler Thromb Vasc Biol, 1997, 17(10): 1947-1953.
19. Verhoef P, Hennekens CH, Allen RH, et al. Plasma total homocysteine and risk of angina pectoris with subsequent coronary artery bypass surgery. Am J Cardiol, 1997, 79(6): 799-801.
20. Ford ES, Smith SJ, Stroup DF, et al. Homocysteine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol, 2002, 31: 59-70.
21. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA, 2002, 288: 2015-2022.
22. 黄宇彬. 高同型半胱氨酸血症与冠心病关系的研究进展. 心血管病学进展, 2008, 29(1): 73-76.
23. Faraci FM, Lentz SR. Hyperhomocysteinemia, Oxidative Stress, and Cerebral Vascular Dysfunction. Stroke, 2004, 35: 345-347.
24. 谢志娟, 谭小进. 同型半胱氨酸与冠心病相关性研究进展. 中国心血管病研究, 2007, 5(9): 701-704.
25. Franken DG, Boers GH, Blom HJ, et al. Treatment of mild hyperhomocysteinemia in vascular disease patient. Arterioscler. Thromb. Vasc. Biol, 1994, 14(3): 465-470.

Chinese Journal of Evidence-Based Medicine

Association between Plasma Homocysteine Level and the Prevalence of Coronary Heart Disease: A Meta-analysis

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